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History and Physical Examination in Diagnosis of Peripheral Artery Disease.

Interventional cardiology clinics

Rajamanickam A, Krishnan P.
PMID: 28582072
Interv Cardiol Clin. 2014 Oct;3(4):461-467. doi: 10.1016/j.iccl.2014.06.007. Epub 2014 Oct 02.

Peripheral artery disease (PAD) may be silent or present with an assortment of symptoms and signs suggesting peripheral artery ischemia. Peripheral vascular disease includes PAD and disorders of the peripheral venous system and lymphatic system. Generally, PAD is synonymous...

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Rajamanickam A, Krishnan P. History and Physical Examination in Diagnosis of Peripheral Artery Disease. Interv Cardiol Clin. 2014;3(4):461-467doi: 10.1016/j.iccl.2014.06.007.
Rajamanickam, A., & Krishnan, P. (2014). History and Physical Examination in Diagnosis of Peripheral Artery Disease. Interventional cardiology clinics, 3(4), 461-467. https://doi.org/10.1016/j.iccl.2014.06.007
Rajamanickam, Anitha, and Krishnan, Prakash. "History and Physical Examination in Diagnosis of Peripheral Artery Disease." Interventional cardiology clinics vol. 3,4 (2014): 461-467. doi: https://doi.org/10.1016/j.iccl.2014.06.007
Rajamanickam A, Krishnan P. History and Physical Examination in Diagnosis of Peripheral Artery Disease. Interv Cardiol Clin. 2014 Oct;3(4):461-467. doi: 10.1016/j.iccl.2014.06.007. Epub 2014 Oct 02. PMID: 28582072.
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Antioxidant and Nephroprotective Activities of Aconitum heterophyllum Root in Glycerol Induced Acute Renal Failure in Rats.

Journal of clinical and diagnostic research : JCDR

Konda VG, Eerike M, Raghuraman LP, Rajamanickam MK.
PMID: 27134892
J Clin Diagn Res. 2016 Mar;10(3):FF01-2. doi: 10.7860/JCDR/2016/10798.7388. Epub 2016 Mar 01.

AIM: The present study was to evaluate the antioxidant and nephroprotective activities of ethanolic extract of Aconitum heterophyllum root (EEAHR) in glycerol induced acute renal failure (ARF) in Wistar albino rats.MATERIALS AND METHODS: In vitro antioxidant activity of EEAHR...

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Konda VG, Eerike M, Raghuraman LP, et al. Antioxidant and Nephroprotective Activities of Aconitum heterophyllum Root in Glycerol Induced Acute Renal Failure in Rats. J Clin Diagn Res. 2016;10(3):FF01-2doi: 10.7860/JCDR/2016/10798.7388.
Konda, V. G., Eerike, M., Raghuraman, L. P., & Rajamanickam, M. K. (2016). Antioxidant and Nephroprotective Activities of Aconitum heterophyllum Root in Glycerol Induced Acute Renal Failure in Rats. Journal of clinical and diagnostic research : JCDR, 10(3), FF01-2. https://doi.org/10.7860/JCDR/2016/10798.7388
Konda, Venu Gopala Rao, et al. "Antioxidant and Nephroprotective Activities of Aconitum heterophyllum Root in Glycerol Induced Acute Renal Failure in Rats." Journal of clinical and diagnostic research : JCDR vol. 10,3 (2016): FF01-2. doi: https://doi.org/10.7860/JCDR/2016/10798.7388
Konda VG, Eerike M, Raghuraman LP, Rajamanickam MK. Antioxidant and Nephroprotective Activities of Aconitum heterophyllum Root in Glycerol Induced Acute Renal Failure in Rats. J Clin Diagn Res. 2016 Mar;10(3):FF01-2. doi: 10.7860/JCDR/2016/10798.7388. Epub 2016 Mar 01. PMID: 27134892; PMCID: PMC4843278.
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Quality control standards for the roots of three plumbago species.

Indian journal of pharmaceutical sciences

Ariyanathan S, Saraswathy A, Rajamanickam GV.
PMID: 20582195
Indian J Pharm Sci. 2010 Jan;72(1):86-91. doi: 10.4103/0250-474X.62254.

Physicochemical parameters of roots of three Plumbago species, Plumbago capensis, P. rosea and P. zeylanica belonging to Plumbaginaceae were analyzed. Microbial contamination, aflatoxins, pesticide residue and heavy metal content were also determined. Attempt has also been made to estimate...

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Ariyanathan S, Saraswathy A, Rajamanickam GV. Quality control standards for the roots of three plumbago species. Indian J Pharm Sci. 2010;72(1):86-91doi: 10.4103/0250-474X.62254.
Ariyanathan, S., Saraswathy, A., & Rajamanickam, G. V. (2010). Quality control standards for the roots of three plumbago species. Indian journal of pharmaceutical sciences, 72(1), 86-91. https://doi.org/10.4103/0250-474X.62254
Ariyanathan, S, et al. "Quality control standards for the roots of three plumbago species." Indian journal of pharmaceutical sciences vol. 72,1 (2010): 86-91. doi: https://doi.org/10.4103/0250-474X.62254
Ariyanathan S, Saraswathy A, Rajamanickam GV. Quality control standards for the roots of three plumbago species. Indian J Pharm Sci. 2010 Jan;72(1):86-91. doi: 10.4103/0250-474X.62254. PMID: 20582195; PMCID: PMC2883232.
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On the synergistic catalytic properties of bimetallic mesoporous materials containing aluminum and zirconium: the Prins cyclisation of citronellal.

Chemistry (Weinheim an der Bergstrasse, Germany)

Telalović S, Ramanathan A, Ng JF, Maheswari R, Kwakernaak C, Soulimani F, Brouwer HC, Chuah GK, Weckhuysen BM, Hanefeld U.
PMID: 21259348
Chemistry. 2011 Feb 11;17(7):2077-88. doi: 10.1002/chem.201002909. Epub 2011 Jan 21.

Bimetallic three-dimensional amorphous mesoporous materials, Al-Zr-TUD-1 materials, were synthesised by using a surfactant-free, one-pot procedure employing triethanolamine (TEA) as a complexing reagent. The amount of aluminium and zirconium was varied in order to study the effect of these metals...

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Telalović S, Ramanathan A, Ng JF, et al. On the synergistic catalytic properties of bimetallic mesoporous materials containing aluminum and zirconium: the Prins cyclisation of citronellal. Chemistry. 2011;17(7):2077-88doi: 10.1002/chem.201002909.
Telalović, S., Ramanathan, A., Ng, J. F., Maheswari, R., Kwakernaak, C., Soulimani, F., Brouwer, H. C., Chuah, G. K., Weckhuysen, B. M., & Hanefeld, U. (2011). On the synergistic catalytic properties of bimetallic mesoporous materials containing aluminum and zirconium: the Prins cyclisation of citronellal. Chemistry (Weinheim an der Bergstrasse, Germany), 17(7), 2077-88. https://doi.org/10.1002/chem.201002909
Telalović, Selvedin, et al. "On the synergistic catalytic properties of bimetallic mesoporous materials containing aluminum and zirconium: the Prins cyclisation of citronellal." Chemistry (Weinheim an der Bergstrasse, Germany) vol. 17,7 (2011): 2077-88. doi: https://doi.org/10.1002/chem.201002909
Telalović S, Ramanathan A, Ng JF, Maheswari R, Kwakernaak C, Soulimani F, Brouwer HC, Chuah GK, Weckhuysen BM, Hanefeld U. On the synergistic catalytic properties of bimetallic mesoporous materials containing aluminum and zirconium: the Prins cyclisation of citronellal. Chemistry. 2011 Feb 11;17(7):2077-88. doi: 10.1002/chem.201002909. Epub 2011 Jan 21. PMID: 21259348; PMCID: PMC3072521.
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Association between primary hypothyroidism and metabolic syndrome and the role of C reactive protein: a cross-sectional study from South India.

Thyroid research

Shantha GP, Kumar AA, Jeyachandran V, Rajamanickam D, Rajkumar K, Salim S, Subramanian KK, Natesan S.
PMID: 19272156
Thyroid Res. 2009 Mar 09;2(1):2. doi: 10.1186/1756-6614-2-2.

BACKGROUND: Hypothyroidism (sub-clinical and overt) and metabolic syndrome are recognized risk factors for atherosclerotic cardiovascular disease. This study is an effort to identify the proposed association between these two disease entities and the risk factors involved in this association.METHODS:...

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Shantha GP, Kumar AA, Jeyachandran V, et al. Association between primary hypothyroidism and metabolic syndrome and the role of C reactive protein: a cross-sectional study from South India. Thyroid Res. 2009;2(1):2doi: 10.1186/1756-6614-2-2.
Shantha, G. P., Kumar, A. A., Jeyachandran, V., Rajamanickam, D., Rajkumar, K., Salim, S., Subramanian, K. K., & Natesan, S. (2009). Association between primary hypothyroidism and metabolic syndrome and the role of C reactive protein: a cross-sectional study from South India. Thyroid research, 2(1), 2. https://doi.org/10.1186/1756-6614-2-2
Shantha, Ghanshyam Palamaner Subash, et al. "Association between primary hypothyroidism and metabolic syndrome and the role of C reactive protein: a cross-sectional study from South India." Thyroid research vol. 2,1 (2009): 2. doi: https://doi.org/10.1186/1756-6614-2-2
Shantha GP, Kumar AA, Jeyachandran V, Rajamanickam D, Rajkumar K, Salim S, Subramanian KK, Natesan S. Association between primary hypothyroidism and metabolic syndrome and the role of C reactive protein: a cross-sectional study from South India. Thyroid Res. 2009 Mar 09;2(1):2. doi: 10.1186/1756-6614-2-2. PMID: 19272156; PMCID: PMC2655275.
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Simultaneous Determination of Celecoxib, Erlotinib, and its Metabolite Desmethyl-Erlotinib (OSI-420) in Rat Plasma by Liquid chromatography/Tandem Mass Spectrometry with Positive/Negative Ion-Switching Electrospray Ionisation.

Scientia pharmaceutica

Thappali SR, Varanasi K, Veeraraghavan S, Arla R, Chennupati S, Rajamanickam M, Vakkalanka S, Khagga M.
PMID: 23008811
Sci Pharm. 2012 Jul-Sep;80(3):633-46. doi: 10.3797/scipharm.1205-09. Epub 2012 Jun 18.

A new method for the simultaneous determination of celecoxib, erlotinib, and its active metabolite desmethyl-erlotinib (OSI-420) in rat plasma, by liquid chromatography/tandem mass spectrometry with positive/negative ion-switching electrospray ionization mode, was developed and validated. Protein precipitation with methanol was...

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Thappali SR, Varanasi K, Veeraraghavan S, et al. Simultaneous Determination of Celecoxib, Erlotinib, and its Metabolite Desmethyl-Erlotinib (OSI-420) in Rat Plasma by Liquid chromatography/Tandem Mass Spectrometry with Positive/Negative Ion-Switching Electrospray Ionisation. Sci Pharm. 2012;80(3):633-46doi: 10.3797/scipharm.1205-09.
Thappali, S. R., Varanasi, K., Veeraraghavan, S., Arla, R., Chennupati, S., Rajamanickam, M., Vakkalanka, S., & Khagga, M. (2012). Simultaneous Determination of Celecoxib, Erlotinib, and its Metabolite Desmethyl-Erlotinib (OSI-420) in Rat Plasma by Liquid chromatography/Tandem Mass Spectrometry with Positive/Negative Ion-Switching Electrospray Ionisation. Scientia pharmaceutica, 80(3), 633-46. https://doi.org/10.3797/scipharm.1205-09
Thappali, Satheeshmanikandan R S, et al. "Simultaneous Determination of Celecoxib, Erlotinib, and its Metabolite Desmethyl-Erlotinib (OSI-420) in Rat Plasma by Liquid chromatography/Tandem Mass Spectrometry with Positive/Negative Ion-Switching Electrospray Ionisation." Scientia pharmaceutica vol. 80,3 (2012): 633-46. doi: https://doi.org/10.3797/scipharm.1205-09
Thappali SR, Varanasi K, Veeraraghavan S, Arla R, Chennupati S, Rajamanickam M, Vakkalanka S, Khagga M. Simultaneous Determination of Celecoxib, Erlotinib, and its Metabolite Desmethyl-Erlotinib (OSI-420) in Rat Plasma by Liquid chromatography/Tandem Mass Spectrometry with Positive/Negative Ion-Switching Electrospray Ionisation. Sci Pharm. 2012 Jul-Sep;80(3):633-46. doi: 10.3797/scipharm.1205-09. Epub 2012 Jun 18. PMID: 23008811; PMCID: PMC3447620.
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Terminalia arjuna's antioxidant effect in isolated perfused kidney.

Research in pharmaceutical sciences

Raj CD, Shabi MM, Jipnomon J, Dhevi R, Gayathri K, Subashini U, Rajamanickam GV.
PMID: 23181096
Res Pharm Sci. 2012 Jul;7(3):181-8.

Standardization of induction of oxidative stress with Fenton mixture (FM) in isolated perfused rat kidney and the antioxidant effect of Terminalia arjuna bark in the isolated oxidatively stressed rat kidney has been evaluated. Six groups each containing eight isolated...

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Raj CD, Shabi MM, Jipnomon J, et al. Terminalia arjuna's antioxidant effect in isolated perfused kidney. Res Pharm Sci. 2012;7(3):181-8
Raj, C. D., Shabi, M. M., Jipnomon, J., Dhevi, R., Gayathri, K., Subashini, U., & Rajamanickam, G. V. (2012). Terminalia arjuna's antioxidant effect in isolated perfused kidney. Research in pharmaceutical sciences, 7(3), 181-8.
Raj, C David, et al. "Terminalia arjuna's antioxidant effect in isolated perfused kidney." Research in pharmaceutical sciences vol. 7,3 (2012): 181-8.
Raj CD, Shabi MM, Jipnomon J, Dhevi R, Gayathri K, Subashini U, Rajamanickam GV. Terminalia arjuna's antioxidant effect in isolated perfused kidney. Res Pharm Sci. 2012 Jul;7(3):181-8. PMID: 23181096; PMCID: PMC3501927.
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TLR Specific Immune Responses against Helminth Infections.

Journal of parasitology research

Rajasekaran S, Anuradha R, Bethunaickan R.
PMID: 29225962
J Parasitol Res. 2017;2017:6865789. doi: 10.1155/2017/6865789. Epub 2017 Oct 31.

Despite marked improvement in the quality of lives across the globe, more than 2 million individuals in socioeconomically disadvantaged environments remain infected by helminth (worm) parasites. Owing to the longevity of the worms and paucity of immunologic controls, these...

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Rajasekaran S, Anuradha R, Bethunaickan R. TLR Specific Immune Responses against Helminth Infections. J Parasitol Res. 2017;2017:6865789doi: 10.1155/2017/6865789.
Rajasekaran, S., Anuradha, R., & Bethunaickan, R. (2017). TLR Specific Immune Responses against Helminth Infections. Journal of parasitology research, 20176865789. https://doi.org/10.1155/2017/6865789
Rajasekaran, Sivaprakasam, et al. "TLR Specific Immune Responses against Helminth Infections." Journal of parasitology research vol. 2017 (2017): 6865789. doi: https://doi.org/10.1155/2017/6865789
Rajasekaran S, Anuradha R, Bethunaickan R. TLR Specific Immune Responses against Helminth Infections. J Parasitol Res. 2017;2017:6865789. doi: 10.1155/2017/6865789. Epub 2017 Oct 31. PMID: 29225962; PMCID: PMC5684585.
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Normal Sequence and Activity but Reduced Levels of DNA-Pkcs in Human Lymphoblastic Cells Implicate Impaired Protein Stability with Radiosensitive Phenotype.

Journal of Cancer

Yap SF, Boo CS, Loong SL, Baskar R.
PMID: 24155772
J Cancer. 2013 Sep 07;4(8):606-13. doi: 10.7150/jca.6453.

BACKGROUND: Non-homologous end joining (NHEJ) is the main repair pathway for DNA double strand breaks (DSBs) induced by ionizing radiation in mammalian cells. Subsets of cancer patients are hypersensitive to radiotherapy after standard doses. We sought to determine the...

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Yap SF, Boo CS, Loong SL, et al. Normal Sequence and Activity but Reduced Levels of DNA-Pkcs in Human Lymphoblastic Cells Implicate Impaired Protein Stability with Radiosensitive Phenotype. J Cancer. 2013;4(8):606-13doi: 10.7150/jca.6453.
Yap, S. F., Boo, C. S., Loong, S. L., & Baskar, R. (2013). Normal Sequence and Activity but Reduced Levels of DNA-Pkcs in Human Lymphoblastic Cells Implicate Impaired Protein Stability with Radiosensitive Phenotype. Journal of Cancer, 4(8), 606-13. https://doi.org/10.7150/jca.6453
Yap, Seow Fong, et al. "Normal Sequence and Activity but Reduced Levels of DNA-Pkcs in Human Lymphoblastic Cells Implicate Impaired Protein Stability with Radiosensitive Phenotype." Journal of Cancer vol. 4,8 (2013): 606-13. doi: https://doi.org/10.7150/jca.6453
Yap SF, Boo CS, Loong SL, Baskar R. Normal Sequence and Activity but Reduced Levels of DNA-Pkcs in Human Lymphoblastic Cells Implicate Impaired Protein Stability with Radiosensitive Phenotype. J Cancer. 2013 Sep 07;4(8):606-13. doi: 10.7150/jca.6453. PMID: 24155772; PMCID: PMC3805988.
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Preparing sparse solvers for exascale computing.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences

Anzt H, Boman E, Falgout R, Ghysels P, Heroux M, Li X, Curfman McInnes L, Tran Mills R, Rajamanickam S, Rupp K, Smith B, Yamazaki I, Meier Yang U.
PMID: 31955673
Philos Trans A Math Phys Eng Sci. 2020 Mar 06;378(2166):20190053. doi: 10.1098/rsta.2019.0053. Epub 2020 Jan 20.

Sparse solvers provide essential functionality for a wide variety of scientific applications. Highly parallel sparse solvers are essential for continuing advances in high-fidelity, multi-physics and multi-scale simulations, especially as we target exascale platforms. This paper describes the challenges, strategies...

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Anzt H, Boman E, Falgout R, et al. Preparing sparse solvers for exascale computing. Philos Trans A Math Phys Eng Sci. 2020;378(2166):20190053doi: 10.1098/rsta.2019.0053.
Anzt, H., Boman, E., Falgout, R., Ghysels, P., Heroux, M., Li, X., Curfman McInnes, L., Tran Mills, R., Rajamanickam, S., Rupp, K., Smith, B., Yamazaki, I., & Meier Yang, U. (2020). Preparing sparse solvers for exascale computing. Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 378(2166), 20190053. https://doi.org/10.1098/rsta.2019.0053
Anzt, Hartwig, et al. "Preparing sparse solvers for exascale computing." Philosophical transactions. Series A, Mathematical, physical, and engineering sciences vol. 378,2166 (2020): 20190053. doi: https://doi.org/10.1098/rsta.2019.0053
Anzt H, Boman E, Falgout R, Ghysels P, Heroux M, Li X, Curfman McInnes L, Tran Mills R, Rajamanickam S, Rupp K, Smith B, Yamazaki I, Meier Yang U. Preparing sparse solvers for exascale computing. Philos Trans A Math Phys Eng Sci. 2020 Mar 06;378(2166):20190053. doi: 10.1098/rsta.2019.0053. Epub 2020 Jan 20. PMID: 31955673; PMCID: PMC7015295.
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Allylated Curcumin Analog CA6 Inhibits TrxR1 and Leads to ROS-Dependent Apoptotic Cell Death in Gastric Cancer Through Akt-FoxO3a.

Cancer management and research

Rajamanickam V, Yan T, Wu L, Zhao Y, Xu X, Zhu H, Chen X, Wang M, Liu Z, Liu Z, Liang G, Wang Y.
PMID: 32021440
Cancer Manag Res. 2020 Jan 13;12:247-263. doi: 10.2147/CMAR.S227415. eCollection 2020.

BACKGROUND: Gastric cancer is one of the leading causes of cancer-related deaths. Allylated monocarbonyl analogs of curcumin (MACs) have been reported to selectively inhibit a broad range of human cancers including gastric cancer. However, the precise molecular mechanisms underlying...

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Rajamanickam V, Yan T, Wu L, et al. Allylated Curcumin Analog CA6 Inhibits TrxR1 and Leads to ROS-Dependent Apoptotic Cell Death in Gastric Cancer Through Akt-FoxO3a. Cancer Manag Res. 2020;12:247-263doi: 10.2147/CMAR.S227415.
Rajamanickam, V., Yan, T., Wu, L., Zhao, Y., Xu, X., Zhu, H., Chen, X., Wang, M., Liu, Z., Liu, Z., Liang, G., & Wang, Y. (2020). Allylated Curcumin Analog CA6 Inhibits TrxR1 and Leads to ROS-Dependent Apoptotic Cell Death in Gastric Cancer Through Akt-FoxO3a. Cancer management and research, 12247-263. https://doi.org/10.2147/CMAR.S227415
Rajamanickam, Vinothkumar, et al. "Allylated Curcumin Analog CA6 Inhibits TrxR1 and Leads to ROS-Dependent Apoptotic Cell Death in Gastric Cancer Through Akt-FoxO3a." Cancer management and research vol. 12 (2020): 247-263. doi: https://doi.org/10.2147/CMAR.S227415
Rajamanickam V, Yan T, Wu L, Zhao Y, Xu X, Zhu H, Chen X, Wang M, Liu Z, Liu Z, Liang G, Wang Y. Allylated Curcumin Analog CA6 Inhibits TrxR1 and Leads to ROS-Dependent Apoptotic Cell Death in Gastric Cancer Through Akt-FoxO3a. Cancer Manag Res. 2020 Jan 13;12:247-263. doi: 10.2147/CMAR.S227415. eCollection 2020. PMID: 32021440; PMCID: PMC6968823.
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A mono-carbonyl analog of curcumin induces apoptosis in drug-resistant EGFR-mutant lung cancer through the generation of oxidative stress and mitochondrial dysfunction.

Cancer management and research

Dai X, Zhang J, Guo G, Cai Y, Cui R, Yin C, Liu W, Vinothkumar R, Zhang T, Liang G, Zhang X.
PMID: 30214301
Cancer Manag Res. 2018 Aug 29;10:3069-3082. doi: 10.2147/CMAR.S159660. eCollection 2018.

INTRODUCTION: Targeted therapies using epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) have revolutionized the treatment of non-small cell lung cancer (NSCLC) patients harboring EGFR mutations, leading to the approval of gefitinib and erlotinib as standard first-line clinical treatment. Inevitably,...

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Dai X, Zhang J, Guo G, et al. A mono-carbonyl analog of curcumin induces apoptosis in drug-resistant EGFR-mutant lung cancer through the generation of oxidative stress and mitochondrial dysfunction. Cancer Manag Res. 2018;10:3069-3082doi: 10.2147/CMAR.S159660.
Dai, X., Zhang, J., Guo, G., Cai, Y., Cui, R., Yin, C., Liu, W., Vinothkumar, R., Zhang, T., Liang, G., & Zhang, X. (2018). A mono-carbonyl analog of curcumin induces apoptosis in drug-resistant EGFR-mutant lung cancer through the generation of oxidative stress and mitochondrial dysfunction. Cancer management and research, 103069-3082. https://doi.org/10.2147/CMAR.S159660
Dai, Xuanxuan, et al. "A mono-carbonyl analog of curcumin induces apoptosis in drug-resistant EGFR-mutant lung cancer through the generation of oxidative stress and mitochondrial dysfunction." Cancer management and research vol. 10 (2018): 3069-3082. doi: https://doi.org/10.2147/CMAR.S159660
Dai X, Zhang J, Guo G, Cai Y, Cui R, Yin C, Liu W, Vinothkumar R, Zhang T, Liang G, Zhang X. A mono-carbonyl analog of curcumin induces apoptosis in drug-resistant EGFR-mutant lung cancer through the generation of oxidative stress and mitochondrial dysfunction. Cancer Manag Res. 2018 Aug 29;10:3069-3082. doi: 10.2147/CMAR.S159660. eCollection 2018. PMID: 30214301; PMCID: PMC6124478.
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