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Showing 1 to 12 of 68 entries
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Quantitative analysis of dynamic .

EJNMMI research

Coello C, Fisk M, Mohan D, Wilson FJ, Brown AP, Polkey MI, Wilkinson I, Tal-Singer R, Murphy PS, Cheriyan J, Gunn RN.
PMID: 28547129
EJNMMI Res. 2017 Dec;7(1):47. doi: 10.1186/s13550-017-0291-2. Epub 2017 May 25.

BACKGROUND: An inflammatory reaction in the airways and lung parenchyma, comprised mainly of neutrophils and alveolar macrophages, is present in some patients with chronic obstructive pulmonary disease (COPD). Thoracic fluorodeoxyglucose (RESULTS: The qABL method detected no difference (Hedge's g...

Nutrition and health technology assessment: when two worlds meet.

Frontiers in pharmacology

Poley MJ.
PMID: 26539116
Front Pharmacol. 2015 Oct 20;6:232. doi: 10.3389/fphar.2015.00232. eCollection 2015.

There is a growing recognition that nutrition may have a positive impact on public health and that it may reduce medical expenditures. Yet, such claims need to be substantiated by evidence. This evidence could be delivered by health technology...

Growth differentiation factor-15 is associated with muscle mass in chronic obstructive pulmonary disease and promotes muscle wasting in vivo.

Journal of cachexia, sarcopenia and muscle

Patel MS, Lee J, Baz M, Wells CE, Bloch S, Lewis A, Donaldson AV, Garfield BE, Hopkinson NS, Natanek A, Man WD, Wells DJ, Baker EH, Polkey MI, Kemp PR.
PMID: 27239406
J Cachexia Sarcopenia Muscle. 2016 Sep;7(4):436-48. doi: 10.1002/jcsm.12096. Epub 2015 Dec 29.

BACKGROUND: Loss of muscle mass is a co-morbidity common to a range of chronic diseases including chronic obstructive pulmonary disease (COPD). Several systemic features of COPD including increased inflammatory signalling, oxidative stress, and hypoxia are known to increase the...

Increased expression of H19/miR-675 is associated with a low fat-free mass index in patients with COPD.

Journal of cachexia, sarcopenia and muscle

Lewis A, Lee JY, Donaldson AV, Natanek SA, Vaidyanathan S, Man WD, Hopkinson NS, Sayer AA, Patel HP, Cooper C, Syddall H, Polkey MI, Kemp PR.
PMID: 27239417
J Cachexia Sarcopenia Muscle. 2016 Jun;7(3):330-44. doi: 10.1002/jcsm.12078. Epub 2016 Jan 05.

BACKGROUND: Loss of muscle mass and strength is a significant comorbidity in patients with chronic obstructive pulmonary disease (COPD) that limits their quality of life and has prognostic implications but does not affect everyone equally. To identify mechanisms that...

An evaluation of factors associated with completion and benefit from pulmonary rehabilitation in COPD.

BMJ open respiratory research

Boutou AK, Tanner RJ, Lord VM, Hogg L, Nolan J, Jefford H, Corner EJ, Falzon C, Lee C, Garrod R, Polkey MI, Hopkinson NS.
PMID: 25478193
BMJ Open Respir Res. 2014 Nov 03;1(1):e000051. doi: 10.1136/bmjresp-2014-000051. eCollection 2014.

BACKGROUND: Pulmonary Rehabilitation (PR) is an important treatment for patients with chronic obstructive pulmonary disease (COPD) but it is not established whether any baseline parameter can predict response or compliance.AIM: To identify whether baseline measures can predict who will...

Magnetic phrenic nerve stimulation to assess diaphragm function in children following liver transplantation.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Rafferty GF, Greenough A, Manczur T, Polkey MI, Harris ML, Heaton ND, Rela M, Moxham J.
PMID: 12797870
Pediatr Crit Care Med. 2001 Apr;2(2):122-126. doi: 10.1097/00130478-200104000-00005.

BACKGROUND: An accurate and practical test of diaphragm function in children in the intensive care unit is desirable. Diaphragm dysfunction can occur after liver transplantation and may be a contributory factor in the respiratory complications after the procedure. OBJECTIVE:...

Biocompatibility, biodegradation and excretion of polylactic acid (PLA) in medical implants and theranostic systems.

Chemical engineering journal (Lausanne, Switzerland : 1996)

da Silva D, Kaduri M, Poley M, Adir O, Krinsky N, Shainsky-Roitman J, Schroeder A.
PMID: 31384170
Chem Eng J. 2018 May 15;340:9-14. doi: 10.1016/j.cej.2018.01.010. Epub 2018 Jan 03.

Polylactic acid (PLA) is the most commonly used biodegradable polymer in clinical applications today. Examples range from drug delivery systems, tissue engineering, temporary and long-term implantable devices; constantly expanding to new fields. This is owed greatly to the polymer's...

Response.

Chest

Polkey MI, Zhong NS, Luo YM.
PMID: 30195368
Chest. 2018 Sep;154(3):733-734. doi: 10.1016/j.chest.2018.07.008.

No abstract available.

Patient symptoms and experience following COVID-19: results from a UK-wide survey.

BMJ open respiratory research

Buttery S, Philip KEJ, Williams P, Fallas A, West B, Cumella A, Cheung C, Walker S, Quint JK, Polkey MI, Hopkinson NS.
PMID: 34732518
BMJ Open Respir Res. 2021 Nov;8(1). doi: 10.1136/bmjresp-2021-001075.

OBJECTIVES: To investigate the experience of people who continue to be unwell after acute COVID-19, often referred to as 'long COVID', both in terms of their symptoms and their interactions with healthcare.DESIGN: We conducted a mixed-methods analysis of responses...

Characteristics and Spatially Defined Immune (micro)landscapes of Early-stage PD-L1-positive Triple-negative Breast Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Carter JM, Polley MC, Leon-Ferre RA, Sinnwell J, Thompson KJ, Wang X, Ma Y, Zahrieh D, Kachergus JM, Solanki M, Boughey JC, Liu MC, Ingle JN, Kalari KR, Couch FJ, Thompson EA, Goetz MP.
PMID: 34108182
Clin Cancer Res. 2021 Oct 15;27(20):5628-5637. doi: 10.1158/1078-0432.CCR-21-0343. Epub 2021 Jun 09.

PURPOSE: Programmed death ligand 1 [PD-(L)1]-targeted therapies have shown modest survival benefit in triple-negative breast cancer (TNBC). PD-L1EXPERIMENTAL DESIGN: From a large cohort of chemotherapy-naïve TNBC, clinicopathologic features, deconvoluted RNA immune signatures, and intraepithelial and stromal TIME (Nanostring GeoMX)...

A Flow-assay for Farnesol Removal from Adherent .

Bio-protocol

Polke M, Jacobsen ID.
PMID: 34595247
Bio Protoc. 2017 Oct 05;7(19):e2562. doi: 10.21769/BioProtoc.2562. eCollection 2017 Oct 05.

Here, we describe a protocol for a continuous flow system for

Impact of COVID-19 on people with asthma: a mixed methods analysis from a UK wide survey.

BMJ open respiratory research

Philip KEJ, Buttery S, Williams P, Vijayakumar B, Tonkin J, Cumella A, Renwick L, Ogden L, Quint JK, Johnston SL, Polkey MI, Hopkinson NS.
PMID: 35027428
BMJ Open Respir Res. 2022 Jan;9(1). doi: 10.1136/bmjresp-2021-001056.

INTRODUCTION: The impact of acute COVID-19 on people with asthma appears complex, being moderated by multiple interacting disease-specific, demographic and environmental factors. Research regarding longer-term effects in this group is limited. We aimed to assess impacts of COVID-19 and...

Showing 1 to 12 of 68 entries