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Showing 1 to 12 of 24 entries
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Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient.

International journal of endocrinology

Camargo RY, Kanamura CT, Friguglietti CU, Nogueira CR, Iorcansky S, Tincani AJ, Bezerra AK, Brust E, Koyama FC, Camargo AA, Rego FOR, Galante PAF, Medeiros-Neto G, Rubio IGS.
PMID: 29593791
Int J Endocrinol. 2018 Feb 08;2018:4682876. doi: 10.1155/2018/4682876. eCollection 2018.

Ectopic thyroid results from a migration defect of the developing gland during embryogenesis causing congenital hypothyroidism. But it has also been detected in asymptomatic individuals. This study aimed to investigate the histopathological, functional, and genetic features of human ectopic...

Effect of Therapy on Periodontal Infections.

Journal of periodontology

Socransky SS, Haffajee AD.
PMID: 29539759
J Periodontol. 1993 Aug;64:754-759. doi: 10.1902/jop.1993.64.8s.754.

Periodontal disease progression requires the simultaneous presence of high numbers of pathogens, low numbers of compatible or beneficial species, a conducive local environment, and a susceptible host. Effective therapy acts by altering one or more of these factors. Data...

Precise druggability of the PTH type 1 receptor.

Nature chemical biology

Sutkeviciute I, Lee JY, White AD, Maria CS, Peña KA, Savransky S, Doruker P, Li H, Lei S, Kaynak B, Tu C, Clark LJ, Sanker S, Gardella TJ, Chang W, Bahar I, Vilardaga JP.
PMID: 34949836
Nat Chem Biol. 2021 Dec 23; doi: 10.1038/s41589-021-00929-w. Epub 2021 Dec 23.

Class B G protein-coupled receptors (GPCRs) are notoriously difficult to target by small molecules because their large orthosteric peptide-binding pocket embedded deep within the transmembrane domain limits the identification and development of nonpeptide small molecule ligands. Using the parathyroid...

Genotype-specific features reduce the susceptibility of South American yellow fever virus strains to vaccine-induced antibodies.

Cell host & microbe

Haslwanter D, Lasso G, Wec AZ, Furtado ND, Raphael LMS, Tse AL, Sun Y, Stransky S, Pedreño-Lopez N, Correia CA, Bornholdt ZA, Sakharkar M, Avelino-Silva VI, Moyer CL, Watkins DI, Kallas EG, Sidoli S, Walker LM, Bonaldo MC, Chandran K.
PMID: 34998466
Cell Host Microbe. 2022 Jan 06; doi: 10.1016/j.chom.2021.12.009. Epub 2022 Jan 06.

The resurgence of yellow fever in South America has prompted vaccination against the etiologic agent, yellow fever virus (YFV). Current vaccines are based on a live-attenuated YF-17D virus derived from a virulent African isolate. The capacity of these vaccines...

Efficacy of Clindamycin Hydrochloride in Refractory Periodontitis: 12-Month Results.

Journal of periodontology

Gordon J, Walker C, Lamster I, West T, Socransky S, Seiger M, Fasciano R.
PMID: 29538955
J Periodontol. 1985 Nov;56:75-80. doi: 10.1902/jop.1985.56.11s.75.

The purpose of this study was to evaluate the use of Clindamycin hydrochloride as an adjunct to conventional periodontal therapy in the treatment of patients who had previously been unsuccessfully treated with scaling, periodontal surgery and the use of...

Ultrasound-Assisted Distal Radius Fracture Reduction.

Cureus

Socransky S, Skinner A, Bromley M, Smith A, Anawati A, Middaugh J, Ross P, Atkinson P.
PMID: 27551652
Cureus. 2016 Jul 07;8(7):e674. doi: 10.7759/cureus.674.

Introduction Closed reduction of distal radius fractures (CRDRF) is a commonly performed emergency department (ED) procedure. The use of point-of-care ultrasound (PoCUS) to diagnose fractures and guide reduction has previously been described. The primary objective of this study was...

Intra-articular lidocaine for the reduction of posterior shoulder dislocation.

CJEM

Socransky SJ, Toner LV.
PMID: 17355712
CJEM. 2005 Nov;7(6):423-6.

Anterior shoulder dislocations are the most common major joint dislocation seen in emergency departments. Intra-articular lidocaine is a useful method of analgesia for facilitating the reduction of anterior shoulder dislocations. Posterior shoulder dislocations represent a small minority of shoulder...

M-Mode in the Emergency Department: Is it Really Necessary?.

The Journal of emergency medicine

Blanco P, Socransky S, Hall G.
PMID: 27431870
J Emerg Med. 2016 Sep;51(3):330-1. doi: 10.1016/j.jemermed.2015.12.023. Epub 2016 Jul 16.

No abstract available.

Is B-mode ultrasound alone a sufficient screening tool for carotid stenosis? A pilot study.

Critical ultrasound journal

Bhandari T, Socransky SJ.
PMID: 25505941
Crit Ultrasound J. 2014 Oct 01;6(1):17. doi: 10.1186/s13089-014-0017-x. eCollection 2014.

BACKGROUND: Carotid ultrasound is performed solely in hospital ultrasound departments or outpatient labs, using both B- and Doppler modes. We hypothesize that B-mode without Doppler can be used to classify patients as having carotid stenosis (CS) above or below...

Quantitative subcellular acyl-CoA analysis reveals distinct nuclear metabolism and isoleucine-dependent histone propionylation.

Molecular cell

Trefely S, Huber K, Liu J, Noji M, Stransky S, Singh J, Doan MT, Lovell CD, von Krusenstiern E, Jiang H, Bostwick A, Pepper HL, Izzo L, Zhao S, Xu JP, Bedi KC, Rame JE, Bogner-Strauss JG, Mesaros C, Sidoli S, Wellen KE, Snyder NW.
PMID: 34856123
Mol Cell. 2021 Nov 22; doi: 10.1016/j.molcel.2021.11.006. Epub 2021 Nov 22.

Quantitative subcellular metabolomic measurements can explain the roles of metabolites in cellular processes but are subject to multiple confounding factors. We developed stable isotope labeling of essential nutrients in cell culture-subcellular fractionation (SILEC-SF), which uses isotope-labeled internal standard controls...

Precise druggability of the PTH type 1 receptor.

Nature chemical biology

Sutkeviciute I, Lee JY, White AD, Maria CS, Peña KA, Savransky S, Doruker P, Li H, Lei S, Kaynak B, Tu C, Clark LJ, Sanker S, Gardella TJ, Chang W, Bahar I, Vilardaga JP.
PMID: 34949836
Nat Chem Biol. 2021 Dec 23; doi: 10.1038/s41589-021-00929-w. Epub 2021 Dec 23.

Class B G protein-coupled receptors (GPCRs) are notoriously difficult to target by small molecules because their large orthosteric peptide-binding pocket embedded deep within the transmembrane domain limits the identification and development of nonpeptide small molecule ligands. Using the parathyroid...

DNA methylation and hydroxymethylation analysis using a high throughput and low bias direct injection mass spectrometry platform.

MethodsX

Sun Y, Stransky S, Aguilan J, Brenowitz M, Sidoli S.
PMID: 35004218
MethodsX. 2021 Nov 18;8:101585. doi: 10.1016/j.mex.2021.101585. eCollection 2021.

DNA modifications are small covalent chemical groups that modify nucleotides to regulate DNA readout. Anomalous abundance and genome-wide localization of these modifications can negatively tune gene expression and propagate into unbalanced epigenetics regulation, which is known to be associated...

Showing 1 to 12 of 24 entries