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Etiology-Specific Remodeling in Ventricular Tissue of Heart Failure Patients and Its Implications for Computational Modeling of Electrical Conduction.

Frontiers in physiology

Sankarankutty AC, Greiner J, Bragard J, Visker JR, Shankar TS, Kyriakopoulos CP, Drakos SG, Sachse FB.
PMID: 34675817
Front Physiol. 2021 Oct 05;12:730933. doi: 10.3389/fphys.2021.730933. eCollection 2021.

With an estimated 64.3 million cases worldwide, heart failure (HF) imposes an enormous burden on healthcare systems. Sudden death from arrhythmia is the major cause of mortality in HF patients. Computational modeling of the failing heart provides insights into...

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Sankarankutty AC, Greiner J, Bragard J, et al. Etiology-Specific Remodeling in Ventricular Tissue of Heart Failure Patients and Its Implications for Computational Modeling of Electrical Conduction. Front Physiol. 2021;12:730933doi: 10.3389/fphys.2021.730933.
Sankarankutty, A. C., Greiner, J., Bragard, J., Visker, J. R., Shankar, T. S., Kyriakopoulos, C. P., Drakos, S. G., & Sachse, F. B. (2021). Etiology-Specific Remodeling in Ventricular Tissue of Heart Failure Patients and Its Implications for Computational Modeling of Electrical Conduction. Frontiers in physiology, 12730933. https://doi.org/10.3389/fphys.2021.730933
Sankarankutty, Aparna C, et al. "Etiology-Specific Remodeling in Ventricular Tissue of Heart Failure Patients and Its Implications for Computational Modeling of Electrical Conduction." Frontiers in physiology vol. 12 (2021): 730933. doi: https://doi.org/10.3389/fphys.2021.730933
Sankarankutty AC, Greiner J, Bragard J, Visker JR, Shankar TS, Kyriakopoulos CP, Drakos SG, Sachse FB. Etiology-Specific Remodeling in Ventricular Tissue of Heart Failure Patients and Its Implications for Computational Modeling of Electrical Conduction. Front Physiol. 2021 Oct 05;12:730933. doi: 10.3389/fphys.2021.730933. eCollection 2021. PMID: 34675817; PMCID: PMC8523803.
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Remodeling of t-system and proteins underlying excitation-contraction coupling in aging versus failing human heart.

NPJ aging and mechanisms of disease

Lyu Y, Verma VK, Lee Y, Taleb I, Badolia R, Shankar TS, Kyriakopoulos CP, Selzman CH, Caine W, Alharethi R, Navankasattusas S, Seidel T, Drakos SG, Sachse FB.
PMID: 34050186
NPJ Aging Mech Dis. 2021 May 28;7(1):16. doi: 10.1038/s41514-021-00066-7.

It is well established that the aging heart progressively remodels towards a senescent phenotype, but alterations of cellular microstructure and their differences to chronic heart failure (HF) associated remodeling remain ill-defined. Here, we show that the transverse tubular system...

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Lyu Y, Verma VK, Lee Y, et al. Remodeling of t-system and proteins underlying excitation-contraction coupling in aging versus failing human heart. NPJ Aging Mech Dis. 2021;7(1):16doi: 10.1038/s41514-021-00066-7.
Lyu, Y., Verma, V. K., Lee, Y., Taleb, I., Badolia, R., Shankar, T. S., Kyriakopoulos, C. P., Selzman, C. H., Caine, W., Alharethi, R., Navankasattusas, S., Seidel, T., Drakos, S. G., & Sachse, F. B. (2021). Remodeling of t-system and proteins underlying excitation-contraction coupling in aging versus failing human heart. NPJ aging and mechanisms of disease, 7(1), 16. https://doi.org/10.1038/s41514-021-00066-7
Lyu, Yankun, et al. "Remodeling of t-system and proteins underlying excitation-contraction coupling in aging versus failing human heart." NPJ aging and mechanisms of disease vol. 7,1 (2021): 16. doi: https://doi.org/10.1038/s41514-021-00066-7
Lyu Y, Verma VK, Lee Y, Taleb I, Badolia R, Shankar TS, Kyriakopoulos CP, Selzman CH, Caine W, Alharethi R, Navankasattusas S, Seidel T, Drakos SG, Sachse FB. Remodeling of t-system and proteins underlying excitation-contraction coupling in aging versus failing human heart. NPJ Aging Mech Dis. 2021 May 28;7(1):16. doi: 10.1038/s41514-021-00066-7. PMID: 34050186; PMCID: PMC8163749.
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The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure.

Cell metabolism

Cluntun AA, Badolia R, Lettlova S, Parnell KM, Shankar TS, Diakos NA, Olson KA, Taleb I, Tatum SM, Berg JA, Cunningham CN, Van Ry T, Bott AJ, Krokidi AT, Fogarty S, Skedros S, Swiatek WI, Yu X, Luo B, Merx S, Navankasattusas S, Cox JE, Ducker GS, Holland WL, McKellar SH, Rutter J, Drakos SG.
PMID: 33333007
Cell Metab. 2021 Mar 02;33(3):629-648.e10. doi: 10.1016/j.cmet.2020.12.003. Epub 2020 Dec 16.

The metabolic rewiring of cardiomyocytes is a widely accepted hallmark of heart failure (HF). These metabolic changes include a decrease in mitochondrial pyruvate oxidation and an increased export of lactate. We identify the mitochondrial pyruvate carrier (MPC) and the...

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Cluntun AA, Badolia R, Lettlova S, et al. The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure. Cell Metab. 2020;33(3):629-648.e10doi: 10.1016/j.cmet.2020.12.003.
Cluntun, A. A., Badolia, R., Lettlova, S., Parnell, K. M., Shankar, T. S., Diakos, N. A., Olson, K. A., Taleb, I., Tatum, S. M., Berg, J. A., Cunningham, C. N., Van Ry, T., Bott, A. J., Krokidi, A. T., Fogarty, S., Skedros, S., Swiatek, W. I., Yu, X., Luo, B., Merx, S., Navankasattusas, S., Cox, J. E., Ducker, G. S., Holland, W. L., McKellar, S. H., Rutter, J., & Drakos, S. G. (2021). The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure. Cell metabolism, 33(3), 629-648.e10. https://doi.org/10.1016/j.cmet.2020.12.003
Cluntun, Ahmad A, et al. "The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure." Cell metabolism vol. 33,3 (2021): 629-648.e10. doi: https://doi.org/10.1016/j.cmet.2020.12.003
Cluntun AA, Badolia R, Lettlova S, Parnell KM, Shankar TS, Diakos NA, Olson KA, Taleb I, Tatum SM, Berg JA, Cunningham CN, Van Ry T, Bott AJ, Krokidi AT, Fogarty S, Skedros S, Swiatek WI, Yu X, Luo B, Merx S, Navankasattusas S, Cox JE, Ducker GS, Holland WL, McKellar SH, Rutter J, Drakos SG. The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure. Cell Metab. 2021 Mar 02;33(3):629-648.e10. doi: 10.1016/j.cmet.2020.12.003. Epub 2020 Dec 16. PMID: 33333007; PMCID: PMC7933116.
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Showing 1 to 3 of 3 entries