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Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells.

Molecular metabolism

Engelstoft MS, Park WM, Sakata I, Kristensen LV, Husted AS, Osborne-Lawrence S, Piper PK, Walker AK, Pedersen MH, Nøhr MK, Pan J, Sinz CJ, Carrington PE, Akiyama TE, Jones RM, Tang C, Ahmed K, Offermanns S, Egerod KL, Zigman JM, Schwartz TW.
PMID: 24327954
Mol Metab. 2013 Sep 04;2(4):376-92. doi: 10.1016/j.molmet.2013.08.006. eCollection 2013.

The molecular mechanisms regulating secretion of the orexigenic-glucoregulatory hormone ghrelin remain unclear. Based on qPCR analysis of FACS-purified gastric ghrelin cells, highly expressed and enriched 7TM receptors were comprehensively identified and functionally characterized using in vitro, ex vivo and...

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Engelstoft MS, Park WM, Sakata I, et al. Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. Mol Metab. 2013;2(4):376-92doi: 10.1016/j.molmet.2013.08.006.
Engelstoft, M. S., Park, W. M., Sakata, I., Kristensen, L. V., Husted, A. S., Osborne-Lawrence, S., Piper, P. K., Walker, A. K., Pedersen, M. H., Nøhr, M. K., Pan, J., Sinz, C. J., Carrington, P. E., Akiyama, T. E., Jones, R. M., Tang, C., Ahmed, K., Offermanns, S., Egerod, K. L., Zigman, J. M., & Schwartz, T. W. (2013). Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. Molecular metabolism, 2(4), 376-92. https://doi.org/10.1016/j.molmet.2013.08.006
Engelstoft, Maja S, et al. "Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells." Molecular metabolism vol. 2,4 (2013): 376-92. doi: https://doi.org/10.1016/j.molmet.2013.08.006
Engelstoft MS, Park WM, Sakata I, Kristensen LV, Husted AS, Osborne-Lawrence S, Piper PK, Walker AK, Pedersen MH, Nøhr MK, Pan J, Sinz CJ, Carrington PE, Akiyama TE, Jones RM, Tang C, Ahmed K, Offermanns S, Egerod KL, Zigman JM, Schwartz TW. Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. Mol Metab. 2013 Sep 04;2(4):376-92. doi: 10.1016/j.molmet.2013.08.006. eCollection 2013. PMID: 24327954; PMCID: PMC3854997.
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Proton- and ammonium-sensing by histaminergic neurons controlling wakefulness.

Frontiers in systems neuroscience

Yanovsky Y, Zigman JM, Kernder A, Bein A, Sakata I, Osborne-Lawrence S, Haas HL, Sergeeva OA.
PMID: 22509157
Front Syst Neurosci. 2012 Apr 13;6:23. doi: 10.3389/fnsys.2012.00023. eCollection 2012.

The histaminergic neurons in the tuberomamillary nucleus (TMN) of the posterior hypothalamus are involved in the control of arousal. These neurons are sensitive to hypercapnia as has been shown in experiments examining c-Fos expression, a marker for increased neuronal...

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Yanovsky Y, Zigman JM, Kernder A, et al. Proton- and ammonium-sensing by histaminergic neurons controlling wakefulness. Front Syst Neurosci. 2012;6:23doi: 10.3389/fnsys.2012.00023.
Yanovsky, Y., Zigman, J. M., Kernder, A., Bein, A., Sakata, I., Osborne-Lawrence, S., Haas, H. L., & Sergeeva, O. A. (2012). Proton- and ammonium-sensing by histaminergic neurons controlling wakefulness. Frontiers in systems neuroscience, 623. https://doi.org/10.3389/fnsys.2012.00023
Yanovsky, Yevgenij, et al. "Proton- and ammonium-sensing by histaminergic neurons controlling wakefulness." Frontiers in systems neuroscience vol. 6 (2012): 23. doi: https://doi.org/10.3389/fnsys.2012.00023
Yanovsky Y, Zigman JM, Kernder A, Bein A, Sakata I, Osborne-Lawrence S, Haas HL, Sergeeva OA. Proton- and ammonium-sensing by histaminergic neurons controlling wakefulness. Front Syst Neurosci. 2012 Apr 13;6:23. doi: 10.3389/fnsys.2012.00023. eCollection 2012. PMID: 22509157; PMCID: PMC3325548.
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LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue.

Molecular metabolism

Shankar K, Metzger NP, Singh O, Mani BK, Osborne-Lawrence S, Varshney S, Gupta D, Ogden SB, Takemi S, Richard CP, Nandy K, Liu C, Zigman JM.
PMID: 34428557
Mol Metab. 2021 Nov;53:101327. doi: 10.1016/j.molmet.2021.101327. Epub 2021 Aug 21.

OBJECTIVE: The hormone liver-expressed antimicrobial peptide-2 (LEAP2) is a recently identified antagonist and an inverse agonist of the growth hormone secretagogue receptor (GHSR). GHSR's other well-known endogenous ligand, acyl-ghrelin, increases food intake, body weight, and GH secretion and is...

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Shankar K, Metzger NP, Singh O, et al. LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue. Mol Metab. 2021;53:101327doi: 10.1016/j.molmet.2021.101327.
Shankar, K., Metzger, N. P., Singh, O., Mani, B. K., Osborne-Lawrence, S., Varshney, S., Gupta, D., Ogden, S. B., Takemi, S., Richard, C. P., Nandy, K., Liu, C., & Zigman, J. M. (2021). LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue. Molecular metabolism, 53101327. https://doi.org/10.1016/j.molmet.2021.101327
Shankar, Kripa, et al. "LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue." Molecular metabolism vol. 53 (2021): 101327. doi: https://doi.org/10.1016/j.molmet.2021.101327
Shankar K, Metzger NP, Singh O, Mani BK, Osborne-Lawrence S, Varshney S, Gupta D, Ogden SB, Takemi S, Richard CP, Nandy K, Liu C, Zigman JM. LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue. Mol Metab. 2021 Nov;53:101327. doi: 10.1016/j.molmet.2021.101327. Epub 2021 Aug 21. PMID: 34428557; PMCID: PMC8452786.
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High Coexpression of the Ghrelin and LEAP2 Receptor GHSR With Pancreatic Polypeptide in Mouse and Human Islets.

Endocrinology

Gupta D, Dowsett GKC, Mani BK, Shankar K, Osborne-Lawrence S, Metzger NP, Lam BYH, Yeo GSH, Zigman JM.
PMID: 34289060
Endocrinology. 2021 Oct 01;162(10). doi: 10.1210/endocr/bqab148.

Islets represent an important site of direct action of the hormone ghrelin, with expression of the ghrelin receptor (growth hormone secretagogue receptor; GHSR) having been localized variably to alpha cells, beta cells, and/or somatostatin (SST)-secreting delta cells. To our...

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Gupta D, Dowsett GKC, Mani BK, et al. High Coexpression of the Ghrelin and LEAP2 Receptor GHSR With Pancreatic Polypeptide in Mouse and Human Islets. Endocrinology. 2021;162(10)doi: 10.1210/endocr/bqab148.
Gupta, D., Dowsett, G. K. C., Mani, B. K., Shankar, K., Osborne-Lawrence, S., Metzger, N. P., Lam, B. Y. H., Yeo, G. S. H., & Zigman, J. M. (2021). High Coexpression of the Ghrelin and LEAP2 Receptor GHSR With Pancreatic Polypeptide in Mouse and Human Islets. Endocrinology, 162(10), . https://doi.org/10.1210/endocr/bqab148
Gupta, Deepali, et al. "High Coexpression of the Ghrelin and LEAP2 Receptor GHSR With Pancreatic Polypeptide in Mouse and Human Islets." Endocrinology vol. 162,10 (2021). doi: https://doi.org/10.1210/endocr/bqab148
Gupta D, Dowsett GKC, Mani BK, Shankar K, Osborne-Lawrence S, Metzger NP, Lam BYH, Yeo GSH, Zigman JM. High Coexpression of the Ghrelin and LEAP2 Receptor GHSR With Pancreatic Polypeptide in Mouse and Human Islets. Endocrinology. 2021 Oct 01;162(10). doi: 10.1210/endocr/bqab148. PMID: 34289060; PMCID: PMC8379901.
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Evaluation of Spring Wheat Germplasm for Resistance to Bacterial Leaf Streak Caused by Xanthomonas campestris pv. translucens.

Plant disease

Kandel YR, Glover KD, Tande CA, Osborne LE.
PMID: 30727254
Plant Dis. 2012 Dec;96(12):1743-1748. doi: 10.1094/PDIS-03-12-0303-RE.

Bacterial leaf streak (caused by Xanthomonas campestris pv. translucens) has reemerged as a potential threat in spring wheat (Triticum aestivum) production areas in the northern Great Plains. As with other foliar bacterial diseases, chemical control under field situations is...

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Kandel YR, Glover KD, Tande CA, et al. Evaluation of Spring Wheat Germplasm for Resistance to Bacterial Leaf Streak Caused by Xanthomonas campestris pv. translucens. Plant Dis. 2012;96(12):1743-1748doi: 10.1094/PDIS-03-12-0303-RE.
Kandel, Y. R., Glover, K. D., Tande, C. A., & Osborne, L. E. (2012). Evaluation of Spring Wheat Germplasm for Resistance to Bacterial Leaf Streak Caused by Xanthomonas campestris pv. translucens. Plant disease, 96(12), 1743-1748. https://doi.org/10.1094/PDIS-03-12-0303-RE
Kandel, Yuba R, et al. "Evaluation of Spring Wheat Germplasm for Resistance to Bacterial Leaf Streak Caused by Xanthomonas campestris pv. translucens." Plant disease vol. 96,12 (2012): 1743-1748. doi: https://doi.org/10.1094/PDIS-03-12-0303-RE
Kandel YR, Glover KD, Tande CA, Osborne LE. Evaluation of Spring Wheat Germplasm for Resistance to Bacterial Leaf Streak Caused by Xanthomonas campestris pv. translucens. Plant Dis. 2012 Dec;96(12):1743-1748. doi: 10.1094/PDIS-03-12-0303-RE. PMID: 30727254.
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Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin.

Molecular metabolism

Wang Q, Liu C, Uchida A, Chuang JC, Walker A, Liu T, Osborne-Lawrence S, Mason BL, Mosher C, Berglund ED, Elmquist JK, Zigman JM.
PMID: 24567905
Mol Metab. 2013 Oct 17;3(1):64-72. doi: 10.1016/j.molmet.2013.10.001. eCollection 2014 Feb.

The hormone ghrelin stimulates eating and helps maintain blood glucose upon caloric restriction. While previous studies have demonstrated that hypothalamic arcuate AgRP neurons are targets of ghrelin, the overall relevance of ghrelin signaling within intact AgRP neurons is unclear....

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Wang Q, Liu C, Uchida A, et al. Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin. Mol Metab. 2013;3(1):64-72doi: 10.1016/j.molmet.2013.10.001.
Wang, Q., Liu, C., Uchida, A., Chuang, J. C., Walker, A., Liu, T., Osborne-Lawrence, S., Mason, B. L., Mosher, C., Berglund, E. D., Elmquist, J. K., & Zigman, J. M. (2014). Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin. Molecular metabolism, 3(1), 64-72. https://doi.org/10.1016/j.molmet.2013.10.001
Wang, Qian, et al. "Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin." Molecular metabolism vol. 3,1 (2014): 64-72. doi: https://doi.org/10.1016/j.molmet.2013.10.001
Wang Q, Liu C, Uchida A, Chuang JC, Walker A, Liu T, Osborne-Lawrence S, Mason BL, Mosher C, Berglund ED, Elmquist JK, Zigman JM. Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin. Mol Metab. 2013 Oct 17;3(1):64-72. doi: 10.1016/j.molmet.2013.10.001. eCollection 2014 Feb. PMID: 24567905; PMCID: PMC3929914.
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Ghrelin cell-expressed insulin receptors mediate meal- and obesity-induced declines in plasma ghrelin.

JCI insight

Shankar K, Takemi S, Gupta D, Varshney S, Mani BK, Osborne-Lawrence S, Metzger NP, Richard CP, Berglund ED, Zigman JM.
PMID: 34473648
JCI Insight. 2021 Sep 02;6(18). doi: 10.1172/jci.insight.146983.

Mechanisms underlying postprandial and obesity-associated plasma ghrelin reductions are incompletely understood. Here, using ghrelin cell-selective insulin receptor-KO (GhIRKO) mice, we tested the impact of insulin, acting via ghrelin cell-expressed insulin receptors (IRs), to suppress ghrelin secretion. Insulin reduced ghrelin...

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Shankar K, Takemi S, Gupta D, et al. Ghrelin cell-expressed insulin receptors mediate meal- and obesity-induced declines in plasma ghrelin. JCI Insight. 2021;6(18)doi: 10.1172/jci.insight.146983.
Shankar, K., Takemi, S., Gupta, D., Varshney, S., Mani, B. K., Osborne-Lawrence, S., Metzger, N. P., Richard, C. P., Berglund, E. D., & Zigman, J. M. (2021). Ghrelin cell-expressed insulin receptors mediate meal- and obesity-induced declines in plasma ghrelin. JCI insight, 6(18), . https://doi.org/10.1172/jci.insight.146983
Shankar, Kripa, et al. "Ghrelin cell-expressed insulin receptors mediate meal- and obesity-induced declines in plasma ghrelin." JCI insight vol. 6,18 (2021). doi: https://doi.org/10.1172/jci.insight.146983
Shankar K, Takemi S, Gupta D, Varshney S, Mani BK, Osborne-Lawrence S, Metzger NP, Richard CP, Berglund ED, Zigman JM. Ghrelin cell-expressed insulin receptors mediate meal- and obesity-induced declines in plasma ghrelin. JCI Insight. 2021 Sep 02;6(18). doi: 10.1172/jci.insight.146983. PMID: 34473648; PMCID: PMC8492315.
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Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions.

Molecular metabolism

Gupta D, Patterson AM, Osborne-Lawrence S, Bookout AL, Varshney S, Shankar K, Singh O, Metzger NP, Richard CP, Wyler SC, Elmquist JK, Zigman JM.
PMID: 34023483
Mol Metab. 2021 Nov;53:101258. doi: 10.1016/j.molmet.2021.101258. Epub 2021 May 21.

OBJECTIVE: Acyl-ghrelin regulates eating, body weight, blood glucose, and GH secretion upon binding to its receptor GHSR (growth hormone secretagogue receptor; ghrelin receptor). GHSR is distributed in several brain regions and some peripheral cell-types including pituitary somatotrophs. The objective...

Cite
Gupta D, Patterson AM, Osborne-Lawrence S, et al. Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions. Mol Metab. 2021;53:101258doi: 10.1016/j.molmet.2021.101258.
Gupta, D., Patterson, A. M., Osborne-Lawrence, S., Bookout, A. L., Varshney, S., Shankar, K., Singh, O., Metzger, N. P., Richard, C. P., Wyler, S. C., Elmquist, J. K., & Zigman, J. M. (2021). Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions. Molecular metabolism, 53101258. https://doi.org/10.1016/j.molmet.2021.101258
Gupta, Deepali, et al. "Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions." Molecular metabolism vol. 53 (2021): 101258. doi: https://doi.org/10.1016/j.molmet.2021.101258
Gupta D, Patterson AM, Osborne-Lawrence S, Bookout AL, Varshney S, Shankar K, Singh O, Metzger NP, Richard CP, Wyler SC, Elmquist JK, Zigman JM. Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions. Mol Metab. 2021 Nov;53:101258. doi: 10.1016/j.molmet.2021.101258. Epub 2021 May 21. PMID: 34023483; PMCID: PMC8203846.
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Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions.

Molecular metabolism

Gupta D, Patterson AM, Osborne-Lawrence S, Bookout AL, Varshney S, Shankar K, Singh O, Metzger NP, Richard CP, Wyler SC, Elmquist JK, Zigman JM.
PMID: 34023483
Mol Metab. 2021 Nov;53:101258. doi: 10.1016/j.molmet.2021.101258. Epub 2021 May 21.

OBJECTIVE: Acyl-ghrelin regulates eating, body weight, blood glucose, and GH secretion upon binding to its receptor GHSR (growth hormone secretagogue receptor; ghrelin receptor). GHSR is distributed in several brain regions and some peripheral cell-types including pituitary somatotrophs. The objective...

Cite
Gupta D, Patterson AM, Osborne-Lawrence S, et al. Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions. Mol Metab. 2021;53:101258doi: 10.1016/j.molmet.2021.101258.
Gupta, D., Patterson, A. M., Osborne-Lawrence, S., Bookout, A. L., Varshney, S., Shankar, K., Singh, O., Metzger, N. P., Richard, C. P., Wyler, S. C., Elmquist, J. K., & Zigman, J. M. (2021). Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions. Molecular metabolism, 53101258. https://doi.org/10.1016/j.molmet.2021.101258
Gupta, Deepali, et al. "Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions." Molecular metabolism vol. 53 (2021): 101258. doi: https://doi.org/10.1016/j.molmet.2021.101258
Gupta D, Patterson AM, Osborne-Lawrence S, Bookout AL, Varshney S, Shankar K, Singh O, Metzger NP, Richard CP, Wyler SC, Elmquist JK, Zigman JM. Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions. Mol Metab. 2021 Nov;53:101258. doi: 10.1016/j.molmet.2021.101258. Epub 2021 May 21. PMID: 34023483; PMCID: PMC8203846.
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LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue.

Molecular metabolism

Shankar K, Metzger NP, Singh O, Mani BK, Osborne-Lawrence S, Varshney S, Gupta D, Ogden SB, Takemi S, Richard CP, Nandy K, Liu C, Zigman JM.
PMID: 34428557
Mol Metab. 2021 Nov;53:101327. doi: 10.1016/j.molmet.2021.101327. Epub 2021 Aug 21.

OBJECTIVE: The hormone liver-expressed antimicrobial peptide-2 (LEAP2) is a recently identified antagonist and an inverse agonist of the growth hormone secretagogue receptor (GHSR). GHSR's other well-known endogenous ligand, acyl-ghrelin, increases food intake, body weight, and GH secretion and is...

Cite
Shankar K, Metzger NP, Singh O, et al. LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue. Mol Metab. 2021;53:101327doi: 10.1016/j.molmet.2021.101327.
Shankar, K., Metzger, N. P., Singh, O., Mani, B. K., Osborne-Lawrence, S., Varshney, S., Gupta, D., Ogden, S. B., Takemi, S., Richard, C. P., Nandy, K., Liu, C., & Zigman, J. M. (2021). LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue. Molecular metabolism, 53101327. https://doi.org/10.1016/j.molmet.2021.101327
Shankar, Kripa, et al. "LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue." Molecular metabolism vol. 53 (2021): 101327. doi: https://doi.org/10.1016/j.molmet.2021.101327
Shankar K, Metzger NP, Singh O, Mani BK, Osborne-Lawrence S, Varshney S, Gupta D, Ogden SB, Takemi S, Richard CP, Nandy K, Liu C, Zigman JM. LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue. Mol Metab. 2021 Nov;53:101327. doi: 10.1016/j.molmet.2021.101327. Epub 2021 Aug 21. PMID: 34428557; PMCID: PMC8452786.
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