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Current Concepts: Aseptic Nonunion of Femoral Shaft Diaphysis.

European journal of trauma and emergency surgery : official publication of the European Trauma Society

Lambiris E, Panagopoulos A, Zouboulis P, Sourgiadaki E.
PMID: 26816142
Eur J Trauma Emerg Surg. 2007 Apr;33(2):120-34. doi: 10.1007/s00068-007-6195-5. Epub 2007 Apr 04.

In spite of increased understanding of biomechanics and improvements of implant design, nonunion of femoral shaft fractures continues to hinder the treatment of these injuries. Femoral nonunion presents a difficult treatment challenge for the surgeon and a formidable personal...

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Lambiris E, Panagopoulos A, Zouboulis P, et al. Current Concepts: Aseptic Nonunion of Femoral Shaft Diaphysis. Eur J Trauma Emerg Surg. 2007;33(2):120-34doi: 10.1007/s00068-007-6195-5.
Lambiris, E., Panagopoulos, A., Zouboulis, P., & Sourgiadaki, E. (2007). Current Concepts: Aseptic Nonunion of Femoral Shaft Diaphysis. European journal of trauma and emergency surgery : official publication of the European Trauma Society, 33(2), 120-34. https://doi.org/10.1007/s00068-007-6195-5
Lambiris, Elias, et al. "Current Concepts: Aseptic Nonunion of Femoral Shaft Diaphysis." European journal of trauma and emergency surgery : official publication of the European Trauma Society vol. 33,2 (2007): 120-34. doi: https://doi.org/10.1007/s00068-007-6195-5
Lambiris E, Panagopoulos A, Zouboulis P, Sourgiadaki E. Current Concepts: Aseptic Nonunion of Femoral Shaft Diaphysis. Eur J Trauma Emerg Surg. 2007 Apr;33(2):120-34. doi: 10.1007/s00068-007-6195-5. Epub 2007 Apr 04. PMID: 26816142.
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The stuck dialysis catheter: A nasty astonishment.

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia

Galanopoulos G, Lambidis C.
PMID: 26022028
Saudi J Kidney Dis Transpl. 2015 May-Jun;26(3):560-3. doi: 10.4103/1319-2442.157366.

Removal of a tunneled cuffed central venous catheter can be challenging and risky. In some cases, the catheter firmly adheres to the surrounding tissues, becoming an integrated part of the vessel wall. We present the case of an adult...

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Galanopoulos G, Lambidis C. The stuck dialysis catheter: A nasty astonishment. Saudi J Kidney Dis Transpl. 2015;26(3):560-3doi: 10.4103/1319-2442.157366.
Galanopoulos, G., & Lambidis, C. (2015). The stuck dialysis catheter: A nasty astonishment. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 26(3), 560-3. https://doi.org/10.4103/1319-2442.157366
Galanopoulos, Georgios, and Lambidis, Constantinos. "The stuck dialysis catheter: A nasty astonishment." Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia vol. 26,3 (2015): 560-3. doi: https://doi.org/10.4103/1319-2442.157366
Galanopoulos G, Lambidis C. The stuck dialysis catheter: A nasty astonishment. Saudi J Kidney Dis Transpl. 2015 May-Jun;26(3):560-3. doi: 10.4103/1319-2442.157366. PMID: 26022028.
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Dynamic Interactions Between Cancer Stem Cells And Their Stromal Partners.

Current pathobiology reports

Park TS, Donnenberg VS, Donnenberg AD, Zambidis ET, Zimmerlin L.
PMID: 24660130
Curr Pathobiol Rep. 2014 Mar 01;2(1):41-52. doi: 10.1007/s40139-013-0036-5.

The cancer stem cell (CSC) paradigm presumes the existence of self-renewing cancer cells capable of regenerating all tumor compartments and exhibiting stem cell-associated phenotypes. Recent interpretations of the CSC hypothesis envision stemness as a dynamic trait of tumor-initiating cells...

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Park TS, Donnenberg VS, Donnenberg AD, et al. Dynamic Interactions Between Cancer Stem Cells And Their Stromal Partners. Curr Pathobiol Rep. 2014;2(1):41-52doi: 10.1007/s40139-013-0036-5.
Park, T. S., Donnenberg, V. S., Donnenberg, A. D., Zambidis, E. T., & Zimmerlin, L. (2014). Dynamic Interactions Between Cancer Stem Cells And Their Stromal Partners. Current pathobiology reports, 2(1), 41-52. https://doi.org/10.1007/s40139-013-0036-5
Park, Tea Soon, et al. "Dynamic Interactions Between Cancer Stem Cells And Their Stromal Partners." Current pathobiology reports vol. 2,1 (2014): 41-52. doi: https://doi.org/10.1007/s40139-013-0036-5
Park TS, Donnenberg VS, Donnenberg AD, Zambidis ET, Zimmerlin L. Dynamic Interactions Between Cancer Stem Cells And Their Stromal Partners. Curr Pathobiol Rep. 2014 Mar 01;2(1):41-52. doi: 10.1007/s40139-013-0036-5. PMID: 24660130; PMCID: PMC3956651.
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Site-Specific .

Pharmaceutics

Lumen D, Näkki S, Imlimthan S, Lambidis E, Sarparanta M, Xu W, Lehto VP, Airaksinen AJ.
PMID: 31861119
Pharmaceutics. 2019 Dec 17;11(12). doi: 10.3390/pharmaceutics11120686.

Polyethylene glycol (PEG) has been successfully used for improving circulation time of several nanomaterials but prolonging the circulation of porous silicon nanoparticles (PSi NPs) has remained challenging. Here, we report a site specific radiolabeling of dual-PEGylated thermally oxidized porous...

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Lumen D, Näkki S, Imlimthan S, et al. Site-Specific . Pharmaceutics. 2019;11(12)doi: 10.3390/pharmaceutics11120686.
Lumen, D., Näkki, S., Imlimthan, S., Lambidis, E., Sarparanta, M., Xu, W., Lehto, V. P., & Airaksinen, A. J. (2019). Site-Specific . Pharmaceutics, 11(12), . https://doi.org/10.3390/pharmaceutics11120686
Lumen, Dave, et al. "Site-Specific ." Pharmaceutics vol. 11,12 (2019). doi: https://doi.org/10.3390/pharmaceutics11120686
Lumen D, Näkki S, Imlimthan S, Lambidis E, Sarparanta M, Xu W, Lehto VP, Airaksinen AJ. Site-Specific . Pharmaceutics. 2019 Dec 17;11(12). doi: 10.3390/pharmaceutics11120686. PMID: 31861119; PMCID: PMC6969933.
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Draft for internal testing Scientific Committee guidance on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments.

EFSA journal. European Food Safety Authority

, More S, Bambidis V, Benford D, Bragard C, Hernandez-Jerez A, Bennekou SH, Koutsoumanis K, Machera K, Naegeli H, Nielsen SS, Schlatter JR, Schrenk D, Silano V, Turck D, Younes M, Fletcher T, Greiner M, Ntzani E, Pearce N, Vinceti M, Ciccolallo L, Georgiadis M, Gervelmeyer A, Halldorsson TI.
PMID: 32831946
EFSA J. 2020 Aug 18;18(8):e06221. doi: 10.2903/j.efsa.2020.6221. eCollection 2020 Aug.

EFSA requested its Scientific Committee to prepare a guidance document on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments. The guidance document provides an introduction to epidemiological studies and illustrates the typical biases of...

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, More S, Bambidis V, et al. Draft for internal testing Scientific Committee guidance on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments. EFSA J. 2020;18(8):e06221doi: 10.2903/j.efsa.2020.6221.
, More, S., Bambidis, V., Benford, D., Bragard, C., Hernandez-Jerez, A., Bennekou, S. H., Koutsoumanis, K., Machera, K., Naegeli, H., Nielsen, S. S., Schlatter, J. R., Schrenk, D., Silano, V., Turck, D., Younes, M., Fletcher, T., Greiner, M., Ntzani, E., Pearce, N., Vinceti, M., Ciccolallo, L., Georgiadis, M., Gervelmeyer, A., & Halldorsson, T. I. (2020). Draft for internal testing Scientific Committee guidance on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments. EFSA journal. European Food Safety Authority, 18(8), e06221. https://doi.org/10.2903/j.efsa.2020.6221
, et al. "Draft for internal testing Scientific Committee guidance on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments." EFSA journal. European Food Safety Authority vol. 18,8 (2020): e06221. doi: https://doi.org/10.2903/j.efsa.2020.6221
, More S, Bambidis V, Benford D, Bragard C, Hernandez-Jerez A, Bennekou SH, Koutsoumanis K, Machera K, Naegeli H, Nielsen SS, Schlatter JR, Schrenk D, Silano V, Turck D, Younes M, Fletcher T, Greiner M, Ntzani E, Pearce N, Vinceti M, Ciccolallo L, Georgiadis M, Gervelmeyer A, Halldorsson TI. Draft for internal testing Scientific Committee guidance on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments. EFSA J. 2020 Aug 18;18(8):e06221. doi: 10.2903/j.efsa.2020.6221. eCollection 2020 Aug. PMID: 32831946; PMCID: PMC7433401.
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Human induced pluripotent stem cell-derived endothelial cells exhibit functional heterogeneity.

American journal of translational research

Rufaihah AJ, Huang NF, Kim J, Herold J, Volz KS, Park TS, Lee JC, Zambidis ET, Reijo-Pera R, Cooke JP.
PMID: 23390563
Am J Transl Res. 2013;5(1):21-35. Epub 2013 Jan 21.

Human induced pluripotent stem cell-derived endothelial cells (hiPSC-ECs) are promising for treatment of vascular diseases. However, hiPSC-ECs purified based on CD31 expression are comprised of arterial, venous, and lymphatic subtypes. It is unclear whether hiPSC-ECs are heterogeneous in nature,...

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Rufaihah AJ, Huang NF, Kim J, et al. Human induced pluripotent stem cell-derived endothelial cells exhibit functional heterogeneity. Am J Transl Res. 2013;5(1):21-35
Rufaihah, A. J., Huang, N. F., Kim, J., Herold, J., Volz, K. S., Park, T. S., Lee, J. C., Zambidis, E. T., Reijo-Pera, R., & Cooke, J. P. (2013). Human induced pluripotent stem cell-derived endothelial cells exhibit functional heterogeneity. American journal of translational research, 5(1), 21-35.
Rufaihah, Abdul Jalil, et al. "Human induced pluripotent stem cell-derived endothelial cells exhibit functional heterogeneity." American journal of translational research vol. 5,1 (2013): 21-35.
Rufaihah AJ, Huang NF, Kim J, Herold J, Volz KS, Park TS, Lee JC, Zambidis ET, Reijo-Pera R, Cooke JP. Human induced pluripotent stem cell-derived endothelial cells exhibit functional heterogeneity. Am J Transl Res. 2013;5(1):21-35. Epub 2013 Jan 21. PMID: 23390563; PMCID: PMC3560482.
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Generation of Pericytic-Vascular Progenitors from Tankyrase/PARP-Inhibitor-Regulated Naïve (TIRN) Human Pluripotent Stem Cells.

Methods in molecular biology (Clifton, N.J.)

Zimmerlin L, Park TS, Bhutto I, Lutty G, Zambidis ET.
PMID: 34870835
Methods Mol Biol. 2022;2416:133-156. doi: 10.1007/978-1-0716-1908-7_10.

Tankyrase/PARP inhibitor-regulated naïve human pluripotent stem cells (TIRN-hPSC) represent a new class of human stem cells for regenerative medicine that can differentiate into multi-lineage progenitors with improved in vivo functionality. Chemical reversion of conventional, primed hPSC to a TIRN-hPSC...

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Zimmerlin L, Park TS, Bhutto I, et al. Generation of Pericytic-Vascular Progenitors from Tankyrase/PARP-Inhibitor-Regulated Naïve (TIRN) Human Pluripotent Stem Cells. Methods Mol Biol. 2022;2416:133-156doi: 10.1007/978-1-0716-1908-7_10.
Zimmerlin, L., Park, T. S., Bhutto, I., Lutty, G., & Zambidis, E. T. (2022). Generation of Pericytic-Vascular Progenitors from Tankyrase/PARP-Inhibitor-Regulated Naïve (TIRN) Human Pluripotent Stem Cells. Methods in molecular biology (Clifton, N.J.), 2416133-156. https://doi.org/10.1007/978-1-0716-1908-7_10
Zimmerlin, Ludovic, et al. "Generation of Pericytic-Vascular Progenitors from Tankyrase/PARP-Inhibitor-Regulated Naïve (TIRN) Human Pluripotent Stem Cells." Methods in molecular biology (Clifton, N.J.) vol. 2416 (2022): 133-156. doi: https://doi.org/10.1007/978-1-0716-1908-7_10
Zimmerlin L, Park TS, Bhutto I, Lutty G, Zambidis ET. Generation of Pericytic-Vascular Progenitors from Tankyrase/PARP-Inhibitor-Regulated Naïve (TIRN) Human Pluripotent Stem Cells. Methods Mol Biol. 2022;2416:133-156. doi: 10.1007/978-1-0716-1908-7_10. PMID: 34870835.
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Elevated glucosylsphingosine in Gaucher disease induced pluripotent stem cell neurons deregulates lysosomal compartment through mammalian target of rapamycin complex 1.

Stem cells translational medicine

Srikanth MP, Jones JW, Kane M, Awad O, Park TS, Zambidis ET, Feldman RA.
PMID: 33656802
Stem Cells Transl Med. 2021 Jul;10(7):1081-1094. doi: 10.1002/sctm.20-0386. Epub 2021 Mar 03.

Gaucher disease (GD) is a lysosomal storage disorder caused by mutations in GBA1, the gene that encodes lysosomal β-glucocerebrosidase (GCase). Mild mutations in GBA1 cause type 1 non-neuronopathic GD, whereas severe mutations cause types 2 and 3 neuronopathic GD...

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Srikanth MP, Jones JW, Kane M, et al. Elevated glucosylsphingosine in Gaucher disease induced pluripotent stem cell neurons deregulates lysosomal compartment through mammalian target of rapamycin complex 1. Stem Cells Transl Med. 2021;10(7):1081-1094doi: 10.1002/sctm.20-0386.
Srikanth, M. P., Jones, J. W., Kane, M., Awad, O., Park, T. S., Zambidis, E. T., & Feldman, R. A. (2021). Elevated glucosylsphingosine in Gaucher disease induced pluripotent stem cell neurons deregulates lysosomal compartment through mammalian target of rapamycin complex 1. Stem cells translational medicine, 10(7), 1081-1094. https://doi.org/10.1002/sctm.20-0386
Srikanth, Manasa P, et al. "Elevated glucosylsphingosine in Gaucher disease induced pluripotent stem cell neurons deregulates lysosomal compartment through mammalian target of rapamycin complex 1." Stem cells translational medicine vol. 10,7 (2021): 1081-1094. doi: https://doi.org/10.1002/sctm.20-0386
Srikanth MP, Jones JW, Kane M, Awad O, Park TS, Zambidis ET, Feldman RA. Elevated glucosylsphingosine in Gaucher disease induced pluripotent stem cell neurons deregulates lysosomal compartment through mammalian target of rapamycin complex 1. Stem Cells Transl Med. 2021 Jul;10(7):1081-1094. doi: 10.1002/sctm.20-0386. Epub 2021 Mar 03. PMID: 33656802; PMCID: PMC8235124.
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A Phase II Study of Docetaxel and Epirubicin in Advanced Adult Soft Tissue Sarcomas (STS).

Sarcoma

Kalofonos HP, Kourousis C, Karamouzis MV, Iconomou G, Tsiata E, Tzorzidis F, Megas P, Lambiris E, Georgoulias V.
PMID: 18521407
Sarcoma. 2004;8(4):129-33. doi: 10.1080/13577140400016705.

PURPOSE: The aim of this study was to determine the efficacy and safety of docetaxel plus epirubicin combination as first-line chemotherapy in patients with locally advanced and/or metastatic adult STS.PATIENTS AND METHODS: Eighteen patients were treated with epirubicin 30...

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Kalofonos HP, Kourousis C, Karamouzis MV, et al. A Phase II Study of Docetaxel and Epirubicin in Advanced Adult Soft Tissue Sarcomas (STS). Sarcoma. 2004;8(4):129-33doi: 10.1080/13577140400016705.
Kalofonos, H. P., Kourousis, C., Karamouzis, M. V., Iconomou, G., Tsiata, E., Tzorzidis, F., Megas, P., Lambiris, E., & Georgoulias, V. (2004). A Phase II Study of Docetaxel and Epirubicin in Advanced Adult Soft Tissue Sarcomas (STS). Sarcoma, 8(4), 129-33. https://doi.org/10.1080/13577140400016705
Kalofonos, Haralabos P, et al. "A Phase II Study of Docetaxel and Epirubicin in Advanced Adult Soft Tissue Sarcomas (STS)." Sarcoma vol. 8,4 (2004): 129-33. doi: https://doi.org/10.1080/13577140400016705
Kalofonos HP, Kourousis C, Karamouzis MV, Iconomou G, Tsiata E, Tzorzidis F, Megas P, Lambiris E, Georgoulias V. A Phase II Study of Docetaxel and Epirubicin in Advanced Adult Soft Tissue Sarcomas (STS). Sarcoma. 2004;8(4):129-33. doi: 10.1080/13577140400016705. PMID: 18521407; PMCID: PMC2395619.
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High-Fidelity Reprogrammed Human IPSCs Have a High Efficacy of DNA Repair and Resemble hESCs in Their MYC Transcriptional Signature.

Stem cells international

Nagaria PK, Robert C, Park TS, Huo JS, Zambidis ET, Rassool FV.
PMID: 27688775
Stem Cells Int. 2016;2016:3826249. doi: 10.1155/2016/3826249. Epub 2016 Sep 01.

Human induced pluripotent stem cells (hiPSCs) are reprogrammed from adult or progenitor somatic cells and must make substantial adaptations to ensure genomic stability in order to become "embryonic stem cell- (ESC-) like." The DNA damage response (DDR) is critical...

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Nagaria PK, Robert C, Park TS, et al. High-Fidelity Reprogrammed Human IPSCs Have a High Efficacy of DNA Repair and Resemble hESCs in Their MYC Transcriptional Signature. Stem Cells Int. 2016;2016:3826249doi: 10.1155/2016/3826249.
Nagaria, P. K., Robert, C., Park, T. S., Huo, J. S., Zambidis, E. T., & Rassool, F. V. (2016). High-Fidelity Reprogrammed Human IPSCs Have a High Efficacy of DNA Repair and Resemble hESCs in Their MYC Transcriptional Signature. Stem cells international, 20163826249. https://doi.org/10.1155/2016/3826249
Nagaria, Pratik K, et al. "High-Fidelity Reprogrammed Human IPSCs Have a High Efficacy of DNA Repair and Resemble hESCs in Their MYC Transcriptional Signature." Stem cells international vol. 2016 (2016): 3826249. doi: https://doi.org/10.1155/2016/3826249
Nagaria PK, Robert C, Park TS, Huo JS, Zambidis ET, Rassool FV. High-Fidelity Reprogrammed Human IPSCs Have a High Efficacy of DNA Repair and Resemble hESCs in Their MYC Transcriptional Signature. Stem Cells Int. 2016;2016:3826249. doi: 10.1155/2016/3826249. Epub 2016 Sep 01. PMID: 27688775; PMCID: PMC5023833.
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Reduced Intensity Bone Marrow Transplantation with Post-Transplant Cyclophosphamide for Pediatric Inherited Immune Deficiencies and Bone Marrow Failure Syndromes.

Journal of clinical immunology

Klein OR, Bapty S, Lederman HM, Younger MEM, Zambidis ET, Jones RJ, Cooke KR, Symons HJ.
PMID: 33159275
J Clin Immunol. 2021 Feb;41(2):414-426. doi: 10.1007/s10875-020-00898-0. Epub 2020 Nov 06.

PURPOSE: Allogeneic bone marrow transplantation (alloBMT) is the only cure for many primary immune deficiency disorders (PIDD), primary immune regulatory disorders (PIRD), and inherited bone marrow failure syndromes (IBMFS).METHODS: We report the results of 25 patients who underwent alloBMT...

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Klein OR, Bapty S, Lederman HM, et al. Reduced Intensity Bone Marrow Transplantation with Post-Transplant Cyclophosphamide for Pediatric Inherited Immune Deficiencies and Bone Marrow Failure Syndromes. J Clin Immunol. 2020;41(2):414-426doi: 10.1007/s10875-020-00898-0.
Klein, O. R., Bapty, S., Lederman, H. M., Younger, M. E. M., Zambidis, E. T., Jones, R. J., Cooke, K. R., & Symons, H. J. (2021). Reduced Intensity Bone Marrow Transplantation with Post-Transplant Cyclophosphamide for Pediatric Inherited Immune Deficiencies and Bone Marrow Failure Syndromes. Journal of clinical immunology, 41(2), 414-426. https://doi.org/10.1007/s10875-020-00898-0
Klein, Orly R, et al. "Reduced Intensity Bone Marrow Transplantation with Post-Transplant Cyclophosphamide for Pediatric Inherited Immune Deficiencies and Bone Marrow Failure Syndromes." Journal of clinical immunology vol. 41,2 (2021): 414-426. doi: https://doi.org/10.1007/s10875-020-00898-0
Klein OR, Bapty S, Lederman HM, Younger MEM, Zambidis ET, Jones RJ, Cooke KR, Symons HJ. Reduced Intensity Bone Marrow Transplantation with Post-Transplant Cyclophosphamide for Pediatric Inherited Immune Deficiencies and Bone Marrow Failure Syndromes. J Clin Immunol. 2021 Feb;41(2):414-426. doi: 10.1007/s10875-020-00898-0. Epub 2020 Nov 06. PMID: 33159275; PMCID: PMC7647188.
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Generation of Pericytic-Vascular Progenitors from Tankyrase/PARP-Inhibitor-Regulated Naïve (TIRN) Human Pluripotent Stem Cells.

Methods in molecular biology (Clifton, N.J.)

Zimmerlin L, Park TS, Bhutto I, Lutty G, Zambidis ET.
PMID: 34870835
Methods Mol Biol. 2022;2416:133-156. doi: 10.1007/978-1-0716-1908-7_10.

Tankyrase/PARP inhibitor-regulated naïve human pluripotent stem cells (TIRN-hPSC) represent a new class of human stem cells for regenerative medicine that can differentiate into multi-lineage progenitors with improved in vivo functionality. Chemical reversion of conventional, primed hPSC to a TIRN-hPSC...

Cite
Zimmerlin L, Park TS, Bhutto I, et al. Generation of Pericytic-Vascular Progenitors from Tankyrase/PARP-Inhibitor-Regulated Naïve (TIRN) Human Pluripotent Stem Cells. Methods Mol Biol. 2022;2416:133-156doi: 10.1007/978-1-0716-1908-7_10.
Zimmerlin, L., Park, T. S., Bhutto, I., Lutty, G., & Zambidis, E. T. (2022). Generation of Pericytic-Vascular Progenitors from Tankyrase/PARP-Inhibitor-Regulated Naïve (TIRN) Human Pluripotent Stem Cells. Methods in molecular biology (Clifton, N.J.), 2416133-156. https://doi.org/10.1007/978-1-0716-1908-7_10
Zimmerlin, Ludovic, et al. "Generation of Pericytic-Vascular Progenitors from Tankyrase/PARP-Inhibitor-Regulated Naïve (TIRN) Human Pluripotent Stem Cells." Methods in molecular biology (Clifton, N.J.) vol. 2416 (2022): 133-156. doi: https://doi.org/10.1007/978-1-0716-1908-7_10
Zimmerlin L, Park TS, Bhutto I, Lutty G, Zambidis ET. Generation of Pericytic-Vascular Progenitors from Tankyrase/PARP-Inhibitor-Regulated Naïve (TIRN) Human Pluripotent Stem Cells. Methods Mol Biol. 2022;2416:133-156. doi: 10.1007/978-1-0716-1908-7_10. PMID: 34870835.
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