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Showing 1 to 12 of 347 entries
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Impaired Decision Making and Loss of Inhibitory-Control in a Rat Model of Huntington Disease.

Frontiers in behavioral neuroscience

El Massioui N, Lamirault C, Yagüe S, Adjeroud N, Garces D, Maillard A, Tallot L, Yu-Taeger L, Riess O, Allain P, Nguyen HP, von Hörsten S, Doyère V.
PMID: 27833538
Front Behav Neurosci. 2016 Oct 26;10:204. doi: 10.3389/fnbeh.2016.00204. eCollection 2016.

Cognitive deficits associated with Huntington disease (HD) are generally dominated by executive function disorders often associated with disinhibition and impulsivity/compulsivity. Few studies have directly examined symptoms and consequences of behavioral disinhibition in HD and its relation with decision-making. To...

Anomeric Effects in Sulfamides.

The journal of physical chemistry. A

Hansen E, Limé E, Norrby PO, Wiest O.
PMID: 27135551
J Phys Chem A. 2016 May 26;120(20):3677-82. doi: 10.1021/acs.jpca.6b02757. Epub 2016 May 10.

Sulfamides, together with their simpler sulfonamide analogs, are common functional groups in a significant number of biologically active compounds. This is partly due to their unique electronic structure and conformational behavior, which mimics the tetrahedral intermediate involved in many...

Engineered liquid crystal anchoring energies with nanopatterned surfaces.

Optics express

Gear C, Diest K, Liberman V, Rothschild M.
PMID: 25835840
Opt Express. 2015 Jan 26;23(2):807-14. doi: 10.1364/OE.23.000807.

The anchoring energy of liquid crystals was shown to be tunable by surface nanopatterning of periodic lines and spaces. Both the pitch and height were varied using hydrogen silsesquioxane negative tone electron beam resist, providing for flexibility in magnitude...

Immune cells subpopulations in cerebrospinal fluid and peripheral blood of patients with Aneurysmal Subarachnoid Hemorrhage.

SpringerPlus

Moraes L, Grille S, Morelli P, Mila R, Trias N, Brugnini A, LLuberas N, Biestro A, Lens D.
PMID: 25977890
Springerplus. 2015 Apr 23;4:195. doi: 10.1186/s40064-015-0970-2. eCollection 2015.

BACKGROUND: There is growing evidence supporting the role of inflammation in aneurysmal subarachnoid hemorrhage (aSAH) pathophysiology and it is of great interest to elucidate which immune mechanisms are involved.METHODS: 12 aSAH patients and 28 healthy controls were enrolled prospectively....

Monitoring the extraction of additives and additive degradation products from polymer packaging into solutions by multi-residue method including solid phase extraction and ultra-high performance liquid chromatography-tandem mass spectrometry analysis.

Analytical and bioanalytical chemistry

Pouech C, Lafay F, Wiest L, Baudot R, Léonard D, Cren-Olivé C.
PMID: 24374840
Anal Bioanal Chem. 2014 Feb;406(5):1493-507. doi: 10.1007/s00216-013-7551-4. Epub 2013 Dec 29.

The use of polymer materials in industry for product packaging is increasing. The presence of additives in the polymer matrix enables the modification or improvement of the properties and performance of the polymer, but these industries are concerned regarding...

The calpain-suppressing effects of olesoxime in Huntington's disease.

Rare diseases (Austin, Tex.)

Weber JJ, Ortiz Rios MM, Riess O, Clemens LE, Nguyen HP.
PMID: 27141414
Rare Dis. 2016 Apr 06;4(1):e1153778. doi: 10.1080/21675511.2016.1153778. eCollection 2016.

Olesoxime, a small molecule drug candidate, has recently attracted attention due to its significant beneficial effects in models of several neurodegenerative disorders including Huntington's disease. Olesoxime's neuroprotective effects have been assumed to be conveyed through a direct, positive influence...

7-Tesla MRI demonstrates absence of structural lesions in patients with vestibular paroxysmia.

Frontiers in neuroanatomy

Rommer PS, Wiest G, Kronnerwetter C, Zach H, Loader B, Elwischger K, Trattnig S.
PMID: 26106306
Front Neuroanat. 2015 Jun 09;9:81. doi: 10.3389/fnana.2015.00081. eCollection 2015.

Vestibular parxoysmia (VP) is a rare vestibular disorder. A neurovascular cross-compression (NVCC) between the vestibulochochlear nerve and an artery seems to be responsible for short attacks of vertigo in this entity. An NVCC can be seen in up to...

Editorial for the special issue on mechanisms in metal-based organic chemistry.

The Journal of organic chemistry

Poulter D, Bolm C, Wiest O.
PMID: 25522676
J Org Chem. 2014 Dec 19;79(24):11829. doi: 10.1021/jo502624k.

No abstract available.

CBT reduces CBF: cognitive-behavioral therapy reduces cerebral blood flow in fear-relevant brain regions in spider phobia.

Brain and behavior

Soravia LM, Orosz A, Schwab S, Nakataki M, Wiest R, Federspiel A.
PMID: 27688940
Brain Behav. 2016 Jul 06;6(9):e00510. doi: 10.1002/brb3.510. eCollection 2016 Sep.

BACKGROUND: Imaging studies have provided evidence that cognitive-behavioral therapy (CBT) is able to change brain activation in phobic patients in response to threatening stimuli. The changes occurred in both emotion-generating and modulatory regions. In this study, we use a...

Single-Flask Multicomponent Palladium-Catalyzed α,γ-Coupling of Ketone Enolates: Facile Preparation of Complex Carbon Scaffolds.

Angewandte Chemie (International ed. in English)

Grigalunas M, Norrby PO, Wiest O, Helquist P.
PMID: 26276904
Angew Chem Int Ed Engl. 2015 Sep 28;54(40):11822-5. doi: 10.1002/anie.201505895. Epub 2015 Aug 14.

A three-component palladium-catalyzed reaction sequence has been developed in which γ-substituted α,β-unsaturated products are obtained in a single flask by an α-alkenylation with either a subsequent γ-alkenylation or γ-arylation of a ketone enolate. Coupling of a variety of electronically...

Surgical patient selection and counseling.

Translational andrology and urology

Ziegelmann M, Köhler TS, Bailey GC, Miest T, Alom M, Trost L.
PMID: 28904893
Transl Androl Urol. 2017 Aug;6(4):609-619. doi: 10.21037/tau.2017.07.19.

The objectives of patient selection and counseling are ultimately to enhance successful outcomes. However, the definition for success is often narrowly defined in published literature (ability to complete surgery, complications, satisfaction) and fails to account for patient desires and...

International Charter of principles for sharing bio-specimens and data.

European journal of human genetics : EJHG

Mascalzoni D, Dove ES, Rubinstein Y, Dawkins HJ, Kole A, McCormack P, Woods S, Riess O, Schaefer F, Lochmüller H, Knoppers BM, Hansson M.
PMID: 27307116
Eur J Hum Genet. 2016 Jul;24(7):1096. doi: 10.1038/ejhg.2015.237.

No abstract available.

Showing 1 to 12 of 347 entries