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A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease.

Alzheimer's research & therapy

Nygaard HB, Wagner AF, Bowen GS, Good SP, MacAvoy MG, Strittmatter KA, Kaufman AC, Rosenberg BJ, Sekine-Konno T, Varma P, Chen K, Koleske AJ, Reiman EM, Strittmatter SM, van Dyck CH.
PMID: 25874001
Alzheimers Res Ther. 2015 Apr 14;7(1):35. doi: 10.1186/s13195-015-0119-0. eCollection 2015.

INTRODUCTION: Despite significant progress, a disease-modifying therapy for Alzheimer's disease (AD) has not yet been developed. Recent findings implicate soluble oligomeric amyloid beta as the most relevant protein conformation in AD pathogenesis. We recently described a signaling cascade whereby...

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Nygaard HB, Wagner AF, Bowen GS, et al. A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease. Alzheimers Res Ther. 2015;7(1):35doi: 10.1186/s13195-015-0119-0.
Nygaard, H. B., Wagner, A. F., Bowen, G. S., Good, S. P., MacAvoy, M. G., Strittmatter, K. A., Kaufman, A. C., Rosenberg, B. J., Sekine-Konno, T., Varma, P., Chen, K., Koleske, A. J., Reiman, E. M., Strittmatter, S. M., & van Dyck, C. H. (2015). A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease. Alzheimer's research & therapy, 7(1), 35. https://doi.org/10.1186/s13195-015-0119-0
Nygaard, Haakon B, et al. "A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease." Alzheimer's research & therapy vol. 7,1 (2015): 35. doi: https://doi.org/10.1186/s13195-015-0119-0
Nygaard HB, Wagner AF, Bowen GS, Good SP, MacAvoy MG, Strittmatter KA, Kaufman AC, Rosenberg BJ, Sekine-Konno T, Varma P, Chen K, Koleske AJ, Reiman EM, Strittmatter SM, van Dyck CH. A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease. Alzheimers Res Ther. 2015 Apr 14;7(1):35. doi: 10.1186/s13195-015-0119-0. eCollection 2015. PMID: 25874001; PMCID: PMC4396171.
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Effects of improved hospital architecture on coercive measures.

World psychiatry : official journal of the World Psychiatric Association (WPA)

Dresler T, Rohe T, Weber M, Strittmatter T, Fallgatter AJ.
PMID: 25655168
World Psychiatry. 2015 Feb;14(1):105-6. doi: 10.1002/wps.20201.

No abstract available.

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Dresler T, Rohe T, Weber M, et al. Effects of improved hospital architecture on coercive measures. World Psychiatry. 2015;14(1):105-6doi: 10.1002/wps.20201.
Dresler, T., Rohe, T., Weber, M., Strittmatter, T., & Fallgatter, A. J. (2015). Effects of improved hospital architecture on coercive measures. World psychiatry : official journal of the World Psychiatric Association (WPA), 14(1), 105-6. https://doi.org/10.1002/wps.20201
Dresler, Thomas, et al. "Effects of improved hospital architecture on coercive measures." World psychiatry : official journal of the World Psychiatric Association (WPA) vol. 14,1 (2015): 105-6. doi: https://doi.org/10.1002/wps.20201
Dresler T, Rohe T, Weber M, Strittmatter T, Fallgatter AJ. Effects of improved hospital architecture on coercive measures. World Psychiatry. 2015 Feb;14(1):105-6. doi: 10.1002/wps.20201. PMID: 25655168; PMCID: PMC4329907.
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[Autonomic dysfunction in migraine und tension-type headache--pilot study].

Schmerz (Berlin, Germany)

Ostertag D, Strittmatter M, Schimrigk K.
PMID: 12799989
Schmerz. 1998 Feb 28;12(1):25-9. doi: 10.1007/s004829800013.

UNLABELLED: Autonomic nervous system (ANS) dysfunction in migraine has been hypothesized during the last years. However, the pathophysiological relevance of this dysfunction on the etiology and the maintenance of the headaches remains unclear. The aim of this study was...

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Ostertag D, Strittmatter M, Schimrigk K. Autonome Regulationsstörung bei Migräne und Spannungskopfschmerz. Pilotstudie. [Autonomic dysfunction in migraine und tension-type headache--pilot study]. Schmerz. 1998;12(1):25-9doi: 10.1007/s004829800013.
Ostertag, D., Strittmatter, M., & Schimrigk, K. (1998). Autonome Regulationsstörung bei Migräne und Spannungskopfschmerz. Pilotstudie. [Autonomic dysfunction in migraine und tension-type headache--pilot study]. Schmerz (Berlin, Germany), 12(1), 25-9. https://doi.org/10.1007/s004829800013
Ostertag, D, et al. "Autonome Regulationsstörung bei Migräne und Spannungskopfschmerz. Pilotstudie." [Autonomic dysfunction in migraine und tension-type headache--pilot study]. Schmerz (Berlin, Germany) vol. 12,1 (1998): 25-9. doi: https://doi.org/10.1007/s004829800013
Ostertag D, Strittmatter M, Schimrigk K. Autonome Regulationsstörung bei Migräne und Spannungskopfschmerz. Pilotstudie. [Autonomic dysfunction in migraine und tension-type headache--pilot study]. Schmerz. 1998 Feb 28;12(1):25-9. doi: 10.1007/s004829800013. German. PMID: 12799989.
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Effects of Gas-Phase Basicity on the Proton Transfer between Organic Bases and Trifluoroacetic Acid in the Gas Phase: Energetics of Charge Solvation and Salt Bridges.

The journal of physical chemistry. A

Strittmatter EF, Wong RL, Williams ER.
PMID: 16554909
J Phys Chem A. 2000 Nov 16;104(45):10271-9. doi: 10.1021/jp0012505.

The unimolecular dissociation pathways and kinetics of a series of protonated trimer ions consisting of two organic bases and trifluoroacetic acid were investigated using blackbody infrared radiative dissociation. Five bases with gas-phase basicities (GB) ranging from 238.4 to 246.2...

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Strittmatter EF, Wong RL, Williams ER. Effects of Gas-Phase Basicity on the Proton Transfer between Organic Bases and Trifluoroacetic Acid in the Gas Phase: Energetics of Charge Solvation and Salt Bridges. J Phys Chem A. 2000;104(45):10271-9doi: 10.1021/jp0012505.
Strittmatter, E. F., Wong, R. L., & Williams, E. R. (2000). Effects of Gas-Phase Basicity on the Proton Transfer between Organic Bases and Trifluoroacetic Acid in the Gas Phase: Energetics of Charge Solvation and Salt Bridges. The journal of physical chemistry. A, 104(45), 10271-9. https://doi.org/10.1021/jp0012505
Strittmatter, E F, et al. "Effects of Gas-Phase Basicity on the Proton Transfer between Organic Bases and Trifluoroacetic Acid in the Gas Phase: Energetics of Charge Solvation and Salt Bridges." The journal of physical chemistry. A vol. 104,45 (2000): 10271-9. doi: https://doi.org/10.1021/jp0012505
Strittmatter EF, Wong RL, Williams ER. Effects of Gas-Phase Basicity on the Proton Transfer between Organic Bases and Trifluoroacetic Acid in the Gas Phase: Energetics of Charge Solvation and Salt Bridges. J Phys Chem A. 2000 Nov 16;104(45):10271-9. doi: 10.1021/jp0012505. PMID: 16554909; PMCID: PMC1409764.
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Structure of cationized glycine, gly.m (m = be, mg, ca, sr, ba), in the gas phase: intrinsic effect of cation size on zwitterion stability.

The journal of physical chemistry. A

Strittmatter EF, Lemoff AS, Williams ER.
PMID: 16467899
J Phys Chem A. 2000 Nov 02;104(43):9793-6. doi: 10.1021/jp002970e.

Interactions between divalent metal ions and biomolecules are common both in solution and in the gas phase. Here, the intrinsic effect of divalent alkaline earth metal ions (Be, Mg, Ca, Sr, Ba) on the structure of glycine in the...

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Strittmatter EF, Lemoff AS, Williams ER. Structure of cationized glycine, gly.m (m = be, mg, ca, sr, ba), in the gas phase: intrinsic effect of cation size on zwitterion stability. J Phys Chem A. 2000;104(43):9793-6doi: 10.1021/jp002970e.
Strittmatter, E. F., Lemoff, A. S., & Williams, E. R. (2000). Structure of cationized glycine, gly.m (m = be, mg, ca, sr, ba), in the gas phase: intrinsic effect of cation size on zwitterion stability. The journal of physical chemistry. A, 104(43), 9793-6. https://doi.org/10.1021/jp002970e
Strittmatter, E F, et al. "Structure of cationized glycine, gly.m (m = be, mg, ca, sr, ba), in the gas phase: intrinsic effect of cation size on zwitterion stability." The journal of physical chemistry. A vol. 104,43 (2000): 9793-6. doi: https://doi.org/10.1021/jp002970e
Strittmatter EF, Lemoff AS, Williams ER. Structure of cationized glycine, gly.m (m = be, mg, ca, sr, ba), in the gas phase: intrinsic effect of cation size on zwitterion stability. J Phys Chem A. 2000 Nov 02;104(43):9793-6. doi: 10.1021/jp002970e. PMID: 16467899; PMCID: PMC1343513.
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Activation energies for dissociation of double strand oligonucleotide anions: evidence for watson-crick base pairing in vacuo.

Journal of the American Chemical Society

Schnier PD, Klassen JS, Strittmatter EF, Williams ER.
PMID: 16498487
J Am Chem Soc. 1998 Sep 23;120(37):9605-13. doi: 10.1021/ja973534h.

The dissociation kinetics of a series of complementary and noncomplementary DNA duplexes, (TGCA)(2) (3-), (CCGG)(2) (3-), (AATTAAT)(2) (3-), (CCGGCCG)(2) (3-), A(7)*T(7) (3-), A(7)*A(7) (3-), T(7)*T(7) (3-), and A(7)*C(7) (3-) were investigated using blackbody infrared radiative dissociation in a Fourier...

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Schnier PD, Klassen JS, Strittmatter EF, et al. Activation energies for dissociation of double strand oligonucleotide anions: evidence for watson-crick base pairing in vacuo. J Am Chem Soc. 1998;120(37):9605-13doi: 10.1021/ja973534h.
Schnier, P. D., Klassen, J. S., Strittmatter, E. F., & Williams, E. R. (1998). Activation energies for dissociation of double strand oligonucleotide anions: evidence for watson-crick base pairing in vacuo. Journal of the American Chemical Society, 120(37), 9605-13. https://doi.org/10.1021/ja973534h
Schnier, P D, et al. "Activation energies for dissociation of double strand oligonucleotide anions: evidence for watson-crick base pairing in vacuo." Journal of the American Chemical Society vol. 120,37 (1998): 9605-13. doi: https://doi.org/10.1021/ja973534h
Schnier PD, Klassen JS, Strittmatter EF, Williams ER. Activation energies for dissociation of double strand oligonucleotide anions: evidence for watson-crick base pairing in vacuo. J Am Chem Soc. 1998 Sep 23;120(37):9605-13. doi: 10.1021/ja973534h. PMID: 16498487; PMCID: PMC1380309.
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[Medical therapy of lower urinary tract symptoms [corrected]].

Der Urologe. Ausg. A

Strittmatter F, Madersbacher S, Stief CG, Gratzke C.
PMID: 22782192
Urologe A. 2012 Aug;51(8):1125-36. doi: 10.1007/s00120-012-2943-1.

Male lower urinary tract symptoms (LUTS) include storage and voiding disorders and should be carefully evaluated before the start of any treatment. Medical therapy is directed at improving symptoms and reducing the risk of progression in order to improve...

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Strittmatter F, Madersbacher S, Stief CG, et al. Medikamentöse Therapie des benignen Prostatasyndroms. [Medical therapy of lower urinary tract symptoms [corrected]]. Urologe A. 2012;51(8):1125-36doi: 10.1007/s00120-012-2943-1.
Strittmatter, F., Madersbacher, S., Stief, C. G., & Gratzke, C. (2012). Medikamentöse Therapie des benignen Prostatasyndroms. [Medical therapy of lower urinary tract symptoms [corrected]]. Der Urologe. Ausg. A, 51(8), 1125-36. https://doi.org/10.1007/s00120-012-2943-1
Strittmatter, F, et al. "Medikamentöse Therapie des benignen Prostatasyndroms." [Medical therapy of lower urinary tract symptoms [corrected]]. Der Urologe. Ausg. A vol. 51,8 (2012): 1125-36. doi: https://doi.org/10.1007/s00120-012-2943-1
Strittmatter F, Madersbacher S, Stief CG, Gratzke C. Medikamentöse Therapie des benignen Prostatasyndroms. [Medical therapy of lower urinary tract symptoms [corrected]]. Urologe A. 2012 Aug;51(8):1125-36. doi: 10.1007/s00120-012-2943-1. German. PMID: 22782192.
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Fyn kinase inhibition as a novel therapy for Alzheimer's disease.

Alzheimer's research & therapy

Nygaard HB, van Dyck CH, Strittmatter SM.
PMID: 24495408
Alzheimers Res Ther. 2014 Feb 05;6(1):8. doi: 10.1186/alzrt238. eCollection 2014.

Alzheimer's disease (AD) is a devastating neurodegenerative disorder, afflicting more than one-third of people over the age of 85. While many therapies for AD are in late-stage clinical testing, rational drug design based on distinct signaling pathways in this...

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Nygaard HB, van Dyck CH, Strittmatter SM. Fyn kinase inhibition as a novel therapy for Alzheimer's disease. Alzheimers Res Ther. 2014;6(1):8doi: 10.1186/alzrt238.
Nygaard, H. B., van Dyck, C. H., & Strittmatter, S. M. (2014). Fyn kinase inhibition as a novel therapy for Alzheimer's disease. Alzheimer's research & therapy, 6(1), 8. https://doi.org/10.1186/alzrt238
Nygaard, Haakon B, et al. "Fyn kinase inhibition as a novel therapy for Alzheimer's disease." Alzheimer's research & therapy vol. 6,1 (2014): 8. doi: https://doi.org/10.1186/alzrt238
Nygaard HB, van Dyck CH, Strittmatter SM. Fyn kinase inhibition as a novel therapy for Alzheimer's disease. Alzheimers Res Ther. 2014 Feb 05;6(1):8. doi: 10.1186/alzrt238. eCollection 2014. PMID: 24495408; PMCID: PMC3978417.
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Light-Controlled Mammalian Cells and Their Therapeutic Applications in Synthetic Biology.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Mansouri M, Strittmatter T, Fussenegger M.
PMID: 30643713
Adv Sci (Weinh). 2018 Sep 30;6(1):1800952. doi: 10.1002/advs.201800952. eCollection 2019 Jan 09.

The ability to remote control the expression of therapeutic genes in mammalian cells in order to treat disease is a central goal of synthetic biology-inspired therapeutic strategies. Furthermore, optogenetics, a combination of light and genetic sciences, provides an unprecedented...

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Mansouri M, Strittmatter T, Fussenegger M. Light-Controlled Mammalian Cells and Their Therapeutic Applications in Synthetic Biology. Adv Sci (Weinh). 2018;6(1):1800952doi: 10.1002/advs.201800952.
Mansouri, M., Strittmatter, T., & Fussenegger, M. (2019). Light-Controlled Mammalian Cells and Their Therapeutic Applications in Synthetic Biology. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 6(1), 1800952. https://doi.org/10.1002/advs.201800952
Mansouri, Maysam, et al. "Light-Controlled Mammalian Cells and Their Therapeutic Applications in Synthetic Biology." Advanced science (Weinheim, Baden-Wurttemberg, Germany) vol. 6,1 (2019): 1800952. doi: https://doi.org/10.1002/advs.201800952
Mansouri M, Strittmatter T, Fussenegger M. Light-Controlled Mammalian Cells and Their Therapeutic Applications in Synthetic Biology. Adv Sci (Weinh). 2018 Sep 30;6(1):1800952. doi: 10.1002/advs.201800952. eCollection 2019 Jan 09. PMID: 30643713; PMCID: PMC6325585.
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Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells.

Neuron

Franjic D, Skarica M, Ma S, Arellano JI, Tebbenkamp ATN, Choi J, Xu C, Li Q, Morozov YM, Andrijevic D, Vrselja Z, Spajic A, Santpere G, Li M, Zhang S, Liu Y, Spurrier J, Zhang L, Gudelj I, Rapan L, Takahashi H, Huttner A, Fan R, Strittmatter SM, Sousa AMM, Rakic P, Sestan N.
PMID: 34798047
Neuron. 2021 Nov 18; doi: 10.1016/j.neuron.2021.10.036. Epub 2021 Nov 18.

The hippocampal-entorhinal system supports cognitive functions, has lifelong neurogenic capabilities in many species, and is selectively vulnerable to Alzheimer's disease. To investigate neurogenic potential and cellular diversity, we profiled single-nucleus transcriptomes in five hippocampal-entorhinal subregions in humans, macaques, and...

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Franjic D, Skarica M, Ma S, et al. Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells. Neuron. 2021;doi: 10.1016/j.neuron.2021.10.036.
Franjic, D., Skarica, M., Ma, S., Arellano, J. I., Tebbenkamp, A. T. N., Choi, J., Xu, C., Li, Q., Morozov, Y. M., Andrijevic, D., Vrselja, Z., Spajic, A., Santpere, G., Li, M., Zhang, S., Liu, Y., Spurrier, J., Zhang, L., Gudelj, I., Rapan, L., Takahashi, H., Huttner, A., Fan, R., Strittmatter, S. M., Sousa, A. M. M., Rakic, P., & Sestan, N. (2021). Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells. Neuron, . https://doi.org/10.1016/j.neuron.2021.10.036
Franjic, Daniel, et al. "Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells." Neuron vol. (2021). doi: https://doi.org/10.1016/j.neuron.2021.10.036
Franjic D, Skarica M, Ma S, Arellano JI, Tebbenkamp ATN, Choi J, Xu C, Li Q, Morozov YM, Andrijevic D, Vrselja Z, Spajic A, Santpere G, Li M, Zhang S, Liu Y, Spurrier J, Zhang L, Gudelj I, Rapan L, Takahashi H, Huttner A, Fan R, Strittmatter SM, Sousa AMM, Rakic P, Sestan N. Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells. Neuron. 2021 Nov 18; doi: 10.1016/j.neuron.2021.10.036. Epub 2021 Nov 18. PMID: 34798047.
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Evaluation of intrarenal pressure stability at different lithotripter suction settings in a porcine kidney model.

World journal of urology

Strittmatter F, Nagele U, Schachtner J, Bader MJ.
PMID: 33774719
World J Urol. 2021 Sep;39(9):3665-3670. doi: 10.1007/s00345-021-03679-5. Epub 2021 Mar 28.

PURPOSE: Using the Swiss LithoClastMETHODS: In an ex vivo porcine kidney model, we recorded intrarenal pressure levels with different suction levels. StorzRESULTS: Pressure stabilized at 19 cm HCONCLUSIONS: When using the LithoClast

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Strittmatter F, Nagele U, Schachtner J, et al. Evaluation of intrarenal pressure stability at different lithotripter suction settings in a porcine kidney model. World J Urol. 2021;39(9):3665-3670doi: 10.1007/s00345-021-03679-5.
Strittmatter, F., Nagele, U., Schachtner, J., & Bader, M. J. (2021). Evaluation of intrarenal pressure stability at different lithotripter suction settings in a porcine kidney model. World journal of urology, 39(9), 3665-3670. https://doi.org/10.1007/s00345-021-03679-5
Strittmatter, Frank, et al. "Evaluation of intrarenal pressure stability at different lithotripter suction settings in a porcine kidney model." World journal of urology vol. 39,9 (2021): 3665-3670. doi: https://doi.org/10.1007/s00345-021-03679-5
Strittmatter F, Nagele U, Schachtner J, Bader MJ. Evaluation of intrarenal pressure stability at different lithotripter suction settings in a porcine kidney model. World J Urol. 2021 Sep;39(9):3665-3670. doi: 10.1007/s00345-021-03679-5. Epub 2021 Mar 28. PMID: 33774719.
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Optic nerve regeneration screen identifies multiple genes restricting adult neural repair.

Cell reports

Lindborg JA, Tran NM, Chenette DM, DeLuca K, Foli Y, Kannan R, Sekine Y, Wang X, Wollan M, Kim IJ, Sanes JR, Strittmatter SM.
PMID: 33657370
Cell Rep. 2021 Mar 02;34(9):108777. doi: 10.1016/j.celrep.2021.108777.

Adult mammalian central nervous system (CNS) trauma interrupts neural networks and, because axonal regeneration is minimal, neurological deficits persist. Repair via axonal growth is limited by extracellular inhibitors and cell-autonomous factors. Based on results from a screen in vitro,...

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Lindborg JA, Tran NM, Chenette DM, et al. Optic nerve regeneration screen identifies multiple genes restricting adult neural repair. Cell Rep. 2021;34(9):108777doi: 10.1016/j.celrep.2021.108777.
Lindborg, J. A., Tran, N. M., Chenette, D. M., DeLuca, K., Foli, Y., Kannan, R., Sekine, Y., Wang, X., Wollan, M., Kim, I. J., Sanes, J. R., & Strittmatter, S. M. (2021). Optic nerve regeneration screen identifies multiple genes restricting adult neural repair. Cell reports, 34(9), 108777. https://doi.org/10.1016/j.celrep.2021.108777
Lindborg, Jane A, et al. "Optic nerve regeneration screen identifies multiple genes restricting adult neural repair." Cell reports vol. 34,9 (2021): 108777. doi: https://doi.org/10.1016/j.celrep.2021.108777
Lindborg JA, Tran NM, Chenette DM, DeLuca K, Foli Y, Kannan R, Sekine Y, Wang X, Wollan M, Kim IJ, Sanes JR, Strittmatter SM. Optic nerve regeneration screen identifies multiple genes restricting adult neural repair. Cell Rep. 2021 Mar 02;34(9):108777. doi: 10.1016/j.celrep.2021.108777. PMID: 33657370; PMCID: PMC8009559.
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