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Lumbers RT, Shah S, Lin H, et al. The genomics of heart failure: design and rationale of the HERMES consortium. ESC Heart Fail. 2021;doi: 10.1002/ehf2.13517.
Lumbers, R. T., Shah, S., Lin, H., Czuba, T., Henry, A., Swerdlow, D. I., Mälarstig, A., Andersson, C., Verweij, N., Holmes, M. V., Ärnlöv, J., Svensson, P., Hemingway, H., Sallah, N., Almgren, P., Aragam, K. G., Asselin, G., Backman, J. D., Biggs, M. L., Bloom, H. L., Boersma, E., Brandimarto, J., Brown, M. R., Brunner-La Rocca, H. P., Carey, D. J., Chaffin, M. D., Chasman, D. I., Chazara, O., Chen, X., Chen, X., Chung, J. H., Chutkow, W., Cleland, J. G. F., Cook, J. P., de Denus, S., Dehghan, A., Delgado, G. E., Denaxas, S., Doney, A. S., Dörr, M., Dudley, S. C., Engström, G., Esko, T., Fatemifar, G., Felix, S. B., Finan, C., Ford, I., Fougerousse, F., Fouodjio, R., Ghanbari, M., Ghasemi, S., Giedraitis, V., Giulianini, F., Gottdiener, J. S., Gross, S., Guðbjartsson, D. F., Gui, H., Gutmann, R., Haggerty, C. M., van der Harst, P., Hedman, �. �. K., Helgadottir, A., Hillege, H., Hyde, C. L., Jacob, J., Jukema, J. W., Kamanu, F., Kardys, I., Kavousi, M., Khaw, K. T., Kleber, M. E., Køber, L., Koekemoer, A., Kraus, B., Kuchenbaecker, K., Langenberg, C., Lind, L., Lindgren, C. M., London, B., Lotta, L. A., Lovering, R. C., Luan, J., Magnusson, P., Mahajan, A., Mann, D., Margulies, K. B., Marston, N. A., März, W., McMurray, J. J. V., Melander, O., Melloni, G., Mordi, I. R., Morley, M. P., Morris, A. D., Morris, A. P., Morrison, A. C., Nagle, M. W., Nelson, C. P., Newton-Cheh, C., Niessner, A., Niiranen, T., Nowak, C., O'Donoghue, M. L., Owens, A. T., Palmer, C. N. A., Paré, G., Perola, M., Perreault, L. L., Portilla-Fernandez, E., Psaty, B. M., Rice, K. M., Ridker, P. M., Romaine, S. P. R., Roselli, C., Rotter, J. I., Ruff, C. T., Sabatine, M. S., Salo, P., Salomaa, V., van Setten, J., Shalaby, A. A., Smelser, D. T., Smith, N. L., Stefansson, K., Stender, S., Stott, D. J., Sveinbjörnsson, G., Tammesoo, M. L., Tardif, J. C., Taylor, K. D., Teder-Laving, M., Teumer, A., Thorgeirsson, G., Thorsteinsdottir, U., Torp-Pedersen, C., Trompet, S., Tuckwell, D., Tyl, B., Uitterlinden, A. G., Vaura, F., Veluchamy, A., Visscher, P. M., Völker, U., Voors, A. A., Wang, X., Wareham, N. J., Weeke, P. E., Weiss, R., White, H. D., Wiggins, K. L., Xing, H., Yang, J., Yang, Y., Yerges-Armstrong, L. M., Yu, B., Zannad, F., Zhao, F., Wilk, J. B., Holm, H., Sattar, N., Lubitz, S. A., Lanfear, D. E., Shah, S., Dunn, M. E., Wells, Q. S., Asselbergs, F. W., Hingorani, A. D., Dubé, M. P., Samani, N. J., Lang, C. C., Cappola, T. P., Ellinor, P. T., Vasan, R. S., & Smith, J. G. (2021). The genomics of heart failure: design and rationale of the HERMES consortium. ESC heart failure, . https://doi.org/10.1002/ehf2.13517
Lumbers, R Thomas, et al. "The genomics of heart failure: design and rationale of the HERMES consortium." ESC heart failure vol. (2021). doi: https://doi.org/10.1002/ehf2.13517
Lumbers RT, Shah S, Lin H, Czuba T, Henry A, Swerdlow DI, Mälarstig A, Andersson C, Verweij N, Holmes MV, Ärnlöv J, Svensson P, Hemingway H, Sallah N, Almgren P, Aragam KG, Asselin G, Backman JD, Biggs ML, Bloom HL, Boersma E, Brandimarto J, Brown MR, Brunner-La Rocca HP, Carey DJ, Chaffin MD, Chasman DI, Chazara O, Chen X, Chen X, Chung JH, Chutkow W, Cleland JGF, Cook JP, de Denus S, Dehghan A, Delgado GE, Denaxas S, Doney AS, Dörr M, Dudley SC, Engström G, Esko T, Fatemifar G, Felix SB, Finan C, Ford I, Fougerousse F, Fouodjio R, Ghanbari M, Ghasemi S, Giedraitis V, Giulianini F, Gottdiener JS, Gross S, Guðbjartsson DF, Gui H, Gutmann R, Haggerty CM, van der Harst P, Hedman ÅK, Helgadottir A, Hillege H, Hyde CL, Jacob J, Jukema JW, Kamanu F, Kardys I, Kavousi M, Khaw KT, Kleber ME, Køber L, Koekemoer A, Kraus B, Kuchenbaecker K, Langenberg C, Lind L, Lindgren CM, London B, Lotta LA, Lovering RC, Luan J, Magnusson P, Mahajan A, Mann D, Margulies KB, Marston NA, März W, McMurray JJV, Melander O, Melloni G, Mordi IR, Morley MP, Morris AD, Morris AP, Morrison AC, Nagle MW, Nelson CP, Newton-Cheh C, Niessner A, Niiranen T, Nowak C, O'Donoghue ML, Owens AT, Palmer CNA, Paré G, Perola M, Perreault LL, Portilla-Fernandez E, Psaty BM, Rice KM, Ridker PM, Romaine SPR, Roselli C, Rotter JI, Ruff CT, Sabatine MS, Salo P, Salomaa V, van Setten J, Shalaby AA, Smelser DT, Smith NL, Stefansson K, Stender S, Stott DJ, Sveinbjörnsson G, Tammesoo ML, Tardif JC, Taylor KD, Teder-Laving M, Teumer A, Thorgeirsson G, Thorsteinsdottir U, Torp-Pedersen C, Trompet S, Tuckwell D, Tyl B, Uitterlinden AG, Vaura F, Veluchamy A, Visscher PM, Völker U, Voors AA, Wang X, Wareham NJ, Weeke PE, Weiss R, White HD, Wiggins KL, Xing H, Yang J, Yang Y, Yerges-Armstrong LM, Yu B, Zannad F, Zhao F, Wilk JB, Holm H, Sattar N, Lubitz SA, Lanfear DE, Shah S, Dunn ME, Wells QS, Asselbergs FW, Hingorani AD, Dubé MP, Samani NJ, Lang CC, Cappola TP, Ellinor PT, Vasan RS, Smith JG. The genomics of heart failure: design and rationale of the HERMES consortium. ESC Heart Fail. 2021 Sep 03; doi: 10.1002/ehf2.13517. Epub 2021 Sep 03. PMID: 34480422.
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ESC Heart Fail. 2021 Sep 03; doi: 10.1002/ehf2.13517. Epub 2021 Sep 03.

The genomics of heart failure: design and rationale of the HERMES consortium.

ESC heart failure

R Thomas Lumbers, Sonia Shah, Honghuang Lin, Tomasz Czuba, Albert Henry, Daniel I Swerdlow, Anders Mälarstig, Charlotte Andersson, Niek Verweij, Michael V Holmes, Johan Ärnlöv, Per Svensson, Harry Hemingway, Neneh Sallah, Peter Almgren, Krishna G Aragam, Geraldine Asselin, Joshua D Backman, Mary L Biggs, Heather L Bloom, Eric Boersma, Jeffrey Brandimarto, Michael R Brown, Hans-Peter Brunner-La Rocca, David J Carey, Mark D Chaffin, Daniel I Chasman, Olympe Chazara, Xing Chen, Xu Chen, Jonathan H Chung, William Chutkow, John G F Cleland, James P Cook, Simon de Denus, Abbas Dehghan, Graciela E Delgado, Spiros Denaxas, Alexander S Doney, Marcus Dörr, Samuel C Dudley, Gunnar Engström, Tõnu Esko, Ghazaleh Fatemifar, Stephan B Felix, Chris Finan, Ian Ford, Francoise Fougerousse, René Fouodjio, Mohsen Ghanbari, Sahar Ghasemi, Vilmantas Giedraitis, Franco Giulianini, John S Gottdiener, Stefan Gross, Daníel F Guðbjartsson, Hongsheng Gui, Rebecca Gutmann, Christopher M Haggerty, Pim van der Harst, Åsa K Hedman, Anna Helgadottir, Hans Hillege, Craig L Hyde, Jaison Jacob, J Wouter Jukema, Frederick Kamanu, Isabella Kardys, Maryam Kavousi, Kay-Tee Khaw, Marcus E Kleber, Lars Køber, Andrea Koekemoer, Bill Kraus, Karoline Kuchenbaecker, Claudia Langenberg, Lars Lind, Cecilia M Lindgren, Barry London, Luca A Lotta, Ruth C Lovering, Jian'an Luan, Patrik Magnusson, Anubha Mahajan, Douglas Mann, Kenneth B Margulies, Nicholas A Marston, Winfried März, John J V McMurray, Olle Melander, Giorgio Melloni, Ify R Mordi, Michael P Morley, Andrew D Morris, Andrew P Morris, Alanna C Morrison, Michael W Nagle, Christopher P Nelson, Christopher Newton-Cheh, Alexander Niessner, Teemu Niiranen, Christoph Nowak, Michelle L O'Donoghue, Anjali T Owens, Colin N A Palmer, Guillaume Paré, Markus Perola, Louis-Philippe Lemieux Perreault, Eliana Portilla-Fernandez, Bruce M Psaty, Kenneth M Rice, Paul M Ridker, Simon P R Romaine, Carolina Roselli, Jerome I Rotter, Christian T Ruff, Marc S Sabatine, Perttu Salo, Veikko Salomaa, Jessica van Setten, Alaa A Shalaby, Diane T Smelser, Nicholas L Smith, Kari Stefansson, Steen Stender, David J Stott, Garðar Sveinbjörnsson, Mari-Liis Tammesoo, Jean-Claude Tardif, Kent D Taylor, Maris Teder-Laving, Alexander Teumer, Guðmundur Thorgeirsson, Unnur Thorsteinsdottir, Christian Torp-Pedersen, Stella Trompet, Danny Tuckwell, Benoit Tyl, Andre G Uitterlinden, Felix Vaura, Abirami Veluchamy, Peter M Visscher, Uwe Völker, Adriaan A Voors, Xiaosong Wang, Nicholas J Wareham, Peter E Weeke, Raul Weiss, Harvey D White, Kerri L Wiggins, Heming Xing, Jian Yang, Yifan Yang, Laura M Yerges-Armstrong, Bing Yu, Faiez Zannad, Faye Zhao, Jemma B Wilk, Hilma Holm, Naveed Sattar, Steven A Lubitz, David E Lanfear, Svati Shah, Michael E Dunn, Quinn S Wells, Folkert W Asselbergs, Aroon D Hingorani, Marie-Pierre Dubé, Nilesh J Samani, Chim C Lang, Thomas P Cappola, Patrick T Ellinor, Ramachandran S Vasan, J Gustav Smith

Affiliations

  1. Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.
  2. Health Data Research UK London, University College London, London, UK.
  3. BHF Research Accelerator, University College London, London, UK.
  4. Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
  5. Institute of Cardiovascular Science, University College London, London, UK.
  6. Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
  7. National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
  8. Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.
  9. Department of Medicine, Imperial College London, London, UK.
  10. Pfizer Worldwide Research & Development, Cambridge, MA, USA.
  11. Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden.
  12. Department of Cardiology, Herlev Gentofte Hospital, Herlev, Denmark.
  13. Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  14. Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, UK.
  15. Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, Big Data Institute, University of Oxford, Oxford, UK.
  16. National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, UK.
  17. Department of Neurobiology, Care Sciences and Society/Section of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden.
  18. School of Health and Social Sciences, Dalarna University, Falun, Sweden.
  19. Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden.
  20. Department of Cardiology, Södersjukhuset, Stockholm, Sweden.
  21. The National Institute for Health Research, University College London Hospitals Biomedical Research Centre, University College London, London, UK.
  22. UCL Genetics Institute, University College London, London, UK.
  23. Department of Clinical Sciences, Lund University, Malmö, Sweden.
  24. Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  25. Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
  26. Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
  27. Montreal Heart Institute, Montreal, Quebec, Canada.
  28. Regeneron Genetics Center, Tarrytown, NY, USA.
  29. Department of Biostatistics, University of Washington, Seattle, WA, USA.
  30. Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA.
  31. Division of Cardiology, Department of Medicine, Emory University Medical Center, Atlanta, GA, USA.
  32. Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  33. Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  34. Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  35. Maastricht University Medical Center, Maastricht, The Netherlands.
  36. Department of Molecular and Functional Genomics, Geisinger, Danville, PA, USA.
  37. Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  38. Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  39. Harvard Medical School, Boston, MA, USA.
  40. Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  41. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  42. Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  43. Robertson Centre for Biostatistics & Glasgow Clinical Trials Unit, Institute of Health and Wellbeing, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK.
  44. National Heart and Lung Institute, Imperial College, London, UK.
  45. Department of Biostatistics, University of Liverpool, Liverpool, UK.
  46. Faculty of Pharmacy, Université de Montréal, Montreal, Quebec, Canada.
  47. Department of Epidemiology and Biostatistics, Imperial College London, St Mary's Campus, London, UK.
  48. MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, St Mary's Campus, London, UK.
  49. Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany.
  50. The Alan Turing Institute, British Library, London, UK.
  51. Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
  52. Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
  53. DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
  54. Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
  55. Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
  56. Translational and Clinical Research, Servier Cardiovascular Center for Therapeutic Innovation, Suresnes, France.
  57. Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
  58. Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
  59. Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden.
  60. Department of Medicine, Division of Cardiology, University of Maryland School of Medicine, Baltimore, MD, USA.
  61. deCODE genetics/Amgen Inc., Reykjavik, Iceland.
  62. School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.
  63. Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.
  64. Division of Cardiovascular Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
  65. Department of Translational Data Science and Informatics, Geisinger, Danville, PA, USA.
  66. Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  67. Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands.
  68. Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
  69. Netherlands Heart Institute, Utrecht, The Netherlands.
  70. TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  71. Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  72. Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
  73. Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
  74. Duke Molecular Physiology Institute, Durham, NC, USA.
  75. Division of Psychiatry, University College of London, London, UK.
  76. MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.
  77. Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
  78. Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.
  79. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
  80. Division of Cardiovascular Medicine and Abboud Cardiovascular Research Center, University of Iowa, Iowa City, IA, USA.
  81. Genentech Inc., San Francisco, CA, USA.
  82. Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
  83. Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany.
  84. Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
  85. BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
  86. Department of Internal Medicine, Clinical Sciences, Lund University and Skåne University Hospital, Malmö, Sweden.
  87. Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
  88. Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.
  89. Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria.
  90. Finnish Institute for Health and Welfare, Helsinki, Finland.
  91. Department of Medicine, Turku University Hospital and University of Turku, Turku, Finland.
  92. Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
  93. National Institute for Health and Welfare, Helsinki, Finland.
  94. Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
  95. Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA.
  96. The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
  97. Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.
  98. Division of Cardiology, Department of Medicine, University of Pittsburgh Medical Center and VA Pittsburgh HCS, Pittsburgh, PA, USA.
  99. Department of Epidemiology, University of Washington, Seattle, WA, USA.
  100. Department of Veterans Affairs Office of Research and Development, Seattle Epidemiologic Research and Information Center, Seattle, WA, USA.
  101. Faculty of Medicine, Department of Medicine, University of Iceland, Reykjavik, Iceland.
  102. Department of Clinical Biochemistry, Copenhagen University Hospital, Herlev and Gentofte, Denmark.
  103. Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
  104. Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
  105. Department of Epidemiology and Biostatistics, Aalborg University Hospital, Aalborg, Denmark.
  106. Department of Health, Science and Technology, Aalborg University Hospital, Aalborg, Denmark.
  107. Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
  108. Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.
  109. Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  110. Department of Clinical Medicine, University of Turku, Turku, Finland.
  111. Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
  112. Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH, USA.
  113. Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand.
  114. Department of Medicine, University of Washington, Seattle, WA, USA.
  115. Human Genetics, GlaxoSmithKline, Collegeville, PA, USA.
  116. CHU de Nancy, Inserm and INI-CRCT (F-CRIN), Institut Lorrain du Coeur et des Vaisseaux, Université de Lorraine, Nancy, France.
  117. Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
  118. Heart and Vascular Institute, Henry Ford Hospital, Detroit, MI, USA.
  119. Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
  120. Duke Clinical Research Institute, Durham, NC, USA.
  121. Regeneron Pharmaceuticals, Cardiovascular Research, Tarrytown, NY, USA.
  122. Division of Cardiovascular Medicine and the Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University, Nashville, TN, USA.
  123. Sections of Cardiology, Preventive Medicine and Epidemiology, Department of Medicine, Boston University Schools of Medicine and Public Health, Boston, MA, USA.
  124. Wallenberg Center for Molecular Medicine and Lund University Diabetes Center, Lund University, Lund, Sweden.
  125. The Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and the Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.

PMID: 34480422 DOI: 10.1002/ehf2.13517

Abstract

AIMS: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure.

METHODS AND RESULTS: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome-wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow-up following heart failure diagnosis ranged from 2 to 116 months. Forty-nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34-90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low-frequency variants (allele frequency 0.01-0.05) at P < 5 × 10

CONCLUSIONS: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.

© 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.

Keywords: Association studies; Biomarkers; Cardiomyopathy; Genetics; Heart failure

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