OncoTargets and therapy

Ono M, Ito T, Kanai T, Murayama K, Koyama H, Maeno K, Mochizuki Y, Iesato A, Hanamura T, Okada T, Watanabe T, Ito K.
PMID: 24124381
Onco Targets Ther. 2013 Oct 07;6:1393-8. doi: 10.2147/OTT.S51164. eCollection 2013.

Bevacizumab when combined with chemotherapy exerts significant activity against many solid tumors through tumor angiogenesis inhibition; however, it can induce severe side effects. We report the rare case of a 27-year-old premenopausal woman with locally advanced breast cancer that...

International journal of chronic obstructive pulmonary disease

Kobayashi S, Hanagama M, Yamanda S, Ishida M, Yanai M.
PMID: 27660429
Int J Chron Obstruct Pulmon Dis. 2016 Sep 07;11:2117-2123. doi: 10.2147/COPD.S113647. eCollection 2016.

BACKGROUND: The clinical phenotypes and underlying mechanisms of asthma-COPD overlap syndrome (ACOS) remain elusive. This study aimed to investigate a comparison of COPD patients with and without ACOS, focusing on inflammatory biomarkers, in an outpatient COPD cohort.METHODS: We conducted...

Oncology letters

Kawasaki K, Hamamoto Y, Suzuki T, Hirata K, Sukawa Y, Kasuga A, Hayashi Y, Takaishi H, Kameyama K, Kanai T.
PMID: 28927133
Oncol Lett. 2017 Sep;14(3):3697-3700. doi: 10.3892/ol.2017.6601. Epub 2017 Jul 18.

Rebiopsy is considered an option for specific types of cancer, such as breast, non-small cell lung, and prostate cancer, in clinical trials and in practice. The benefit of rebiopsy comes from the selection of a new treatment strategy based...

Journal of clinical biochemistry and nutrition

Matsuzaki J, Suzuki H, Masaoka T, Tanaka K, Mori H, Kanai T.
PMID: 27698540
J Clin Biochem Nutr. 2016 Sep;59(2):130-133. doi: 10.3164/jcbn.16-29. Epub 2016 Jul 16.

Functional gastrointestinal disorders (FGIDs), including functional dyspepsia (FD), are common chronic disorders even in the younger population. Physical activity is advocated for patients with FGIDs, although the evidence is insufficient. We investigated the association between the intensity of regular...

International medical case reports journal

Othman K, Liza-Sharmini AT, Ibrahim M, Tharakan J, Yanai R, Zunaina E.
PMID: 28223848
Int Med Case Rep J. 2017 Feb 07;10:35-40. doi: 10.2147/IMCRJ.S121863. eCollection 2017.

Behçet's disease (BD) is a multisystemic disease that is very rare in Malaysia. About 5% of patients develop central nervous system involvement, termed neuro-Behçet's. Neuro-Behçet's is one of the most serious causes of long-term morbidity and mortality. We report...

Oncology letters

Kawasaki K, Hamamoto Y, Adachi M, Kanai T, Takaishi H.
PMID: 26870193
Oncol Lett. 2016 Jan;11(1):231-233. doi: 10.3892/ol.2015.3905. Epub 2015 Nov 10.

Tumoral cavity formation is a characteristic phenomenon reported in anti-angiogenic therapy in lung lesions. A 57-year-old male with multiple pulmonary metastases from colorectal cancer treated with an oral tyrosine kinase inhibitor, regorafenib, exhibited a characteristic cavity formation after the...

United European gastroenterology journal

Mori H, Suzuki H, Matsuzaki J, Tsugawa H, Fukuhara S, Miyoshi S, Hirata K, Seino T, Matsushita M, Nishizawa T, Masaoka T, Kanai T.
PMID: 27403304
United European Gastroenterol J. 2016 Jun;4(3):380-7. doi: 10.1177/2050640615618043. Epub 2015 Nov 13.

BACKGROUND AND AIM: This prospective randomized study was designed to assess the efficacy of 10-day and 14-day rifabutin-based triple therapy as a third- or fourth-line rescue therapy.METHODS: Patients who failed first- and second-line eradication therapy were enrolled. H. pylori...

ACS applied materials & interfaces

Matsuo Y, Okada H, Kondo Y, Jeon I, Wang H, Yu Y, Matsushita T, Yanai M, Ikuta T.
PMID: 29485261
ACS Appl Mater Interfaces. 2018 Apr 11;10(14):11810-11817. doi: 10.1021/acsami.8b00603. Epub 2018 Mar 30.

A diphenylanthracene dimethylamine derivative (9-{3,5-di( N, N-dimethylaminoethoxy)phenyl}-10-phenyl-anthracene, DPAMA) was synthesized by the Suzuki-Miyaura cross-coupling reaction. Its ammonium salt, 9-{3,5-di(trimethylammonium ethoxy)phenyl}-10-phenyl-anthracene dichloride (DPAMA-Cl), was also synthesized as a reference material. DPAMA was characterized by UV-vis and fluorescence spectroscopy, cyclic voltammetry,...

Oncology letters

Ito Z, Takakura K, Suka M, Kanai T, Saito R, Fujioka S, Kajihara M, Yanagisawa H, Misawa T, Akiba T, Koido S, Ohkusa T.
PMID: 28599481
Oncol Lett. 2017 Jun;13(6):4799-4805. doi: 10.3892/ol.2017.6071. Epub 2017 Apr 21.

Patients with pancreatic ductal adenocarcinoma (PDA) typically succumb to mortality early, even following surgical resection. Therefore, prognostic factors associated with early mortality are required to improve the survival of patients with PDA following surgical resection. Carbohydrate sulfotransferase 15 (CHST15)...

International journal of surgery case reports

Suda K, Yanai T, Toma M, Aiyoshi T, Sasaki T, Muraji T.
PMID: 28601030
Int J Surg Case Rep. 2017;36:175-178. doi: 10.1016/j.ijscr.2017.05.038. Epub 2017 Jun 02.

INTRODUCTION: The incidence of gastrointestinal food allergy (FA) in neonates is increasing. Despite this, cases of patients with gastrointestinal FA who develop necrotizing enterocolitis (NEC) requiring laparotomy are extremely rare.PRESENTATION OF CASE: We describe two cases that presented with...

Annals of the New York Academy of Sciences

Anani T, Sindou P, Richard L, Diot M, Vallat JM.
PMID: 29086953
Ann N Y Acad Sci. 1999 Oct;883(1):186-195. doi: 10.1111/j.1749-6632.1999.tb08581.x.

Hereditary sensorimotor neuropathies form a heterogeneous group of genetically determined diseases, of which Charcot-Marie-Tooth (CMT) disease is the most common. In order to establish relations between genotype and the expression of peripheral myelin proteins, we carried out a quantitative...

OncoTargets and therapy

Oba T, Ono M, Iesato A, Hanamura T, Watanabe T, Ito T, Kanai T, Maeno K, Ito K, Tateishi A, Yoshizawa A, Takayama F.
PMID: 27051299
Onco Targets Ther. 2016 Mar 18;9:1641-6. doi: 10.2147/OTT.S88726. eCollection 2016.

Lipid-rich carcinoma (LRC) of the breast is a rare breast cancer variant that accounts for