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Showing 1 to 12 of 111 entries
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Climate change: The need to consider human forcings besides greenhouse gases

Geoscience Opportunities for Leadership in Diversity AND Program Evaluation

Brasseur G, Pielke R.
GSID: nei7wNlCpV0J
R Pielke Sr, K Beven, G Brasseur… - Eos, Transactions …, 2009 - Wiley Online Library

Humans are recognized as having a major role in influencing environmental variability and change, including their influence on the climate system. To advance scientists' understanding of the role of humans within the climate system, there remains a need to...

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Pielke Sr, R., Beven, K., Brasseur, G., Calvert, J., Chahine, M., Dickerson, R. R., ... & Wood, E. (2009). Climate change: The need to consider human forcings besides greenhouse gases. Eos, Transactions American Geophysical Union, 90(45), 413-413.
Pielke Sr, Roger, et al. "Climate change: The need to consider human forcings besides greenhouse gases." Eos, Transactions American Geophysical Union 90.45 (2009): 413-413.
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A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid.

Alzheimer's research & therapy

Yang T, O'Malley TT, Kanmert D, Jerecic J, Zieske LR, Zetterberg H, Hyman BT, Walsh DM, Selkoe DJ.
PMID: 25802556
Alzheimers Res Ther. 2015 Mar 22;7(1):14. doi: 10.1186/s13195-015-0100-y. eCollection 2015.

INTRODUCTION: Amyloid β-protein oligomers play a key role in Alzheimer's disease (AD), but well-validated assays that routinely detect them in cerebrospinal fluid (CSF) are just emerging. We sought to confirm and extend a recent study using the Singulex Erenna...

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Yang T, O'Malley TT, Kanmert D, et al. A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid. Alzheimers Res Ther. 2015;7(1):14doi: 10.1186/s13195-015-0100-y.
Yang, T., O'Malley, T. T., Kanmert, D., Jerecic, J., Zieske, L. R., Zetterberg, H., Hyman, B. T., Walsh, D. M., & Selkoe, D. J. (2015). A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid. Alzheimer's research & therapy, 7(1), 14. https://doi.org/10.1186/s13195-015-0100-y
Yang, Ting, et al. "A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid." Alzheimer's research & therapy vol. 7,1 (2015): 14. doi: https://doi.org/10.1186/s13195-015-0100-y
Yang T, O'Malley TT, Kanmert D, Jerecic J, Zieske LR, Zetterberg H, Hyman BT, Walsh DM, Selkoe DJ. A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid. Alzheimers Res Ther. 2015 Mar 22;7(1):14. doi: 10.1186/s13195-015-0100-y. eCollection 2015. PMID: 25802556; PMCID: PMC4369838.
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Computational and synthetic studies towards improving rescinnamine as an inducer of MSH2-dependent apoptosis in cancer treatment.

Molecular cancer biology

AbdelHafez EM, Diamanduros A, Negureanu L, Luy Y, Bean JH, Zielke K, Crowe B, Vasilyeva A, Clodfelter JE, Aly OM, Abuo-Rahma GE, Scarpinato KD, Salsbury FR, King SB.
PMID: 25485184
Mol Cancer Biol. 2013;1(1).

We, and others, have previously shown that mismatch repair proteins, in addition to their repair function, contribute to cell death initiation. In response to some drugs, this cell death activity is independent of the repair function of the proteins....

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AbdelHafez EM, Diamanduros A, Negureanu L, et al. Computational and synthetic studies towards improving rescinnamine as an inducer of MSH2-dependent apoptosis in cancer treatment. Mol Cancer Biol. 2013;1(1)
AbdelHafez, E. M., Diamanduros, A., Negureanu, L., Luy, Y., Bean, J. H., Zielke, K., Crowe, B., Vasilyeva, A., Clodfelter, J. E., Aly, O. M., Abuo-Rahma, G. E., Scarpinato, K. D., Salsbury, F. R., & King, S. B. (2013). Computational and synthetic studies towards improving rescinnamine as an inducer of MSH2-dependent apoptosis in cancer treatment. Molecular cancer biology, 1(1), .
AbdelHafez, ElShimaa M N, et al. "Computational and synthetic studies towards improving rescinnamine as an inducer of MSH2-dependent apoptosis in cancer treatment." Molecular cancer biology vol. 1,1 (2013).
AbdelHafez EM, Diamanduros A, Negureanu L, Luy Y, Bean JH, Zielke K, Crowe B, Vasilyeva A, Clodfelter JE, Aly OM, Abuo-Rahma GE, Scarpinato KD, Salsbury FR, King SB. Computational and synthetic studies towards improving rescinnamine as an inducer of MSH2-dependent apoptosis in cancer treatment. Mol Cancer Biol. 2013;1(1). PMID: 25485184; PMCID: PMC4254817.
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Evaluation of Gastrointestinal Leakage in Multiple Enteric Inflammation Models in Chickens.

Frontiers in veterinary science

Kuttappan VA, Vicuña EA, Latorre JD, Wolfenden AD, Téllez GI, Hargis BM, Bielke LR.
PMID: 26697435
Front Vet Sci. 2015 Dec 14;2:66. doi: 10.3389/fvets.2015.00066. eCollection 2015.

Enteric inflammation models can help researchers' study methods to improve health and performance and evaluate various growth promoters and dietary formulations targeted to improve performance in poultry. Oral administration of fluorescein isothiocyanate-dextran (FITC-d; 3-5 kDa) and its pericellular mucosal...

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Kuttappan VA, Vicuña EA, Latorre JD, et al. Evaluation of Gastrointestinal Leakage in Multiple Enteric Inflammation Models in Chickens. Front Vet Sci. 2015;2:66doi: 10.3389/fvets.2015.00066.
Kuttappan, V. A., Vicuña, E. A., Latorre, J. D., Wolfenden, A. D., Téllez, G. I., Hargis, B. M., & Bielke, L. R. (2015). Evaluation of Gastrointestinal Leakage in Multiple Enteric Inflammation Models in Chickens. Frontiers in veterinary science, 266. https://doi.org/10.3389/fvets.2015.00066
Kuttappan, Vivek A, et al. "Evaluation of Gastrointestinal Leakage in Multiple Enteric Inflammation Models in Chickens." Frontiers in veterinary science vol. 2 (2015): 66. doi: https://doi.org/10.3389/fvets.2015.00066
Kuttappan VA, Vicuña EA, Latorre JD, Wolfenden AD, Téllez GI, Hargis BM, Bielke LR. Evaluation of Gastrointestinal Leakage in Multiple Enteric Inflammation Models in Chickens. Front Vet Sci. 2015 Dec 14;2:66. doi: 10.3389/fvets.2015.00066. eCollection 2015. PMID: 26697435; PMCID: PMC4677096.
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The Fisher-Pitman permutation test: an attractive alternative to the F test.

Psychological reports

Berry KJ, Mielke PW, Mielke HW.
PMID: 12061589
Psychol Rep. 2002 Apr;90(2):495-502. doi: 10.2466/pr0.2002.90.2.495.

The Fisher-Pitman permutation test is shown to possess significant advantages over conventional alternatives when analyzing differences among independent samples with unequal variances.

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Berry KJ, Mielke PW, Mielke HW. The Fisher-Pitman permutation test: an attractive alternative to the F test. Psychol Rep. 2002;90(2):495-502doi: 10.2466/pr0.2002.90.2.495.
Berry, K. J., Mielke, P. W., & Mielke, H. W. (2002). The Fisher-Pitman permutation test: an attractive alternative to the F test. Psychological reports, 90(2), 495-502. https://doi.org/10.2466/pr0.2002.90.2.495
Berry, Kenneth J, et al. "The Fisher-Pitman permutation test: an attractive alternative to the F test." Psychological reports vol. 90,2 (2002): 495-502. doi: https://doi.org/10.2466/pr0.2002.90.2.495
Berry KJ, Mielke PW, Mielke HW. The Fisher-Pitman permutation test: an attractive alternative to the F test. Psychol Rep. 2002 Apr;90(2):495-502. doi: 10.2466/pr0.2002.90.2.495. PMID: 12061589.
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[Perras' technique in inguinal hernia surgery].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen

ZIELKE H.
PMID: 14879479
Chirurg. 1951 Sep;22(9):414.

No abstract available.

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ZIELKE H. Zur Operationsmethode des Leistenbruchs nach Perras. [Perras' technique in inguinal hernia surgery]. Chirurg. 1951;22(9):414
ZIELKE, H. (1951). Zur Operationsmethode des Leistenbruchs nach Perras. [Perras' technique in inguinal hernia surgery]. Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 22(9), 414.
ZIELKE, H. "Zur Operationsmethode des Leistenbruchs nach Perras." [Perras' technique in inguinal hernia surgery]. Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen vol. 22,9 (1951): 414.
ZIELKE H. Zur Operationsmethode des Leistenbruchs nach Perras. [Perras' technique in inguinal hernia surgery]. Chirurg. 1951 Sep;22(9):414. Undetermined. PMID: 14879479.
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Physiologically based toxicokinetic modelling as a tool to support risk assessment: three case studies.

Journal of toxicology

Mielke H, Gundert-Remy U.
PMID: 22649449
J Toxicol. 2012;2012:359471. doi: 10.1155/2012/359471. Epub 2012 May 09.

In this contribution we present three case studies of physiologically based toxicokinetic (PBTK) modelling in regulatory risk assessment. (1) Age-dependent lower enzyme expression in the newborn leads to bisphenol A (BPA) blood levels which are near the levels of...

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Mielke H, Gundert-Remy U. Physiologically based toxicokinetic modelling as a tool to support risk assessment: three case studies. J Toxicol. 2012;2012:359471doi: 10.1155/2012/359471.
Mielke, H., & Gundert-Remy, U. (2012). Physiologically based toxicokinetic modelling as a tool to support risk assessment: three case studies. Journal of toxicology, 2012359471. https://doi.org/10.1155/2012/359471
Mielke, Hans, and Gundert-Remy, Ursula. "Physiologically based toxicokinetic modelling as a tool to support risk assessment: three case studies." Journal of toxicology vol. 2012 (2012): 359471. doi: https://doi.org/10.1155/2012/359471
Mielke H, Gundert-Remy U. Physiologically based toxicokinetic modelling as a tool to support risk assessment: three case studies. J Toxicol. 2012;2012:359471. doi: 10.1155/2012/359471. Epub 2012 May 09. PMID: 22649449; PMCID: PMC3357559.
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Correlation of π-conjugated oligomer structure with film morphology and organic solar cell performance.

Journal of the American Chemical Society

Fitzner R, Mena-Osteritz E, Mishra A, Schulz G, Reinold E, Weil M, Körner C, Ziehlke H, Elschner C, Leo K, Riede M, Pfeiffer M, Uhrich C, Bäuerle P.
PMID: 22694124
J Am Chem Soc. 2012 Jul 11;134(27):11064-7. doi: 10.1021/ja302320c. Epub 2012 Jun 26.

The novel methyl-substituted dicyanovinyl-capped quinquethiophenes 1-3 led to highly efficient organic solar cells with power conversion efficiencies of 4.8-6.9%. X-ray analysis of single crystals and evaporated neat and blend films gave insights into the packing and morphological behavior of...

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Fitzner R, Mena-Osteritz E, Mishra A, et al. Correlation of π-conjugated oligomer structure with film morphology and organic solar cell performance. J Am Chem Soc. 2012;134(27):11064-7doi: 10.1021/ja302320c.
Fitzner, R., Mena-Osteritz, E., Mishra, A., Schulz, G., Reinold, E., Weil, M., Körner, C., Ziehlke, H., Elschner, C., Leo, K., Riede, M., Pfeiffer, M., Uhrich, C., & Bäuerle, P. (2012). Correlation of π-conjugated oligomer structure with film morphology and organic solar cell performance. Journal of the American Chemical Society, 134(27), 11064-7. https://doi.org/10.1021/ja302320c
Fitzner, Roland, et al. "Correlation of π-conjugated oligomer structure with film morphology and organic solar cell performance." Journal of the American Chemical Society vol. 134,27 (2012): 11064-7. doi: https://doi.org/10.1021/ja302320c
Fitzner R, Mena-Osteritz E, Mishra A, Schulz G, Reinold E, Weil M, Körner C, Ziehlke H, Elschner C, Leo K, Riede M, Pfeiffer M, Uhrich C, Bäuerle P. Correlation of π-conjugated oligomer structure with film morphology and organic solar cell performance. J Am Chem Soc. 2012 Jul 11;134(27):11064-7. doi: 10.1021/ja302320c. Epub 2012 Jun 26. PMID: 22694124.
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Exposure of Infants to Isoniazid via Breast Milk After Maternal Drug Intake of Recommended Doses Is Clinically Insignificant Irrespective of Metaboliser Status. A Physiologically-Based Pharmacokinetic (PBPK) Modelling Approach to Estimate Drug Exposure of Infants via Breast-Feeding.

Frontiers in pharmacology

Garessus EDG, Mielke H, Gundert-Remy U.
PMID: 30723406
Front Pharmacol. 2019 Jan 22;10:5. doi: 10.3389/fphar.2019.00005. eCollection 2019.

Isoniazid is a first-line anti-tuberculosis drug recommended for treatment of drug-susceptible

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Garessus EDG, Mielke H, Gundert-Remy U. Exposure of Infants to Isoniazid via Breast Milk After Maternal Drug Intake of Recommended Doses Is Clinically Insignificant Irrespective of Metaboliser Status. A Physiologically-Based Pharmacokinetic (PBPK) Modelling Approach to Estimate Drug Exposure of Infants via Breast-Feeding. Front Pharmacol. 2019;10:5doi: 10.3389/fphar.2019.00005.
Garessus, E. D. G., Mielke, H., & Gundert-Remy, U. (2019). Exposure of Infants to Isoniazid via Breast Milk After Maternal Drug Intake of Recommended Doses Is Clinically Insignificant Irrespective of Metaboliser Status. A Physiologically-Based Pharmacokinetic (PBPK) Modelling Approach to Estimate Drug Exposure of Infants via Breast-Feeding. Frontiers in pharmacology, 105. https://doi.org/10.3389/fphar.2019.00005
Garessus, Estella Dora Germaine, et al. "Exposure of Infants to Isoniazid via Breast Milk After Maternal Drug Intake of Recommended Doses Is Clinically Insignificant Irrespective of Metaboliser Status. A Physiologically-Based Pharmacokinetic (PBPK) Modelling Approach to Estimate Drug Exposure of Infants via Breast-Feeding." Frontiers in pharmacology vol. 10 (2019): 5. doi: https://doi.org/10.3389/fphar.2019.00005
Garessus EDG, Mielke H, Gundert-Remy U. Exposure of Infants to Isoniazid via Breast Milk After Maternal Drug Intake of Recommended Doses Is Clinically Insignificant Irrespective of Metaboliser Status. A Physiologically-Based Pharmacokinetic (PBPK) Modelling Approach to Estimate Drug Exposure of Infants via Breast-Feeding. Front Pharmacol. 2019 Jan 22;10:5. doi: 10.3389/fphar.2019.00005. eCollection 2019. PMID: 30723406; PMCID: PMC6349757.
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Transkingdom network reveals bacterial players associated with cervical cancer gene expression program.

PeerJ

Lam KC, Vyshenska D, Hu J, Rodrigues RR, Nilsen A, Zielke RA, Brown NS, Aarnes EK, Sikora AE, Shulzhenko N, Lyng H, Morgun A.
PMID: 30294508
PeerJ. 2018 Sep 19;6:e5590. doi: 10.7717/peerj.5590. eCollection 2018.

Cervical cancer is the fourth most common cancer in women worldwide with human papillomavirus (HPV) being the main cause the disease. Chromosomal amplifications have been identified as a source of upregulation for cervical cancer driver genes but cannot fully...

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Lam KC, Vyshenska D, Hu J, et al. Transkingdom network reveals bacterial players associated with cervical cancer gene expression program. PeerJ. 2018;6:e5590doi: 10.7717/peerj.5590.
Lam, K. C., Vyshenska, D., Hu, J., Rodrigues, R. R., Nilsen, A., Zielke, R. A., Brown, N. S., Aarnes, E. K., Sikora, A. E., Shulzhenko, N., Lyng, H., & Morgun, A. (2018). Transkingdom network reveals bacterial players associated with cervical cancer gene expression program. PeerJ, 6e5590. https://doi.org/10.7717/peerj.5590
Lam, Khiem Chi, et al. "Transkingdom network reveals bacterial players associated with cervical cancer gene expression program." PeerJ vol. 6 (2018): e5590. doi: https://doi.org/10.7717/peerj.5590
Lam KC, Vyshenska D, Hu J, Rodrigues RR, Nilsen A, Zielke RA, Brown NS, Aarnes EK, Sikora AE, Shulzhenko N, Lyng H, Morgun A. Transkingdom network reveals bacterial players associated with cervical cancer gene expression program. PeerJ. 2018 Sep 19;6:e5590. doi: 10.7717/peerj.5590. eCollection 2018. PMID: 30294508; PMCID: PMC6170155.
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Ammonium Ylide Mediated Cyclization Reactions.

Asian journal of organic chemistry

Roiser L, Zielke K, Waser M.
PMID: 30210965
Asian J Org Chem. 2018 May;7(5):852-864. doi: 10.1002/ajoc.201800091. Epub 2018 Mar 25.

The use of readily accessible ammonium ylides for (asymmetric) transformations, especially cyclization reactions, has received considerable attention over the past two decades. A variety of highly enantioselective protocols to facilitate annulation reactions have recently been introduced as an alternative...

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Roiser L, Zielke K, Waser M. Ammonium Ylide Mediated Cyclization Reactions. Asian J Org Chem. 2018;7(5):852-864doi: 10.1002/ajoc.201800091.
Roiser, L., Zielke, K., & Waser, M. (2018). Ammonium Ylide Mediated Cyclization Reactions. Asian journal of organic chemistry, 7(5), 852-864. https://doi.org/10.1002/ajoc.201800091
Roiser, Lukas, et al. "Ammonium Ylide Mediated Cyclization Reactions." Asian journal of organic chemistry vol. 7,5 (2018): 852-864. doi: https://doi.org/10.1002/ajoc.201800091
Roiser L, Zielke K, Waser M. Ammonium Ylide Mediated Cyclization Reactions. Asian J Org Chem. 2018 May;7(5):852-864. doi: 10.1002/ajoc.201800091. Epub 2018 Mar 25. PMID: 30210965; PMCID: PMC6130843.
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Syntheses of Highly Functionalized Spirocyclohexenes by Formal [4+2] Annulation of Arylidene Azlactones with Allenoates.

Asian journal of organic chemistry

Eitzinger A, Zielke K, Widhalm M, Robiette R, Waser M.
PMID: 30175031
Asian J Org Chem. 2018 Aug;7(8):1620-1625. doi: 10.1002/ajoc.201800275. Epub 2018 May 04.

A straightforward phosphine-catalyzed formal [4+2] annulation between α-branched allenoates and arylidene azlactones has been developed to access highly functionalized spirocyclohexenes. This cyclization favors the γ-addition of the phosphine-activated allenoates over a β'-addition pathway. Detailed computational studies support the proposed...

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Eitzinger A, Zielke K, Widhalm M, et al. Syntheses of Highly Functionalized Spirocyclohexenes by Formal [4+2] Annulation of Arylidene Azlactones with Allenoates. Asian J Org Chem. 2018;7(8):1620-1625doi: 10.1002/ajoc.201800275.
Eitzinger, A., Zielke, K., Widhalm, M., Robiette, R., & Waser, M. (2018). Syntheses of Highly Functionalized Spirocyclohexenes by Formal [4+2] Annulation of Arylidene Azlactones with Allenoates. Asian journal of organic chemistry, 7(8), 1620-1625. https://doi.org/10.1002/ajoc.201800275
Eitzinger, Andreas, et al. "Syntheses of Highly Functionalized Spirocyclohexenes by Formal [4+2] Annulation of Arylidene Azlactones with Allenoates." Asian journal of organic chemistry vol. 7,8 (2018): 1620-1625. doi: https://doi.org/10.1002/ajoc.201800275
Eitzinger A, Zielke K, Widhalm M, Robiette R, Waser M. Syntheses of Highly Functionalized Spirocyclohexenes by Formal [4+2] Annulation of Arylidene Azlactones with Allenoates. Asian J Org Chem. 2018 Aug;7(8):1620-1625. doi: 10.1002/ajoc.201800275. Epub 2018 May 04. PMID: 30175031; PMCID: PMC6114148.
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Showing 1 to 12 of 111 entries