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Showing 1 to 12 of 468 entries
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Characterization of forebrain neurons derived from late-onset Huntington's disease human embryonic stem cell lines.

Frontiers in cellular neuroscience

Niclis JC, Pinar A, Haynes JM, Alsanie W, Jenny R, Dottori M, Cram DS.
PMID: 23576953
Front Cell Neurosci. 2013 Apr 05;7:37. doi: 10.3389/fncel.2013.00037. eCollection 2013.

Huntington's disease (HD) is an incurable neurodegenerative disorder caused by a CAG repeat expansion in exon 1 of the Huntingtin (HTT) gene. Recently, induced pluripotent stem cell (iPSC) lines carrying atypical and aggressive (CAG60+) HD variants have been generated...

Multiferroic thin-film integration onto semiconductor devices.

Journal of physics. Condensed matter : an Institute of Physics journal

Thomas R, Scott JF, Bose DN, Katiyar RS.
PMID: 21403306
J Phys Condens Matter. 2010 Oct 27;22(42):423201. doi: 10.1088/0953-8984/22/42/423201. Epub 2010 Sep 23.

This review deals with thin films of single-phase materials which exhibit two primary ferroic properties, namely ferroelectricity and (anti)ferromagnetism, deposited directly or through buffer layers onto semiconductors. It is the electrical control of ferromagnetism and magnetic control of ferroelectricity...

Prognostication of Learning Curve on Surgical Management of Vasculobiliary Injuries after Cholecystectomy.

International journal of hepatology

Hafeez Bhatti AB, Dar FS, Zia H, Rafique MS, Khan NY, Salih M, Hassan Shah N.
PMID: 27525124
Int J Hepatol. 2016;2016:2647130. doi: 10.1155/2016/2647130. Epub 2016 Jul 20.

Background. Concomitant vascular injury might adversely impact outcomes after iatrogenic bile duct injury (IBDI). Whether a new HPB center should embark upon repair of complex biliary injuries with associated vascular injuries during learning curve is unknown. The objective of...

Patterns of Care of Node-Positive Prostate Cancer Patients Across the United States: A National Cancer Data Base Analysis.

Clinical genitourinary cancer

Moon DH, Basak RS, Chen RC.
PMID: 28939472
Clin Genitourin Cancer. 2017 Aug 24; doi: 10.1016/j.clgc.2017.08.004. Epub 2017 Aug 24.

BACKGROUND: Twelve percent of newly diagnosed prostate cancers in the United States are node-positive. In a setting of disparate treatment guideline recommendations for node-positive disease, this study describes the treatment patterns for clinical node-positive (cNRESULTS: A total of 8464...

A smoking cessation intervention among tuberculosis patients in rural China.

Public health action

Lin Y, Wang LX, Qiu LX, Huang Q, Shu Q, Lin HX, Meng X, Zeng XL, Xiao LX, Bam TS, Chiang CY.
PMID: 26399289
Public Health Action. 2015 Sep 21;5(3):183-7. doi: 10.5588/pha.15.0025.

OBJECTIVE: To assess the integration of a smoking cessation intervention into routine tuberculosis (TB) services.METHOD: Consecutive TB patients registered from 1 March to 31 August 2010 were enrolled in an intervention for self-reported smoking to promote tobacco cessation during...

Single-junction polymer solar cells with over 10% efficiency by a novel two-dimensional donor-acceptor conjugated copolymer.

ACS applied materials & interfaces

Liu C, Yi C, Wang K, Yang Y, Bhatta RS, Tsige M, Xiao S, Gong X.
PMID: 25671670
ACS Appl Mater Interfaces. 2015 Mar 04;7(8):4928-35. doi: 10.1021/am509047g. Epub 2015 Feb 20.

Recent advances in bulk heterojunction (BHJ) polymer solar cell (PSC) performance have resulted from compressing the band gap to enhance the short-circuit current density (JSC) while lowering the highest occupied molecular orbital to increase the open-circuit voltage (VOC) and...

Therapeutic approaches to drug targets in atherosclerosis.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

Jamkhande PG, Chandak PG, Dhawale SC, Barde SR, Tidke PS, Sakhare RS.
PMID: 25061401
Saudi Pharm J. 2014 Jul;22(3):179-90. doi: 10.1016/j.jsps.2013.04.005. Epub 2013 Nov 05.

Non-communicable diseases such as cancer, atherosclerosis and diabetes are responsible for major social and health burden as millions of people are dying every year. Out of which, atherosclerosis is the leading cause of deaths worldwide. The lipid abnormality is...

Characterization of acetohydroxyacid synthase from the hyperthermophilic bacterium .

Biochemistry and biophysics reports

Eram MS, Sarafuddin B, Gong F, Ma K.
PMID: 29124191
Biochem Biophys Rep. 2015 Aug 28;4:89-97. doi: 10.1016/j.bbrep.2015.08.014. eCollection 2015 Dec.

Acetohydroxyacid synthase (AHAS) is the key enzyme in branched chain amino acid biosynthesis pathway. The enzyme activity and properties of a highly thermostable AHAS from the hyperthermophilic bacterium

Modeling HSV-1 Latency in Human Embryonic Stem Cell-Derived Neurons.

Pathogens (Basel, Switzerland)

Pourchet A, Modrek AS, Placantonakis DG, Mohr I, Wilson AC.
PMID: 28594343
Pathogens. 2017 Jun 08;6(2). doi: 10.3390/pathogens6020024.

Herpes simplex virus 1 (HSV-1) uses latency in peripheral ganglia to persist in its human host, however, recurrent reactivation from this reservoir can cause debilitating and potentially life-threatening disease. Most studies of latency use live-animal infection models, but these...

Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells.

Oncotarget

Bayin NS, Frenster JD, Sen R, Si S, Modrek AS, Galifianakis N, Dolgalev I, Ortenzi V, Illa-Bochaca I, Khahera A, Serrano J, Chiriboga L, Zagzag D, Golfinos JG, Doyle W, Tsirigos A, Heguy A, Chesler M, Barcellos-Hoff MH, Snuderl M, Placantonakis DG.
PMID: 29029402
Oncotarget. 2017 May 23;8(39):64932-64953. doi: 10.18632/oncotarget.18117. eCollection 2017 Sep 12.

Glioblastoma (GBM) stem cells (GSCs) reside in both hypoxic and vascular microenvironments within tumors. The molecular mechanisms that allow GSCs to occupy such contrasting niches are not understood. We used patient-derived GBM cultures to identify GSC subtypes with differential...

A stochastic analysis of distance estimation approaches in single molecule microscopy - quantifying the resolution limits of photon-limited imaging systems.

Multidimensional systems and signal processing

Ram S, Ward ES, Ober RJ.
PMID: 24932067
Multidimens Syst Signal Process. 2013 Sep;24(3):503-542. doi: 10.1007/s11045-012-0175-6.

Optical microscopy is an invaluable tool to visualize biological processes at the cellular scale. In the recent past, there has been significant interest in studying these processes at the single molecule level. An important question that arises in single...

Effectiveness of Topical Antifungal Drugs in the Management of Fungal Keratitis: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)

McDonald EM, Ram FS, Patel DV, McGhee CN.
PMID: 26107307
Asia Pac J Ophthalmol (Phila). 2014 Jan-Feb;3(1):41-7. doi: 10.1097/APO.0b013e3182a618dd.

Fungal keratitis (FK) typically requires intensive therapy with topical antifungal agents. To date, evidence from clinical trials has been conflicting with respect to the most effective topical antifungal drug in the treatment of FK. Therefore, a systematic review and...

Showing 1 to 12 of 468 entries