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The putative P-gp inhibitor telmisartan does not affect the transcellular permeability and cellular uptake of the calcium channel antagonist verapamil in the P-glycoprotein expressing cell line MDCK II MDR1.

Pharmacology research & perspectives

Saaby L, Tfelt-Hansen P, Brodin B.
PMID: 26171231
Pharmacol Res Perspect. 2015 Aug;3(4):e00151. doi: 10.1002/prp2.151. Epub 2015 Jun 11.

Verapamil is used in high doses for the treatment of cluster headache. Verapamil has been described as a P-glycoprotein (P-gp, ABCB1) substrate. We wished to evaluate in vitro whether co administration of a P-gp inhibitor with verapamil could be...

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Saaby L, Tfelt-Hansen P, Brodin B. The putative P-gp inhibitor telmisartan does not affect the transcellular permeability and cellular uptake of the calcium channel antagonist verapamil in the P-glycoprotein expressing cell line MDCK II MDR1. Pharmacol Res Perspect. 2015;3(4):e00151doi: 10.1002/prp2.151.
Saaby, L., Tfelt-Hansen, P., & Brodin, B. (2015). The putative P-gp inhibitor telmisartan does not affect the transcellular permeability and cellular uptake of the calcium channel antagonist verapamil in the P-glycoprotein expressing cell line MDCK II MDR1. Pharmacology research & perspectives, 3(4), e00151. https://doi.org/10.1002/prp2.151
Saaby, Lasse, et al. "The putative P-gp inhibitor telmisartan does not affect the transcellular permeability and cellular uptake of the calcium channel antagonist verapamil in the P-glycoprotein expressing cell line MDCK II MDR1." Pharmacology research & perspectives vol. 3,4 (2015): e00151. doi: https://doi.org/10.1002/prp2.151
Saaby L, Tfelt-Hansen P, Brodin B. The putative P-gp inhibitor telmisartan does not affect the transcellular permeability and cellular uptake of the calcium channel antagonist verapamil in the P-glycoprotein expressing cell line MDCK II MDR1. Pharmacol Res Perspect. 2015 Aug;3(4):e00151. doi: 10.1002/prp2.151. Epub 2015 Jun 11. PMID: 26171231; PMCID: PMC4492727.
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Increase in self-reported migraine prevalence in the Danish adult population: a prospective longitudinal population-based study.

BMJ open

Le H, Tfelt-Hansen P, Skytthe A, Kyvik KO, Olesen J.
PMID: 22761284
BMJ Open. 2012 Jul 02;2(4). doi: 10.1136/bmjopen-2012-000962. Print 2012.

OBJECTIVE: It is uncertain whether migraine prevalence has increased in modern society. The aim of this study was to assess any change in migraine prevalence over an 8-year period among the adult population in Denmark.DESIGN: Prospective longitudinal population-based study.SETTING:...

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Le H, Tfelt-Hansen P, Skytthe A, et al. Increase in self-reported migraine prevalence in the Danish adult population: a prospective longitudinal population-based study. BMJ Open. 2012;2(4)doi: 10.1136/bmjopen-2012-000962.
Le, H., Tfelt-Hansen, P., Skytthe, A., Kyvik, K. O., & Olesen, J. (2012). Increase in self-reported migraine prevalence in the Danish adult population: a prospective longitudinal population-based study. BMJ open, 2(4), . https://doi.org/10.1136/bmjopen-2012-000962
Le, Han, et al. "Increase in self-reported migraine prevalence in the Danish adult population: a prospective longitudinal population-based study." BMJ open vol. 2,4 (2012). doi: https://doi.org/10.1136/bmjopen-2012-000962
Le H, Tfelt-Hansen P, Skytthe A, Kyvik KO, Olesen J. Increase in self-reported migraine prevalence in the Danish adult population: a prospective longitudinal population-based study. BMJ Open. 2012 Jul 02;2(4). doi: 10.1136/bmjopen-2012-000962. Print 2012. PMID: 22761284; PMCID: PMC3391377.
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Vertebral artery dissection associated with generalized convulsive seizures: a case report.

Case reports in neurology

Amin FM, Larsen VA, Tfelt-Hansen P.
PMID: 23904852
Case Rep Neurol. 2013 Jul 18;5(2):125-9. doi: 10.1159/000354033. Print 2013 May.

A 46-year-old male with juvenile myoclonic epilepsy was admitted to the neurological department for convulsive seizures just after lamotrigine was discontinued. On admission he was awake but had a right-sided hemiparesis with Babinski sign and ataxic finger-nose test on...

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Amin FM, Larsen VA, Tfelt-Hansen P. Vertebral artery dissection associated with generalized convulsive seizures: a case report. Case Rep Neurol. 2013;5(2):125-9doi: 10.1159/000354033.
Amin, F. M., Larsen, V. A., & Tfelt-Hansen, P. (2013). Vertebral artery dissection associated with generalized convulsive seizures: a case report. Case reports in neurology, 5(2), 125-9. https://doi.org/10.1159/000354033
Amin, Faisal Mohammad, et al. "Vertebral artery dissection associated with generalized convulsive seizures: a case report." Case reports in neurology vol. 5,2 (2013): 125-9. doi: https://doi.org/10.1159/000354033
Amin FM, Larsen VA, Tfelt-Hansen P. Vertebral artery dissection associated with generalized convulsive seizures: a case report. Case Rep Neurol. 2013 Jul 18;5(2):125-9. doi: 10.1159/000354033. Print 2013 May. PMID: 23904852; PMCID: PMC3728598.
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Sudden cardiac death caused by myocarditis in persons aged 1-49 years: a nationwide study of 14 294 deaths in Denmark.

Forensic sciences research

Lynge TH, Nielsen TS, Gregers Winkel B, Tfelt-Hansen J, Banner J.
PMID: 31489390
Forensic Sci Res. 2019 Aug 19;4(3):247-256. doi: 10.1080/20961790.2019.1595352. eCollection 2019.

Myocarditis is associated with an increased risk of sudden cardiac death (SCD) in the young. However, information on nationwide burden of SCD caused by myocarditis (SCD-myocarditis) is sparse. For this study all deaths among persons in Denmark aged 1-35...

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Lynge TH, Nielsen TS, Gregers Winkel B, et al. Sudden cardiac death caused by myocarditis in persons aged 1-49 years: a nationwide study of 14 294 deaths in Denmark. Forensic Sci Res. 2019;4(3):247-256doi: 10.1080/20961790.2019.1595352.
Lynge, T. H., Nielsen, T. S., Gregers Winkel, B., Tfelt-Hansen, J., & Banner, J. (2019). Sudden cardiac death caused by myocarditis in persons aged 1-49 years: a nationwide study of 14 294 deaths in Denmark. Forensic sciences research, 4(3), 247-256. https://doi.org/10.1080/20961790.2019.1595352
Lynge, Thomas Hadberg, et al. "Sudden cardiac death caused by myocarditis in persons aged 1-49 years: a nationwide study of 14 294 deaths in Denmark." Forensic sciences research vol. 4,3 (2019): 247-256. doi: https://doi.org/10.1080/20961790.2019.1595352
Lynge TH, Nielsen TS, Gregers Winkel B, Tfelt-Hansen J, Banner J. Sudden cardiac death caused by myocarditis in persons aged 1-49 years: a nationwide study of 14 294 deaths in Denmark. Forensic Sci Res. 2019 Aug 19;4(3):247-256. doi: 10.1080/20961790.2019.1595352. eCollection 2019. PMID: 31489390; PMCID: PMC6713107.
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Central Pontine Myelinolysis and Localized Fluorodeoxyglucose Uptake Seen on .

World journal of nuclear medicine

Rønne F, Tfelt-Hansen PC, Rørdam L.
PMID: 28217021
World J Nucl Med. 2017 Jan-Mar;16(1):56-58. doi: 10.4103/1450-1147.174707.

Case report describing the finding of central pontine myelinolysis (CPM) using combined fluorine-18 (

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Rønne F, Tfelt-Hansen PC, Rørdam L. Central Pontine Myelinolysis and Localized Fluorodeoxyglucose Uptake Seen on . World J Nucl Med. 2017;16(1):56-58doi: 10.4103/1450-1147.174707.
Rønne, F., Tfelt-Hansen, P. C., & Rørdam, L. (2017). Central Pontine Myelinolysis and Localized Fluorodeoxyglucose Uptake Seen on . World journal of nuclear medicine, 16(1), 56-58. https://doi.org/10.4103/1450-1147.174707
Rønne, Frederik, et al. "Central Pontine Myelinolysis and Localized Fluorodeoxyglucose Uptake Seen on ." World journal of nuclear medicine vol. 16,1 (2017): 56-58. doi: https://doi.org/10.4103/1450-1147.174707
Rønne F, Tfelt-Hansen PC, Rørdam L. Central Pontine Myelinolysis and Localized Fluorodeoxyglucose Uptake Seen on . World J Nucl Med. 2017 Jan-Mar;16(1):56-58. doi: 10.4103/1450-1147.174707. PMID: 28217021; PMCID: PMC5314665.
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Heritability in genetic heart disease: the role of genetic background.

Open heart

Jansweijer JA, van Spaendonck-Zwarts KY, Tanck MWT, van Tintelen JP, Christiaans I, van der Smagt J, Vermeer A, Bos JM, Moss AJ, Swan H, Priori SG, Rydberg A, Tfelt-Hansen J, Ackerman MJ, Olivotto I, Charron P, Gimeno JR, van den Berg M, Wilde AAM, Pinto YM.
PMID: 31245010
Open Heart. 2019 May 28;6(1):e000929. doi: 10.1136/openhrt-2018-000929. eCollection 2019.

BACKGROUND: Mutations in genes encoding ion channels or sarcomeric proteins are an important cause of hereditary cardiac disease. However, the severity of the resultant disease varies considerably even among those with an identical mutation. Such clinical variation is often...

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Jansweijer JA, van Spaendonck-Zwarts KY, Tanck MWT, et al. Heritability in genetic heart disease: the role of genetic background. Open Heart. 2019;6(1):e000929doi: 10.1136/openhrt-2018-000929.
Jansweijer, J. A., van Spaendonck-Zwarts, K. Y., Tanck, M. W. T., van Tintelen, J. P., Christiaans, I., van der Smagt, J., Vermeer, A., Bos, J. M., Moss, A. J., Swan, H., Priori, S. G., Rydberg, A., Tfelt-Hansen, J., Ackerman, M. J., Olivotto, I., Charron, P., Gimeno, J. R., van den Berg, M., Wilde, A. A. M., & Pinto, Y. M. (2019). Heritability in genetic heart disease: the role of genetic background. Open heart, 6(1), e000929. https://doi.org/10.1136/openhrt-2018-000929
Jansweijer, Joeri A, et al. "Heritability in genetic heart disease: the role of genetic background." Open heart vol. 6,1 (2019): e000929. doi: https://doi.org/10.1136/openhrt-2018-000929
Jansweijer JA, van Spaendonck-Zwarts KY, Tanck MWT, van Tintelen JP, Christiaans I, van der Smagt J, Vermeer A, Bos JM, Moss AJ, Swan H, Priori SG, Rydberg A, Tfelt-Hansen J, Ackerman MJ, Olivotto I, Charron P, Gimeno JR, van den Berg M, Wilde AAM, Pinto YM. Heritability in genetic heart disease: the role of genetic background. Open Heart. 2019 May 28;6(1):e000929. doi: 10.1136/openhrt-2018-000929. eCollection 2019. PMID: 31245010; PMCID: PMC6546190.
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Epilepsy-Related Mortality in Children and Young Adults in Denmark: A Nationwide Cohort Study.

Neurology

Kløvgaard M, Lynge TH, Tsiropoulos I, Uldall PV, Banner J, Winkel BG, Ryvlin P, Tfelt-Hansen J, Sabers A.
PMID: 34795050
Neurology. 2021 Nov 18; doi: 10.1212/WNL.0000000000013068. Epub 2021 Nov 18.

BACKGROUND AND OBJECTIVES: Mortality is increased in epilepsy, but the important issue is that a proportion of epilepsy-related death is potentially preventable by optimized therapy and needs therefore to be identified. A new systematic classification of epilepsy-related mortality has...

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Kløvgaard M, Lynge TH, Tsiropoulos I, et al. Epilepsy-Related Mortality in Children and Young Adults in Denmark: A Nationwide Cohort Study. Neurology. 2021;doi: 10.1212/WNL.0000000000013068.
Kløvgaard, M., Lynge, T. H., Tsiropoulos, I., Uldall, P. V., Banner, J., Winkel, B. G., Ryvlin, P., Tfelt-Hansen, J., & Sabers, A. (2021). Epilepsy-Related Mortality in Children and Young Adults in Denmark: A Nationwide Cohort Study. Neurology, . https://doi.org/10.1212/WNL.0000000000013068
Kløvgaard, Marius, et al. "Epilepsy-Related Mortality in Children and Young Adults in Denmark: A Nationwide Cohort Study." Neurology vol. (2021). doi: https://doi.org/10.1212/WNL.0000000000013068
Kløvgaard M, Lynge TH, Tsiropoulos I, Uldall PV, Banner J, Winkel BG, Ryvlin P, Tfelt-Hansen J, Sabers A. Epilepsy-Related Mortality in Children and Young Adults in Denmark: A Nationwide Cohort Study. Neurology. 2021 Nov 18; doi: 10.1212/WNL.0000000000013068. Epub 2021 Nov 18. PMID: 34795050.
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Sudden unexplained death versus nonautopsied possible sudden cardiac death: Findings in relatives.

Journal of cardiovascular electrophysiology

Dalgaard CV, Hansen BL, Jacobsen EM, Kjerrumgaard A, Tfelt-Hansen J, Weeke PE, Winkel BG, Christensen AH, Bundgaard H.
PMID: 34918422
J Cardiovasc Electrophysiol. 2021 Dec 16; doi: 10.1111/jce.15333. Epub 2021 Dec 16.

BACKGROUND: International guidelines recommend work-up of relatives to autopsy negative sudden cardiac death victims, denoted as sudden unexplained death (SUD) and nonautopsied possible sudden cardiac death (pSCD) victims. This study assesses and compare baseline characteristics and clinical outcome at...

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Dalgaard CV, Hansen BL, Jacobsen EM, et al. Sudden unexplained death versus nonautopsied possible sudden cardiac death: Findings in relatives. J Cardiovasc Electrophysiol. 2021;doi: 10.1111/jce.15333.
Dalgaard, C. V., Hansen, B. L., Jacobsen, E. M., Kjerrumgaard, A., Tfelt-Hansen, J., Weeke, P. E., Winkel, B. G., Christensen, A. H., & Bundgaard, H. (2021). Sudden unexplained death versus nonautopsied possible sudden cardiac death: Findings in relatives. Journal of cardiovascular electrophysiology, . https://doi.org/10.1111/jce.15333
Dalgaard, Cathrine V, et al. "Sudden unexplained death versus nonautopsied possible sudden cardiac death: Findings in relatives." Journal of cardiovascular electrophysiology vol. (2021). doi: https://doi.org/10.1111/jce.15333
Dalgaard CV, Hansen BL, Jacobsen EM, Kjerrumgaard A, Tfelt-Hansen J, Weeke PE, Winkel BG, Christensen AH, Bundgaard H. Sudden unexplained death versus nonautopsied possible sudden cardiac death: Findings in relatives. J Cardiovasc Electrophysiol. 2021 Dec 16; doi: 10.1111/jce.15333. Epub 2021 Dec 16. PMID: 34918422.
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Genotype-Phenotype Correlation of .

Circulation. Genomic and precision medicine

Milman A, Behr ER, Gray B, Johnson DC, Andorin A, Hochstadt A, Gourraud JB, Maeda S, Takahashi Y, Jm Juang J, Kim SH, Kamakura T, Aiba T, Postema PG, Mizusawa Y, Denjoy I, Giustetto C, Conte G, Huang Z, Sarquella-Brugada G, Mazzanti A, Jespersen CH, Arbelo E, Brugada R, Calo L, Corrado D, Casado-Arroyo R, Allocca G, Takagi M, Delise P, Brugada J, Tfelt-Hansen J, Priori SG, Veltmann C, Yan GX, Brugada P, Gaita F, Leenhardt A, Wilde AAM, Kusano KF, Nam GB, Hirao K, Probst V, Belhassen B.
PMID: 34461752
Circ Genom Precis Med. 2021 Oct;14(5):e003222. doi: 10.1161/CIRCGEN.120.003222. Epub 2021 Aug 31.

BACKGROUND: Brugada syndrome (BrS) is associated with mutations in the cardiac sodium channel gene, METHODS: Survey on Arrhythmic Events in Brugada Syndrome is a survey of 10 Western and 4 Asian countries, gathering 678 patients with BrS with first...

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Milman A, Behr ER, Gray B, et al. Genotype-Phenotype Correlation of . Circ Genom Precis Med. 2021;14(5):e003222doi: 10.1161/CIRCGEN.120.003222.
Milman, A., Behr, E. R., Gray, B., Johnson, D. C., Andorin, A., Hochstadt, A., Gourraud, J. B., Maeda, S., Takahashi, Y., Jm Juang, J., Kim, S. H., Kamakura, T., Aiba, T., Postema, P. G., Mizusawa, Y., Denjoy, I., Giustetto, C., Conte, G., Huang, Z., Sarquella-Brugada, G., Mazzanti, A., Jespersen, C. H., Arbelo, E., Brugada, R., Calo, L., Corrado, D., Casado-Arroyo, R., Allocca, G., Takagi, M., Delise, P., Brugada, J., Tfelt-Hansen, J., Priori, S. G., Veltmann, C., Yan, G. X., Brugada, P., Gaita, F., Leenhardt, A., Wilde, A. A. M., Kusano, K. F., Nam, G. B., Hirao, K., Probst, V., & Belhassen, B. (2021). Genotype-Phenotype Correlation of . Circulation. Genomic and precision medicine, 14(5), e003222. https://doi.org/10.1161/CIRCGEN.120.003222
Milman, Anat, et al. "Genotype-Phenotype Correlation of ." Circulation. Genomic and precision medicine vol. 14,5 (2021): e003222. doi: https://doi.org/10.1161/CIRCGEN.120.003222
Milman A, Behr ER, Gray B, Johnson DC, Andorin A, Hochstadt A, Gourraud JB, Maeda S, Takahashi Y, Jm Juang J, Kim SH, Kamakura T, Aiba T, Postema PG, Mizusawa Y, Denjoy I, Giustetto C, Conte G, Huang Z, Sarquella-Brugada G, Mazzanti A, Jespersen CH, Arbelo E, Brugada R, Calo L, Corrado D, Casado-Arroyo R, Allocca G, Takagi M, Delise P, Brugada J, Tfelt-Hansen J, Priori SG, Veltmann C, Yan GX, Brugada P, Gaita F, Leenhardt A, Wilde AAM, Kusano KF, Nam GB, Hirao K, Probst V, Belhassen B. Genotype-Phenotype Correlation of . Circ Genom Precis Med. 2021 Oct;14(5):e003222. doi: 10.1161/CIRCGEN.120.003222. Epub 2021 Aug 31. PMID: 34461752.
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Long QT syndrome is associated with an increased burden of diabetes, psychiatric and neurological comorbidities: a nationwide cohort study.

Open heart

Marstrand P, Theilade J, Andersson C, Bundgaard H, Weeke PE, Tfelt-Hansen J, Jespersen C, Gislason G, Torp-Pedersen C, Kanters JK, Jørgensen ME.
PMID: 31749975
Open Heart. 2019 Oct 28;6(2):e001161. doi: 10.1136/openhrt-2019-001161. eCollection 2019.

OBJECTIVE: Studies have suggested a shared genetic aetiology between congenital long QT syndrome (LQTS) and diabetes, epilepsy and mental disorders. We investigated the prevalence of metabolic, neurological and psychiatric comorbidities in LQTS patients.METHODS: This retrospective cohort study was based...

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Marstrand P, Theilade J, Andersson C, et al. Long QT syndrome is associated with an increased burden of diabetes, psychiatric and neurological comorbidities: a nationwide cohort study. Open Heart. 2019;6(2):e001161doi: 10.1136/openhrt-2019-001161.
Marstrand, P., Theilade, J., Andersson, C., Bundgaard, H., Weeke, P. E., Tfelt-Hansen, J., Jespersen, C., Gislason, G., Torp-Pedersen, C., Kanters, J. K., & Jørgensen, M. E. (2019). Long QT syndrome is associated with an increased burden of diabetes, psychiatric and neurological comorbidities: a nationwide cohort study. Open heart, 6(2), e001161. https://doi.org/10.1136/openhrt-2019-001161
Marstrand, Peter, et al. "Long QT syndrome is associated with an increased burden of diabetes, psychiatric and neurological comorbidities: a nationwide cohort study." Open heart vol. 6,2 (2019): e001161. doi: https://doi.org/10.1136/openhrt-2019-001161
Marstrand P, Theilade J, Andersson C, Bundgaard H, Weeke PE, Tfelt-Hansen J, Jespersen C, Gislason G, Torp-Pedersen C, Kanters JK, Jørgensen ME. Long QT syndrome is associated with an increased burden of diabetes, psychiatric and neurological comorbidities: a nationwide cohort study. Open Heart. 2019 Oct 28;6(2):e001161. doi: 10.1136/openhrt-2019-001161. eCollection 2019. PMID: 31749975; PMCID: PMC6827808.
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Onset of action in placebo-controlled migraine attacks trials: A literature review and recommendation.

Cephalalgia : an international journal of headache

Tfelt-Hansen P, Diener HC.
PMID: 32903063
Cephalalgia. 2021 Feb;41(2):148-155. doi: 10.1177/0333102420956916. Epub 2020 Sep 09.

BACKGROUND: Migraine patients want acute treatment to provide complete relief of the migraine attack within 30 minutes. Traditionally, "speed of onset of effect" is evaluated by estimating the time-point for first statistical separation of drug and placebo. The estimated...

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Tfelt-Hansen P, Diener HC. Onset of action in placebo-controlled migraine attacks trials: A literature review and recommendation. Cephalalgia. 2020;41(2):148-155doi: 10.1177/0333102420956916.
Tfelt-Hansen, P., & Diener, H. C. (2021). Onset of action in placebo-controlled migraine attacks trials: A literature review and recommendation. Cephalalgia : an international journal of headache, 41(2), 148-155. https://doi.org/10.1177/0333102420956916
Tfelt-Hansen, Peer, and Diener, Hans-Christoph. "Onset of action in placebo-controlled migraine attacks trials: A literature review and recommendation." Cephalalgia : an international journal of headache vol. 41,2 (2021): 148-155. doi: https://doi.org/10.1177/0333102420956916
Tfelt-Hansen P, Diener HC. Onset of action in placebo-controlled migraine attacks trials: A literature review and recommendation. Cephalalgia. 2021 Feb;41(2):148-155. doi: 10.1177/0333102420956916. Epub 2020 Sep 09. PMID: 32903063.
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Ventricular Arrhythmias in First Acute Myocardial Infarction: Epidemiology, Mechanisms, and Interventions in Large Animal Models.

Frontiers in cardiovascular medicine

Sattler SM, Skibsbye L, Linz D, Lubberding AF, Tfelt-Hansen J, Jespersen T.
PMID: 31750317
Front Cardiovasc Med. 2019 Nov 05;6:158. doi: 10.3389/fcvm.2019.00158. eCollection 2019.

Ventricular arrhythmia and subsequent sudden cardiac death (SCD) due to acute myocardial infarction (AMI) is one of the most frequent causes of death in humans. Lethal ventricular arrhythmias like ventricular fibrillation (VF) prior to hospitalization have been reported to...

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Sattler SM, Skibsbye L, Linz D, et al. Ventricular Arrhythmias in First Acute Myocardial Infarction: Epidemiology, Mechanisms, and Interventions in Large Animal Models. Front Cardiovasc Med. 2019;6:158doi: 10.3389/fcvm.2019.00158.
Sattler, S. M., Skibsbye, L., Linz, D., Lubberding, A. F., Tfelt-Hansen, J., & Jespersen, T. (2019). Ventricular Arrhythmias in First Acute Myocardial Infarction: Epidemiology, Mechanisms, and Interventions in Large Animal Models. Frontiers in cardiovascular medicine, 6158. https://doi.org/10.3389/fcvm.2019.00158
Sattler, Stefan Michael, et al. "Ventricular Arrhythmias in First Acute Myocardial Infarction: Epidemiology, Mechanisms, and Interventions in Large Animal Models." Frontiers in cardiovascular medicine vol. 6 (2019): 158. doi: https://doi.org/10.3389/fcvm.2019.00158
Sattler SM, Skibsbye L, Linz D, Lubberding AF, Tfelt-Hansen J, Jespersen T. Ventricular Arrhythmias in First Acute Myocardial Infarction: Epidemiology, Mechanisms, and Interventions in Large Animal Models. Front Cardiovasc Med. 2019 Nov 05;6:158. doi: 10.3389/fcvm.2019.00158. eCollection 2019. PMID: 31750317; PMCID: PMC6848060.
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