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Showing 1 to 12 of 37 entries
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N-Arylazetidines: Preparation through Anionic Ring Closure.

The Journal of organic chemistry

Quinodoz P, Drouillat B, Wright K, Marrot J, Couty F.
PMID: 26932242
J Org Chem. 2016 Apr 01;81(7):2899-910. doi: 10.1021/acs.joc.6b00169. Epub 2016 Mar 10.

We report herein an efficient synthesis of diversely substituted N-aryl-2-cyanoazetidines based on an anionic ring-closure reaction. These compounds can be prepared from β-amino alcohols in enantiomerically pure form through a three-step sequence involving (i) copper-catalyzed N-arylation, (ii) N-cyanomethylation of...

SPRITE: a genome-wide method for mapping higher-order 3D interactions in the nucleus using combinatorial split-and-pool barcoding.

Nature protocols

Quinodoz SA, Bhat P, Chovanec P, Jachowicz JW, Ollikainen N, Detmar E, Soehalim E, Guttman M.
PMID: 35013617
Nat Protoc. 2022 Jan;17(1):36-75. doi: 10.1038/s41596-021-00633-y. Epub 2022 Jan 10.

A fundamental question in gene regulation is how cell-type-specific gene expression is influenced by the packaging of DNA within the nucleus of each cell. We recently developed Split-Pool Recognition of Interactions by Tag Extension (SPRITE), which enables mapping of...

Essential Roles for RNA in Shaping Nuclear Organization.

Cold Spring Harbor perspectives in biology

Quinodoz SA, Guttman M.
PMID: 34400555
Cold Spring Harb Perspect Biol. 2021 Aug 16; doi: 10.1101/cshperspect.a039719. Epub 2021 Aug 16.

It has long been proposed that nuclear RNAs might play an important role in organizing the structure of the nucleus. Initial experiments performed more than 30 years ago found that global disruption of RNA led to visible rearrangements of...

Single-cell measurement of higher-order 3D genome organization with scSPRITE.

Nature biotechnology

Arrastia MV, Jachowicz JW, Ollikainen N, Curtis MS, Lai C, Quinodoz SA, Selck DA, Ismagilov RF, Guttman M.
PMID: 34426703
Nat Biotechnol. 2021 Aug 23; doi: 10.1038/s41587-021-00998-1. Epub 2021 Aug 23.

Although three-dimensional (3D) genome organization is central to many aspects of nuclear function, it has been difficult to measure at the single-cell level. To address this, we developed 'single-cell split-pool recognition of interactions by tag extension' (scSPRITE). scSPRITE uses...

Reversal of SARS-CoV2-Induced Hypoxia by Nebulized Sodium Ibuprofenate in a Compassionate Use Program.

Infectious diseases and therapy

Salva O, Doreski PA, Giler CS, Quinodoz DC, Guzmán LG, Muñoz SE, Carrillo MN, Porta DJ, Ambasch G, Coscia E, Diaz JLT, Bueno GD, Fandi JO, Maldonado MA, Peña Chiappero LE, Fournier F, Pérez HA, Quiroga MA, Sala Mercado JA, Martínez Picco C, Beltrán MA, Argañarás LA, Ríos NM, Kalayan GI, Beltramo DM, García NH.
PMID: 34460083
Infect Dis Ther. 2021 Dec;10(4):2511-2524. doi: 10.1007/s40121-021-00527-2. Epub 2021 Aug 30.

INTRODUCTION: Sodium ibuprofenate in hypertonic saline (NaIHS) administered directly to the lungs by nebulization and inhalation has antibacterial and anti-inflammatory effects, with the potential to deliver these benefits to hypoxic patients. We describe a compassionate use program that offered...

Noncoding RNAs: biology and applications-a Keystone Symposia report.

Annals of the New York Academy of Sciences

Cable J, Heard E, Hirose T, Prasanth KV, Chen LL, Henninger JE, Quinodoz SA, Spector DL, Diermeier SD, Porman AM, Kumar D, Feinberg MW, Shen X, Unfried JP, Johnson R, Chen CK, Wilusz JE, Lempradl A, McGeary SE, Wahba L, Pyle AM, Hargrove AE, Simon MD, Marcia M, Przanowska RK, Chang HY, Jaffrey SR, Contreras LM, Chen Q, Shi J, Mendell JT, He L, Song E, Rinn JL, Lalwani MK, Kalem MC, Chuong EB, Maquat LE, Liu X.
PMID: 34791665
Ann N Y Acad Sci. 2021 Nov 17; doi: 10.1111/nyas.14713. Epub 2021 Nov 17.

The human transcriptome contains many types of noncoding RNAs, which rival the number of protein-coding species. From long noncoding RNAs (lncRNAs) that are over 200 nucleotides long to piwi-interacting RNAs (piRNAs) of only 20 nucleotides, noncoding RNAs play important...

Genetic analysis of consanguineous Pakistani families with congenital stationary night blindness.

Ophthalmic research

Azhar Baig HM, Ansar M, Iqbal A, Naeem MA, Quinodoz M, Calzetti G, Iqbal M, Rivolta C.
PMID: 34781300
Ophthalmic Res. 2021 Nov 15; doi: 10.1159/000520895. Epub 2021 Nov 15.

AIM: Congenital stationary night blindness (CSNB) is a rare, largely non progressive, inherited retinal disorder that can be clinically classified on the basis of fundus and electroretinogram (ERG) abnormalities.METHODS: We analyzed four large consanguineous families from the Southern Punjab...

Transcriptomic Signature Differences Between SARS-CoV-2 and Influenza Virus Infected Patients.

Frontiers in immunology

Bibert S, Guex N, Lourenco J, Brahier T, Papadimitriou-Olivgeris M, Damonti L, Manuel O, Liechti R, Götz L, Tschopp J, Quinodoz M, Vollenweider P, Pagani JL, Oddo M, Hügli O, Lamoth F, Erard V, Voide C, Delorenzi M, Rufer N, Candotti F, Rivolta C, Boillat-Blanco N, Bochud PY.
PMID: 34135895
Front Immunol. 2021 May 31;12:666163. doi: 10.3389/fimmu.2021.666163. eCollection 2021.

The reason why most individuals with COVID-19 have relatively limited symptoms while other develop respiratory distress with life-threatening complications remains unknown. Increasing evidence suggests that COVID-19 associated adverse outcomes mainly rely on dysregulated immunity. Here, we compared transcriptomic profiles...

Agenesis of the Corpus Callosum with Facial Dysmorphism and Intellectual Disability in Sibs Associated with Compound Heterozygous .

Genes

Lebon S, Quinodoz M, Peter VG, Gengler C, Blanchard G, Cina V, Campos-Xavier B, Rivolta C, Superti-Furga A.
PMID: 34573379
Genes (Basel). 2021 Sep 10;12(9). doi: 10.3390/genes12091397.

We studied a family in which the first-born child, a girl, had developmental delay, facial dysmorphism, and agenesis of the corpus callosum (ACC). The subsequent pregnancy was interrupted as the fetus was found to be also affected by ACC....

Correction: Phenotypic expansion of CACNA1C-associated disorders to include isolated neurological manifestations.

Genetics in medicine : official journal of the American College of Medical Genetics

Rodan LH, Spillmann RC, Kurata HT, Lamothe SM, Maghera J, Jamra RA, Alkelai A, Antonarakis SE, Atallah I, Bar-Yosef O, Bilan F, Bjorgo K, Blanc X, Van Bogaert P, Bolkier Y, Burrage LC, Christ BU, Granadillo JL, Dickson P, Donald KA, Dubourg C, Eliyahu A, Emrick L, Engleman K, Gonfiantini MV, Good JM, Kalser J, Kloeckner C, Lachmeijer G, Macchiaiolo M, Nicita F, Odent S, O'Heir E, Ortiz-Gonzalez X, Pacio-Miguez M, Palomares-Bralo M, Pena L, Platzer K, Quinodoz M, Ranza E, Rosenfeld JA, Roulet-Perez E, Santani A, Santos-Simarro F, Pode-Shakked B, Skraban C, Slaugh R, Superti-Furga A, Thiffault I, van Jaabrsveld RH, Vincent M, Wang HG, Zacher P, Rush E, Pitt GS, Au PYB, Shashi V.
PMID: 34522029
Genet Med. 2021 Oct;23(10):2016. doi: 10.1038/s41436-021-01306-7.

No abstract available.

Noncoding RNAs: biology and applications-a Keystone Symposia report.

Annals of the New York Academy of Sciences

Cable J, Heard E, Hirose T, Prasanth KV, Chen LL, Henninger JE, Quinodoz SA, Spector DL, Diermeier SD, Porman AM, Kumar D, Feinberg MW, Shen X, Unfried JP, Johnson R, Chen CK, Wilusz JE, Lempradl A, McGeary SE, Wahba L, Pyle AM, Hargrove AE, Simon MD, Marcia M, Przanowska RK, Chang HY, Jaffrey SR, Contreras LM, Chen Q, Shi J, Mendell JT, He L, Song E, Rinn JL, Lalwani MK, Kalem MC, Chuong EB, Maquat LE, Liu X.
PMID: 34791665
Ann N Y Acad Sci. 2021 Dec;1506(1):118-141. doi: 10.1111/nyas.14713. Epub 2021 Nov 17.

The human transcriptome contains many types of noncoding RNAs, which rival the number of protein-coding species. From long noncoding RNAs (lncRNAs) that are over 200 nucleotides long to piwi-interacting RNAs (piRNAs) of only 20 nucleotides, noncoding RNAs play important...

Ultrasound and Histologic Examination after Subcutaneous Injection of Two Volumizing Hyaluronic Acid Fillers: A Preliminary Study.

Plastic and reconstructive surgery. Global open

Micheels P, Besse S, Sarazin D, Quinodoz P, Elias B, Safa M, Vandeputte J.
PMID: 28280664
Plast Reconstr Surg Glob Open. 2017 Feb 24;5(2):e1222. doi: 10.1097/GOX.0000000000001222. eCollection 2017 Feb.

BACKGROUND: This study examined the influence of hyaluronic acid (HA) crosslinking technology on the ultrasound and histologic behavior of HA fillers designed for subcutaneous injection.METHODS: One subject received subcutaneous injections of 0.25 ml Cohesive Polydensified Matrix (CPM) and Vycross...

Showing 1 to 12 of 37 entries