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Realizing present and future promise of DIY biology and medicine through a trust architecture

Broadening participation

Guerrini CJ, Rasmussen LM.
GSID: H0eGfk5dudQJ
LM Rasmussen, CJ Guerrini, T Kuiken… - Hastings Center …, 2020 - Wiley Online Library

The speed and scale of the COVID‐19 pandemic has highlighted the limits of current health systems and the potential promise of non‐establishment research such as “DIY” research …

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Rasmussen, L. M., Guerrini, C. J., Kuiken, T., Nebeker, C., Pearlman, A., Ware, S. B., ... & Zettler, P. J. (2020). Realizing present and future promise of DIY biology and medicine through a trust architecture. Hastings Center Report, 50(6), 10-14.
Rasmussen, Lisa M., et al. "Realizing present and future promise of DIY biology and medicine through a trust architecture." Hastings Center Report 50.6 (2020): 10-14.
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High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring.

Molecular metabolism

de Castro Barbosa T, Ingerslev LR, Alm PS, Versteyhe S, Massart J, Rasmussen M, Donkin I, Sjögren R, Mudry JM, Vetterli L, Gupta S, Krook A, Zierath JR, Barrès R.
PMID: 26977389
Mol Metab. 2015 Dec 25;5(3):184-197. doi: 10.1016/j.molmet.2015.12.002. eCollection 2016 Mar.

OBJECTIVES: Chronic and high consumption of fat constitutes an environmental stress that leads to metabolic diseases. We hypothesized that high-fat diet (HFD) transgenerationally remodels the epigenome of spermatozoa and metabolism of the offspring.METHODS: F0-male rats fed either HFD or...

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de Castro Barbosa T, Ingerslev LR, Alm PS, et al. High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring. Mol Metab. 2015;5(3):184-197doi: 10.1016/j.molmet.2015.12.002.
de Castro Barbosa, T., Ingerslev, L. R., Alm, P. S., Versteyhe, S., Massart, J., Rasmussen, M., Donkin, I., Sjögren, R., Mudry, J. M., Vetterli, L., Gupta, S., Krook, A., Zierath, J. R., & Barrès, R. (2016). High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring. Molecular metabolism, 5(3), 184-197. https://doi.org/10.1016/j.molmet.2015.12.002
de Castro Barbosa, Thais, et al. "High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring." Molecular metabolism vol. 5,3 (2016): 184-197. doi: https://doi.org/10.1016/j.molmet.2015.12.002
de Castro Barbosa T, Ingerslev LR, Alm PS, Versteyhe S, Massart J, Rasmussen M, Donkin I, Sjögren R, Mudry JM, Vetterli L, Gupta S, Krook A, Zierath JR, Barrès R. High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring. Mol Metab. 2015 Dec 25;5(3):184-197. doi: 10.1016/j.molmet.2015.12.002. eCollection 2016 Mar. PMID: 26977389; PMCID: PMC4770269.
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Validity of data in the Danish Colorectal Cancer Screening Database.

Clinical epidemiology

Thomsen MK, Njor SH, Rasmussen M, Linnemann D, Andersen B, Baatrup G, Friis-Hansen LJ, Jørgensen JC, Mikkelsen EM.
PMID: 28255255
Clin Epidemiol. 2017 Feb 17;9:105-111. doi: 10.2147/CLEP.S124454. eCollection 2017.

BACKGROUND: In Denmark, a nationwide screening program for colorectal cancer was implemented in March 2014. Along with this, a clinical database for program monitoring and research purposes was established.OBJECTIVE: The aim of this study was to estimate the agreement...

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Thomsen MK, Njor SH, Rasmussen M, et al. Validity of data in the Danish Colorectal Cancer Screening Database. Clin Epidemiol. 2017;9:105-111doi: 10.2147/CLEP.S124454.
Thomsen, M. K., Njor, S. H., Rasmussen, M., Linnemann, D., Andersen, B., Baatrup, G., Friis-Hansen, L. J., Jørgensen, J. C., & Mikkelsen, E. M. (2017). Validity of data in the Danish Colorectal Cancer Screening Database. Clinical epidemiology, 9105-111. https://doi.org/10.2147/CLEP.S124454
Thomsen, Mette Kielsholm, et al. "Validity of data in the Danish Colorectal Cancer Screening Database." Clinical epidemiology vol. 9 (2017): 105-111. doi: https://doi.org/10.2147/CLEP.S124454
Thomsen MK, Njor SH, Rasmussen M, Linnemann D, Andersen B, Baatrup G, Friis-Hansen LJ, Jørgensen JC, Mikkelsen EM. Validity of data in the Danish Colorectal Cancer Screening Database. Clin Epidemiol. 2017 Feb 17;9:105-111. doi: 10.2147/CLEP.S124454. eCollection 2017. PMID: 28255255; PMCID: PMC5322846.
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Correction for Dietrich et al., Differential Influence of Nutrient-Starved Mycobacterium tuberculosis on Adaptive Immunity Results in Progressive Tuberculosis Disease and Pathology.

Infection and immunity

Dietrich J, Roy S, Rosenkrands I, Lindenstrøm T, Filskov J, Rasmussen EM, Cassidy J, Andersen P.
PMID: 26810750
Infect Immun. 2016 Jan 25;84(2):608. doi: 10.1128/IAI.01427-15. Print 2016 Feb.

No abstract available.

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Dietrich J, Roy S, Rosenkrands I, et al. Correction for Dietrich et al., Differential Influence of Nutrient-Starved Mycobacterium tuberculosis on Adaptive Immunity Results in Progressive Tuberculosis Disease and Pathology. Infect Immun. 2016;84(2):608doi: 10.1128/IAI.01427-15.
Dietrich, J., Roy, S., Rosenkrands, I., Lindenstrøm, T., Filskov, J., Rasmussen, E. M., Cassidy, J., & Andersen, P. (2016). Correction for Dietrich et al., Differential Influence of Nutrient-Starved Mycobacterium tuberculosis on Adaptive Immunity Results in Progressive Tuberculosis Disease and Pathology. Infection and immunity, 84(2), 608. https://doi.org/10.1128/IAI.01427-15
Dietrich, Jes, et al. "Correction for Dietrich et al., Differential Influence of Nutrient-Starved Mycobacterium tuberculosis on Adaptive Immunity Results in Progressive Tuberculosis Disease and Pathology." Infection and immunity vol. 84,2 (2016): 608. doi: https://doi.org/10.1128/IAI.01427-15
Dietrich J, Roy S, Rosenkrands I, Lindenstrøm T, Filskov J, Rasmussen EM, Cassidy J, Andersen P. Correction for Dietrich et al., Differential Influence of Nutrient-Starved Mycobacterium tuberculosis on Adaptive Immunity Results in Progressive Tuberculosis Disease and Pathology. Infect Immun. 2016 Jan 25;84(2):608. doi: 10.1128/IAI.01427-15. Print 2016 Feb. PMID: 26810750; PMCID: PMC4730563.
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Oral Magnesium Supplementation in Chronic Kidney Disease Stages 3 and 4: Efficacy, Safety, and Effect on Serum Calcification Propensity-A Prospective Randomized Double-Blinded Placebo-Controlled Clinical Trial.

Kidney international reports

Bressendorff I, Hansen D, Schou M, Silver B, Pasch A, Bouchelouche P, Pedersen L, Rasmussen LM, Brandi L.
PMID: 29142966
Kidney Int Rep. 2016 Dec 30;2(3):380-389. doi: 10.1016/j.ekir.2016.12.008. eCollection 2017 May.

INTRODUCTION: Chronic kidney disease (CKD) is associated with high cardiovascular morbidity and mortality. Recent evidence suggests that increases in both serum and intracellular magnesium (Mg) can slow or even prevent the development of vascular calcification seen in CKD. Serum...

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Bressendorff I, Hansen D, Schou M, et al. Oral Magnesium Supplementation in Chronic Kidney Disease Stages 3 and 4: Efficacy, Safety, and Effect on Serum Calcification Propensity-A Prospective Randomized Double-Blinded Placebo-Controlled Clinical Trial. Kidney Int Rep. 2016;2(3):380-389doi: 10.1016/j.ekir.2016.12.008.
Bressendorff, I., Hansen, D., Schou, M., Silver, B., Pasch, A., Bouchelouche, P., Pedersen, L., Rasmussen, L. M., & Brandi, L. (2017). Oral Magnesium Supplementation in Chronic Kidney Disease Stages 3 and 4: Efficacy, Safety, and Effect on Serum Calcification Propensity-A Prospective Randomized Double-Blinded Placebo-Controlled Clinical Trial. Kidney international reports, 2(3), 380-389. https://doi.org/10.1016/j.ekir.2016.12.008
Bressendorff, Iain, et al. "Oral Magnesium Supplementation in Chronic Kidney Disease Stages 3 and 4: Efficacy, Safety, and Effect on Serum Calcification Propensity-A Prospective Randomized Double-Blinded Placebo-Controlled Clinical Trial." Kidney international reports vol. 2,3 (2017): 380-389. doi: https://doi.org/10.1016/j.ekir.2016.12.008
Bressendorff I, Hansen D, Schou M, Silver B, Pasch A, Bouchelouche P, Pedersen L, Rasmussen LM, Brandi L. Oral Magnesium Supplementation in Chronic Kidney Disease Stages 3 and 4: Efficacy, Safety, and Effect on Serum Calcification Propensity-A Prospective Randomized Double-Blinded Placebo-Controlled Clinical Trial. Kidney Int Rep. 2016 Dec 30;2(3):380-389. doi: 10.1016/j.ekir.2016.12.008. eCollection 2017 May. PMID: 29142966; PMCID: PMC5678662.
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SU-E-T-530: Relative Electron Density Phantom Comparison.

Medical physics

Rasmussen B, Chu K, Tong S.
PMID: 28518536
Med Phys. 2012 Jun;39(6):3827. doi: 10.1118/1.4735619.

PURPOSE: Modern treatment planning systems require lookup tables to convert Hounsfield Units (HU) to relative electron density (RED) for use in heterogeneity corrections during dose calculations. The purpose of this work is to illustrate the impact of using different...

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Rasmussen B, Chu K, Tong S. SU-E-T-530: Relative Electron Density Phantom Comparison. Med Phys. 2012;39(6):3827doi: 10.1118/1.4735619.
Rasmussen, B., Chu, K., & Tong, S. (2012). SU-E-T-530: Relative Electron Density Phantom Comparison. Medical physics, 39(6), 3827. https://doi.org/10.1118/1.4735619
Rasmussen, B, et al. "SU-E-T-530: Relative Electron Density Phantom Comparison." Medical physics vol. 39,6 (2012): 3827. doi: https://doi.org/10.1118/1.4735619
Rasmussen B, Chu K, Tong S. SU-E-T-530: Relative Electron Density Phantom Comparison. Med Phys. 2012 Jun;39(6):3827. doi: 10.1118/1.4735619. PMID: 28518536.
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Corrigendum: Neuronal IFN-beta-induced PI3K/Akt-FoxA1 signalling is essential for generation of FoxA1.

Nature communications

Liu Y, Marin A, Ejlerskov P, Rasmussen LM, Prinz M, Issazadeh-Navikas S.
PMID: 28530243
Nat Commun. 2017 May 22;8:15792. doi: 10.1038/ncomms15792.

This corrects the article DOI: 10.1038/ncomms14709.

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Liu Y, Marin A, Ejlerskov P, et al. Corrigendum: Neuronal IFN-beta-induced PI3K/Akt-FoxA1 signalling is essential for generation of FoxA1. Nat Commun. 2017;8:15792doi: 10.1038/ncomms15792.
Liu, Y., Marin, A., Ejlerskov, P., Rasmussen, L. M., Prinz, M., & Issazadeh-Navikas, S. (2017). Corrigendum: Neuronal IFN-beta-induced PI3K/Akt-FoxA1 signalling is essential for generation of FoxA1. Nature communications, 815792. https://doi.org/10.1038/ncomms15792
Liu, Yawei, et al. "Corrigendum: Neuronal IFN-beta-induced PI3K/Akt-FoxA1 signalling is essential for generation of FoxA1." Nature communications vol. 8 (2017): 15792. doi: https://doi.org/10.1038/ncomms15792
Liu Y, Marin A, Ejlerskov P, Rasmussen LM, Prinz M, Issazadeh-Navikas S. Corrigendum: Neuronal IFN-beta-induced PI3K/Akt-FoxA1 signalling is essential for generation of FoxA1. Nat Commun. 2017 May 22;8:15792. doi: 10.1038/ncomms15792. PMID: 28530243; PMCID: PMC5458143.
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Erratum for Holm et al., Activation of the Contact System at the Surface of Fusobacterium necrophorum Represents a Possible Virulence Mechanism in Lemièrre's Syndrome.

Infection and immunity

Holm K, Frick IM, Björck L, Rasmussen M.
PMID: 26450975
Infect Immun. 2015 Nov;83(11):4451. doi: 10.1128/IAI.01123-15.

No abstract available.

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Holm K, Frick IM, Björck L, et al. Erratum for Holm et al., Activation of the Contact System at the Surface of Fusobacterium necrophorum Represents a Possible Virulence Mechanism in Lemièrre's Syndrome. Infect Immun. 2015;83(11):4451doi: 10.1128/IAI.01123-15.
Holm, K., Frick, I. M., Björck, L., & Rasmussen, M. (2015). Erratum for Holm et al., Activation of the Contact System at the Surface of Fusobacterium necrophorum Represents a Possible Virulence Mechanism in Lemièrre's Syndrome. Infection and immunity, 83(11), 4451. https://doi.org/10.1128/IAI.01123-15
Holm, Karin, et al. "Erratum for Holm et al., Activation of the Contact System at the Surface of Fusobacterium necrophorum Represents a Possible Virulence Mechanism in Lemièrre's Syndrome." Infection and immunity vol. 83,11 (2015): 4451. doi: https://doi.org/10.1128/IAI.01123-15
Holm K, Frick IM, Björck L, Rasmussen M. Erratum for Holm et al., Activation of the Contact System at the Surface of Fusobacterium necrophorum Represents a Possible Virulence Mechanism in Lemièrre's Syndrome. Infect Immun. 2015 Nov;83(11):4451. doi: 10.1128/IAI.01123-15. PMID: 26450975; PMCID: PMC4598390.
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Normalization of Activated Partial Thromboplastin Time Correlates with Low Levels of Dabigatran in a Patient with Severe Sepsis.

Case reports in critical care

Højland RE, Thorup SB, Rasmussen BS.
PMID: 26221544
Case Rep Crit Care. 2015;2015:137504. doi: 10.1155/2015/137504. Epub 2015 Jun 29.

The oral anticoagulant dabigatran etexilate can be a challenge when patients need acute surgery. Sepsis and acute renal failure exacerbate the anticoagulant effect. There is no specific reversal agent for dabigatran etexilate, but it can be removed by hemodialysis....

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Højland RE, Thorup SB, Rasmussen BS. Normalization of Activated Partial Thromboplastin Time Correlates with Low Levels of Dabigatran in a Patient with Severe Sepsis. Case Rep Crit Care. 2015;2015:137504doi: 10.1155/2015/137504.
Højland, R. E., Thorup, S. B., & Rasmussen, B. S. (2015). Normalization of Activated Partial Thromboplastin Time Correlates with Low Levels of Dabigatran in a Patient with Severe Sepsis. Case reports in critical care, 2015137504. https://doi.org/10.1155/2015/137504
Højland, Rikke Ebenhard, et al. "Normalization of Activated Partial Thromboplastin Time Correlates with Low Levels of Dabigatran in a Patient with Severe Sepsis." Case reports in critical care vol. 2015 (2015): 137504. doi: https://doi.org/10.1155/2015/137504
Højland RE, Thorup SB, Rasmussen BS. Normalization of Activated Partial Thromboplastin Time Correlates with Low Levels of Dabigatran in a Patient with Severe Sepsis. Case Rep Crit Care. 2015;2015:137504. doi: 10.1155/2015/137504. Epub 2015 Jun 29. PMID: 26221544; PMCID: PMC4499610.
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Is Thyroid Autoimmunity per se a Determinant of Quality of Life in Patients with Autoimmune Hypothyroidism?.

European thyroid journal

Watt T, Hegedüs L, Bjorner JB, Groenvold M, Bonnema SJ, Rasmussen AK, Feldt-Rasmussen U.
PMID: 24783018
Eur Thyroid J. 2012 Oct;1(3):186-92. doi: 10.1159/000342623. Epub 2012 Sep 29.

PURPOSE: To evaluate the relationship between thyroid variables and health-related quality of life (QoL) in patients with autoimmune hypothyroidism, using the thyroid-specific QoL questionnaire ThyPRO.METHODS: In a cross-sectional study, responses to the ThyPRO from 199 outpatients with autoimmune hypothyroidism...

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Watt T, Hegedüs L, Bjorner JB, et al. Is Thyroid Autoimmunity per se a Determinant of Quality of Life in Patients with Autoimmune Hypothyroidism?. Eur Thyroid J. 2012;1(3):186-92doi: 10.1159/000342623.
Watt, T., Hegedüs, L., Bjorner, J. B., Groenvold, M., Bonnema, S. J., Rasmussen, A. K., & Feldt-Rasmussen, U. (2012). Is Thyroid Autoimmunity per se a Determinant of Quality of Life in Patients with Autoimmune Hypothyroidism?. European thyroid journal, 1(3), 186-92. https://doi.org/10.1159/000342623
Watt, Torquil, et al. "Is Thyroid Autoimmunity per se a Determinant of Quality of Life in Patients with Autoimmune Hypothyroidism?." European thyroid journal vol. 1,3 (2012): 186-92. doi: https://doi.org/10.1159/000342623
Watt T, Hegedüs L, Bjorner JB, Groenvold M, Bonnema SJ, Rasmussen AK, Feldt-Rasmussen U. Is Thyroid Autoimmunity per se a Determinant of Quality of Life in Patients with Autoimmune Hypothyroidism?. Eur Thyroid J. 2012 Oct;1(3):186-92. doi: 10.1159/000342623. Epub 2012 Sep 29. PMID: 24783018; PMCID: PMC3821477.
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The effect of constructing versus solving virtual patient cases on transfer of learning: a randomized trial.

Perspectives on medical education

Tolsgaard MG, Jepsen RM, Rasmussen MB, Kayser L, Fors U, Laursen LC, Svendsen JH, Ringsted C.
PMID: 26754313
Perspect Med Educ. 2016 Feb;5(1):33-8. doi: 10.1007/s40037-015-0242-4.

The purpose of this study was to explore the effect of actively constructing virtual patient (VP) cases compared with solving VP cases on knowledge gains, skills transfer and time spent on cases. Forty-five fourth-year medical students were randomized to...

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Tolsgaard MG, Jepsen RM, Rasmussen MB, et al. The effect of constructing versus solving virtual patient cases on transfer of learning: a randomized trial. Perspect Med Educ. 2016;5(1):33-8doi: 10.1007/s40037-015-0242-4.
Tolsgaard, M. G., Jepsen, R. M., Rasmussen, M. B., Kayser, L., Fors, U., Laursen, L. C., Svendsen, J. H., & Ringsted, C. (2016). The effect of constructing versus solving virtual patient cases on transfer of learning: a randomized trial. Perspectives on medical education, 5(1), 33-8. https://doi.org/10.1007/s40037-015-0242-4
Tolsgaard, Martin G, et al. "The effect of constructing versus solving virtual patient cases on transfer of learning: a randomized trial." Perspectives on medical education vol. 5,1 (2016): 33-8. doi: https://doi.org/10.1007/s40037-015-0242-4
Tolsgaard MG, Jepsen RM, Rasmussen MB, Kayser L, Fors U, Laursen LC, Svendsen JH, Ringsted C. The effect of constructing versus solving virtual patient cases on transfer of learning: a randomized trial. Perspect Med Educ. 2016 Feb;5(1):33-8. doi: 10.1007/s40037-015-0242-4. PMID: 26754313; PMCID: PMC4754215.
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Bacteremia with Aerococcus sanguinicola: Case Series with Characterization of Virulence Properties.

Open forum infectious diseases

Senneby E, Eriksson B, Fagerholm E, Rasmussen M.
PMID: 25734098
Open Forum Infect Dis. 2014 May 23;1(1):ofu025. doi: 10.1093/ofid/ofu025. eCollection 2014 Mar.

BACKGROUND: Since Aerococcus sanguinicola was designated as a species in 2001, only a few cases of bacteremia have been reported. The aim with this study was to describe the clinical presentation of A sanguinicola bacteremia and to determine the...

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Senneby E, Eriksson B, Fagerholm E, et al. Bacteremia with Aerococcus sanguinicola: Case Series with Characterization of Virulence Properties. Open Forum Infect Dis. 2014;1(1):ofu025doi: 10.1093/ofid/ofu025.
Senneby, E., Eriksson, B., Fagerholm, E., & Rasmussen, M. (2014). Bacteremia with Aerococcus sanguinicola: Case Series with Characterization of Virulence Properties. Open forum infectious diseases, 1(1), ofu025. https://doi.org/10.1093/ofid/ofu025
Senneby, Erik, et al. "Bacteremia with Aerococcus sanguinicola: Case Series with Characterization of Virulence Properties." Open forum infectious diseases vol. 1,1 (2014): ofu025. doi: https://doi.org/10.1093/ofid/ofu025
Senneby E, Eriksson B, Fagerholm E, Rasmussen M. Bacteremia with Aerococcus sanguinicola: Case Series with Characterization of Virulence Properties. Open Forum Infect Dis. 2014 May 23;1(1):ofu025. doi: 10.1093/ofid/ofu025. eCollection 2014 Mar. PMID: 25734098; PMCID: PMC4324188.
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Showing 1 to 12 of 453 entries