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Showing 1 to 12 of 840 entries
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Chiral propargylic cations as intermediates in SN1-type reactions: substitution pattern, nuclear magnetic resonance studies, and origin of the diastereoselectivity.

Journal of the American Chemical Society

Nitsch D, Huber SM, Pöthig A, Narayanan A, Olah GA, Prakash GK, Bach T.
PMID: 24494822
J Am Chem Soc. 2014 Feb 19;136(7):2851-7. doi: 10.1021/ja411772n. Epub 2014 Feb 04.

Nine propargylic acetates, bearing a stereogenic center (-C*HXR(2)) adjacent to the electrophilic carbon atom, were prepared and subjected to SN1-type substitution reactions with various silyl nucleophiles employing bismuth trifluoromethanesulfonate [Bi(OTf)3] as the Lewis acid. The diastereoselectivity of the reactions...

Feasibility of Primary Tumor Culture Models and Preclinical Prediction Assays for Head and Neck Cancer: A Narrative Review.

Cancers

Dohmen AJ, Swartz JE, Van Den Brekel MW, Willems SM, Spijker R, Neefjes J, Zuur CL.
PMID: 26343729
Cancers (Basel). 2015 Aug 28;7(3):1716-42. doi: 10.3390/cancers7030858.

Primary human tumor culture models allow for individualized drug sensitivity testing and are therefore a promising technique to achieve personalized treatment for cancer patients. This would especially be of interest for patients with advanced stage head and neck cancer....

Workshop Report on the European Bone Sarcoma Networking Meeting: Integration of Clinical Trials with Tumor Biology.

Journal of adolescent and young adult oncology

Thomas DM, Wilhelm M, Cleton-Jansen AM, Dirksen U, Entz-Werlé N, Gelderblom H, Hassan B, Jürgens H, Koster J, Kovar H, Lankester AC, Lewis IJ, Myklebost O, Nathrath MH, Picci P, Whelan JS, Hogendoorn PC, Bielack SS.
PMID: 26811922
J Adolesc Young Adult Oncol. 2011 Sep;1(3):118-23. doi: 10.1089/jayao.2012.0005.

A key workshop was held in The Netherlands in June 2011, hosted by several European bone sarcoma networks and with a broad range of stakeholders from Europe and Australia. The purpose of the meeting was to identify the strengths...

Phosphorylation Affects DNA-Binding of the Senescence-Regulating bZIP Transcription Factor GBF1.

Plants (Basel, Switzerland)

Smykowski A, Fischer SM, Zentgraf U.
PMID: 27135347
Plants (Basel). 2015 Sep 16;4(3):691-709. doi: 10.3390/plants4030691.

Massive changes in the transcriptome of Arabidopsis thaliana during onset and progression of leaf senescence imply a central role for transcription factors. While many transcription factors are themselves up- or down-regulated during senescence, the bZIP transcription factor G-box-binding factor...

PTK2/FAK: a new predictive biomarker for response to radiotherapy in head and neck squamous cell carcinoma.

Annals of translational medicine

de Ruiter EJ, Willems SM.
PMID: 27868012
Ann Transl Med. 2016 Oct;4:S44. doi: 10.21037/atm.2016.10.19.

No abstract available.

Burkitt lymphoma: epidemiological features and survival in a South African centre.

Infectious agents and cancer

Stefan DC, Lutchman R.
PMID: 24932211
Infect Agent Cancer. 2014 Jun 10;9:19. doi: 10.1186/1750-9378-9-19. eCollection 2014.

BACKGROUND: The epidemiology of Burkitt Lymphoma (BL) shows that the endemic type is mainly confined to equatorial Africa and has a very close association with the Epstein-Barr virus (EBV), while the sporadic variant shows only a 20% association with...

Fluorescence in situ hybridization and sequential catalyzed reporter deposition (2C-FISH) for the flow cytometric sorting of freshwater ultramicrobacteria.

Frontiers in microbiology

Neuenschwander SM, Salcher MM, Pernthaler J.
PMID: 25873914
Front Microbiol. 2015 Mar 31;6:247. doi: 10.3389/fmicb.2015.00247. eCollection 2015.

Flow cytometric sorting is a powerful tool to physically separate cells within mixed microbial communities. If combined with phylogenetic staining (fluorescence in situ hybridization, FISH) it allows to specifically sort defined genotypic microbial populations from complex natural samples. However,...

Effect of oxidative stress on male reproduction.

The world journal of men's health

Agarwal A, Virk G, Ong C, du Plessis SS.
PMID: 24872947
World J Mens Health. 2014 Apr;32(1):1-17. doi: 10.5534/wjmh.2014.32.1.1. Epub 2014 Apr 25.

Infertility affects approximately 15% of couples trying to conceive, and a male factor contributes to roughly half of these cases. Oxidative stress (OS) has been identified as one of the many mediators of male infertility by causing sperm dysfunction....

Communication: An exact bound on the bridge function in integral equation theories.

The Journal of chemical physics

Kast SM, Tomazic D.
PMID: 23145709
J Chem Phys. 2012 Nov 07;137(17):171102. doi: 10.1063/1.4766465.

We show that the formal solution of the general closure relation occurring in Ornstein-Zernike-type integral equation theories in terms of the Lambert W function leads to an exact relation between the bridge function and correlation functions, most notably to...

Molecular dissection of ependymomas.

Oncoscience

Pajtler KW, Pfister SM, Kool M.
PMID: 26682265
Oncoscience. 2015 Aug 20;2(10):827-8. doi: 10.18632/oncoscience.202. eCollection 2015.

No abstract available.

Successful operative management of an upper lumbar spinal canal stenosis resulting in multilevel lower nerve root radiculopathy.

Journal of neurosciences in rural practice

McClelland S, Kim SS.
PMID: 25552866
J Neurosci Rural Pract. 2015 Jan;6(1):108-11. doi: 10.4103/0976-3147.143216.

Lumbar stenosis is a common disorder, usually characterized clinically by neurogenic claudication with or without lumbar/sacral radiculopathy corresponding to the level of stenosis. We present a case of lumbar stenosis manifesting as a multilevel radiculopathy inferior to the nerve...

Welcome to Neurology: Genetics.

Neurology. Genetics

Pulst SM.
PMID: 27066541
Neurol Genet. 2015 Apr 17;1(1):e2. doi: 10.1212/01.NXG.0000464293.80983.72. eCollection 2015 Jun.

The powers of human genetics and genetic technologies have transformed the complexities of neurology and neuroscience at the basic, translational, and now also the clinical level. We have left an era of black and white views of causative genetic...

Showing 1 to 12 of 840 entries