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Showing 1 to 12 of 26 entries
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The Role of Fibroblasts in Pancreatic Cancer: Extracellular Matrix Versus Paracrine Factors.

Translational oncology

Bolm L, Cigolla S, Wittel UA, Hopt UT, Keck T, Rades D, Bronsert P, Wellner UF.
PMID: 28658650
Transl Oncol. 2017 Aug;10(4):578-588. doi: 10.1016/j.tranon.2017.04.009. Epub 2017 Jun 26.

BACKGROUND AND AIM: Desmoplasia is a characteristic feature and a suspected mechanism of tumor progression in pancreatic ductal adenocarcinoma (PDAC). Main constituents of the stroma involve cancer-associated fibroblasts (CAFs) and extracellular matrix (ECM). The aim of this study was...

Morbidity and Mortality Conference in Emergency Medicine Residencies and the Culture of Safety.

The western journal of emergency medicine

Aaronson EL, Wittels KA, Nadel ES, Schuur JD.
PMID: 26594271
West J Emerg Med. 2015 Nov;16(6):810-7. doi: 10.5811/westjem.2015.8.26559. Epub 2015 Oct 22.

INTRODUCTION: Morbidity and mortality conferences (M+M) are a traditional part of residency training and mandated by the Accreditation Counsel of Graduate Medical Education. This study's objective was to determine the goals, structure, and the prevalence of practices that foster...

Murine genotype impacts pancreatitis severity and systemic inflammation: An experimental study.

Annals of medicine and surgery (2012)

Seifert GJ, Sander KC, Richter S, Wittel UA, Greene D, Hoffmann AL, Stark L.
PMID: 29062479
Ann Med Surg (Lond). 2017 Sep 28;24:8-14. doi: 10.1016/j.amsu.2017.09.012. eCollection 2017 Dec.

BACKGROUND: Little is known regarding the impact of host response in acute pancreatitis. Here, we induce murine necrotizing pancreatitis in 9 different mouse strains.MATERIALS AND METHODS: We examined 9 different mouse strains: Balb/CB4J, C3H/HEJ, NOD/SHILT, A/J, AKR/J, C57BI/6J, DBA/2J,...

Hybrid repair of aortic arch aneurysms: a comprehensive review.

Journal of thoracic disease

Xydas S, Mihos CG, Williams RF, LaPietra A, Mawad M, Wittels SH, Santana O.
PMID: 28740717
J Thorac Dis. 2017 Jun;9:S629-S634. doi: 10.21037/jtd.2017.06.47.

Open total arch replacement (TAR) has become safer with refinements in cerebral protection techniques. The frequent extension of aortic arch aneurysms into the descending thoracic aorta customarily requires a two-staged conventional elephant trunk procedure, carrying relatively high mortality and...

Firearms and the incidence of arrest among respondents to domestic violence restraining orders.

Injury epidemiology

Wintemute GJ, Frattaroli S, Wright MA, Claire BE, Vittes KA, Webster DW.
PMID: 27747746
Inj Epidemiol. 2015 Dec;2(1):14. doi: 10.1186/s40621-015-0047-2. Epub 2015 Jun 23.

BACKGROUND: Persons subject to domestic violence restraining orders (DVROs), known as respondents, are generally prohibited from possessing firearms. Efforts to enforce that prohibition have not been evaluated. The study objective was to determine whether associations exist between risk of...

The Harvard Medical School Pathways Curriculum: Reimagining Developmentally Appropriate Medical Education for Contemporary Learners.

Academic medicine : journal of the Association of American Medical Colleges

Schwartzstein RM, Dienstag JL, King RW, Chang BS, Flanagan JG, Besche HC, Hoenig MP, Miloslavsky EM, Atkins KM, Puig A, Cockrill BA, Wittels KA, Dalrymple JL, Gooding H, Hirsh DA, Alexander EK, Fazio SB, Hundert EM.
PMID: 32134787
Acad Med. 2020 Nov;95(11):1687-1695. doi: 10.1097/ACM.0000000000003270.

As the U.S. health care system changes and technology alters how doctors work and learn, medical schools and their faculty are compelled to modify their curricula and teaching methods. In this article, educational leaders and key faculty describe how...

Emergency Medicine Morbidity and Mortality Conference and Culture of Safety: The Resident Perspective.

AEM education and training

Wittels K, Aaronson E, Dwyer R, Nadel E, Gallahue F, Fee C, Tubbs R, Schuur J.
PMID: 30051034
AEM Educ Train. 2017 May 04;1(3):191-199. doi: 10.1002/aet2.10033. eCollection 2017 Jul.

OBJECTIVE: Morbidity and mortality conference (M&M) is common in emergency medicine (EM) and an Accreditation Council for Graduate Medical Education (ACGME) requirement. We aimed to characterize the prevalence of elements of EM M&M conferences that foster a strong culture...

An Abrupt Change in Mental Status.

The Journal of emergency medicine

Khidir H, White BA, Landry A, Cameron AA, Wittels K, Wilcox SR.
PMID: 34127339
J Emerg Med. 2021 Oct;61(4):449-452. doi: 10.1016/j.jemermed.2021.04.008. Epub 2021 Jun 11.

No abstract available.

A Woman With Metamorphopsia and Visual Hallucinations.

The Journal of emergency medicine

Jansson PS, Kosowsky JM, Faust JS, Wilcox SR, Wittels KA.
PMID: 31708321
J Emerg Med. 2019 Nov 07; doi: 10.1016/j.jemermed.2019.09.022. Epub 2019 Nov 07.

No abstract available.

Metabolic Profiling of Early and Late Recurrent Pancreatic Ductal Adenocarcinoma Using Patient-Derived Organoid Cultures.

Cancers

Braun LM, Lagies S, Klar RFU, Hussung S, Fritsch RM, Kammerer B, Wittel UA.
PMID: 32492856
Cancers (Basel). 2020 Jun 01;12(6). doi: 10.3390/cancers12061440.

Pancreatic ductal adenocarcinoma (PDAC) is associated with high mortality and will become the second most common cause of cancer-associated mortality by 2030. The poor prognosis arises from a lack of sensitive biomarkers, limited therapeutic options, and the astonishingly high...

Rapid Capture of Cancer Extracellular Vesicles by Lipid Patch Microarrays.

Advanced materials (Deerfield Beach, Fla.)

Liu HY, Kumar R, Zhong C, Gorji S, Paniushkina L, Masood R, Wittel UA, Fuchs H, Nazarenko I, Hirtz M.
PMID: 34309083
Adv Mater. 2021 Sep;33(35):e2008493. doi: 10.1002/adma.202008493. Epub 2021 Jul 26.

Extracellular vesicles (EVs) contain various bioactive molecules such as DNA, RNA, and proteins, and play a key role in the regulation of cancer progression. Furthermore, cancer-associated EVs carry specific biomarkers and can be used in liquid biopsy for cancer...

Virtual student experiences: A case study of objectives, outcomes, and anticipated consequences.

AEM education and training

Shappell E, Egan DJ, Eyre A, Nadel E, Wittels K.
PMID: 34124526
AEM Educ Train. 2021 Mar 09;5(3):e10582. doi: 10.1002/aet2.10582. eCollection 2021 Jul.

Due to the COVID-19 pandemic, most in-person visiting clerkship opportunities have been canceled. Many institutions have developed virtual experiences to fill this void; however, the format and objectives of these experiences are variable. This article describes an education intervention...

Showing 1 to 12 of 26 entries