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Showing 1 to 12 of 37 entries
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Advancing the educational and career pathway for clinical trials nurses

Educational trials

Roydhouse JK.
GSID: yW9m0lPrYpQJ
K Scott, K White, JK Roydhouse - The Journal of Continuing …, 2013 - journals.healio.com

… that educational and training opportunities for nurses who are pursu- Clinical trials nurses play a pivotal role in the conduct of clinical research, but the educational and … This article reports findings from a survey of nurses working...

Adrenocorticotropic Hormone-Dependent Cushing's Syndrome: Use of an octreotide trial to distinguish between pituitary or ectopic sources.

Sultan Qaboos University medical journal

El-Shafie OT, Al-Saffi N, Al-Sajwani A, Woodhouse N.
PMID: 25685371
Sultan Qaboos Univ Med J. 2015 Feb;15(1):e120-3. Epub 2015 Jan 21.

OBJECTIVES: Adrenocorticotropic hormone (ACTH) overproduction is usually due to a pituitary tumour which is often not visible on magnetic resonance imaging (MRI). However, ACTH overproduction may be due to an ectopic source. This study aimed to develop a simple...

Radical-carbanion cyclo-coupling in armed aromatics: overriding steric hindrance to ring closure.

Chemical communications (Cambridge, England)

Roydhouse MD, Walton JC.
PMID: 16136248
Chem Commun (Camb). 2005 Sep 21;(35):4453-5. doi: 10.1039/b506391d. Epub 2005 Aug 04.

Omega-(2-Halophenyl)alkyl-2-oxazolines were prepared and reacted via base promoted intramolecular coupling of radical with carbanionic centres to yield 1-phenyl-1-oxazolino-indan and -tetralin derivatives containing quaternary C-atoms.

Axial and equatorial cyclohexylacyl and tetrahydropyranyl-2-acyl radicals. An experimental and theoretical study.

Organic letters

DiLabio GA, Ingold KU, Roydhouse MD, Walton JC.
PMID: 15524473
Org Lett. 2004 Nov 11;6(23):4319-22. doi: 10.1021/ol0481683.

Axial and equatorial cyclohexylacyl and tetrahydropyranyl-2-acyl radicals gave distinct EPR spectra thanks to surprisingly large beta-hydrogen atom hyperfine splittings that enabled them to be characterized and monitored. DFT computations indicated that the axial species (X = CH(2)) had a...

Catecholamine-secreting carotid body paraganglioma: successful preoperative control of hypertension and clinical symptoms using high-dose long-acting octreotide.

Endocrinology, diabetes & metabolism case reports

Elshafie O, Al Badaai Y, Alwahaibi K, Qureshi A, Hussein S, Al Azzri F, Almamari A, Woodhouse N.
PMID: 25136449
Endocrinol Diabetes Metab Case Rep. 2014;2014:140051. doi: 10.1530/EDM-14-0051. Epub 2014 Jul 01.

UNLABELLED: A 48-year-old hypertensive and diabetic patient presented with a 10-year history of progressive right facial pain, tinnitus, hearing loss, sweating, and palpitations. Investigations revealed a 5.6 cm vascular tumor at the carotid bifurcation. Her blood pressure (BP) was...

Investigating Potential Bias in Patient-Reported Outcomes in Open-label Cancer Trials.

JAMA oncology

Roydhouse JK, Fiero MH, Kluetz PG.
PMID: 30653227
JAMA Oncol. 2019 Apr 01;5(4):457-458. doi: 10.1001/jamaoncol.2018.6205.

No abstract available.

Accuracy of documented administration times for intravenous antimicrobial drugs and impact on dosing decisions.

British journal of clinical pharmacology

Roydhouse SA, Carland JE, Debono DS, Baysari MT, Reuter SE, Staciwa AJ, Sandhu APK, Day RO, Stocker SL.
PMID: 33792079
Br J Clin Pharmacol. 2021 Nov;87(11):4273-4282. doi: 10.1111/bcp.14844. Epub 2021 Apr 15.

AIMS: Accurate documentation of medication administration time is imperative for many therapeutic decisions, including dosing of intravenous antimicrobials. The objectives were to determine (1) the discrepancy between actual and documented administration times for antimicrobial infusions and (2) whether day...

The estimand framework and its application in substance use disorder clinical trials: a case study.

The American journal of drug and alcohol abuse

Roydhouse JK, Floden L, Tomko RL, Gray KM, Bell ML.
PMID: 34702088
Am J Drug Alcohol Abuse. 2021 Oct 26;1-6. doi: 10.1080/00952990.2021.1976199. Epub 2021 Oct 26.

Relapse rates among individuals with substance use disorder (SUD) remain high and new treatment approaches are needed, which require evaluation in randomized controlled trials (RCTs). Measurement and interpretation challenges for SUD RCT data are often ignored or presented only...

The use of proxies and proxy-reported measures: a report of the international society for quality of life research (ISOQOL) proxy task force.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

Roydhouse JK, Cohen ML, Eshoj HR, Corsini N, Yucel E, Rutherford C, Wac K, Berrocal A, Lanzi A, Nowinski C, Roberts N, Kassianos AP, Sebille V, King MT, Mercieca-Bebber R.
PMID: 34254262
Qual Life Res. 2021 Jul 12; doi: 10.1007/s11136-021-02937-8. Epub 2021 Jul 12.

AIMS: Proxy reports are often used when patients are unable to self-report. It is unclear how proxy measures are currently in use in adult health care and research settings. We aimed to describe how proxy reports are used in...

VIPoma Crisis: Immediate and life saving reduction of massive stool volumes on starting treatment with octreotide.

Sultan Qaboos University medical journal

Elshafie O, Grant C, Al-Hamdani A, Jain R, Woodhouse N.
PMID: 21509215
Sultan Qaboos Univ Med J. 2011 Feb;11(1):104-7. Epub 2011 Feb 12.

We report the case of a 57-year-old male physician who presented with a life threatening secretory and refractory diarrhoea of around 20 L/day. This was complicated by severe hypotension, hypokalaemia, hypercalcaemia, renal failure requiring dialysis, metabolic acidosis, cardiorespiratory arrest...

The estimand framework and its application in substance use disorder clinical trials: a case study.

The American journal of drug and alcohol abuse

Roydhouse JK, Floden L, Tomko RL, Gray KM, Bell ML.
PMID: 34702088
Am J Drug Alcohol Abuse. 2021 Nov 02;47(6):658-663. doi: 10.1080/00952990.2021.1976199. Epub 2021 Oct 26.

Relapse rates among individuals with substance use disorder (SUD) remain high and new treatment approaches are needed, which require evaluation in randomized controlled trials (RCTs). Measurement and interpretation challenges for SUD RCT data are often ignored or presented only...

Radioactive iodine-131 therapy in the management of ectopic thyroid tissue.

Sultan Qaboos University medical journal

El-Shafie OT, Hussain S, Sankhla D, Woodhouse N.
PMID: 25364564
Sultan Qaboos Univ Med J. 2014 Nov;14(4):e571-4. Epub 2014 Oct 14.

The occurrence of ectopic lingual thyroid tissue was first reported over 100 years ago. We report an unusual presentation of ectopic thyroid tissue occurring in the submental area. A 27-year-old female presented to the Sultan Qaboos University Hospital in...

Showing 1 to 12 of 37 entries