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Showing 1 to 12 of 26 entries
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Neuronal Transdifferentiation Potential of Human Mesenchymal Stem Cells from Neonatal and Adult Sources by a Small Molecule Cocktail.

Stem cells international

Cortés-Medina LV, Pasantes-Morales H, Aguilera-Castrejon A, Picones A, Lara-Figueroa CO, Luis E, Montesinos JJ, Cortés-Morales VA, De la Rosa Ruiz MP, Hernández-Estévez E, Bonifaz LC, Alvarez-Perez MA, Ramos-Mandujano G.
PMID: 31065279
Stem Cells Int. 2019 Apr 01;2019:7627148. doi: 10.1155/2019/7627148. eCollection 2019.

Human mesenchymal stem cells (MSCs) are good candidates for brain cell replacement strategies and have already been used as adjuvant treatments in neurological disorders. MSCs can be obtained from many different sources, and the present study compares the potential...

Increasing market opportunities for renewable energy technologies with innovations in aquifer thermal energy storage.

The Science of the total environment

Hoekstra N, Pellegrini M, Bloemendal M, Spaak G, Andreu Gallego A, Rodriguez Comins J, Grotenhuis T, Picone S, Murrell AJ, Steeman HJ, Verrone A, Doornenbal P, Christophersen M, Bennedsen L, Henssen M, Moinier S, Saccani C.
PMID: 31905556
Sci Total Environ. 2020 Mar 20;709:136142. doi: 10.1016/j.scitotenv.2019.136142. Epub 2019 Dec 17.

Heating and cooling using aquifer thermal energy storage (ATES) has hardly been applied outside the Netherlands, even though it could make a valuable contribution to the energy transition. The Climate-KIC project "Europe-wide Use of Energy from aquifers" - E-USE(aq)...

Convergences and divergences of thymus- and peripherally derived regulatory T cells in cancer.

Frontiers in immunology

Burocchi A, Colombo MP, Piconese S.
PMID: 23986759
Front Immunol. 2013 Aug 27;4:247. doi: 10.3389/fimmu.2013.00247. eCollection 2013.

The expansion of regulatory T cells (Treg) is a common event characterizing the vast majority of human and experimental tumors and it is now well established that Treg represent a crucial hurdle for a successful immunotherapy. Treg are currently...

Leukemia cutis in an infant with congenital leukemia and tetralogy of fallot.

Journal of clinical neonatology

Picone S, Aufieri R, Bressan K, Paolillo P.
PMID: 25024984
J Clin Neonatol. 2014 Apr;3(2):122-3. doi: 10.4103/2249-4847.134715.

Congenital leukemia is a very rare severe condition and leukemia cutis may represent the presenting sign of this malignancy, sometimes preceding hematological findings of weeks. Typical clinical features include multiple red to purple papules, macules and nodules due to...

ISG15 protects human Tregs from interferon alpha-induced contraction in a cell-intrinsic fashion.

Clinical & translational immunology

Pacella I, Spinelli FR, Severa M, Timperi E, Tucci G, Zagaglioni M, Ceccarelli F, Rizzo F, Coccia EM, Patel RS, Martin-Fernandez M, Bogunovic D, Conti F, Barnaba V, Piconese S.
PMID: 33376595
Clin Transl Immunology. 2020 Dec 23;9(12):e1221. doi: 10.1002/cti2.1221. eCollection 2020.

OBJECTIVES: Type I interferons (IFNs) inhibit regulatory T-cell (Treg) expansion and activation, making them beneficial in antiviral responses, but detrimental in autoimmune diseases. Herein, we investigate the role of ISG15 in human Tregs in the context of refractoriness to...

CD8.

Cell death & disease

Feizi N, Focaccetti C, Pacella I, Tucci G, Rossi A, Costanza M, Pedotti R, Sidney J, Sette A, La Rocca C, Procaccini C, Matarese G, Barnaba V, Piconese S.
PMID: 34716313
Cell Death Dis. 2021 Oct 29;12(11):1026. doi: 10.1038/s41419-021-04310-6.

The autoimmune immunopathology occurring in multiple sclerosis (MS) is sustained by myelin-specific and -nonspecific CD8

The role of lipid metabolism in shaping the expansion and the function of regulatory T cells.

Clinical and experimental immunology

Pinzon Grimaldos A, Bini S, Pacella I, Rossi A, Di Costanzo A, Minicocci I, D'Erasmo L, Arca M, Piconese S.
PMID: 35020862
Clin Exp Immunol. 2021 Dec 15; doi: 10.1093/cei/uxab033. Epub 2021 Dec 15.

Metabolic inflammation, defined as a chronic low-grade inflammation, is implicated in numerous metabolic diseases. In recent years, the role of regulatory T cells (Tregs) as key controllers of metabolic inflammation has emerged, but our comprehension on how different metabolic...

The ambiguity in immunology.

Frontiers in immunology

Barnaba V, Paroli M, Piconese S.
PMID: 22566903
Front Immunol. 2012 Feb 22;3:18. doi: 10.3389/fimmu.2012.00018. eCollection 2012.

In the present article, we discuss the various ambiguous aspects of the immune system that render this complex biological network so highly flexible and able to defend the host from different external invaders. This ambiguity stems mainly from the...

Thallium-sensitive fluorescent assay reveals loperamide as a new inhibitor of the potassium channel Kv10.1.

Pharmacological reports : PR

Loza-Huerta A, Milo E, Picones A, Hernández-Cruz A, Luis E.
PMID: 34213738
Pharmacol Rep. 2021 Dec;73(6):1744-1753. doi: 10.1007/s43440-021-00304-5. Epub 2021 Jul 02.

BACKGROUND: Ion channels have been proposed as therapeutic targets for different types of malignancies. One of the most studied ion channels in cancer is the voltage-gated potassium channel ether-à-go-go 1 or Kv10.1. Various studies have shown that Kv10.1 expression...

PGE2 Released by Pancreatic Cancer Cells Undergoing ER Stress Transfers the Stress to DCs Impairing Their Immune Function.

Molecular cancer therapeutics

Gilardini Montani MS, Benedetti R, Piconese S, Pulcinelli FM, Timperio AM, Romeo MA, Masuelli L, Mattei M, Bei R, D'Orazi G, Cirone M.
PMID: 33632872
Mol Cancer Ther. 2021 May;20(5):934-945. doi: 10.1158/1535-7163.MCT-20-0699. Epub 2021 Feb 25.

This study shows that pancreatic cancer cells undergoing cell death by valproic acid (VPA) treatment activated dendritic cells (DCs) more efficiently than those treated with trichostatin A (TSA), as demonstrated by CD86 and CD80 surface expression. Surprisingly though, DCs...

Rha1, a new mutant of Arabidopsis disturbed in root slanting, gravitropism and auxin physiology.

Plant signaling & behavior

Fortunati A, Piconese S, Tassone P, Ferrari S, Migliaccio F.
PMID: 19704429
Plant Signal Behav. 2008 Nov;3(11):989-90. doi: 10.4161/psb.6290.

A new Arabidopsis mutant is characterized (rha1) that shows, in the roots, reduced right-handed slanting, reduced gravitropism and resistance to 2,4-D, TIBA, NPA and ethylene. It also shows reduced length in the shoot and root, reduced number of lateral...

Correction to: Inhibition of the K.

Pflugers Archiv : European journal of physiology

Barriga-Montoya C, Huanosta-Gutiérrez A, Reyes-Vaca A, Hernández-Cruz A, Picones A, Gómez-Lagunas F.
PMID: 29549440
Pflugers Arch. 2018 Jun;470(6):981-993. doi: 10.1007/s00424-018-2131-2.

The original publication of this article contained multiple technical errors that occurred during its production and printing. These errors included sentences and paragraphs with parts missing. The Publisher regrets these mistakes.

Showing 1 to 12 of 26 entries