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Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor.

ACS medicinal chemistry letters

Cho YS, Levell JR, Liu G, Caferro T, Sutton J, Shafer CM, Costales A, Manning JR, Zhao Q, Sendzik M, Shultz M, Chenail G, Dooley J, Villalba B, Farsidjani A, Chen J, Kulathila R, Xie X, Dodd S, Gould T, Liang G, Heimbach T, Slocum K, Firestone B, Pu M, Pagliarini R, Growney JD.
PMID: 29057061
ACS Med Chem Lett. 2017 Sep 18;8(10):1116-1121. doi: 10.1021/acsmedchemlett.7b00342. eCollection 2017 Oct 12.

Inhibition of mutant IDH1 is being evaluated clinically as a promising treatment option for various cancers with hotspot mutation at Arg

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Cho YS, Levell JR, Liu G, et al. Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor. ACS Med Chem Lett. 2017;8(10):1116-1121doi: 10.1021/acsmedchemlett.7b00342.
Cho, Y. S., Levell, J. R., Liu, G., Caferro, T., Sutton, J., Shafer, C. M., Costales, A., Manning, J. R., Zhao, Q., Sendzik, M., Shultz, M., Chenail, G., Dooley, J., Villalba, B., Farsidjani, A., Chen, J., Kulathila, R., Xie, X., Dodd, S., Gould, T., Liang, G., Heimbach, T., Slocum, K., Firestone, B., Pu, M., Pagliarini, R., & Growney, J. D. (2017). Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor. ACS medicinal chemistry letters, 8(10), 1116-1121. https://doi.org/10.1021/acsmedchemlett.7b00342
Cho, Young Shin, et al. "Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor." ACS medicinal chemistry letters vol. 8,10 (2017): 1116-1121. doi: https://doi.org/10.1021/acsmedchemlett.7b00342
Cho YS, Levell JR, Liu G, Caferro T, Sutton J, Shafer CM, Costales A, Manning JR, Zhao Q, Sendzik M, Shultz M, Chenail G, Dooley J, Villalba B, Farsidjani A, Chen J, Kulathila R, Xie X, Dodd S, Gould T, Liang G, Heimbach T, Slocum K, Firestone B, Pu M, Pagliarini R, Growney JD. Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor. ACS Med Chem Lett. 2017 Sep 18;8(10):1116-1121. doi: 10.1021/acsmedchemlett.7b00342. eCollection 2017 Oct 12. PMID: 29057061; PMCID: PMC5641959.
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Site-directed mutagenesis reveals regions implicated in the stability and fiber formation of human λ3r light chains.

The Journal of biological chemistry

Villalba MI, Canul-Tec JC, Luna-Martínez OD, Sánchez-Alcalá R, Olamendi-Portugal T, Rudiño-Piñera E, Rojas S, Sánchez-López R, Fernández-Velasco DA, Becerril B.
PMID: 26002949
J Biol Chem. 2015 May 22;290(21):13039. doi: 10.1074/jbc.A114.629550.

No abstract available.

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Villalba MI, Canul-Tec JC, Luna-Martínez OD, et al. Site-directed mutagenesis reveals regions implicated in the stability and fiber formation of human λ3r light chains. J Biol Chem. 2015;290(21):13039doi: 10.1074/jbc.A114.629550.
Villalba, M. I., Canul-Tec, J. C., Luna-Martínez, O. D., Sánchez-Alcalá, R., Olamendi-Portugal, T., Rudiño-Piñera, E., Rojas, S., Sánchez-López, R., Fernández-Velasco, D. A., & Becerril, B. (2015). Site-directed mutagenesis reveals regions implicated in the stability and fiber formation of human λ3r light chains. The Journal of biological chemistry, 290(21), 13039. https://doi.org/10.1074/jbc.A114.629550
Villalba, Miryam I, et al. "Site-directed mutagenesis reveals regions implicated in the stability and fiber formation of human λ3r light chains." The Journal of biological chemistry vol. 290,21 (2015): 13039. doi: https://doi.org/10.1074/jbc.A114.629550
Villalba MI, Canul-Tec JC, Luna-Martínez OD, Sánchez-Alcalá R, Olamendi-Portugal T, Rudiño-Piñera E, Rojas S, Sánchez-López R, Fernández-Velasco DA, Becerril B. Site-directed mutagenesis reveals regions implicated in the stability and fiber formation of human λ3r light chains. J Biol Chem. 2015 May 22;290(21):13039. doi: 10.1074/jbc.A114.629550. PMID: 26002949; PMCID: PMC4505558.
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The incidence of erectile dysfunction after pelvic fracture urethral injury: A systematic review and meta-analysis.

Arab journal of urology

Blaschko SD, Sanford MT, Schlomer BJ, Alwaal A, Yang G, Villalta JD, Wessells H, McAninch JW, Breyer BN.
PMID: 26019983
Arab J Urol. 2015 Mar;13(1):68-74. doi: 10.1016/j.aju.2014.09.004. Epub 2014 Oct 16.

BACKGROUND: Pelvic fracture urethral injury (PFUI) is associated with a high risk of erectile dysfunction (ED). The effect of the type of posterior urethral disruption repair on erectile function has not been clearly established. We systematically reviewed and conducted...

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Blaschko SD, Sanford MT, Schlomer BJ, et al. The incidence of erectile dysfunction after pelvic fracture urethral injury: A systematic review and meta-analysis. Arab J Urol. 2014;13(1):68-74doi: 10.1016/j.aju.2014.09.004.
Blaschko, S. D., Sanford, M. T., Schlomer, B. J., Alwaal, A., Yang, G., Villalta, J. D., Wessells, H., McAninch, J. W., & Breyer, B. N. (2015). The incidence of erectile dysfunction after pelvic fracture urethral injury: A systematic review and meta-analysis. Arab journal of urology, 13(1), 68-74. https://doi.org/10.1016/j.aju.2014.09.004
Blaschko, Sarah D, et al. "The incidence of erectile dysfunction after pelvic fracture urethral injury: A systematic review and meta-analysis." Arab journal of urology vol. 13,1 (2015): 68-74. doi: https://doi.org/10.1016/j.aju.2014.09.004
Blaschko SD, Sanford MT, Schlomer BJ, Alwaal A, Yang G, Villalta JD, Wessells H, McAninch JW, Breyer BN. The incidence of erectile dysfunction after pelvic fracture urethral injury: A systematic review and meta-analysis. Arab J Urol. 2015 Mar;13(1):68-74. doi: 10.1016/j.aju.2014.09.004. Epub 2014 Oct 16. PMID: 26019983; PMCID: PMC4435659.
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Copper inducing effect on laccase production of white rot fungi native from Misiones (Argentina).

Enzyme and microbial technology

Fonseca MI, Shimizu E, Zapata PD, Villalba LL.
PMID: 25919631
Enzyme Microb Technol. 2010 May 05;46(6):534-9. doi: 10.1016/j.enzmictec.2009.12.017. Epub 2010 Jan 07.

Fungi may be selected as models for gene expression studies and further adaptation for biotechnological enzyme production. The aim of this work was to evaluate laccase production and to analyze the effect of Cu(2+) on selected fungi natives of...

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Fonseca MI, Shimizu E, Zapata PD, et al. Copper inducing effect on laccase production of white rot fungi native from Misiones (Argentina). Enzyme Microb Technol. 2010;46(6):534-9doi: 10.1016/j.enzmictec.2009.12.017.
Fonseca, M. I., Shimizu, E., Zapata, P. D., & Villalba, L. L. (2010). Copper inducing effect on laccase production of white rot fungi native from Misiones (Argentina). Enzyme and microbial technology, 46(6), 534-9. https://doi.org/10.1016/j.enzmictec.2009.12.017
Fonseca, María I, et al. "Copper inducing effect on laccase production of white rot fungi native from Misiones (Argentina)." Enzyme and microbial technology vol. 46,6 (2010): 534-9. doi: https://doi.org/10.1016/j.enzmictec.2009.12.017
Fonseca MI, Shimizu E, Zapata PD, Villalba LL. Copper inducing effect on laccase production of white rot fungi native from Misiones (Argentina). Enzyme Microb Technol. 2010 May 05;46(6):534-9. doi: 10.1016/j.enzmictec.2009.12.017. Epub 2010 Jan 07. PMID: 25919631.
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Tobacco and end stage renal disease: a multicenter, cross-sectional study in Argentinian Northern Patagonia.

Tobacco induced diseases

Alba MM, Citarelli AN, Menni F, Agricola M, Braicovich A, De Horta E, De Rosa F, Filanino G, Gaggiotti R, Junqueras N, Martinelli S, Milan A, Morales ME, Setti S, Villalba DO.
PMID: 26327820
Tob Induc Dis. 2015 Sep 01;13(1):28. doi: 10.1186/s12971-015-0051-x. eCollection 2015.

BACKGROUND: Smoking and chronic kidney disease are major public health problems with common features -high prevalence and mortality, high cardiovascular risk, gender differences and high prevalence in low income people-, but the link between them is poorly recognized. Our...

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Alba MM, Citarelli AN, Menni F, et al. Tobacco and end stage renal disease: a multicenter, cross-sectional study in Argentinian Northern Patagonia. Tob Induc Dis. 2015;13(1):28doi: 10.1186/s12971-015-0051-x.
Alba, M. M., Citarelli, A. N., Menni, F., Agricola, M., Braicovich, A., De Horta, E., De Rosa, F., Filanino, G., Gaggiotti, R., Junqueras, N., Martinelli, S., Milan, A., Morales, M. E., Setti, S., & Villalba, D. O. (2015). Tobacco and end stage renal disease: a multicenter, cross-sectional study in Argentinian Northern Patagonia. Tobacco induced diseases, 13(1), 28. https://doi.org/10.1186/s12971-015-0051-x
Alba, Maria M, et al. "Tobacco and end stage renal disease: a multicenter, cross-sectional study in Argentinian Northern Patagonia." Tobacco induced diseases vol. 13,1 (2015): 28. doi: https://doi.org/10.1186/s12971-015-0051-x
Alba MM, Citarelli AN, Menni F, Agricola M, Braicovich A, De Horta E, De Rosa F, Filanino G, Gaggiotti R, Junqueras N, Martinelli S, Milan A, Morales ME, Setti S, Villalba DO. Tobacco and end stage renal disease: a multicenter, cross-sectional study in Argentinian Northern Patagonia. Tob Induc Dis. 2015 Sep 01;13(1):28. doi: 10.1186/s12971-015-0051-x. eCollection 2015. PMID: 26327820; PMCID: PMC4553923.
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[Evaluation of primary health care].

Atencion primaria

Villalbí JR, Pasarín M, Montaner I, Cabezas C, Starfield B.
PMID: 12716574
Aten Primaria. 2003;31(6):382-5. doi: 10.1016/s0212-6567(03)70703-3.

No abstract available.

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Villalbí JR, Pasarín M, Montaner I, et al. Evaluación de la atención primaria de salud. [Evaluation of primary health care]. Aten Primaria. 2003;31(6):382-5doi: 10.1016/s0212-6567(03)70703-3.
Villalbí, J. R., Pasarín, M., Montaner, I., Cabezas, C., & Starfield, B. (2003). Evaluación de la atención primaria de salud. [Evaluation of primary health care]. Atencion primaria, 31(6), 382-5. https://doi.org/10.1016/s0212-6567(03)70703-3
Villalbí, J R, et al. "Evaluación de la atención primaria de salud." [Evaluation of primary health care]. Atencion primaria vol. 31,6 (2003): 382-5. doi: https://doi.org/10.1016/s0212-6567(03)70703-3
Villalbí JR, Pasarín M, Montaner I, Cabezas C, Starfield B. Evaluación de la atención primaria de salud. [Evaluation of primary health care]. Aten Primaria. 2003;31(6):382-5. doi: 10.1016/s0212-6567(03)70703-3. Spanish. PMID: 12716574; PMCID: PMC7681685.
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Self-organization of foraging behaviour: from simplicity to complexity without goals.

Nutrition research reviews

Provenza FD, Villalba JJ, Cheney CD, Werner SJ.
PMID: 19094247
Nutr Res Rev. 1998 Dec;11(2):199-222. doi: 10.1079/NRR19980015.

A herbivore faces challenges while foraging-ongoing changes in its physiological condition along with variation in the nutrient and toxin concentrations of foods, spatially and temporally-that make selecting a nutritious diet a vital affair. Foraging behaviours arise from simple rules...

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Provenza FD, Villalba JJ, Cheney CD, et al. Self-organization of foraging behaviour: from simplicity to complexity without goals. Nutr Res Rev. 1998;11(2):199-222doi: 10.1079/NRR19980015.
Provenza, F. D., Villalba, J. J., Cheney, C. D., & Werner, S. J. (1998). Self-organization of foraging behaviour: from simplicity to complexity without goals. Nutrition research reviews, 11(2), 199-222. https://doi.org/10.1079/NRR19980015
Provenza, F D, et al. "Self-organization of foraging behaviour: from simplicity to complexity without goals." Nutrition research reviews vol. 11,2 (1998): 199-222. doi: https://doi.org/10.1079/NRR19980015
Provenza FD, Villalba JJ, Cheney CD, Werner SJ. Self-organization of foraging behaviour: from simplicity to complexity without goals. Nutr Res Rev. 1998 Dec;11(2):199-222. doi: 10.1079/NRR19980015. PMID: 19094247.
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Implementation of a Quality Plan (ISO 9002) In a Regional Tissue Bank.

Cell and tissue banking

Villalba R, Eisman M, Fornés G, Mesa A, De Torres P, Ariza MJ, Gutierrez Guzmán A, Gómez Villagrán JL.
PMID: 15256930
Cell Tissue Bank. 2001;2(1):45-49. doi: 10.1023/A:1011576332362.

Quality control and standardized preservation methods are essential in the field of transplantation. The International Organization for Standardization (ISO) has established a common set of manufacturing, trade and communications standards that are applicable worldwide and that provide the basis...

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Villalba R, Eisman M, Fornés G, et al. Implementation of a Quality Plan (ISO 9002) In a Regional Tissue Bank. Cell Tissue Bank. 2001;2(1):45-49doi: 10.1023/A:1011576332362.
Villalba, R., Eisman, M., Fornés, G., Mesa, A., De Torres, P., Ariza, M. J., Gutierrez Guzmán, A., & Gómez Villagrán, J. L. (2001). Implementation of a Quality Plan (ISO 9002) In a Regional Tissue Bank. Cell and tissue banking, 2(1), 45-49. https://doi.org/10.1023/A:1011576332362
Villalba, R., et al. "Implementation of a Quality Plan (ISO 9002) In a Regional Tissue Bank." Cell and tissue banking vol. 2,1 (2001): 45-49. doi: https://doi.org/10.1023/A:1011576332362
Villalba R, Eisman M, Fornés G, Mesa A, De Torres P, Ariza MJ, Gutierrez Guzmán A, Gómez Villagrán JL. Implementation of a Quality Plan (ISO 9002) In a Regional Tissue Bank. Cell Tissue Bank. 2001;2(1):45-49. doi: 10.1023/A:1011576332362. PMID: 15256930.
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Role of early experience in the development of preference for low-quality food in sheep.

Animal : an international journal of animal bioscience

Catanese F, Distel RA, Rodríguez Iglesias RM, Villalba JJ.
PMID: 22444134
Animal. 2010 May;4(5):784-91. doi: 10.1017/S1751731109991637.

Domestic ruminant selectivity induces floristic changes in pasturelands, risking sustainability and limiting the subsequent availability of susceptible plant species. Development of preferences for species of lower nutritional quality may help to overcome those problems. In this study, we tested...

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Catanese F, Distel RA, Rodríguez Iglesias RM, et al. Role of early experience in the development of preference for low-quality food in sheep. Animal. 2010;4(5):784-91doi: 10.1017/S1751731109991637.
Catanese, F., Distel, R. A., Rodríguez Iglesias, R. M., & Villalba, J. J. (2010). Role of early experience in the development of preference for low-quality food in sheep. Animal : an international journal of animal bioscience, 4(5), 784-91. https://doi.org/10.1017/S1751731109991637
Catanese, F, et al. "Role of early experience in the development of preference for low-quality food in sheep." Animal : an international journal of animal bioscience vol. 4,5 (2010): 784-91. doi: https://doi.org/10.1017/S1751731109991637
Catanese F, Distel RA, Rodríguez Iglesias RM, Villalba JJ. Role of early experience in the development of preference for low-quality food in sheep. Animal. 2010 May;4(5):784-91. doi: 10.1017/S1751731109991637. PMID: 22444134.
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Role of early experience in the development of preference for low-quality food in sheep.

Animal : an international journal of animal bioscience

Catanese F, Distel RA, Rodríguez Iglesias RM, Villalba JJ.
PMID: 22444134
Animal. 2010 May;4(5):784-91. doi: 10.1017/S1751731109991637.

Domestic ruminant selectivity induces floristic changes in pasturelands, risking sustainability and limiting the subsequent availability of susceptible plant species. Development of preferences for species of lower nutritional quality may help to overcome those problems. In this study, we tested...

Cite
Catanese F, Distel RA, Rodríguez Iglesias RM, et al. Role of early experience in the development of preference for low-quality food in sheep. Animal. 2010;4(5):784-91doi: 10.1017/S1751731109991637.
Catanese, F., Distel, R. A., Rodríguez Iglesias, R. M., & Villalba, J. J. (2010). Role of early experience in the development of preference for low-quality food in sheep. Animal : an international journal of animal bioscience, 4(5), 784-91. https://doi.org/10.1017/S1751731109991637
Catanese, F, et al. "Role of early experience in the development of preference for low-quality food in sheep." Animal : an international journal of animal bioscience vol. 4,5 (2010): 784-91. doi: https://doi.org/10.1017/S1751731109991637
Catanese F, Distel RA, Rodríguez Iglesias RM, Villalba JJ. Role of early experience in the development of preference for low-quality food in sheep. Animal. 2010 May;4(5):784-91. doi: 10.1017/S1751731109991637. PMID: 22444134.
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The thalamostriatal system in normal and diseased states.

Frontiers in systems neuroscience

Smith Y, Galvan A, Ellender TJ, Doig N, Villalba RM, Huerta-Ocampo I, Wichmann T, Bolam JP.
PMID: 24523677
Front Syst Neurosci. 2014 Jan 30;8:5. doi: 10.3389/fnsys.2014.00005. eCollection 2014.

Because of our limited knowledge of the functional role of the thalamostriatal system, this massive network is often ignored in models of the pathophysiology of brain disorders of basal ganglia origin, such as Parkinson's disease (PD). However, over the...

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Smith Y, Galvan A, Ellender TJ, et al. The thalamostriatal system in normal and diseased states. Front Syst Neurosci. 2014;8:5doi: 10.3389/fnsys.2014.00005.
Smith, Y., Galvan, A., Ellender, T. J., Doig, N., Villalba, R. M., Huerta-Ocampo, I., Wichmann, T., & Bolam, J. P. (2014). The thalamostriatal system in normal and diseased states. Frontiers in systems neuroscience, 85. https://doi.org/10.3389/fnsys.2014.00005
Smith, Yoland, et al. "The thalamostriatal system in normal and diseased states." Frontiers in systems neuroscience vol. 8 (2014): 5. doi: https://doi.org/10.3389/fnsys.2014.00005
Smith Y, Galvan A, Ellender TJ, Doig N, Villalba RM, Huerta-Ocampo I, Wichmann T, Bolam JP. The thalamostriatal system in normal and diseased states. Front Syst Neurosci. 2014 Jan 30;8:5. doi: 10.3389/fnsys.2014.00005. eCollection 2014. PMID: 24523677; PMCID: PMC3906602.
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Protein Kinase C-θ (PKC-θ) in Natural Killer Cell Function and Anti-Tumor Immunity.

Frontiers in immunology

Anel A, Aguiló JI, Catalán E, Garaude J, Rathore MG, Pardo J, Villalba M.
PMID: 22783260
Front Immunol. 2012 Jul 05;3:187. doi: 10.3389/fimmu.2012.00187. eCollection 2012.

The protein kinase C-θ (PKCθ), which is essential for T cell function and survival, is also required for efficient anti-tumor immune surveillance. Natural killer (NK) cells, which express PKCθ, play a prominent role in this process, mainly by elimination...

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Anel A, Aguiló JI, Catalán E, et al. Protein Kinase C-θ (PKC-θ) in Natural Killer Cell Function and Anti-Tumor Immunity. Front Immunol. 2012;3:187doi: 10.3389/fimmu.2012.00187.
Anel, A., Aguiló, J. I., Catalán, E., Garaude, J., Rathore, M. G., Pardo, J., & Villalba, M. (2012). Protein Kinase C-θ (PKC-θ) in Natural Killer Cell Function and Anti-Tumor Immunity. Frontiers in immunology, 3187. https://doi.org/10.3389/fimmu.2012.00187
Anel, Alberto, et al. "Protein Kinase C-θ (PKC-θ) in Natural Killer Cell Function and Anti-Tumor Immunity." Frontiers in immunology vol. 3 (2012): 187. doi: https://doi.org/10.3389/fimmu.2012.00187
Anel A, Aguiló JI, Catalán E, Garaude J, Rathore MG, Pardo J, Villalba M. Protein Kinase C-θ (PKC-θ) in Natural Killer Cell Function and Anti-Tumor Immunity. Front Immunol. 2012 Jul 05;3:187. doi: 10.3389/fimmu.2012.00187. eCollection 2012. PMID: 22783260; PMCID: PMC3389606.
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Showing 1 to 12 of 210 entries