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Personalization of regorafenib treatment in metastatic gastrointestinal stromal tumours in real-life clinical practice.

Therapeutic advances in medical oncology

Nannini M, Nigro MC, Vincenzi B, Fumagalli E, Grignani G, D'Ambrosio L, Badalamenti G, Incorvaia L, Bracci R, Gasperoni S, Saponara M, Gatto L, Indio V, Astolfi A, Di Scioscio V, Casali PG, Tonini G, Aglietta M, Russo A, Biasco G, Pantaleo MA.
PMID: 29449894
Ther Adv Med Oncol. 2017 Dec;9(12):731-739. doi: 10.1177/1758834017742627. Epub 2017 Dec 19.

BACKGROUND: Regorafenib (REG) has now been approved as the standard third-line therapy in metastatic gastrointestinal stromal tumour (GIST) patients at the recommended dose and schedule of 160 mg once daily for the first 3 weeks of each 4-week cycle....

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Nannini M, Nigro MC, Vincenzi B, et al. Personalization of regorafenib treatment in metastatic gastrointestinal stromal tumours in real-life clinical practice. Ther Adv Med Oncol. 2017;9(12):731-739doi: 10.1177/1758834017742627.
Nannini, M., Nigro, M. C., Vincenzi, B., Fumagalli, E., Grignani, G., D'Ambrosio, L., Badalamenti, G., Incorvaia, L., Bracci, R., Gasperoni, S., Saponara, M., Gatto, L., Indio, V., Astolfi, A., Di Scioscio, V., Casali, P. G., Tonini, G., Aglietta, M., Russo, A., Biasco, G., & Pantaleo, M. A. (2017). Personalization of regorafenib treatment in metastatic gastrointestinal stromal tumours in real-life clinical practice. Therapeutic advances in medical oncology, 9(12), 731-739. https://doi.org/10.1177/1758834017742627
Nannini, Margherita, et al. "Personalization of regorafenib treatment in metastatic gastrointestinal stromal tumours in real-life clinical practice." Therapeutic advances in medical oncology vol. 9,12 (2017): 731-739. doi: https://doi.org/10.1177/1758834017742627
Nannini M, Nigro MC, Vincenzi B, Fumagalli E, Grignani G, D'Ambrosio L, Badalamenti G, Incorvaia L, Bracci R, Gasperoni S, Saponara M, Gatto L, Indio V, Astolfi A, Di Scioscio V, Casali PG, Tonini G, Aglietta M, Russo A, Biasco G, Pantaleo MA. Personalization of regorafenib treatment in metastatic gastrointestinal stromal tumours in real-life clinical practice. Ther Adv Med Oncol. 2017 Dec;9(12):731-739. doi: 10.1177/1758834017742627. Epub 2017 Dec 19. PMID: 29449894; PMCID: PMC5808843.
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Normocalcemic primary hyperparathyroidism: a survey in a small village of Southern Italy.

Endocrine connections

Vignali E, Cetani F, Chiavistelli S, Meola A, Saponaro F, Centoni R, Cianferotti L, Marcocci C.
PMID: 26155986
Endocr Connect. 2015 Sep;4(3):172-8. doi: 10.1530/EC-15-0030.

We investigated the prevalence of normocalcemic primary hyperparathyroidism (NPHPT) in the adult population living in a village in Southern Italy. All residents in 2010 (n=2045) were invited by calls and 1046 individuals accepted to participate. Medical history, calcium intake,...

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Vignali E, Cetani F, Chiavistelli S, et al. Normocalcemic primary hyperparathyroidism: a survey in a small village of Southern Italy. Endocr Connect. 2015;4(3):172-8doi: 10.1530/EC-15-0030.
Vignali, E., Cetani, F., Chiavistelli, S., Meola, A., Saponaro, F., Centoni, R., Cianferotti, L., & Marcocci, C. (2015). Normocalcemic primary hyperparathyroidism: a survey in a small village of Southern Italy. Endocrine connections, 4(3), 172-8. https://doi.org/10.1530/EC-15-0030
Vignali, E, et al. "Normocalcemic primary hyperparathyroidism: a survey in a small village of Southern Italy." Endocrine connections vol. 4,3 (2015): 172-8. doi: https://doi.org/10.1530/EC-15-0030
Vignali E, Cetani F, Chiavistelli S, Meola A, Saponaro F, Centoni R, Cianferotti L, Marcocci C. Normocalcemic primary hyperparathyroidism: a survey in a small village of Southern Italy. Endocr Connect. 2015 Sep;4(3):172-8. doi: 10.1530/EC-15-0030. PMID: 26155986; PMCID: PMC4496527.
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Expression of a maize storage protein gene in petunia plants is not restricted to seeds.

Plant physiology

Ueng P, Galili G, Sapanara V, Goldsbrough PB, Dube P, Beachy RN, Larkins BA.
PMID: 16666067
Plant Physiol. 1988 Apr;86(4):1281-5. doi: 10.1104/pp.86.4.1281.

Genes encoding maize seed storage proteins, zeins, are expressed in developing endosperm tissue. To determine whether the DNA sequences controlling the developmental expression of these genes are recognized in dicots, we introduced a gene encoding a M(r) 19,000 zein...

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Ueng P, Galili G, Sapanara V, et al. Expression of a maize storage protein gene in petunia plants is not restricted to seeds. Plant Physiol. 1988;86(4):1281-5doi: 10.1104/pp.86.4.1281.
Ueng, P., Galili, G., Sapanara, V., Goldsbrough, P. B., Dube, P., Beachy, R. N., & Larkins, B. A. (1988). Expression of a maize storage protein gene in petunia plants is not restricted to seeds. Plant physiology, 86(4), 1281-5. https://doi.org/10.1104/pp.86.4.1281
Ueng, P, et al. "Expression of a maize storage protein gene in petunia plants is not restricted to seeds." Plant physiology vol. 86,4 (1988): 1281-5. doi: https://doi.org/10.1104/pp.86.4.1281
Ueng P, Galili G, Sapanara V, Goldsbrough PB, Dube P, Beachy RN, Larkins BA. Expression of a maize storage protein gene in petunia plants is not restricted to seeds. Plant Physiol. 1988 Apr;86(4):1281-5. doi: 10.1104/pp.86.4.1281. PMID: 16666067; PMCID: PMC1054665.
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Three cases of bone metastases in patients with gastrointestinal stromal tumors.

Rare tumors

Di Scioscio V, Greco L, Pallotti MC, Pantaleo MA, Maleddu A, Nannini M, Bazzocchi A, Di Battista M, Mandrioli A, Lolli C, Saponara M, Giorgio G, Biasco G, Zompatori M.
PMID: 21769316
Rare Tumors. 2011 Apr 04;3(2):e17. doi: 10.4081/rt.2011.e17.

Gastrointestinal stromal tumors (GISTs) are rare, but represent the most common mesenchymal neoplasms of the gastrointestinal tract. Tumor resection is the treatment of choice for localized disease. Tyrosine kinase inhibitors (imatinib, sunitinib) are the standard therapy for metastatic or...

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Di Scioscio V, Greco L, Pallotti MC, et al. Three cases of bone metastases in patients with gastrointestinal stromal tumors. Rare Tumors. 2011;3(2):e17doi: 10.4081/rt.2011.e17.
Di Scioscio, V., Greco, L., Pallotti, M. C., Pantaleo, M. A., Maleddu, A., Nannini, M., Bazzocchi, A., Di Battista, M., Mandrioli, A., Lolli, C., Saponara, M., Giorgio, G., Biasco, G., & Zompatori, M. (2011). Three cases of bone metastases in patients with gastrointestinal stromal tumors. Rare tumors, 3(2), e17. https://doi.org/10.4081/rt.2011.e17
Di Scioscio, Valerio, et al. "Three cases of bone metastases in patients with gastrointestinal stromal tumors." Rare tumors vol. 3,2 (2011): e17. doi: https://doi.org/10.4081/rt.2011.e17
Di Scioscio V, Greco L, Pallotti MC, Pantaleo MA, Maleddu A, Nannini M, Bazzocchi A, Di Battista M, Mandrioli A, Lolli C, Saponara M, Giorgio G, Biasco G, Zompatori M. Three cases of bone metastases in patients with gastrointestinal stromal tumors. Rare Tumors. 2011 Apr 04;3(2):e17. doi: 10.4081/rt.2011.e17. PMID: 21769316; PMCID: PMC3132121.
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Anisotropic linear elastic properties of fractal-like composites.

Physical review. E, Statistical, nonlinear, and soft matter physics

Carpinteri A, Cornetti P, Pugno N, Sapora A.
PMID: 21230552
Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Nov;82(5):056114. doi: 10.1103/PhysRevE.82.056114. Epub 2010 Nov 16.

In this work, the anisotropic linear elastic properties of two-phase composite materials, made up of square inclusions embedded in a matrix, are investigated. The inclusions present a fractal hierarchical distribution and are supposed to have the same Poisson's ratio...

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Carpinteri A, Cornetti P, Pugno N, et al. Anisotropic linear elastic properties of fractal-like composites. Phys Rev E Stat Nonlin Soft Matter Phys. 2010;82(5):056114doi: 10.1103/PhysRevE.82.056114.
Carpinteri, A., Cornetti, P., Pugno, N., & Sapora, A. (2010). Anisotropic linear elastic properties of fractal-like composites. Physical review. E, Statistical, nonlinear, and soft matter physics, 82(5), 056114. https://doi.org/10.1103/PhysRevE.82.056114
Carpinteri, Alberto, et al. "Anisotropic linear elastic properties of fractal-like composites." Physical review. E, Statistical, nonlinear, and soft matter physics vol. 82,5 (2010): 056114. doi: https://doi.org/10.1103/PhysRevE.82.056114
Carpinteri A, Cornetti P, Pugno N, Sapora A. Anisotropic linear elastic properties of fractal-like composites. Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Nov;82(5):056114. doi: 10.1103/PhysRevE.82.056114. Epub 2010 Nov 16. PMID: 21230552.
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Alternative schedules or integration strategies to maximise treatment duration with sunitinib in patients with gastrointestinal stromal tumours.

Oncology letters

Saponara M, Lolli C, Nannini M, DI Scioscio V, Serra C, Mandrioli A, Pallotti MC, Biasco G, Pantaleo MA.
PMID: 25202412
Oncol Lett. 2014 Oct;8(4):1793-1799. doi: 10.3892/ol.2014.2348. Epub 2014 Jul 11.

Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal tumour of the gastrointestinal tract. The advent of targeted kinase-inhibitors has revolutionised treatment strategies and clinical outcomes for patients with advanced GIST. In the majority of countries, sunitinib is the...

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Saponara M, Lolli C, Nannini M, et al. Alternative schedules or integration strategies to maximise treatment duration with sunitinib in patients with gastrointestinal stromal tumours. Oncol Lett. 2014;8(4):1793-1799doi: 10.3892/ol.2014.2348.
Saponara, M., Lolli, C., Nannini, M., DI Scioscio, V., Serra, C., Mandrioli, A., Pallotti, M. C., Biasco, G., & Pantaleo, M. A. (2014). Alternative schedules or integration strategies to maximise treatment duration with sunitinib in patients with gastrointestinal stromal tumours. Oncology letters, 8(4), 1793-1799. https://doi.org/10.3892/ol.2014.2348
Saponara, Maristella, et al. "Alternative schedules or integration strategies to maximise treatment duration with sunitinib in patients with gastrointestinal stromal tumours." Oncology letters vol. 8,4 (2014): 1793-1799. doi: https://doi.org/10.3892/ol.2014.2348
Saponara M, Lolli C, Nannini M, DI Scioscio V, Serra C, Mandrioli A, Pallotti MC, Biasco G, Pantaleo MA. Alternative schedules or integration strategies to maximise treatment duration with sunitinib in patients with gastrointestinal stromal tumours. Oncol Lett. 2014 Oct;8(4):1793-1799. doi: 10.3892/ol.2014.2348. Epub 2014 Jul 11. PMID: 25202412; PMCID: PMC4156266.
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Obstructive sleep apnea and bone mineral density in obese patients.

Diabetes, metabolic syndrome and obesity : targets and therapy

Mariani S, Fiore D, Varone L, Basciani S, Persichetti A, Watanabe M, Saponara M, Spera G, Moretti C, Gnessi L.
PMID: 23152692
Diabetes Metab Syndr Obes. 2012;5:395-401. doi: 10.2147/DMSO.S37761. Epub 2012 Nov 07.

CONTEXT: Obesity and its co-morbidities may adversely affect bone mineral density (BMD). Obstructive sleep apnea (OSA) is a major complication of obesity. To date, the effects of OSA on BMD in obese patients have been poorly studied.OBJECTIVE: To examine...

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Mariani S, Fiore D, Varone L, et al. Obstructive sleep apnea and bone mineral density in obese patients. Diabetes Metab Syndr Obes. 2012;5:395-401doi: 10.2147/DMSO.S37761.
Mariani, S., Fiore, D., Varone, L., Basciani, S., Persichetti, A., Watanabe, M., Saponara, M., Spera, G., Moretti, C., & Gnessi, L. (2012). Obstructive sleep apnea and bone mineral density in obese patients. Diabetes, metabolic syndrome and obesity : targets and therapy, 5395-401. https://doi.org/10.2147/DMSO.S37761
Mariani, Stefania, et al. "Obstructive sleep apnea and bone mineral density in obese patients." Diabetes, metabolic syndrome and obesity : targets and therapy vol. 5 (2012): 395-401. doi: https://doi.org/10.2147/DMSO.S37761
Mariani S, Fiore D, Varone L, Basciani S, Persichetti A, Watanabe M, Saponara M, Spera G, Moretti C, Gnessi L. Obstructive sleep apnea and bone mineral density in obese patients. Diabetes Metab Syndr Obes. 2012;5:395-401. doi: 10.2147/DMSO.S37761. Epub 2012 Nov 07. PMID: 23152692; PMCID: PMC3496369.
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CDC73 mutational status and loss of parafibromin in the outcome of parathyroid cancer.

Endocrine connections

Cetani F, Banti C, Pardi E, Borsari S, Viacava P, Miccoli P, Torregrossa L, Basolo F, Pelizzo MR, Rugge M, Pennelli G, Gasparri G, Papotti M, Volante M, Vignali E, Saponaro F, Marcocci C.
PMID: 24145611
Endocr Connect. 2013 Oct 28;2(4):186-95. doi: 10.1530/EC-13-0046. Print 2013.

Inactivating mutations of the CDC73 tumor suppressor gene have been reported in parathyroid carcinomas (PC), in association with the loss of nuclear expression of the encoded protein, parafibromin. The aim of this study was to further investigate the role...

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Cetani F, Banti C, Pardi E, et al. CDC73 mutational status and loss of parafibromin in the outcome of parathyroid cancer. Endocr Connect. 2013;2(4):186-95doi: 10.1530/EC-13-0046.
Cetani, F., Banti, C., Pardi, E., Borsari, S., Viacava, P., Miccoli, P., Torregrossa, L., Basolo, F., Pelizzo, M. R., Rugge, M., Pennelli, G., Gasparri, G., Papotti, M., Volante, M., Vignali, E., Saponaro, F., & Marcocci, C. (2013). CDC73 mutational status and loss of parafibromin in the outcome of parathyroid cancer. Endocrine connections, 2(4), 186-95. https://doi.org/10.1530/EC-13-0046
Cetani, Filomena, et al. "CDC73 mutational status and loss of parafibromin in the outcome of parathyroid cancer." Endocrine connections vol. 2,4 (2013): 186-95. doi: https://doi.org/10.1530/EC-13-0046
Cetani F, Banti C, Pardi E, Borsari S, Viacava P, Miccoli P, Torregrossa L, Basolo F, Pelizzo MR, Rugge M, Pennelli G, Gasparri G, Papotti M, Volante M, Vignali E, Saponaro F, Marcocci C. CDC73 mutational status and loss of parafibromin in the outcome of parathyroid cancer. Endocr Connect. 2013 Oct 28;2(4):186-95. doi: 10.1530/EC-13-0046. Print 2013. PMID: 24145611; PMCID: PMC3847926.
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Vitamin D measurement and effect on outcome in a cohort of patients with heart failure.

Endocrine connections

Saponaro F, Saba A, Frascarelli S, Frontera C, Clerico A, Scalese M, Sessa MR, Cetani F, Borsari S, Pardi E, Marvelli A, Marcocci C, Passino C, Zucchi R.
PMID: 30300540
Endocr Connect. 2018 Sep 01;7(9):957-964. doi: 10.1530/EC-18-0207.

OBJECTIVES: The aims of this paper were to evaluate the levels of Vitamin D (VitD) in patients with heart failure (HF), compared to a control group, to assess the effects of VitD on HF outcome and to compare VitD...

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Saponaro F, Saba A, Frascarelli S, et al. Vitamin D measurement and effect on outcome in a cohort of patients with heart failure. Endocr Connect. 2018;7(9):957-964doi: 10.1530/EC-18-0207.
Saponaro, F., Saba, A., Frascarelli, S., Frontera, C., Clerico, A., Scalese, M., Sessa, M. R., Cetani, F., Borsari, S., Pardi, E., Marvelli, A., Marcocci, C., Passino, C., & Zucchi, R. (2018). Vitamin D measurement and effect on outcome in a cohort of patients with heart failure. Endocrine connections, 7(9), 957-964. https://doi.org/10.1530/EC-18-0207
Saponaro, Federica, et al. "Vitamin D measurement and effect on outcome in a cohort of patients with heart failure." Endocrine connections vol. 7,9 (2018): 957-964. doi: https://doi.org/10.1530/EC-18-0207
Saponaro F, Saba A, Frascarelli S, Frontera C, Clerico A, Scalese M, Sessa MR, Cetani F, Borsari S, Pardi E, Marvelli A, Marcocci C, Passino C, Zucchi R. Vitamin D measurement and effect on outcome in a cohort of patients with heart failure. Endocr Connect. 2018 Sep 01;7(9):957-964. doi: 10.1530/EC-18-0207. PMID: 30300540; PMCID: PMC6176284.
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Use of an Oral Device in the Stabilization of Facial Advancement after Early Removal of the Osteodistraction Device for Postoperative Sequelae.

Dentistry journal

Gasparini G, Saponaro G, Perina M, Boniello R, Azzuni C, Foresta E, D'Amato G, Todaro M, Doneddu P, Massimi L, Tamburrini G, Pelo S, Garagiola U, Moro A.
PMID: 31963781
Dent J (Basel). 2020 Jan 19;8(1). doi: 10.3390/dj8010012.

The aim of this study is to present an oral device that improves splanchnocranium stability after osteodistraction in children treated for correction of craniofacial malformations. When removal of the distraction device before the end of the treatment is necessary,...

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Gasparini G, Saponaro G, Perina M, et al. Use of an Oral Device in the Stabilization of Facial Advancement after Early Removal of the Osteodistraction Device for Postoperative Sequelae. Dent J (Basel). 2020;8(1)doi: 10.3390/dj8010012.
Gasparini, G., Saponaro, G., Perina, M., Boniello, R., Azzuni, C., Foresta, E., D'Amato, G., Todaro, M., Doneddu, P., Massimi, L., Tamburrini, G., Pelo, S., Garagiola, U., & Moro, A. (2020). Use of an Oral Device in the Stabilization of Facial Advancement after Early Removal of the Osteodistraction Device for Postoperative Sequelae. Dentistry journal, 8(1), . https://doi.org/10.3390/dj8010012
Gasparini, Giulio, et al. "Use of an Oral Device in the Stabilization of Facial Advancement after Early Removal of the Osteodistraction Device for Postoperative Sequelae." Dentistry journal vol. 8,1 (2020). doi: https://doi.org/10.3390/dj8010012
Gasparini G, Saponaro G, Perina M, Boniello R, Azzuni C, Foresta E, D'Amato G, Todaro M, Doneddu P, Massimi L, Tamburrini G, Pelo S, Garagiola U, Moro A. Use of an Oral Device in the Stabilization of Facial Advancement after Early Removal of the Osteodistraction Device for Postoperative Sequelae. Dent J (Basel). 2020 Jan 19;8(1). doi: 10.3390/dj8010012. PMID: 31963781; PMCID: PMC7148519.
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Prevention of Invasive Pneumococcal Disease: Problems Emerged After Some Years of the 13-Valent Pneumococcal Conjugate Vaccine Use.

Current infectious disease reports

Principi N, Di Cara G, Bizzarri I, Isidori C, Borgia P, Mignini C, Saponara M, Argentiero A, Esposito S.
PMID: 29368250
Curr Infect Dis Rep. 2018 Jan 24;20(1):1. doi: 10.1007/s11908-018-0607-z.

Starting from 2010, the 13-valent pneumococcal conjugate vaccine (PCV13) was introduced in several countries. This paper discusses some of the problems recently emerged after PCV13 use and their clinical impact. The impact of PCV13 has been relevant and has...

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Principi N, Di Cara G, Bizzarri I, et al. Prevention of Invasive Pneumococcal Disease: Problems Emerged After Some Years of the 13-Valent Pneumococcal Conjugate Vaccine Use. Curr Infect Dis Rep. 2018;20(1):1doi: 10.1007/s11908-018-0607-z.
Principi, N., Di Cara, G., Bizzarri, I., Isidori, C., Borgia, P., Mignini, C., Saponara, M., Argentiero, A., & Esposito, S. (2018). Prevention of Invasive Pneumococcal Disease: Problems Emerged After Some Years of the 13-Valent Pneumococcal Conjugate Vaccine Use. Current infectious disease reports, 20(1), 1. https://doi.org/10.1007/s11908-018-0607-z
Principi, Nicola, et al. "Prevention of Invasive Pneumococcal Disease: Problems Emerged After Some Years of the 13-Valent Pneumococcal Conjugate Vaccine Use." Current infectious disease reports vol. 20,1 (2018): 1. doi: https://doi.org/10.1007/s11908-018-0607-z
Principi N, Di Cara G, Bizzarri I, Isidori C, Borgia P, Mignini C, Saponara M, Argentiero A, Esposito S. Prevention of Invasive Pneumococcal Disease: Problems Emerged After Some Years of the 13-Valent Pneumococcal Conjugate Vaccine Use. Curr Infect Dis Rep. 2018 Jan 24;20(1):1. doi: 10.1007/s11908-018-0607-z. PMID: 29368250.
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Coding-Complete Genome Sequence of a .

Microbiology resource announcements

Abou Kubaa R, Giampetruzzi A, Addante R, Saponari M.
PMID: 32646905
Microbiol Resour Announc. 2020 Jul 09;9(28). doi: 10.1128/MRA.00552-20.

In this study, we documented the complete coding genome sequence of a

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Abou Kubaa R, Giampetruzzi A, Addante R, et al. Coding-Complete Genome Sequence of a . Microbiol Resour Announc. 2020;9(28)doi: 10.1128/MRA.00552-20.
Abou Kubaa, R., Giampetruzzi, A., Addante, R., & Saponari, M. (2020). Coding-Complete Genome Sequence of a . Microbiology resource announcements, 9(28), . https://doi.org/10.1128/MRA.00552-20
Abou Kubaa, Raied, et al. "Coding-Complete Genome Sequence of a ." Microbiology resource announcements vol. 9,28 (2020). doi: https://doi.org/10.1128/MRA.00552-20
Abou Kubaa R, Giampetruzzi A, Addante R, Saponari M. Coding-Complete Genome Sequence of a . Microbiol Resour Announc. 2020 Jul 09;9(28). doi: 10.1128/MRA.00552-20. PMID: 32646905; PMCID: PMC7348023.
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