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Clinical Relevance of Environmental Factors in the Pathogenesis of Autoimmune Thyroid Disease.

Endocrinology and metabolism (Seoul, Korea)

Wiersinga WM.
PMID: 27184015
Endocrinol Metab (Seoul). 2016 Jun;31(2):213-22. doi: 10.3803/EnM.2016.31.2.213. Epub 2016 May 13.

Genetic factors contribute for about 70% to 80% and environmental factors for about 20% to 30% to the pathogenesis of autoimmune thyroid disease (AITD). Relatives of AITD patients carry a risk to contract AITD themselves. The 5-year risk can...

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Wiersinga WM. Clinical Relevance of Environmental Factors in the Pathogenesis of Autoimmune Thyroid Disease. Endocrinol Metab (Seoul). 2016;31(2):213-22doi: 10.3803/EnM.2016.31.2.213.
Wiersinga, W. M. (2016). Clinical Relevance of Environmental Factors in the Pathogenesis of Autoimmune Thyroid Disease. Endocrinology and metabolism (Seoul, Korea), 31(2), 213-22. https://doi.org/10.3803/EnM.2016.31.2.213
Wiersinga, Wilmar M. "Clinical Relevance of Environmental Factors in the Pathogenesis of Autoimmune Thyroid Disease." Endocrinology and metabolism (Seoul, Korea) vol. 31,2 (2016): 213-22. doi: https://doi.org/10.3803/EnM.2016.31.2.213
Wiersinga WM. Clinical Relevance of Environmental Factors in the Pathogenesis of Autoimmune Thyroid Disease. Endocrinol Metab (Seoul). 2016 Jun;31(2):213-22. doi: 10.3803/EnM.2016.31.2.213. Epub 2016 May 13. PMID: 27184015; PMCID: PMC4923404.
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Neutrophil extracellular traps in the host defense against sepsis induced by Burkholderia pseudomallei (melioidosis).

Intensive care medicine experimental

de Jong HK, Koh GC, Achouiti A, van der Meer AJ, Bulder I, Stephan F, Roelofs JJ, Day NP, Peacock SJ, Zeerleder S, Wiersinga WJ.
PMID: 26215706
Intensive Care Med Exp. 2014 Dec;2(1):21. doi: 10.1186/s40635-014-0021-2. Epub 2014 Sep 03.

BACKGROUND: Neutrophil extracellular traps (NETs) are a central player in the host response to bacteria: neutrophils release extracellular DNA (nucleosomes) and neutrophil elastase to entrap and kill bacteria. We studied the role of NETs in Burkholderia pseudomallei infection (melioidosis),...

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de Jong HK, Koh GC, Achouiti A, et al. Neutrophil extracellular traps in the host defense against sepsis induced by Burkholderia pseudomallei (melioidosis). Intensive Care Med Exp. 2014;2(1):21doi: 10.1186/s40635-014-0021-2.
de Jong, H. K., Koh, G. C., Achouiti, A., van der Meer, A. J., Bulder, I., Stephan, F., Roelofs, J. J., Day, N. P., Peacock, S. J., Zeerleder, S., & Wiersinga, W. J. (2014). Neutrophil extracellular traps in the host defense against sepsis induced by Burkholderia pseudomallei (melioidosis). Intensive care medicine experimental, 2(1), 21. https://doi.org/10.1186/s40635-014-0021-2
de Jong, Hanna K, et al. "Neutrophil extracellular traps in the host defense against sepsis induced by Burkholderia pseudomallei (melioidosis)." Intensive care medicine experimental vol. 2,1 (2014): 21. doi: https://doi.org/10.1186/s40635-014-0021-2
de Jong HK, Koh GC, Achouiti A, van der Meer AJ, Bulder I, Stephan F, Roelofs JJ, Day NP, Peacock SJ, Zeerleder S, Wiersinga WJ. Neutrophil extracellular traps in the host defense against sepsis induced by Burkholderia pseudomallei (melioidosis). Intensive Care Med Exp. 2014 Dec;2(1):21. doi: 10.1186/s40635-014-0021-2. Epub 2014 Sep 03. PMID: 26215706; PMCID: PMC4678137.
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Immunosuppressive treatment of Graves' ophthalmopathy.

Trends in endocrinology and metabolism: TEM

Wiersinga WM.
PMID: 18411147
Trends Endocrinol Metab. 1990 Nov-Dec;1(8):377-81. doi: 10.1016/1043-2760(90)90095-k.

Steroids or orbital irradiation are effective in approximately 60% of patients with severe Graves' ophthalmopathy; the improvement of proptosis and extraocular muscle dysfunction, however, is limited. Better results are obtained by the combination of orbital irradiation and systemic steroids....

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Wiersinga WM. Immunosuppressive treatment of Graves' ophthalmopathy. Trends Endocrinol Metab. 1990;1(8):377-81doi: 10.1016/1043-2760(90)90095-k.
Wiersinga, W. M. (1990). Immunosuppressive treatment of Graves' ophthalmopathy. Trends in endocrinology and metabolism: TEM, 1(8), 377-81. https://doi.org/10.1016/1043-2760(90)90095-k
Wiersinga, W M. "Immunosuppressive treatment of Graves' ophthalmopathy." Trends in endocrinology and metabolism: TEM vol. 1,8 (1990): 377-81. doi: https://doi.org/10.1016/1043-2760(90)90095-k
Wiersinga WM. Immunosuppressive treatment of Graves' ophthalmopathy. Trends Endocrinol Metab. 1990 Nov-Dec;1(8):377-81. doi: 10.1016/1043-2760(90)90095-k. PMID: 18411147.
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Gut Microbiome Modulation by Antibiotics in Adult Asthma: A Human Proof-of-Concept Intervention Trial.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Van Engelen TSR, Yang J, Haak BW, Bonta PI, Van Der Poll T, Wiersinga WJ.
PMID: 34303860
Clin Gastroenterol Hepatol. 2021 Jul 22; doi: 10.1016/j.cgh.2021.07.030. Epub 2021 Jul 22.

Although the pathophysiology of asthma is complex, perturbation of the gut microbiota has been associated with an increased risk of asthma development in childhood.

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Van Engelen TSR, Yang J, Haak BW, et al. Gut Microbiome Modulation by Antibiotics in Adult Asthma: A Human Proof-of-Concept Intervention Trial. Clin Gastroenterol Hepatol. 2021;doi: 10.1016/j.cgh.2021.07.030.
Van Engelen, T. S. R., Yang, J., Haak, B. W., Bonta, P. I., Van Der Poll, T., & Wiersinga, W. J. (2021). Gut Microbiome Modulation by Antibiotics in Adult Asthma: A Human Proof-of-Concept Intervention Trial. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, . https://doi.org/10.1016/j.cgh.2021.07.030
Van Engelen, Tjitske S R, et al. "Gut Microbiome Modulation by Antibiotics in Adult Asthma: A Human Proof-of-Concept Intervention Trial." Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association vol. (2021). doi: https://doi.org/10.1016/j.cgh.2021.07.030
Van Engelen TSR, Yang J, Haak BW, Bonta PI, Van Der Poll T, Wiersinga WJ. Gut Microbiome Modulation by Antibiotics in Adult Asthma: A Human Proof-of-Concept Intervention Trial. Clin Gastroenterol Hepatol. 2021 Jul 22; doi: 10.1016/j.cgh.2021.07.030. Epub 2021 Jul 22. PMID: 34303860.
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Proposal for Standardization of Primary and Secondary Outcomes in Patients with Active, Moderate-to-Severe Graves' Orbitopathy.

European thyroid journal

Bartalena L, Wiersinga WM.
PMID: 33511081
Eur Thyroid J. 2020 Dec;9:3-16. doi: 10.1159/000510700. Epub 2020 Sep 21.

Standardization of treatment outcomes in randomized clinical trials (RCTs) for active, moderate-to-severe Graves' orbitopathy (GO) is needed to make results of different RCTs comparable and to draw sound conclusions on the efficacy of a given treatment. Both subjective patient-reported...

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Bartalena L, Wiersinga WM. Proposal for Standardization of Primary and Secondary Outcomes in Patients with Active, Moderate-to-Severe Graves' Orbitopathy. Eur Thyroid J. 2020;9:3-16doi: 10.1159/000510700.
Bartalena, L., & Wiersinga, W. M. (2020). Proposal for Standardization of Primary and Secondary Outcomes in Patients with Active, Moderate-to-Severe Graves' Orbitopathy. European thyroid journal, 93-16. https://doi.org/10.1159/000510700
Bartalena, Luigi, and Wiersinga, Wilmar M. "Proposal for Standardization of Primary and Secondary Outcomes in Patients with Active, Moderate-to-Severe Graves' Orbitopathy." European thyroid journal vol. 9 (2020): 3-16. doi: https://doi.org/10.1159/000510700
Bartalena L, Wiersinga WM. Proposal for Standardization of Primary and Secondary Outcomes in Patients with Active, Moderate-to-Severe Graves' Orbitopathy. Eur Thyroid J. 2020 Dec;9:3-16. doi: 10.1159/000510700. Epub 2020 Sep 21. PMID: 33511081; PMCID: PMC7802435.
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Correction: Increased Von Willebrand factor, decreased ADAMTS13 and thrombocytopenia in melioidosis.

PLoS neglected tropical diseases

Birnie E, Koh GCKW, Löwenberg EC, Meijers JCM, Maude RR, Day NPJ, Peacock SJ, van der Poll T, Wiersinga WJ.
PMID: 32870904
PLoS Negl Trop Dis. 2020 Sep 01;14(9):e0008722. doi: 10.1371/journal.pntd.0008722. eCollection 2020 Sep.

[This corrects the article DOI: 10.1371/journal.pntd.0005468.].

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Birnie E, Koh GCKW, Löwenberg EC, et al. Correction: Increased Von Willebrand factor, decreased ADAMTS13 and thrombocytopenia in melioidosis. PLoS Negl Trop Dis. 2020;14(9):e0008722doi: 10.1371/journal.pntd.0008722.
Birnie, E., Koh, G. C. K. W., Löwenberg, E. C., Meijers, J. C. M., Maude, R. R., Day, N. P. J., Peacock, S. J., van der Poll, T., & Wiersinga, W. J. (2020). Correction: Increased Von Willebrand factor, decreased ADAMTS13 and thrombocytopenia in melioidosis. PLoS neglected tropical diseases, 14(9), e0008722. https://doi.org/10.1371/journal.pntd.0008722
Birnie, Emma, et al. "Correction: Increased Von Willebrand factor, decreased ADAMTS13 and thrombocytopenia in melioidosis." PLoS neglected tropical diseases vol. 14,9 (2020): e0008722. doi: https://doi.org/10.1371/journal.pntd.0008722
Birnie E, Koh GCKW, Löwenberg EC, Meijers JCM, Maude RR, Day NPJ, Peacock SJ, van der Poll T, Wiersinga WJ. Correction: Increased Von Willebrand factor, decreased ADAMTS13 and thrombocytopenia in melioidosis. PLoS Negl Trop Dis. 2020 Sep 01;14(9):e0008722. doi: 10.1371/journal.pntd.0008722. eCollection 2020 Sep. PMID: 32870904; PMCID: PMC7462254.
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T4+T3 Combination Therapy: An Unsolved Problem of Increasing Magnitude and Complexity.

Endocrinology and metabolism (Seoul, Korea)

Wiersinga WM.
PMID: 34587734
Endocrinol Metab (Seoul). 2021 Oct;36(5):938-951. doi: 10.3803/EnM.2021.501. Epub 2021 Sep 30.

Thyroxine (T4)+triiodothyronine (T3) combination therapy can be considered in case of persistent symptoms despite normal serum thyroid stimulating hormone in levothyroxine (LT4)-treated hypothyroid patients. Combination therapy has gained popularity in the last two decades, especially in countries with a...

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Wiersinga WM. T4+T3 Combination Therapy: An Unsolved Problem of Increasing Magnitude and Complexity. Endocrinol Metab (Seoul). 2021;36(5):938-951doi: 10.3803/EnM.2021.501.
Wiersinga, W. M. (2021). T4+T3 Combination Therapy: An Unsolved Problem of Increasing Magnitude and Complexity. Endocrinology and metabolism (Seoul, Korea), 36(5), 938-951. https://doi.org/10.3803/EnM.2021.501
Wiersinga, Wilmar M. "T4+T3 Combination Therapy: An Unsolved Problem of Increasing Magnitude and Complexity." Endocrinology and metabolism (Seoul, Korea) vol. 36,5 (2021): 938-951. doi: https://doi.org/10.3803/EnM.2021.501
Wiersinga WM. T4+T3 Combination Therapy: An Unsolved Problem of Increasing Magnitude and Complexity. Endocrinol Metab (Seoul). 2021 Oct;36(5):938-951. doi: 10.3803/EnM.2021.501. Epub 2021 Sep 30. PMID: 34587734; PMCID: PMC8566135.
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European Thyroid Journal Is Completing Its First Quinquennium.

European thyroid journal

Wiersinga WM.
PMID: 27099832
Eur Thyroid J. 2016 Mar;5(1):1-3. doi: 10.1159/000444424. Epub 2016 Mar 09.

No abstract available.

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Wiersinga WM. European Thyroid Journal Is Completing Its First Quinquennium. Eur Thyroid J. 2016;5(1):1-3doi: 10.1159/000444424.
Wiersinga, W. M. (2016). European Thyroid Journal Is Completing Its First Quinquennium. European thyroid journal, 5(1), 1-3. https://doi.org/10.1159/000444424
Wiersinga, Wilmar M. "European Thyroid Journal Is Completing Its First Quinquennium." European thyroid journal vol. 5,1 (2016): 1-3. doi: https://doi.org/10.1159/000444424
Wiersinga WM. European Thyroid Journal Is Completing Its First Quinquennium. Eur Thyroid J. 2016 Mar;5(1):1-3. doi: 10.1159/000444424. Epub 2016 Mar 09. PMID: 27099832; PMCID: PMC4836122.
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Timeliness of antibiotics for patients with sepsis and septic shock.

Journal of thoracic disease

Schinkel M, Nannan Panday RS, Wiersinga WJ, Nanayakkara PWB.
PMID: 32148927
J Thorac Dis. 2020 Feb;12:S66-S71. doi: 10.21037/jtd.2019.10.35.

For many years, sepsis guidelines have focused on early administration of antibiotics. While this practice may benefit some patients, for others it might have detrimental consequences. The increasingly shortened timeframes in which administration of antibiotics is recommended, have forced...

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Schinkel M, Nannan Panday RS, Wiersinga WJ, et al. Timeliness of antibiotics for patients with sepsis and septic shock. J Thorac Dis. 2020;12:S66-S71doi: 10.21037/jtd.2019.10.35.
Schinkel, M., Nannan Panday, R. S., Wiersinga, W. J., & Nanayakkara, P. W. B. (2020). Timeliness of antibiotics for patients with sepsis and septic shock. Journal of thoracic disease, 12S66-S71. https://doi.org/10.21037/jtd.2019.10.35
Schinkel, Michiel, et al. "Timeliness of antibiotics for patients with sepsis and septic shock." Journal of thoracic disease vol. 12 (2020): S66-S71. doi: https://doi.org/10.21037/jtd.2019.10.35
Schinkel M, Nannan Panday RS, Wiersinga WJ, Nanayakkara PWB. Timeliness of antibiotics for patients with sepsis and septic shock. J Thorac Dis. 2020 Feb;12:S66-S71. doi: 10.21037/jtd.2019.10.35. PMID: 32148927; PMCID: PMC7024760.
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Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis.

Infection

Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM, Deutschman C, Drechsler S, Efron P, Frostell C, Fritsch G, Gozdzik W, Hellman J, Huber-Lang M, Inoue S, Knapp S, Kozlov AV, Libert C, Marshall JC, Moldawer LL, Radermacher P, Redl H, Remick DG, Singer M, Thiemermann C, Wang P, Wiersinga WJ, Xiao X, Zingarelli B.
PMID: 30225655
Infection. 2018 Oct;46(5):745-747. doi: 10.1007/s15010-018-1197-2.

The original version of this article unfortunately contained mistakes.

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Osuchowski MF, Ayala A, Bahrami S, et al. Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis. Infection. 2018;46(5):745-747doi: 10.1007/s15010-018-1197-2.
Osuchowski, M. F., Ayala, A., Bahrami, S., Bauer, M., Boros, M., Cavaillon, J. M., Chaudry, I. H., Coopersmith, C. M., Deutschman, C., Drechsler, S., Efron, P., Frostell, C., Fritsch, G., Gozdzik, W., Hellman, J., Huber-Lang, M., Inoue, S., Knapp, S., Kozlov, A. V., Libert, C., Marshall, J. C., Moldawer, L. L., Radermacher, P., Redl, H., Remick, D. G., Singer, M., Thiemermann, C., Wang, P., Wiersinga, W. J., Xiao, X., & Zingarelli, B. (2018). Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis. Infection, 46(5), 745-747. https://doi.org/10.1007/s15010-018-1197-2
Osuchowski, Marcin F, et al. "Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis." Infection vol. 46,5 (2018): 745-747. doi: https://doi.org/10.1007/s15010-018-1197-2
Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM, Deutschman C, Drechsler S, Efron P, Frostell C, Fritsch G, Gozdzik W, Hellman J, Huber-Lang M, Inoue S, Knapp S, Kozlov AV, Libert C, Marshall JC, Moldawer LL, Radermacher P, Redl H, Remick DG, Singer M, Thiemermann C, Wang P, Wiersinga WJ, Xiao X, Zingarelli B. Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis. Infection. 2018 Oct;46(5):745-747. doi: 10.1007/s15010-018-1197-2. PMID: 30225655; PMCID: PMC6182465.
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Graves' orbitopathy: Management of difficult cases.

Indian journal of endocrinology and metabolism

Wiersinga WM.
PMID: 23565365
Indian J Endocrinol Metab. 2012 Dec;16:S150-2. doi: 10.4103/2230-8210.104026.

Management of Graves' ophthalmopathy (GO) is based on three pillars: to stop smoking, to restore and maintain euthyroidism, and to treat the eye changes according to severity and activity of GO. Difficulties are frequently encountered in each of these...

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Wiersinga WM. Graves' orbitopathy: Management of difficult cases. Indian J Endocrinol Metab. 2012;16:S150-2doi: 10.4103/2230-8210.104026.
Wiersinga, W. M. (2012). Graves' orbitopathy: Management of difficult cases. Indian journal of endocrinology and metabolism, 16S150-2. https://doi.org/10.4103/2230-8210.104026
Wiersinga, Wilmar M. "Graves' orbitopathy: Management of difficult cases." Indian journal of endocrinology and metabolism vol. 16 (2012): S150-2. doi: https://doi.org/10.4103/2230-8210.104026
Wiersinga WM. Graves' orbitopathy: Management of difficult cases. Indian J Endocrinol Metab. 2012 Dec;16:S150-2. doi: 10.4103/2230-8210.104026. PMID: 23565365; PMCID: PMC3603013.
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Guidance in Subclinical Hyperthyroidism and Subclinical Hypothyroidism: Are We Making Progress?.

European thyroid journal

Wiersinga WM.
PMID: 26558231
Eur Thyroid J. 2015 Sep;4(3):143-8. doi: 10.1159/000438909. Epub 2015 Aug 21.

No abstract available.

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Wiersinga WM. Guidance in Subclinical Hyperthyroidism and Subclinical Hypothyroidism: Are We Making Progress?. Eur Thyroid J. 2015;4(3):143-8doi: 10.1159/000438909.
Wiersinga, W. M. (2015). Guidance in Subclinical Hyperthyroidism and Subclinical Hypothyroidism: Are We Making Progress?. European thyroid journal, 4(3), 143-8. https://doi.org/10.1159/000438909
Wiersinga, Wilmar M. "Guidance in Subclinical Hyperthyroidism and Subclinical Hypothyroidism: Are We Making Progress?." European thyroid journal vol. 4,3 (2015): 143-8. doi: https://doi.org/10.1159/000438909
Wiersinga WM. Guidance in Subclinical Hyperthyroidism and Subclinical Hypothyroidism: Are We Making Progress?. Eur Thyroid J. 2015 Sep;4(3):143-8. doi: 10.1159/000438909. Epub 2015 Aug 21. PMID: 26558231; PMCID: PMC4637509.
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Showing 1 to 12 of 65 entries