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Showing 1 to 12 of 37 entries
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Consequences of mRNA wardrobe malfunctions.

Cell

Wilusz CJ, Wilusz J.
PMID: 21145451
Cell. 2010 Dec 10;143(6):863-5. doi: 10.1016/j.cell.2010.11.041.

As mRNAs are generated, they are clothed with proteins to form messenger ribonucleoprotein particles (mRNPs), which are then actively remodeled during various steps of gene expression. Franks et al. (2010) now show that mRNP remodeling is required even for...

A plant-infecting subviral RNA associated with poleroviruses produces a subgenomic RNA which resists exonuclease XRN1 in vitro.

Virology

Campbell AJ, Anderson JR, Wilusz J.
PMID: 34808564
Virology. 2021 Nov 17;566:1-8. doi: 10.1016/j.virol.2021.11.002. Epub 2021 Nov 17.

Subviral agents are nucleic acids which lack the features for classification as a virus. Tombusvirus-like associated RNAs (tlaRNAs) are subviral positive-sense, single-stranded RNAs that replicate autonomously, yet depend on a coinfecting virus for encapsidation and transmission. TlaRNAs produce abundant...

Noncoding RNAs: biology and applications-a Keystone Symposia report.

Annals of the New York Academy of Sciences

Cable J, Heard E, Hirose T, Prasanth KV, Chen LL, Henninger JE, Quinodoz SA, Spector DL, Diermeier SD, Porman AM, Kumar D, Feinberg MW, Shen X, Unfried JP, Johnson R, Chen CK, Wilusz JE, Lempradl A, McGeary SE, Wahba L, Pyle AM, Hargrove AE, Simon MD, Marcia M, Przanowska RK, Chang HY, Jaffrey SR, Contreras LM, Chen Q, Shi J, Mendell JT, He L, Song E, Rinn JL, Lalwani MK, Kalem MC, Chuong EB, Maquat LE, Liu X.
PMID: 34791665
Ann N Y Acad Sci. 2021 Nov 17; doi: 10.1111/nyas.14713. Epub 2021 Nov 17.

The human transcriptome contains many types of noncoding RNAs, which rival the number of protein-coding species. From long noncoding RNAs (lncRNAs) that are over 200 nucleotides long to piwi-interacting RNAs (piRNAs) of only 20 nucleotides, noncoding RNAs play important...

Noncoding RNAs: biology and applications-a Keystone Symposia report.

Annals of the New York Academy of Sciences

Cable J, Heard E, Hirose T, Prasanth KV, Chen LL, Henninger JE, Quinodoz SA, Spector DL, Diermeier SD, Porman AM, Kumar D, Feinberg MW, Shen X, Unfried JP, Johnson R, Chen CK, Wilusz JE, Lempradl A, McGeary SE, Wahba L, Pyle AM, Hargrove AE, Simon MD, Marcia M, Przanowska RK, Chang HY, Jaffrey SR, Contreras LM, Chen Q, Shi J, Mendell JT, He L, Song E, Rinn JL, Lalwani MK, Kalem MC, Chuong EB, Maquat LE, Liu X.
PMID: 34791665
Ann N Y Acad Sci. 2021 Dec;1506(1):118-141. doi: 10.1111/nyas.14713. Epub 2021 Nov 17.

The human transcriptome contains many types of noncoding RNAs, which rival the number of protein-coding species. From long noncoding RNAs (lncRNAs) that are over 200 nucleotides long to piwi-interacting RNAs (piRNAs) of only 20 nucleotides, noncoding RNAs play important...

A plant-infecting subviral RNA associated with poleroviruses produces a subgenomic RNA which resists exonuclease XRN1 in vitro.

Virology

Campbell AJ, Anderson JR, Wilusz J.
PMID: 34808564
Virology. 2021 Nov 17;566:1-8. doi: 10.1016/j.virol.2021.11.002. Epub 2021 Nov 17.

Subviral agents are nucleic acids which lack the features for classification as a virus. Tombusvirus-like associated RNAs (tlaRNAs) are subviral positive-sense, single-stranded RNAs that replicate autonomously, yet depend on a coinfecting virus for encapsidation and transmission. TlaRNAs produce abundant...

Engineering highly efficient backsplicing and translation of synthetic circRNAs.

Molecular therapy. Nucleic acids

Meganck RM, Liu J, Hale AE, Simon KE, Fanous MM, Vincent HA, Wilusz JE, Moorman NJ, Marzluff WF, Asokan A.
PMID: 33614232
Mol Ther Nucleic Acids. 2021 Jan 16;23:821-834. doi: 10.1016/j.omtn.2021.01.003. eCollection 2021 Mar 05.

Circular RNAs (circRNAs) are highly stable RNA molecules that are attractive templates for expression of therapeutic proteins and non-coding RNAs. In eukaryotes, circRNAs are primarily generated by the spliceosome through backsplicing. Here, we interrogate different molecular elements including intron...

A plant-infecting subviral RNA associated with poleroviruses produces a subgenomic RNA which resists exonuclease XRN1 in vitro.

Virology

Campbell AJ, Anderson JR, Wilusz J.
PMID: 34808564
Virology. 2021 Nov 17;566:1-8. doi: 10.1016/j.virol.2021.11.002. Epub 2021 Nov 17.

Subviral agents are nucleic acids which lack the features for classification as a virus. Tombusvirus-like associated RNAs (tlaRNAs) are subviral positive-sense, single-stranded RNAs that replicate autonomously, yet depend on a coinfecting virus for encapsidation and transmission. TlaRNAs produce abundant...

Radial Tears of the Lateral Meniscus-Two Novel Repair Techniques: A Biomechanical Study.

Orthopaedic journal of sports medicine

Stender ZC, Cracchiolo AM, Walsh MP, Patterson DP, Wilusz MJ, Lemos SE.
PMID: 29780840
Orthop J Sports Med. 2018 Apr 27;6(4):2325967118768086. doi: 10.1177/2325967118768086. eCollection 2018 Apr.

BACKGROUND: A common treatment for radial tears of the meniscus has historically been partial meniscectomy. Owing to the poor outcomes associated with partial meniscectomy, repair of the meniscus is an important treatment option. It is important to evaluate different...

Metallo-proteinase from the seedlings of kale (Brassica oleracea L. var. sabellica): : Preparation, partial characterization and substrate specificity.

Planta

Wilimowska-Pelc A, Dryjański M, Zal T, Wilusz T.
PMID: 24186416
Planta. 1991 Oct;185(3):344-9. doi: 10.1007/BF00201054.

Metallo-proteinase from 8-d-old seedlings of kale was isolated. The enzyme was extracted with 1% NaCl, concentrated by ammonium sulfate and finally purified by high-performance liquid chromatography. The isolated enzyme had a molecular weight of 22.4 kDa and showed a...

HuR and translation--the missing linc(RNA).

Molecular cell

Wilusz CJ, Wilusz J.
PMID: 22920290
Mol Cell. 2012 Aug 24;47(4):495-6. doi: 10.1016/j.molcel.2012.08.005.

In this issue, Yoon et al. (2012) reveal that HuR influences decay of a long noncoding RNA (lincRNA-p21) that in turn hybridizes to mRNA targets and represses their translation-an indirect, but elegant explanation for the impact of HuR on...

Nucleophilic Polymers and Gels in Hydrolytic Degradation of Chemical Warfare Agents.

ACS applied materials & interfaces

Bromberg L, Creasy WR, McGarvey DJ, Wilusz E, Hatton TA.
PMID: 26359671
ACS Appl Mater Interfaces. 2015 Oct 07;7(39):22001-11. doi: 10.1021/acsami.5b06905. Epub 2015 Sep 23.

Water- and solvent-soluble polymeric materials based on polyalkylamines modified with nucleophilic groups are introduced as catalysts of chemical warfare agent (CWA) hydrolysis. A comparative study conducted at constant pH and based on the criteria of the synthetic route simplicity,...

A plant-infecting subviral RNA associated with poleroviruses produces a subgenomic RNA which resists exonuclease XRN1 in vitro.

Virology

Campbell AJ, Anderson JR, Wilusz J.
PMID: 34808564
Virology. 2021 Nov 17;566:1-8. doi: 10.1016/j.virol.2021.11.002. Epub 2021 Nov 17.

Subviral agents are nucleic acids which lack the features for classification as a virus. Tombusvirus-like associated RNAs (tlaRNAs) are subviral positive-sense, single-stranded RNAs that replicate autonomously, yet depend on a coinfecting virus for encapsidation and transmission. TlaRNAs produce abundant...

Showing 1 to 12 of 37 entries