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Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors.

ACS medicinal chemistry letters

Cadoni R, Pala N, Lomelino C, Mahon BP, McKenna R, Dallocchio R, Dessì A, Carcelli M, Rogolino D, Sanna V, Rassu M, Iaccarino C, Vullo D, Supuran CT, Sechi M.
PMID: 28947941
ACS Med Chem Lett. 2017 Jul 31;8(9):941-946. doi: 10.1021/acsmedchemlett.7b00229. eCollection 2017 Sep 14.

We report the synthesis, biological evaluation, and structural study of a series of substituted heteroaryl-pyrazole carboxylic acid derivatives. These compounds have been developed as inhibitors of specific isoforms of carbonic anhydrase (CA), with potential as prototypes of a new...

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Cadoni R, Pala N, Lomelino C, et al. Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors. ACS Med Chem Lett. 2017;8(9):941-946doi: 10.1021/acsmedchemlett.7b00229.
Cadoni, R., Pala, N., Lomelino, C., Mahon, B. P., McKenna, R., Dallocchio, R., Dessì, A., Carcelli, M., Rogolino, D., Sanna, V., Rassu, M., Iaccarino, C., Vullo, D., Supuran, C. T., & Sechi, M. (2017). Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors. ACS medicinal chemistry letters, 8(9), 941-946. https://doi.org/10.1021/acsmedchemlett.7b00229
Cadoni, Roberta, et al. "Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors." ACS medicinal chemistry letters vol. 8,9 (2017): 941-946. doi: https://doi.org/10.1021/acsmedchemlett.7b00229
Cadoni R, Pala N, Lomelino C, Mahon BP, McKenna R, Dallocchio R, Dessì A, Carcelli M, Rogolino D, Sanna V, Rassu M, Iaccarino C, Vullo D, Supuran CT, Sechi M. Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors. ACS Med Chem Lett. 2017 Jul 31;8(9):941-946. doi: 10.1021/acsmedchemlett.7b00229. eCollection 2017 Sep 14. PMID: 28947941; PMCID: PMC5601383.
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ERRα regulates the growth of triple-negative breast cancer cells via S6K1-dependent mechanism.

Signal transduction and targeted therapy

Berman AY, Manna S, Schwartz NS, Katz YE, Sun Y, Behrmann CA, Yu JJ, Plas DR, Alayev A, Holz MK.
PMID: 28890840
Signal Transduct Target Ther. 2017;2. doi: 10.1038/sigtrans.2017.35. Epub 2017 Aug 25.

Estrogen-related receptor alpha (ERRα) is an orphan nuclear factor that is a master regulator of cellular energy metabolism. ERRα is overexpressed in a variety of tumors, including ovarian, prostate, colorectal, cervical and breast, and is associated with a more...

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Berman AY, Manna S, Schwartz NS, et al. ERRα regulates the growth of triple-negative breast cancer cells via S6K1-dependent mechanism. Signal Transduct Target Ther. 2017;2doi: 10.1038/sigtrans.2017.35.
Berman, A. Y., Manna, S., Schwartz, N. S., Katz, Y. E., Sun, Y., Behrmann, C. A., Yu, J. J., Plas, D. R., Alayev, A., & Holz, M. K. (2017). ERRα regulates the growth of triple-negative breast cancer cells via S6K1-dependent mechanism. Signal transduction and targeted therapy, 2. https://doi.org/10.1038/sigtrans.2017.35
Berman, Adi Y, et al. "ERRα regulates the growth of triple-negative breast cancer cells via S6K1-dependent mechanism." Signal transduction and targeted therapy vol. 2 (2017). doi: https://doi.org/10.1038/sigtrans.2017.35
Berman AY, Manna S, Schwartz NS, Katz YE, Sun Y, Behrmann CA, Yu JJ, Plas DR, Alayev A, Holz MK. ERRα regulates the growth of triple-negative breast cancer cells via S6K1-dependent mechanism. Signal Transduct Target Ther. 2017;2. doi: 10.1038/sigtrans.2017.35. Epub 2017 Aug 25. PMID: 28890840; PMCID: PMC5589335.
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On-demand intermittent beclomethasone is effective for mild asthma in Brazil.

Clinical and translational allergy

Camargos P, Affonso A, Calazans G, Ramalho L, Ribeiro ML, Jentzsch N, Senna S, Stein RT.
PMID: 29515802
Clin Transl Allergy. 2018 Mar 05;8:7. doi: 10.1186/s13601-018-0192-0. eCollection 2018.

BACKGROUND: Daily inhaled corticosteroids are widely recommended for mild persistent asthma. This study aimed to assess the efficacy of the intermittent use of beclomethasone as an alternative treatment for mild persistent asthma.METHODS: In this 16-week trial, children aged 6-18...

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Camargos P, Affonso A, Calazans G, et al. On-demand intermittent beclomethasone is effective for mild asthma in Brazil. Clin Transl Allergy. 2018;8:7doi: 10.1186/s13601-018-0192-0.
Camargos, P., Affonso, A., Calazans, G., Ramalho, L., Ribeiro, M. L., Jentzsch, N., Senna, S., & Stein, R. T. (2018). On-demand intermittent beclomethasone is effective for mild asthma in Brazil. Clinical and translational allergy, 87. https://doi.org/10.1186/s13601-018-0192-0
Camargos, Paulo, et al. "On-demand intermittent beclomethasone is effective for mild asthma in Brazil." Clinical and translational allergy vol. 8 (2018): 7. doi: https://doi.org/10.1186/s13601-018-0192-0
Camargos P, Affonso A, Calazans G, Ramalho L, Ribeiro ML, Jentzsch N, Senna S, Stein RT. On-demand intermittent beclomethasone is effective for mild asthma in Brazil. Clin Transl Allergy. 2018 Mar 05;8:7. doi: 10.1186/s13601-018-0192-0. eCollection 2018. PMID: 29515802; PMCID: PMC5836456.
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Mapping spiral structure on the far side of the Milky Way.

Science (New York, N.Y.)

Sanna A, Reid MJ, Dame TM, Menten KM, Brunthaler A.
PMID: 29026043
Science. 2017 Oct 13;358(6360):227-230. doi: 10.1126/science.aan5452.

Little is known about the portion of the Milky Way lying beyond the Galactic center at distances of more than 9 kiloparsec from the Sun. These regions are opaque at optical wavelengths because of absorption by interstellar dust, and...

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Sanna A, Reid MJ, Dame TM, et al. Mapping spiral structure on the far side of the Milky Way. Science. 2017;358(6360):227-230doi: 10.1126/science.aan5452.
Sanna, A., Reid, M. J., Dame, T. M., Menten, K. M., & Brunthaler, A. (2017). Mapping spiral structure on the far side of the Milky Way. Science (New York, N.Y.), 358(6360), 227-230. https://doi.org/10.1126/science.aan5452
Sanna, Alberto, et al. "Mapping spiral structure on the far side of the Milky Way." Science (New York, N.Y.) vol. 358,6360 (2017): 227-230. doi: https://doi.org/10.1126/science.aan5452
Sanna A, Reid MJ, Dame TM, Menten KM, Brunthaler A. Mapping spiral structure on the far side of the Milky Way. Science. 2017 Oct 13;358(6360):227-230. doi: 10.1126/science.aan5452. PMID: 29026043.
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The state of coronary arteries in perimenopausal women with chest pain.

Journal of clinical medicine research

Isayeva GS.
PMID: 25247019
J Clin Med Res. 2014 Dec;6(6):451-5. doi: 10.14740/jocmr1915w. Epub 2014 Sep 09.

BACKGROUND: The goal of the study was to assess the state of coronary arteries in perimenopausal women undergoing examination before prescription of hormonal replacement therapy.METHODS: One hundred ninety-three patients were screened, and 43 of them were selected for inclusion...

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Isayeva GS. The state of coronary arteries in perimenopausal women with chest pain. J Clin Med Res. 2014;6(6):451-5doi: 10.14740/jocmr1915w.
Isayeva, G. S. (2014). The state of coronary arteries in perimenopausal women with chest pain. Journal of clinical medicine research, 6(6), 451-5. https://doi.org/10.14740/jocmr1915w
Isayeva, Ganna S. "The state of coronary arteries in perimenopausal women with chest pain." Journal of clinical medicine research vol. 6,6 (2014): 451-5. doi: https://doi.org/10.14740/jocmr1915w
Isayeva GS. The state of coronary arteries in perimenopausal women with chest pain. J Clin Med Res. 2014 Dec;6(6):451-5. doi: 10.14740/jocmr1915w. Epub 2014 Sep 09. PMID: 25247019; PMCID: PMC4169087.
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Analysis of Prescribing Patterns of Atypical Antipsychotics in Lhu Caserta.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

Farina G, Menditto E, Manna S, Pagliaro C, Troncone C, Putignano D, Orlando V, Linguiti C, Buffardi GF, Tari MG.
PMID: 27201311
Value Health. 2014 Nov;17(7):A464-5. doi: 10.1016/j.jval.2014.08.1297. Epub 2014 Oct 26.

No abstract available.

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Farina G, Menditto E, Manna S, et al. Analysis of Prescribing Patterns of Atypical Antipsychotics in Lhu Caserta. Value Health. 2014;17(7):A464-5doi: 10.1016/j.jval.2014.08.1297.
Farina, G., Menditto, E., Manna, S., Pagliaro, C., Troncone, C., Putignano, D., Orlando, V., Linguiti, C., Buffardi, G. F., & Tari, M. G. (2014). Analysis of Prescribing Patterns of Atypical Antipsychotics in Lhu Caserta. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 17(7), A464-5. https://doi.org/10.1016/j.jval.2014.08.1297
Farina, G, et al. "Analysis of Prescribing Patterns of Atypical Antipsychotics in Lhu Caserta." Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research vol. 17,7 (2014): A464-5. doi: https://doi.org/10.1016/j.jval.2014.08.1297
Farina G, Menditto E, Manna S, Pagliaro C, Troncone C, Putignano D, Orlando V, Linguiti C, Buffardi GF, Tari MG. Analysis of Prescribing Patterns of Atypical Antipsychotics in Lhu Caserta. Value Health. 2014 Nov;17(7):A464-5. doi: 10.1016/j.jval.2014.08.1297. Epub 2014 Oct 26. PMID: 27201311.
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Heart Rate Unreliability during Interval Training Recovery in Middle Distance Runners.

Journal of sports science & medicine

Tocco F, Sanna I, Mulliri G, Magnani S, Todde F, Mura R, Ghiani G, Concu A, Melis F, Crisafulli A.
PMID: 25983598
J Sports Sci Med. 2015 May 08;14(2):466-72. eCollection 2015 Jun.

Heart rate (HR) was tested as a reliable index for recovery management during interval training (IT), considering its relationship with the several factors involved in respiratory, metabolic and cardiovascular homeostasis. Thirteen runners underwent two different IT sessions: at 80%...

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Tocco F, Sanna I, Mulliri G, et al. Heart Rate Unreliability during Interval Training Recovery in Middle Distance Runners. J Sports Sci Med. 2015;14(2):466-72
Tocco, F., Sanna, I., Mulliri, G., Magnani, S., Todde, F., Mura, R., Ghiani, G., Concu, A., Melis, F., & Crisafulli, A. (2015). Heart Rate Unreliability during Interval Training Recovery in Middle Distance Runners. Journal of sports science & medicine, 14(2), 466-72.
Tocco, Filippo, et al. "Heart Rate Unreliability during Interval Training Recovery in Middle Distance Runners." Journal of sports science & medicine vol. 14,2 (2015): 466-72.
Tocco F, Sanna I, Mulliri G, Magnani S, Todde F, Mura R, Ghiani G, Concu A, Melis F, Crisafulli A. Heart Rate Unreliability during Interval Training Recovery in Middle Distance Runners. J Sports Sci Med. 2015 May 08;14(2):466-72. eCollection 2015 Jun. PMID: 25983598; PMCID: PMC4424478.
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Cohort Profile: The Helsinki Businessmen Study (HBS).

International journal of epidemiology

Strandberg TE, Salomaa V, Strandberg AY, Vanhanen H, Sarna S, Pitkälä K, Rantanen K, Savela S, Pienimäki T, Huohvanainen E, Stenholm S, Räikkönen K, Tilvis RS, Tienari PJ, Huttunen J.
PMID: 26705307
Int J Epidemiol. 2016 Aug;45(4):1074-1074h. doi: 10.1093/ije/dyv310. Epub 2015 Dec 24.

No abstract available.

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Strandberg TE, Salomaa V, Strandberg AY, et al. Cohort Profile: The Helsinki Businessmen Study (HBS). Int J Epidemiol. 2015;45(4):1074-1074hdoi: 10.1093/ije/dyv310.
Strandberg, T. E., Salomaa, V., Strandberg, A. Y., Vanhanen, H., Sarna, S., Pitkälä, K., Rantanen, K., Savela, S., Pienimäki, T., Huohvanainen, E., Stenholm, S., Räikkönen, K., Tilvis, R. S., Tienari, P. J., & Huttunen, J. (2016). Cohort Profile: The Helsinki Businessmen Study (HBS). International journal of epidemiology, 45(4), 1074-1074h. https://doi.org/10.1093/ije/dyv310
Strandberg, Timo E, et al. "Cohort Profile: The Helsinki Businessmen Study (HBS)." International journal of epidemiology vol. 45,4 (2016): 1074-1074h. doi: https://doi.org/10.1093/ije/dyv310
Strandberg TE, Salomaa V, Strandberg AY, Vanhanen H, Sarna S, Pitkälä K, Rantanen K, Savela S, Pienimäki T, Huohvanainen E, Stenholm S, Räikkönen K, Tilvis RS, Tienari PJ, Huttunen J. Cohort Profile: The Helsinki Businessmen Study (HBS). Int J Epidemiol. 2016 Aug;45(4):1074-1074h. doi: 10.1093/ije/dyv310. Epub 2015 Dec 24. PMID: 26705307.
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Erratum: Whole-genome sequence-based analysis of thyroid function.

Nature communications

Taylor PN, Porcu E, Chew S, Campbell PJ, Traglia M, Brown SJ, Mullin BH, Shihab HA, Min J, Walter K, Memari Y, Huang J, Barnes MR, Beilby JP, Charoen P, Danecek P, Dudbridge F, Forgetta V, Greenwood C, Grundberg E, Johnson AD, Hui J, Lim EM, McCarthy S, Muddyman D, Panicker V, Perry JR, Bell JT, Yuan W, Relton C, Gaunt T, Schlessinger D, Abecasis G, Cucca F, Surdulescu GL, Woltersdorf W, Zeggini E, Zheng HF, Toniolo D, Dayan CM, Naitza S, Walsh JP, Spector T, Smith GD, Durbin R, Richards JB, Sanna S, Soranzo N, Timpson NJ, Wilson SG.
PMID: 25989729
Nat Commun. 2015 May 20;6:7172. doi: 10.1038/ncomms8172.

No abstract available.

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Taylor PN, Porcu E, Chew S, et al. Erratum: Whole-genome sequence-based analysis of thyroid function. Nat Commun. 2015;6:7172doi: 10.1038/ncomms8172.
Taylor, P. N., Porcu, E., Chew, S., Campbell, P. J., Traglia, M., Brown, S. J., Mullin, B. H., Shihab, H. A., Min, J., Walter, K., Memari, Y., Huang, J., Barnes, M. R., Beilby, J. P., Charoen, P., Danecek, P., Dudbridge, F., Forgetta, V., Greenwood, C., Grundberg, E., Johnson, A. D., Hui, J., Lim, E. M., McCarthy, S., Muddyman, D., Panicker, V., Perry, J. R., Bell, J. T., Yuan, W., Relton, C., Gaunt, T., Schlessinger, D., Abecasis, G., Cucca, F., Surdulescu, G. L., Woltersdorf, W., Zeggini, E., Zheng, H. F., Toniolo, D., Dayan, C. M., Naitza, S., Walsh, J. P., Spector, T., Smith, G. D., Durbin, R., Richards, J. B., Sanna, S., Soranzo, N., Timpson, N. J., Wilson, S. G. (2015). Erratum: Whole-genome sequence-based analysis of thyroid function. Nature communications, 67172. https://doi.org/10.1038/ncomms8172
Taylor, Peter N, et al. "Erratum: Whole-genome sequence-based analysis of thyroid function." Nature communications vol. 6 (2015): 7172. doi: https://doi.org/10.1038/ncomms8172
Taylor PN, Porcu E, Chew S, Campbell PJ, Traglia M, Brown SJ, Mullin BH, Shihab HA, Min J, Walter K, Memari Y, Huang J, Barnes MR, Beilby JP, Charoen P, Danecek P, Dudbridge F, Forgetta V, Greenwood C, Grundberg E, Johnson AD, Hui J, Lim EM, McCarthy S, Muddyman D, Panicker V, Perry JR, Bell JT, Yuan W, Relton C, Gaunt T, Schlessinger D, Abecasis G, Cucca F, Surdulescu GL, Woltersdorf W, Zeggini E, Zheng HF, Toniolo D, Dayan CM, Naitza S, Walsh JP, Spector T, Smith GD, Durbin R, Richards JB, Sanna S, Soranzo N, Timpson NJ, Wilson SG. Erratum: Whole-genome sequence-based analysis of thyroid function. Nat Commun. 2015 May 20;6:7172. doi: 10.1038/ncomms8172. PMID: 25989729; PMCID: PMC4462835.
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Production of Farmstead Lactose-Free .

Italian journal of food safety

Pulinas L, Spanu C, Idda I, Ibba I, Nieddu G, Virdis S, Scarano C, Piras F, Spano N, Sanna G, De Santis EPL.
PMID: 28462205
Ital J Food Saf. 2017 Feb 17;6(1):6353. doi: 10.4081/ijfs.2017.6353. eCollection 2017 Jan 24.

The present work was aimed to define and validate farmstead production of lactose-free

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Pulinas L, Spanu C, Idda I, et al. Production of Farmstead Lactose-Free . Ital J Food Saf. 2017;6(1):6353doi: 10.4081/ijfs.2017.6353.
Pulinas, L., Spanu, C., Idda, I., Ibba, I., Nieddu, G., Virdis, S., Scarano, C., Piras, F., Spano, N., Sanna, G., & De Santis, E. P. L. (2017). Production of Farmstead Lactose-Free . Italian journal of food safety, 6(1), 6353. https://doi.org/10.4081/ijfs.2017.6353
Pulinas, Luisa, et al. "Production of Farmstead Lactose-Free ." Italian journal of food safety vol. 6,1 (2017): 6353. doi: https://doi.org/10.4081/ijfs.2017.6353
Pulinas L, Spanu C, Idda I, Ibba I, Nieddu G, Virdis S, Scarano C, Piras F, Spano N, Sanna G, De Santis EPL. Production of Farmstead Lactose-Free . Ital J Food Saf. 2017 Feb 17;6(1):6353. doi: 10.4081/ijfs.2017.6353. eCollection 2017 Jan 24. PMID: 28462205; PMCID: PMC5391506.
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Radical trideuteromethylation with deuterated dimethyl sulfoxide in the synthesis of heterocycles and labelled building blocks.

Chemical communications (Cambridge, England)

Caporaso R, Manna S, Zinken S, Kochnev AR, Lukyanenko ER, Kurkin AV, Antonchick AP.
PMID: 27711354
Chem Commun (Camb). 2016 Oct 13;52(84):12486-12489. doi: 10.1039/c6cc07196a.

The potential of deuterated pharmaceuticals is being widely demonstrated. Here we describe the first trideuteromethylation under radical reaction conditions using deuterated dimethyl sulfoxide as a reagent for the synthesis of labelled heterocycles and trideuteromethylated compounds. A broad scope of...

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Caporaso R, Manna S, Zinken S, et al. Radical trideuteromethylation with deuterated dimethyl sulfoxide in the synthesis of heterocycles and labelled building blocks. Chem Commun (Camb). 2016;52(84):12486-12489doi: 10.1039/c6cc07196a.
Caporaso, R., Manna, S., Zinken, S., Kochnev, A. R., Lukyanenko, E. R., Kurkin, A. V., & Antonchick, A. P. (2016). Radical trideuteromethylation with deuterated dimethyl sulfoxide in the synthesis of heterocycles and labelled building blocks. Chemical communications (Cambridge, England), 52(84), 12486-12489. https://doi.org/10.1039/c6cc07196a
Caporaso, Roberta, et al. "Radical trideuteromethylation with deuterated dimethyl sulfoxide in the synthesis of heterocycles and labelled building blocks." Chemical communications (Cambridge, England) vol. 52,84 (2016): 12486-12489. doi: https://doi.org/10.1039/c6cc07196a
Caporaso R, Manna S, Zinken S, Kochnev AR, Lukyanenko ER, Kurkin AV, Antonchick AP. Radical trideuteromethylation with deuterated dimethyl sulfoxide in the synthesis of heterocycles and labelled building blocks. Chem Commun (Camb). 2016 Oct 13;52(84):12486-12489. doi: 10.1039/c6cc07196a. PMID: 27711354.
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Origin, Branching, and Communications of the Intercostobrachial Nerve: a Meta-Analysis with Implications for Mastectomy and Axillary Lymph Node Dissection in Breast Cancer.

Cureus

Henry BM, Graves MJ, Pękala JR, Sanna B, Hsieh WC, Tubbs RS, Walocha JA, Tomaszewski KA.
PMID: 28428928
Cureus. 2017 Mar 17;9(3):e1101. doi: 10.7759/cureus.1101.

The intercostobrachial nerve (ICBN), which usually originates from the lateral cutaneous branch of the second intercostal nerve, innervates areas of the axilla, lateral chest, and medial arm. It is at risk for injury during operative procedures that are often...

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Henry BM, Graves MJ, Pękala JR, et al. Origin, Branching, and Communications of the Intercostobrachial Nerve: a Meta-Analysis with Implications for Mastectomy and Axillary Lymph Node Dissection in Breast Cancer. Cureus. 2017;9(3):e1101doi: 10.7759/cureus.1101.
Henry, B. M., Graves, M. J., Pękala, J. R., Sanna, B., Hsieh, W. C., Tubbs, R. S., Walocha, J. A., & Tomaszewski, K. A. (2017). Origin, Branching, and Communications of the Intercostobrachial Nerve: a Meta-Analysis with Implications for Mastectomy and Axillary Lymph Node Dissection in Breast Cancer. Cureus, 9(3), e1101. https://doi.org/10.7759/cureus.1101
Henry, Brandon Michael, et al. "Origin, Branching, and Communications of the Intercostobrachial Nerve: a Meta-Analysis with Implications for Mastectomy and Axillary Lymph Node Dissection in Breast Cancer." Cureus vol. 9,3 (2017): e1101. doi: https://doi.org/10.7759/cureus.1101
Henry BM, Graves MJ, Pękala JR, Sanna B, Hsieh WC, Tubbs RS, Walocha JA, Tomaszewski KA. Origin, Branching, and Communications of the Intercostobrachial Nerve: a Meta-Analysis with Implications for Mastectomy and Axillary Lymph Node Dissection in Breast Cancer. Cureus. 2017 Mar 17;9(3):e1101. doi: 10.7759/cureus.1101. PMID: 28428928; PMCID: PMC5393909.
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Showing 1 to 12 of 803 entries