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Showing 1 to 12 of 25 entries
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Post-operative radiation therapy.

Translational lung cancer research

Paumier A, Le Péchoux C.
PMID: 25806262
Transl Lung Cancer Res. 2013 Oct;2(5):423-32. doi: 10.3978/j.issn.2218-6751.2013.10.03.

In completely resected non-small-cell lung cancer (NSCLC) patients with pathologically involved mediastinal lymph nodes (N2), administration of adjuvant platinum-based chemotherapy is now considered the standard of care, based on level 1 evidence. The role of post-operative radiotherapy (PORT) in...

Excimer laser use for microetching computer-generated holographic structures.

Applied optics

Vainos NA, Mailis S, Pissadakis S, Boutsikaris L, Parmiter PJ, Dainty P, Hall TJ.
PMID: 21127656
Appl Opt. 1996 Nov 10;35(32):6304-19. doi: 10.1364/AO.35.006304.

Excimer-laser microetching of a variety of materials is applied to the fabrication of surface-relief optical microstructures of arbitrary morphology, with particular emphasis on computer-generated holographic structures. High-definition, high-radiation-intensity selective laser ablative etching in conjunction with step-and-repeat (period) replication or...

An integrative knowledge graph for rare diseases, derived from the Genetic and Rare Diseases Information Center (GARD).

Journal of biomedical semantics

Zhu Q, Nguyen DT, Grishagin I, Southall N, Sid E, Pariser A.
PMID: 33183351
J Biomed Semantics. 2020 Nov 12;11(1):13. doi: 10.1186/s13326-020-00232-y.

BACKGROUND: The Genetic and Rare Diseases (GARD) Information Center was established by the National Institutes of Health (NIH) to provide freely accessible consumer health information on over 6500 genetic and rare diseases. As the cumulative scientific understanding and underlying...

Modelling inorganic solids and their interfaces: a combined approach of atomistic and electronic structure simulation techniques.

Faraday discussions

Parker SC, Kerisit S, Marmier A, Grigoleit S, Watson GW.
PMID: 14527215
Faraday Discuss. 2003;124:155-70; discussion 205-13, 453-5. doi: 10.1039/b211988a.

We are seeking to combine the reliability of the structures and energies obtained from quantum mechanical methods with the insights given by larger scale simulations, which are better able to search configurational space. We will discuss our recent work...

A framework for the investigation of rare genetic disorders in neuropsychiatry.

Nature medicine

Sanders SJ, Sahin M, Hostyk J, Thurm A, Jacquemont S, Avillach P, Douard E, Martin CL, Modi ME, Moreno-De-Luca A, Raznahan A, Anticevic A, Dolmetsch R, Feng G, Geschwind DH, Glahn DC, Goldstein DB, Ledbetter DH, Mulle JG, Pasca SP, Samaco R, Sebat J, Pariser A, Lehner T, Gur RE, Bearden CE.
PMID: 31548702
Nat Med. 2019 Oct;25(10):1477-1487. doi: 10.1038/s41591-019-0581-5. Epub 2019 Sep 23.

De novo and inherited rare genetic disorders (RGDs) are a major cause of human morbidity, frequently involving neuropsychiatric symptoms. Recent advances in genomic technologies and data sharing have revolutionized the identification and diagnosis of RGDs, presenting an opportunity to...

Surface structure of (10(-)10) and (11(-)20) surfaces of ZnO with density functional theory and atomistic simulation.

The journal of physical chemistry. B

Cooke DJ, Marmier A, Parker SC.
PMID: 16610898
J Phys Chem B. 2006 Apr 20;110(15):7985-91. doi: 10.1021/jp0564445.

We have calculated the stability of two of the low-index surfaces known to dominate the morphology of ZnO as a function of stoichiometry. These two surfaces are (10(-)10) and (11(-)20). In each case, two terminations only are stable for...

Postoperative radiotherapy versus no postoperative radiotherapy in patients with completely resected non-small-cell lung cancer and proven mediastinal N2 involvement (Lung ART): an open-label, randomised, phase 3 trial.

The Lancet. Oncology

Le Pechoux C, Pourel N, Barlesi F, Lerouge D, Antoni D, Lamezec B, Nestle U, Boisselier P, Dansin E, Paumier A, Peignaux K, Thillays F, Zalcman G, Madelaine J, Pichon E, Larrouy A, Lavole A, Argo-Leignel D, Derollez M, Faivre-Finn C, Hatton MQ, Riesterer O, Bouvier-Morel E, Dunant A, Edwards JG, Thomas PA, Mercier O, Bardet A.
PMID: 34919827
Lancet Oncol. 2021 Dec 14; doi: 10.1016/S1470-2045(21)00606-9. Epub 2021 Dec 14.

BACKGROUND: In patients with non-small-cell lung cancer (NSCLC), the use of postoperative radiotherapy (PORT) has been controversial since 1998, because of one meta-analysis showing a deleterious effect on survival in patients with pN0 and pN1, but with an unclear...

Scientific evidence based rare disease research discovery with research funding data in knowledge graph.

Orphanet journal of rare diseases

Zhu Q, Nguyễn ÐT, Sheils T, Alyea G, Sid E, Xu Y, Dickens J, Mathé EA, Pariser A.
PMID: 34794473
Orphanet J Rare Dis. 2021 Nov 18;16(1):483. doi: 10.1186/s13023-021-02120-9.

BACKGROUND: Limited knowledge and unclear underlying biology of many rare diseases pose significant challenges to patients, clinicians, and scientists. To address these challenges, there is an urgent need to inspire and encourage scientists to propose and pursue innovative research...

Lung stereotactic body radiation therapy: personalized PTV margins according to tumor location and number of four-dimensional CT scans.

Radiation oncology (London, England)

Trémolières P, Gonzalez-Moya A, Paumier A, Mege M, Blanchecotte J, Theotime C, Autret D, Dufreneix S.
PMID: 35012579
Radiat Oncol. 2022 Jan 10;17(1):5. doi: 10.1186/s13014-021-01973-5.

OBJECTIVES: To characterise the motion of pulmonary tumours during stereotactic body radiation therapy (SBRT) and to evaluate different margins when creating the planning target volume (PTV) on a single 4D CT scan (4DCT).METHODS: We conducted a retrospective single-site analysis...

One pot synthesis of nitrogen-containing polycyclic delta-lactones by double nucleophilic addition of bis(trimethylsilyl)ketene acetals to pyridines.

Chemical communications (Cambridge, England)

Rudler H, Denise B, Parlier A, Daran JC.
PMID: 12123058
Chem Commun (Camb). 2002 May 07;(9):940-1. doi: 10.1039/b201780f.

Pyridine and bis(TMS)ketene acetals (TMS = trimethylsilyl) react successively with methylchloroformate and iodine (or peracids) to give, via functionalized dihydropyridines, bicyclic nitrogen-containing lactones which have been characterized by X-ray crystallography.

Atomistic simulation of charged iron oxyhydroxide surfaces in contact with aqueous solution.

Chemical communications (Cambridge, England)

Kerisit S, Cooke DJ, Marmier A, Parker SC.
PMID: 15959573
Chem Commun (Camb). 2005 Jun 28;(24):3027-9. doi: 10.1039/b503899e. Epub 2005 May 13.

Molecular dynamics simulations of aqueous solution/goethite interfaces show that the classical models of the electrical double layer do not accurately describe the distribution of ions near the surface (such a distribution is present even when the surface is neutral)...

Flexibility in MOFs: do scalar and group-theoretical counting rules work?.

Dalton transactions (Cambridge, England : 2003)

Marmier A, Evans KE.
PMID: 26732663
Dalton Trans. 2016 Mar 14;45(10):4360-9. doi: 10.1039/c5dt03586d.

We investigate the ability of counting rules drafted from engineering to predict the flexibility or rigidity of bar-and-joint or body-and-joint assemblies representing metal organic frameworks. We show that while scalar counting rules are not reliable, group-theoretical approaches are able...

Showing 1 to 12 of 25 entries