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Showing 1 to 12 of 131 entries
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The new therapeutical scenario of Hodgkin lymphoma.

Annals of oncology : official journal of the European Society for Medical Oncology

Stathis A, Younes A.
PMID: 26037796
Ann Oncol. 2015 Oct;26(10):2026-33. doi: 10.1093/annonc/mdv256. Epub 2015 Jun 02.

Hodgkin lymphoma (HL) remains one of the most curable human cancers, as modern combination chemotherapy and radiation therapy cure ∼ 80% of patients. Over the last two decades, the major efforts were focused on the development of more intensive...

Allosteric Glutaminase Inhibitors Based on a 1,4-Di(5-amino-1,3,4-thiadiazol-2-yl)butane Scaffold.

ACS medicinal chemistry letters

Zimmermann SC, Wolf EF, Luu A, Thomas AG, Stathis M, Poore B, Nguyen C, Le A, Rojas C, Slusher BS, Tsukamoto T.
PMID: 27200176
ACS Med Chem Lett. 2016 Mar 13;7(5):520-4. doi: 10.1021/acsmedchemlett.6b00060. eCollection 2016 May 12.

A series of allosteric kidney-type glutaminase (GLS) inhibitors were designed and synthesized using 1,4-di(5-amino-1,3,4-thiadiazol-2-yl)butane as a core scaffold. A variety of modified phenylacetyl groups were incorporated into the 5-amino group of the two thiadiazole rings in an attempt to...

Molecular evidence of synaptic pathology in the CA1 region in schizophrenia.

NPJ schizophrenia

Matosin N, Fernandez-Enright F, Lum JS, Engel M, Andrews JL, Gassen NC, Wagner KV, Schmidt MV, Newell KA.
PMID: 27430010
NPJ Schizophr. 2016 Jun 29;2:16022. doi: 10.1038/npjschz.2016.22. eCollection 2016.

Alterations of postsynaptic density (PSD)95-complex proteins in schizophrenia ostensibly induce deficits in synaptic plasticity, the molecular process underlying cognitive functions. Although some PSD95-complex proteins have been previously examined in the hippocampus in schizophrenia, the status of other equally important...

Inflammatory bowel disease-the role of cross-sectional imaging techniques in the investigation of the small bowel.

Insights into imaging

Athanasakos A, Mazioti A, Economopoulos N, Kontopoulou C, Stathis G, Filippiadis D, Spyridopoulos T, Alexopoulou E.
PMID: 25537967
Insights Imaging. 2015 Feb;6(1):73-83. doi: 10.1007/s13244-014-0377-6. Epub 2014 Dec 24.

BACKGROUND: The diagnosis of inflammatory bowel disease (IBD) in children and adolescents is based on the integration of clinical, biological, endoscopic, histological and radiological data.METHODS: The most important part of the diagnosis is the histology, which is acquired by...

Dorsalis Pedis Free Flap: The Salvage Option following Failure of the Radial Forearm Flap in Total Lower Lip Reconstruction.

Case reports in medicine

Stathas T, Tsinias G, Tsiliboti D, Tsiros A, Mastronikolis N, Goumas P.
PMID: 24803937
Case Rep Med. 2014;2014:458286. doi: 10.1155/2014/458286. Epub 2014 Apr 02.

Reconstruction after resection of large tumors of the lower lip requires the use of free flaps in order to restore the shape and the function of the lip, with the free radial forearm flap being the most popular. In...

Malignant neuroleptic syndrome following deep brain stimulation surgery: a case report.

Journal of medical case reports

Themistocleous MS, Boviatsis EJ, Stavrinou LC, Stathis P, Sakas DE.
PMID: 21714889
J Med Case Rep. 2011 Jun 29;5:255. doi: 10.1186/1752-1947-5-255.

BACKGROUND: The neuroleptic malignant syndrome is an uncommon but dangerous complication characterized by hyperthermia, autonomic dysfunction, altered mental state, hemodynamic dysregulation, elevated serum creatine kinase, and rigor. It is most often caused by an adverse reaction to anti-psychotic drugs...

Gene expression profiling following maternal deprivation: involvement of the brain Renin-Angiotensin system.

Frontiers in molecular neuroscience

Liebl C, Panhuysen M, Pütz B, Trümbach D, Wurst W, Deussing JM, Müller MB, Schmidt MV.
PMID: 19506703
Front Mol Neurosci. 2009 May 14;2:1. doi: 10.3389/neuro.02.001.2009. eCollection 2009.

The postnatal development of the mouse is characterized by a stress hypo-responsive period (SHRP), where basal corticosterone levels are low and responsiveness to mild stressors is reduced. Maternal separation is able to disrupt the SHRP and is widely used...

Growth restriction before and after birth increases kinase signaling pathways in the adult rat heart.

Journal of developmental origins of health and disease

Wadley GD, Wlodek ME, Ng G, Goodman C, Stathis C, McConell GK.
PMID: 25142009
J Dev Orig Health Dis. 2010 Dec;1(6):376-85. doi: 10.1017/S2040174410000607.

To investigate the mechanisms for the previously reported development of adult cardiac hypertrophy in male rats following growth restriction, the levels of oxidative stress and activation of signaling kinases were measured in the left ventricle (LV) of adult rat...

Non-resolving Findings in a Long-term Radiographic Follow-up of an Infant with Acute Paraffin Oil Aspiration.

Journal of clinical imaging science

Stathis G, Priftis KN, Moustaki M, Alexopoulou E.
PMID: 24678434
J Clin Imaging Sci. 2014 Jan 30;4:2. doi: 10.4103/2156-7514.126028. eCollection 2014.

Acute lipoid pneumonia (LP) in children is a rare disorder caused by the aspiration of oil-based substances and is difficult to diagnose due to non-specific clinical symptoms and radiological findings. We report the case of a 5-month-old male infant...

BET bromodomain inhibitor birabresib in mantle cell lymphoma: in vivo activity and identification of novel combinations to overcome adaptive resistance.

ESMO open

Tarantelli C, Bernasconi E, Gaudio E, Cascione L, Restelli V, Arribas AJ, Spriano F, Rinaldi A, Mensah AA, Kwee I, Ponzoni M, Zucca E, Carrassa L, Riveiro ME, Rezai K, Stathis A, Cvitkovic E, Bertoni F.
PMID: 30305939
ESMO Open. 2018 Sep 26;3(6):e000387. doi: 10.1136/esmoopen-2018-000387. eCollection 2018.

BACKGROUND: The outcome of patients affected by mantle cell lymphoma (MCL) has improved in recent years, but there is still a need for novel treatment strategies for these patients. Human cancers, including MCL, present recurrent alterations in genes that...

A Rare Case of Classical Hodgkin Lymphoma Diagnosed 10 Years after Liver Transplant.

Case reports in oncology

Zhang L, Pereira Mestre R, Bihl F, Bühler M, Vannata B, Stathis A.
PMID: 29279693
Case Rep Oncol. 2017 Oct 17;10(3):923-927. doi: 10.1159/000481452. eCollection 2017.

Posttransplant lymphoproliferative disorders (PTLD) represent a rare and potentially life-threatening complication after liver transplantation. Classical Hodgkin lymphoma (cHL), with an incidence of approximately 1.8-3.4% of all PTLD cases, represents a minority of PTLD, mainly presenting as a late transplant...

Chronic Stress Reduces Nectin-1 mRNA Levels and Disrupts Dendritic Spine Plasticity in the Adult Mouse Perirhinal Cortex.

Frontiers in cellular neuroscience

Gong Q, Su YA, Wu C, Si TM, Deussing JM, Schmidt MV, Wang XD.
PMID: 29593501
Front Cell Neurosci. 2018 Mar 13;12:67. doi: 10.3389/fncel.2018.00067. eCollection 2018.

In adulthood, chronic exposure to stressful experiences disrupts synaptic plasticity and cognitive function. Previous studies have shown that perirhinal cortex-dependent object recognition memory is impaired by chronic stress. However, the stress effects on molecular expression and structural plasticity in...

Showing 1 to 12 of 131 entries