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A selective histone deacetylase-6 inhibitor improves BDNF trafficking in hippocampal neurons from Mecp2 knockout mice: implications for Rett syndrome.

Frontiers in cellular neuroscience

Xu X, Kozikowski AP, Pozzo-Miller L.
PMID: 24639629
Front Cell Neurosci. 2014 Mar 07;8:68. doi: 10.3389/fncel.2014.00068. eCollection 2014.

Rett syndrome (RTT) is a neurodevelopmental disorder caused by loss-of-function mutations in the transcriptional modulator methyl-CpG-binding protein 2 (MECP2). One of the most prominent gene targets of MeCP2 is brain-derived neurotrophic factor (Bdnf), a potent modulator of activity-dependent synaptic...

Trends in R-X Bond Dissociation Energies (R(•) = Me, Et, i-Pr, t-Bu, X(•) = H, Me, Cl, OH).

Journal of chemical theory and computation

Zhang IY, Wu J, Luo Y, Xu X.
PMID: 26615683
J Chem Theory Comput. 2010 May 11;6(5):1462-9. doi: 10.1021/ct100010d.

Trends for R-X bond dissociation energies have been examined with density functional methods of B3LYP, BMK, M06-2X, MC3MPW, B2PLYP, MCG3-MPW, and XYG3, as well as G3, MCG3/3, G3X, and G4 theories as functions of alkylation (i.e., R(•) = Me,...

Enantioselective Synthesis of gem-Diaryl Benzofuran-3(2H)-ones via One-Pot Asymmetric Rhodium/Palladium Relay Catalysis.

Organic letters

Zhang ZF, Zhu DX, Chen WW, Xu B, Xu MH.
PMID: 28485148
Org Lett. 2017 May 19;19(10):2726-2729. doi: 10.1021/acs.orglett.7b01070. Epub 2017 May 09.

An asymmetric dual-metal relay catalysis strategy that combines Rh/chiral sulfur-olefin-catalyzed enantioselective 1,2-addition with a Pd-catalyzed intramolecular C-O coupling has been developed. The method allows rapid and efficient synthesis of quaternary carbon-containing gem-diaryl benzofuran-3(2H)-ones in good yields in a highly...

Detection and analysis of hepatitis C virus in HIV-infected patients in the Guangxi province of China.

Experimental and therapeutic medicine

Wu SZ, Wei JL, Xu B, Wei PH, Yang Y, Qin B, Xie ZC.
PMID: 28450920
Exp Ther Med. 2017 Mar;13(3):917-923. doi: 10.3892/etm.2017.4067. Epub 2017 Jan 20.

The aim of the present study was to investigate the prevalence rate of hepatitis C virus (HCV) infection in human immunodeficiency virus (HIV)-positive individuals and to study the infection status of HCV RNA in HIV-infected individuals who did not...

Epidemiologic characteristics and outcomes of open globe injury in Shanghai.

International journal of ophthalmology

Ji YR, Zhu DQ, Zhou HF, Fan XQ.
PMID: 28861358
Int J Ophthalmol. 2017 Aug 18;10(8):1295-1300. doi: 10.18240/ijo.2017.08.18. eCollection 2017.

AIM: To investigate the epidemiologic characteristics and outcomes of open globe injury in Shanghai.METHODS: A retrospective study was conducted for 148 unilateral open globe injury cases presenting to a tertiary referral hospital of Shanghai. Electronic medical records were reviewed...

Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.

Nature chemical biology

Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu MR, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A, Liu L, Rai G, Westover KD, Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM.
PMID: 27434767
Nat Chem Biol. 2016 Jul 19;12(8):656. doi: 10.1038/nchembio0816-656.

No abstract available.

A systematic study of the effect of molecular weights of polyvinyl alcohol on polyvinyl alcohol-graphene oxide composite hydrogels.

Physical chemistry chemical physics : PCCP

Xue R, Xin X, Wang L, Shen J, Ji F, Li W, Jia C, Xu G.
PMID: 25613714
Phys Chem Chem Phys. 2015 Feb 21;17(7):5431-40. doi: 10.1039/c4cp05766j.

Polyvinyl alcohol (PVA) hydrogels have been proposed for use as promising biomaterials in biomedical and tissue engineering, and graphene oxide (GO) has been recognized as a unique two-dimensional building block for various graphene-based supramolecular architectures. In this article, we...

Accumulation of p53 is prognostic for aromatase inhibitor resistance in early-stage postmenopausal patients with ER-positive breast cancer.

OncoTargets and therapy

Jia XQ, Hong Q, Cheng JY, Li JW, Wang YJ, Mo M, Shao ZM, Shen ZZ, Liu GY.
PMID: 25767399
Onco Targets Ther. 2015 Mar 03;8:549-55. doi: 10.2147/OTT.S76879. eCollection 2015.

OBJECTIVE: Studies have indicated that p53 protein accumulation exerts an adverse effect on the survival of breast cancer patients; however, the prognostic value of p53 protein accumulation for aromatase inhibitor (AI) resistance in ER-positive breast cancer is uncertain.METHODS: The...

Coupling-length phase matching for efficient third-harmonic generation based on parallel-coupled waveguides.

Optics letters

Huang T, Shum PP, Shao X, Lee T, Wu Z, Li H, Wu T, Zhang M, Dinh XQ, Brambilla G.
PMID: 25768140
Opt Lett. 2015 Mar 15;40(6):894-7. doi: 10.1364/OL.40.000894.

We study third-harmonic generation (THG) in parallel-coupled waveguides where the spatial modulation of the mode intensity provides quasi-phase matching, called coupling-length phase matching (CLPM), for efficient nonlinear frequency conversion. Different types of CLPM are investigated for THG, and it...

Broadband-tunable CW laser operation of Pr(3+):LiYF(4) around 900  nm.

Optics letters

Qu B, Moncorgé R, Cai Z, Doualan JL, Xu B, Xu H, Braud A, Camy P.
PMID: 26125365
Opt Lett. 2015 Jul 01;40(13):3053-6. doi: 10.1364/OL.40.003053.

We present here the first broadband-tunable CW laser operation of a Pr(3+)-doped LiYF(4) crystal in the 900-nm spectral range after pumping with an optically pumped semiconductor laser at 479 nm. It is confirmed that the entire emission band can...

Benchmarking Density Functionals on Structural Parameters of Small-/Medium-Sized Organic Molecules.

Journal of chemical theory and computation

Brémond É, Savarese M, Su NQ, Pérez-Jiménez ÁJ, Xu X, Sancho-García JC, Adamo C.
PMID: 26730741
J Chem Theory Comput. 2016 Feb 09;12(2):459-65. doi: 10.1021/acs.jctc.5b01144. Epub 2016 Jan 11.

In this Letter we report the error analysis of 59 exchange-correlation functionals in evaluating the structural parameters of small- and medium-sized organic molecules. From this analysis, recently developed double hybrids, such as xDH-PBE0, emerge as the most reliable methods,...

Metallic State FeS Anchored (Fe)/Fe.

ACS applied materials & interfaces

Xu X, Dai Y, Yu J, Hao L, Duan Y, Sun Y, Zhang Y, Lin Y, Zou J.
PMID: 28291333
ACS Appl Mater Interfaces. 2017 Mar 29;9(12):10777-10787. doi: 10.1021/acsami.7b01531. Epub 2017 Mar 20.

The critical issues in practical application of microbial fuel cells (MFCs) for wastewater treatment are the high cost and poor activity and durability of precious metal catalysts. To alleviate the activity loss and kinetic barriers for oxygen reduction reaction...

Showing 1 to 12 of 2604 entries