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Showing 1 to 12 of 1157 entries
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HIV-1 Capsid Function Is Regulated by Dynamics: Quantitative Atomic-Resolution Insights by Integrating Magic-Angle-Spinning NMR, QM/MM, and MD.

Journal of the American Chemical Society

Zhang H, Hou G, Lu M, Ahn J, Byeon IL, Langmead CJ, Perilla JR, Hung I, Gor'kov PL, Gan Z, Brey WW, Case DA, Schulten K, Gronenborn AM, Polenova T.
PMID: 27701859
J Am Chem Soc. 2016 Oct 26;138(42):14066-14075. doi: 10.1021/jacs.6b08744. Epub 2016 Oct 18.

HIV-1 CA capsid protein possesses intrinsic conformational flexibility, which is essential for its assembly into conical capsids and interactions with host factors. CA is dynamic in the assembled capsid, and residues in functionally important regions of the protein undergo...

Auto-Rejection of Renal Donor-Origin Metastatic Melanoma.

Radiology case reports

Kriegshauser JS, Weidenfeld PL, Wochos DN, Williams JW.
PMID: 27298706
Radiol Case Rep. 2015 Dec 07;1(4):149-53. doi: 10.2484/rcr.v1i4.44. eCollection 2006.

We report a case of metastatic malignant melanoma discovered in a living related donor shortly after renal transplant and subsequently diagnosed in the recipient. The recipient hepatic metastases were followed with serial computed tomography (CT) during regression/rejection of tumor...

Reducing morbidity with surgical adhesives following inguinal lymph node dissections for the treatment of malignant skin tumors.

GMS Interdisciplinary plastic and reconstructive surgery DGPW

Stollwerck PL, Schlarb D, Münstermann N, Stenske S, Kruess C, Brodner G, Krapohl BD, Krause-Bergmann AF.
PMID: 26816671
GMS Interdiscip Plast Reconstr Surg DGPW. 2016 Jan 20;5:Doc05. doi: 10.3205/iprs000084. eCollection 2016.

BACKGROUND: Inguinal lymph node dissection (ILND) is associated with a high rate of morbidity. To evaluate the clinical benefit of surgical adhesives to reduce complications in patients undergoing ILND, we compared the use of TissuGlu(®) Surgical Adhesive and ARTISS(®)...

Changes in pain and concurrent pain medication use following compounded topical analgesic treatment for chronic pain: 3- and 6-month follow-up results from the prospective, observational Optimizing Patient Experience and Response to Topical Analgesics study.

Journal of pain research

Gudin JA, Brennan MJ, Harris ED, Hurwitz PL, Dietze DT, Strader JD.
PMID: 29042810
J Pain Res. 2017 Oct 03;10:2341-2354. doi: 10.2147/JPR.S143513. eCollection 2017.

BACKGROUND: Opioids and other controlled substances prescribed for chronic pain are associated with abuse, addiction, and death, prompting national initiatives to identify safe and effective pain management strategies including topical analgesics.METHODS: This prospective, observational study evaluated changes from baseline...

Screening of cancer tissue arrays identifies CXCR4 on adrenocortical carcinoma: correlates with expression and quantification on metastases using .

Oncotarget

Weiss ID, Huff LM, Evbuomwan MO, Xu X, Dang HD, Velez DS, Singh SP, Zhang HH, Gardina PJ, Lee JH, Lindenberg L, Myers TG, Paik CH, Schrump DS, Pittaluga S, Choyke PL, Fojo T, Farber JM.
PMID: 29088715
Oncotarget. 2017 Aug 04;8(43):73387-73406. doi: 10.18632/oncotarget.19945. eCollection 2017 Sep 26.

Expression of the chemokine receptor CXCR4 by many cancers correlates with aggressive clinical behavior. As part of the initial studies in a project whose goal was to quantify CXCR4 expression on cancers non-invasively, we examined CXCR4 expression in cancer...

Detection of prostate cancer in multiparametric MRI using random forest with instance weighting.

Journal of medical imaging (Bellingham, Wash.)

Lay N, Tsehay Y, Greer MD, Turkbey B, Kwak JT, Choyke PL, Pinto P, Wood BJ, Summers RM.
PMID: 28630883
J Med Imaging (Bellingham). 2017 Apr;4(2):024506. doi: 10.1117/1.JMI.4.2.024506. Epub 2017 Jun 12.

A prostate computer-aided diagnosis (CAD) based on random forest to detect prostate cancer using a combination of spatial, intensity, and texture features extracted from three sequences, T2W, ADC, and B2000 images, is proposed. The random forest training considers instance-level...

Safe Opioid Prescription: A SMART on FHIR Approach to Clinical Decision Support.

Online journal of public health informatics

Sinha S, Jensen M, Mullin S, Elkin PL.
PMID: 29026458
Online J Public Health Inform. 2017 Sep 08;9(2):e193. doi: 10.5210/ojphi.v9i2.8034. eCollection 2017.

No abstract available.

Erratum to: Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development.

Genome biology

Szabo L, Morey R, Palpant NJ, Wang PL, Afari N, Jiang C, Parast MM, Murry CE, Laurent LC, Salzman J.
PMID: 27993159
Genome Biol. 2016 Dec 19;17(1):263. doi: 10.1186/s13059-016-1123-9.

No abstract available.

Solid-binding peptides for immobilisation of thermostable enzymes to hydrolyse biomass polysaccharides.

Biotechnology for biofuels

Care A, Petroll K, Gibson ESY, Bergquist PL, Sunna A.
PMID: 28184244
Biotechnol Biofuels. 2017 Feb 02;10:29. doi: 10.1186/s13068-017-0715-2. eCollection 2017.

BACKGROUND: Solid-binding peptides (SBPs) bind strongly to a diverse range of solid materials without the need for any chemical reactions. They have been used mainly for the functionalisation of nanomaterials but little is known about their use for the...

On the Balance of Simplification and Reality in Molecular Modeling of the Electron Density.

Journal of chemical theory and computation

Warburton PL, Wang JL, Mezey PG.
PMID: 26620169
J Chem Theory Comput. 2008 Oct 14;4(10):1627-36. doi: 10.1021/ct800268c.

Fused-sphere (van der Waals) surfaces and their variants such as solvent accessible surfaces and molecular surfaces are simple molecular models that are commonly used for many diverse purposes across a broad range of scientific disciplines due to their low...

Roles of gap junctions, connexins, and pannexins in epilepsy.

Frontiers in physiology

Mylvaganam S, Ramani M, Krawczyk M, Carlen PL.
PMID: 24847276
Front Physiol. 2014 May 07;5:172. doi: 10.3389/fphys.2014.00172. eCollection 2014.

Enhanced gap junctional communication (GJC) between neurons is considered a major factor underlying the neuronal synchrony driving seizure activity. In addition, the hippocampal sharp wave ripple complexes, associated with learning and seizures, are diminished by GJC blocking agents. Although...

Cancer-Associated Venous Thromboembolism: A Practical Review Beyond Low-Molecular-Weight Heparins.

Frontiers in medicine

Smrke A, Gross PL.
PMID: 28894738
Front Med (Lausanne). 2017 Aug 28;4:142. doi: 10.3389/fmed.2017.00142. eCollection 2017.

Patients with cancer are at significantly higher risk of developing, and dying from, venous thromboembolism (VTE). The CLOT trial demonstrated superiority of low-molecular-weight heparins (LMWH) over warfarin for recurrent VTE and established LMWH as the standard of care for...

Showing 1 to 12 of 1157 entries