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Showing 1 to 12 of 45 entries
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Immunomagnetic separation as a final purification step of liver endothelial cells.

In vitro cellular & developmental biology. Animal

Gomez DE, Hartzler JL, Corbitt RH, Nason AM, Thorgeirsson UP.
PMID: 27519745
In Vitro Cell Dev Biol Anim. 1993 Jun;29(6):451-5. doi: 10.1007/BF02639378.

We describe a fast and reproducible method that can be used as a final step in obtaining pure populations of liver endothelial cells. This method employs endothelial cell specific lectin covalently bound to magnetic polystyrene beads (Dynabeads). Evonymus europaeus...

Psychometric properties of the Icelandic NEO-FFI in a general population sample compared to a sample recruited for a study on the genetics of addiction.

Personality and individual differences

Bjornsdottir G, Jonsson FH, Hansdottir I, Almarsdottir AB, Heimisdottir M, Tyrfingsson T, Runarsdottir VA, Kristjansson K, Stefansson H, Thorgeirsson TE.
PMID: 24415821
Pers Individ Dif. 2014 Feb;58. doi: 10.1016/j.paid.2013.10.010.

Personality traits are major determinants of social behavior influencing various diseases including addiction. Twin and family studies suggest personality and addiction to be under genetic influence. Identification of DNA susceptibility variants relies on valid and reliable phenotyping approaches. We...

[Immediate PTCA for acute myocardial infarction in Iceland.].

Laeknabladid

Gudnason T, Thorgeirsson G, Eyjolfsson K, Jonmundsson EH.
PMID: 20065409
Laeknabladid. 1996 Apr;82(4):269-75.

In recently published articles it has been possible to show better results with primary immediate PTCA (percutaneous transluminal coronary angioplasty) than thrombolysis in acute myocardial infarction. This method also has advantages for patients after failed thrombolysis and if thrombolysis...

Wnt and the cancer niche: paracrine interactions with gastrointestinal cancer cells undergoing asymmetric cell division.

Journal of Cancer

Xin HW, Ambe CM, Ray S, Kim BK, Koizumi T, Wiegand GW, Hari D, Mullinax JE, Jaiswal KR, Garfield SH, Stojadinovic A, Rudloff U, Thorgeirsson SS, Avital I.
PMID: 23901343
J Cancer. 2013 Jul 02;4(6):447-57. doi: 10.7150/jca.6896. Print 2013.

OBJECTIVE: Stem-like cancer cells contribute to cancer initiation and maintenance. Stem cells can self-renew by asymmetric cell division (ACD). ACD with non-random chromosomal cosegregation (ACD-NRCC) is one possible self-renewal mechanism. There is a paucity of evidence supporting ACD-NRCC in...

Liver Label Retaining Cancer Cells Are Relatively Resistant to the Reported Anti-Cancer Stem Cell Drug Metformin.

Journal of Cancer

Xin HW, Ambe CM, Miller TC, Chen JQ, Wiegand GW, Anderson AJ, Ray S, Mullinax JE, Hari DM, Koizumi T, Godbout JD, Goldsmith PK, Stojadinovic A, Rudloff U, Thorgeirsson SS, Avital I.
PMID: 27326258
J Cancer. 2016 Jun 06;7(9):1142-51. doi: 10.7150/jca.10047. eCollection 2016.

BACKGROUND & AIMS: Recently, we reported that liver Label Retaining Cancer Cells (LRCC) can initiate tumors with only 10 cells and are relatively resistant to the targeted drug Sorafenib, a standard of practice in advanced hepatocellular carcinoma (HCC). LRCC...

The genomics of heart failure: design and rationale of the HERMES consortium.

ESC heart failure

Lumbers RT, Shah S, Lin H, Czuba T, Henry A, Swerdlow DI, Mälarstig A, Andersson C, Verweij N, Holmes MV, Ärnlöv J, Svensson P, Hemingway H, Sallah N, Almgren P, Aragam KG, Asselin G, Backman JD, Biggs ML, Bloom HL, Boersma E, Brandimarto J, Brown MR, Brunner-La Rocca HP, Carey DJ, Chaffin MD, Chasman DI, Chazara O, Chen X, Chen X, Chung JH, Chutkow W, Cleland JGF, Cook JP, de Denus S, Dehghan A, Delgado GE, Denaxas S, Doney AS, Dörr M, Dudley SC, Engström G, Esko T, Fatemifar G, Felix SB, Finan C, Ford I, Fougerousse F, Fouodjio R, Ghanbari M, Ghasemi S, Giedraitis V, Giulianini F, Gottdiener JS, Gross S, Guðbjartsson DF, Gui H, Gutmann R, Haggerty CM, van der Harst P, Hedman ÅK, Helgadottir A, Hillege H, Hyde CL, Jacob J, Jukema JW, Kamanu F, Kardys I, Kavousi M, Khaw KT, Kleber ME, Køber L, Koekemoer A, Kraus B, Kuchenbaecker K, Langenberg C, Lind L, Lindgren CM, London B, Lotta LA, Lovering RC, Luan J, Magnusson P, Mahajan A, Mann D, Margulies KB, Marston NA, März W, McMurray JJV, Melander O, Melloni G, Mordi IR, Morley MP, Morris AD, Morris AP, Morrison AC, Nagle MW, Nelson CP, Newton-Cheh C, Niessner A, Niiranen T, Nowak C, O'Donoghue ML, Owens AT, Palmer CNA, Paré G, Perola M, Perreault LL, Portilla-Fernandez E, Psaty BM, Rice KM, Ridker PM, Romaine SPR, Roselli C, Rotter JI, Ruff CT, Sabatine MS, Salo P, Salomaa V, van Setten J, Shalaby AA, Smelser DT, Smith NL, Stefansson K, Stender S, Stott DJ, Sveinbjörnsson G, Tammesoo ML, Tardif JC, Taylor KD, Teder-Laving M, Teumer A, Thorgeirsson G, Thorsteinsdottir U, Torp-Pedersen C, Trompet S, Tuckwell D, Tyl B, Uitterlinden AG, Vaura F, Veluchamy A, Visscher PM, Völker U, Voors AA, Wang X, Wareham NJ, Weeke PE, Weiss R, White HD, Wiggins KL, Xing H, Yang J, Yang Y, Yerges-Armstrong LM, Yu B, Zannad F, Zhao F, Wilk JB, Holm H, Sattar N, Lubitz SA, Lanfear DE, Shah S, Dunn ME, Wells QS, Asselbergs FW, Hingorani AD, Dubé MP, Samani NJ, Lang CC, Cappola TP, Ellinor PT, Vasan RS, Smith JG.
PMID: 34480422
ESC Heart Fail. 2021 Sep 03; doi: 10.1002/ehf2.13517. Epub 2021 Sep 03.

AIMS: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure.METHODS AND RESULTS: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases...

Randomized Trial for Weight Loss Using a Digital Therapeutic Application.

Journal of diabetes science and technology

Thorgeirsson T, Torfadottir JE, Egilsson E, Oddsson S, Gunnarsdottir T, Aspelund T, Olafsdottir AS, Valdimarsdottir UA, Kawachi I, Adami HO, Bjarnason RG.
PMID: 33736484
J Diabetes Sci Technol. 2021 Mar 19;19322968211000815. doi: 10.1177/19322968211000815. Epub 2021 Mar 19.

BACKGROUND: Smartphones present a near-ubiquitous channel through which structured lifestyle change can reduce risk or progression of the most common noncommunicable diseases. We explored whether a digital structured lifestyle program enhances weight loss.METHODS: We randomized overweight and obese participants...

Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis.

JCI insight

Czauderna C, Poplawski A, O'Rourke CJ, Castven D, Pérez-Aguilar B, Becker D, Heilmann-Heimbach S, Odenthal M, Amer W, Schmiel M, Drebber U, Binder H, Ridder DA, Schindeldecker M, Straub BK, Galle PR, Andersen JB, Thorgeirsson SS, Park YN, Marquardt JU.
PMID: 34375307
JCI Insight. 2021 Sep 08;6(17). doi: 10.1172/jci.insight.146196.

Development of primary liver cancer is a multistage process. Detailed understanding of sequential epigenetic alterations is largely missing. Here, we performed Infinium Human Methylation 450k BeadChips and RNA-Seq analyses for genome-wide methylome and transcriptome profiling of cirrhotic liver (n...

Activation of mutagenic and carcinogenic heterocyclic amines by S-9 from the liver of a rhesus monkey.

Toxicology in vitro : an international journal published in association with BIBRA

Ishida Y, Negishi C, Umemoto A, Fujita Y, Sato S, Sugimura T, Thorgeirsson SS, Adamson RH.
PMID: 20702378
Toxicol In Vitro. 1987;1(1):45-8. doi: 10.1016/0887-2333(87)90037-3.

The mutagenicity of a series of heterocyclic amines isolated from various cooked foods and from pyrolysates of amino acids and protein was assayed in Salmonella typhimurium TA98 in the presence of an S-9 fraction prepared from the liver of...

The almighty MYC: orchestrating the micro-RNA universe to generate aggressive liver cancer.

Journal of hepatology

Thorgeirsson SS.
PMID: 21349304
J Hepatol. 2011 Aug;55(2):486-7. doi: 10.1016/j.jhep.2011.01.042. Epub 2011 Feb 22.

No abstract available.

[How is cholesterol lowering therapy implemented among patients with coronary heart disease in Iceland?].

Laeknabladid

Sigurdsson EL, Jonsson JS, Thorgeirsson G.
PMID: 19321915
Laeknabladid. 1999 Feb;85(2):109-94.

OBJECTIVE: High serum cholesterol is one of the major risk factors for coronary heart disease (CHD). RESULTS from large clinical trials have convincingly shown the importance of cholesterol lowering therapy among patients with established CHD. Revised guidelines for cholesterol...

Lectins as tools for the purification of liver endothelial cells.

Methods in molecular medicine

Gomez DE, Thorgeirsson UP.
PMID: 21374472
Methods Mol Med. 1998;9:319-28. doi: 10.1385/0-89603-396-1:319.

Successful procedures for the isolation and culture of large-vessel endothelial cells (EC), were first reported in the early seventies (1,2). Since then, microvascular EC have been isolated from various organs, such as adrenal gland (3), brain (4), skin (5),...

Showing 1 to 12 of 45 entries