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Stereodivergent Dual Catalytic α-Allylation of Protected α-Amino- and α-Hydroxyacetaldehydes.

Angewandte Chemie (International ed. in English)

Sandmeier T, Krautwald S, Zipfel HF, Carreira EM.
PMID: 26427612
Angew Chem Int Ed Engl. 2015 Nov 23;54(48):14363-7. doi: 10.1002/anie.201506933. Epub 2015 Oct 02.

Fully stereodivergent dual-catalytic α-allylation of protected α-amino- and α-hydroxyacetaldehydes is achieved through iridium- and amine-catalyzed substitution of racemic allylic alcohols with chiral enamines generated in situ. The operationally simple method furnishes useful aldehyde building blocks in good yields, more...

HIF-1α Mediates Isoflurane-Induced Vascular Protection in Subarachnoid Hemorrhage.

Annals of clinical and translational neurology

Milner E, Johnson AW, Nelson JW, Harries MD, Gidday JM, Han BH, Zipfel GJ.
PMID: 25909079
Ann Clin Transl Neurol. 2015 Apr;2(4):325-37. doi: 10.1002/acn3.170. Epub 2015 Feb 21.

OBJECTIVE: Outcome after aneurysmal subarachnoid hemorrhage (SAH) depends critically on delayed cerebral ischemia (DCI) - a process driven primarily by vascular events including cerebral vasospasm, microvessel thrombosis, and microvascular dysfunction. This study sought to determine the impact of postconditioning...

Monitoring and analysis of the change process in curriculum mapping compared to the National Competency-based Learning Objective Catalogue for Undergraduate Medical Education (NKLM) at four medical faculties. Part II: Key factors for motivating the faculty during the process.

GMS journal for medical education

Lammerding-Koeppel M, Giesler M, Gornostayeva M, Narciss E, Wosnik A, Zipfel S, Griewatz J, Fritze O.
PMID: 28293673
GMS J Med Educ. 2017 Feb 15;34(1):Doc6. doi: 10.3205/zma001083. eCollection 2017.

No abstract available.

Flg22-Triggered Immunity Negatively Regulates Key BR Biosynthetic Genes.

Frontiers in plant science

Jiménez-Góngora T, Kim SK, Lozano-Durán R, Zipfel C.
PMID: 26617621
Front Plant Sci. 2015 Nov 09;6:981. doi: 10.3389/fpls.2015.00981. eCollection 2015.

In plants, activation of growth and activation of immunity are opposing processes that define a trade-off. In the past few years, the growth-promoting hormones brassinosteroids (BR) have emerged as negative regulators of pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI), promoting...

A model case of a positive outcome in super-super obesity.

Clinical obesity

Hipp A, Kramer M, Gallwitz B, Fritsche A, Zipfel S, Reutershan J, Niess A.
PMID: 25586391
Clin Obes. 2013 Feb;3(1):51-5. doi: 10.1111/cob.12007. Epub 2013 Jan 31.

For an increasing number of obese patients, bariatric surgery is considered as the treatment of choice after the failure of conventional strategies. While numerous studies on bariatric surgery have shown substantial health benefits, there is a broad inter-individual variation...

Antiangiogenic agents for nonmalignant brain tumors.

Journal of neurological surgery. Part B, Skull base

Hawasli AH, Rubin JB, Tran DD, Adkins DR, Waheed S, Hullar TE, Gutmann DH, Evans J, Leonard JR, Zipfel GJ, Chicoine MR.
PMID: 24436903
J Neurol Surg B Skull Base. 2013 Jun;74(3):136-41. doi: 10.1055/s-0033-1338262. Epub 2013 Mar 13.

Objective To assess the treatment response and side effects for the use of antiangiogenic agents such as vascular endothelial growth factor (VEGF) inhibitors for patients with vestibular schwannomas and meningiomas. Design and Methods Retrospective review of eight male and...

Structural and Functional Models for the Dinuclear Copper Active Site in Catechol Oxidases: Syntheses, X-ray Crystal Structures, Magnetic and Spectral Properties, and X-ray Absorption Spectroscopic Studies in Solid State and in Solution.

Inorganic chemistry

Zippel F, Ahlers F, Werner R, Haase W, Nolting HF, Krebs B.
PMID: 11666546
Inorg Chem. 1996 May 22;35(11):3409-3419. doi: 10.1021/ic9513604.

Two novel tridentate dinucleating ligands containing benzimidazole were prepared, 1,3-bis(2-benzimidazolyl)-2-propanol (Hbbp, 1) and 1,5-bis(2-benzimidazolyl)-3-pentanol (Hbbpen, 2). Their complexing properties toward copper were studied in order to obtain structural and functional models for catechol oxidases. Syntheses and crystal structures of...

Nuclei of symbiotic arbuscular mycorrhizal fungi as revealed by in vivo two-photon microscopy.

Protoplasma

Bago B, Zipfel W, Williams RM, Piché Y.
PMID: 18987796
Protoplasma. 1999;209(1):77-89. doi: 10.1007/BF01415703.

The present work reports the results obtained from in vivo studies on the distribution and behavior of nuclei of two arbuscular mycorrhizal (AM) fungi growing in symbiosis with tomato root organ cultures (AM monoxenic cultures). Upon staining with 4',6-diamidino-2-phenylindole...

State-Selected Kinetics from Laser-Excited Fluorescence: Energy transfer and chemical reaction rates can be measured for individual molecular energy states.

Science (New York, N.Y.)

Moore CB, Zittel PF.
PMID: 17739713
Science. 1973 Nov 09;182(4112):541-6. doi: 10.1126/science.182.4112.541.

No abstract available.

Delivery of nanojoule femtosecond pulses through large-core microstructured fibers.

Optics letters

Ouzounov DG, Moll KD, Foster MA, Zipfel WR, Webb WW, Gaeta AL.
PMID: 18026490
Opt Lett. 2002 Sep 01;27(17):1513-5. doi: 10.1364/ol.27.001513.

We investigate femtosecond-pulse propagation through large-core microstructured fibers. Although these fibers are highly multimode, excitation of the fundamental mode is readily achieved, and coupling to higher-order modes is weak even when the fiber is bent or twisted. For prechirped...

Feasibility of using multiphoton excited tissue autofluorescence for in vivo human histopathology.

Biomedical optics express

Dela Cruz JM, McMullen JD, Williams RM, Zipfel WR.
PMID: 21258552
Biomed Opt Express. 2010 Nov 05;1(5):1320-1330. doi: 10.1364/BOE.1.001320.

Rapid and direct imaging of microscopic tissue morphology and pathology can be achieved by multiphoton imaging of intrinsic tissue fluorophores and second harmonic signals. Engineering parameters for developing this technology for clinical applications include excitation levels and collection efficiencies...

Moyamoya disease in adults: the role of cerebral revascularization.

Skull base : official journal of North American Skull Base Society ... [et al.]

Zipfel GJ, Fox DJ, Rivet DJ.
PMID: 16148982
Skull Base. 2005 Feb;15(1):27-41. doi: 10.1055/s-2005-868161.

Moyamoya disease is a disorder characterized by bilateral progressive steno-occlusion of the terminal internal carotid arteries with associated development of a fragile network of basal collateral vessels. It most commonly presents in children, but is also frequently seen in...

Showing 1 to 12 of 250 entries