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Cable J, Heard E, Hirose T, et al. Noncoding RNAs: biology and applications-a Keystone Symposia report. Ann N Y Acad Sci. 2021;doi: 10.1111/nyas.14713.
Cable, J., Heard, E., Hirose, T., Prasanth, K. V., Chen, L. L., Henninger, J. E., Quinodoz, S. A., Spector, D. L., Diermeier, S. D., Porman, A. M., Kumar, D., Feinberg, M. W., Shen, X., Unfried, J. P., Johnson, R., Chen, C. K., Wilusz, J. E., Lempradl, A., McGeary, S. E., Wahba, L., Pyle, A. M., Hargrove, A. E., Simon, M. D., Marcia, M., Przanowska, R. K., Chang, H. Y., Jaffrey, S. R., Contreras, L. M., Chen, Q., Shi, J., Mendell, J. T., He, L., Song, E., Rinn, J. L., Lalwani, M. K., Kalem, M. C., Chuong, E. B., Maquat, L. E., & Liu, X. (2021). Noncoding RNAs: biology and applications-a Keystone Symposia report. Annals of the New York Academy of Sciences, . https://doi.org/10.1111/nyas.14713
Cable, Jennifer, et al. "Noncoding RNAs: biology and applications-a Keystone Symposia report." Annals of the New York Academy of Sciences vol. (2021). doi: https://doi.org/10.1111/nyas.14713
Cable J, Heard E, Hirose T, Prasanth KV, Chen LL, Henninger JE, Quinodoz SA, Spector DL, Diermeier SD, Porman AM, Kumar D, Feinberg MW, Shen X, Unfried JP, Johnson R, Chen CK, Wilusz JE, Lempradl A, McGeary SE, Wahba L, Pyle AM, Hargrove AE, Simon MD, Marcia M, Przanowska RK, Chang HY, Jaffrey SR, Contreras LM, Chen Q, Shi J, Mendell JT, He L, Song E, Rinn JL, Lalwani MK, Kalem MC, Chuong EB, Maquat LE, Liu X. Noncoding RNAs: biology and applications-a Keystone Symposia report. Ann N Y Acad Sci. 2021 Nov 17; doi: 10.1111/nyas.14713. Epub 2021 Nov 17. PMID: 34791665.
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Ann N Y Acad Sci. 2021 Nov 17; doi: 10.1111/nyas.14713. Epub 2021 Nov 17.

Noncoding RNAs: biology and applications-a Keystone Symposia report.

Annals of the New York Academy of Sciences

Jennifer Cable, Edith Heard, Tetsuro Hirose, Kannanganattu V Prasanth, Ling-Ling Chen, Jonathan E Henninger, Sofia A Quinodoz, David L Spector, Sarah D Diermeier, Allison M Porman, Dhiraj Kumar, Mark W Feinberg, Xiaohua Shen, Juan Pablo Unfried, Rory Johnson, Chun-Kan Chen, Jeremy E Wilusz, Adelheid Lempradl, Sean E McGeary, Lamia Wahba, Anna Marie Pyle, Amanda E Hargrove, Matthew D Simon, Marco Marcia, Róża K Przanowska, Howard Y Chang, Samie R Jaffrey, Lydia M Contreras, Qi Chen, Junchao Shi, Joshua T Mendell, Lin He, Erwei Song, John L Rinn, Mukesh Kumar Lalwani, Murat Can Kalem, Edward B Chuong, Lynne E Maquat, Xuhang Liu

Affiliations

  1. PhD Science Writer, New York, New York.
  2. European Molecular Biology Laboratory (EMBL), Heidelberg, Heidelberg, Germany.
  3. Collège de France, Paris, France.
  4. Graduate School of Frontier Biosciences, Osaka University, Suita, Japan.
  5. Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan.
  6. Department of Cell and Developmental Biology, Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois.
  7. State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of the Chinese Academy of Sciences, Shanghai, China.
  8. School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
  9. School of Life Sciences, Hangzhou Institute for Advanced Study, University of the Chinese Academy of Sciences, Hangzhou, China.
  10. Whitehead Institute for Biomedical Research, Cambridge, Massachusetts.
  11. Department of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey.
  12. Cold Spring Harbor Laboratory, Cold Spring Harbor and Genetics Program, Stony Brook University, Stony Brook, New York.
  13. Department of Biochemistry, University of Otago, Dunedin, New Zealand.
  14. Biochemistry and Molecular Genetics Department, University of Colorado, Anschutz Medical Campus, Aurora, Colorado.
  15. Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  16. Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
  17. Tsinghua-Peking Joint Center for Life Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing, China.
  18. Center for Applied Medical Research (CIMA), Department of Gene Therapy and Regulation of Gene Expression, Universidad de Navarra (UNAV), Pamplona, Spain.
  19. Department of Medical Oncology, Inselspital, Bern University Hospital; and Department for BioMedical Research University of Bern, Bern, Switzerland.
  20. School of Biology and Environmental Science and Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.
  21. Center for Personal Dynamic Regulomes, Stanford University, Stanford, California.
  22. Department of Genetics, Stanford University School of Medicine, Stanford, California.
  23. Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  24. Department of Metabolism and Nutritional Programming, Van Andel Research Institute, Grand Rapids, Michigan.
  25. Howard Hughes Medical Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts.
  26. Department of Pathology, Stanford University School of Medicine, Stanford, California.
  27. Department of Genetics, Yale School of Medicine, New Haven, Connecticut.
  28. Connecticut and Howard Hughes Medical Institute, Chevy Chase, Maryland.
  29. Department of Chemistry, Duke University, Durham, North Carolina.
  30. Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut.
  31. European Molecular Biology Laboratory (EMBL) Grenoble, Grenoble, France.
  32. Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia.
  33. Howard Hughes Medical Institute, Stanford University, Stanford, California.
  34. Department of Pharmacology, Weill Medical College of Cornell University, New York, New York.
  35. McKetta Department of Chemical Engineering, University of Texas at Austin, Austin, Texas.
  36. Division of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, California.
  37. Department of Molecular Biology, Harold C. Simmons Comprehensive Cancer Center, Hamon Center for Regenerative Science and Medicine; and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas.
  38. Division of Cellular and Developmental Biology, Molecular and Cell Biology Department, University of California at Berkeley, Berkeley, California.
  39. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center and Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University; Bioland Laboratory; Program of Molecular Medicine, Zhongshan School of Medicine, Sun Yat-sen University; and Fountain-Valley Institute for Life Sciences, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences Guangzhou, Guangzhou, China.
  40. Department of Biochemistry, BioFrontiers Institute, and Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, Colorado.
  41. Queens Medical Research Institute, BHF Centre for Cardiovascular Sciences, University of Edinburgh, Scotland, United Kingdom.
  42. Department of Microbiology and Immunology, Witebsky Center for Microbial Pathogenesis and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, New York.
  43. Department of Molecular, Cellular, and Developmental Biology and BioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado.
  44. Department of Biochemistry and Biophysics, School of Medicine and Dentistry and Center for RNA Biology, University of Rochester, Rochester, New York.
  45. Laboratory of Systems Cancer Biology, The Rockefeller University, New York, New York.

PMID: 34791665 DOI: 10.1111/nyas.14713

Abstract

The human transcriptome contains many types of noncoding RNAs, which rival the number of protein-coding species. From long noncoding RNAs (lncRNAs) that are over 200 nucleotides long to piwi-interacting RNAs (piRNAs) of only 20 nucleotides, noncoding RNAs play important roles in regulating transcription, epigenetic modifications, translation, and cell signaling. Roles for noncoding RNAs in disease mechanisms are also being uncovered, and several species have been identified as potential drug targets. On May 11-14, 2021, the Keystone eSymposium "Noncoding RNAs: Biology and Applications" brought together researchers working in RNA biology, structure, and technologies to accelerate both the understanding of RNA basic biology and the translation of those findings into clinical applications.

© 2021 New York Academy of Sciences.

Keywords: Xist; circRNA; lncRNA; noncoding RNA; nuclear condensate; phase transition; piRNA; transcription

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