Frontiers in pharmacology
Wati RK, de Graaf EF, Bogarín D, Heijungs R, van Vugt R, Smets EF, Gravendeel B.
Front Pharmacol. 2021 Mar 12;11:586345. doi: 10.3389/fphar.2020.586345. eCollection 2020.
Necklace orchids (Coelogyninae, Epidendroideae) have been used in traditional medicine practices for centuries. Previous studies on a subset of unrelated orchid species utilized in these traditional practices revealed they possessed antimicrobial, anti-inflammatory, and anti-oxidant activity, providing experimental proof for...
Brodschneider R, Kalcher-Sommersguter E, Kuchling S, Dietemann V, Gray A, Božič J, Briedis A, Carreck NL, Chlebo R, Crailsheim K, Coffey MF, Dahle B, González-Porto AV, Filipi J, de Graaf DC, Hatjina F, Ioannidis P, Ion N, Jørgensen AS, Kristiansen P, Lecocq A, Odoux JF, Özkirim A, Peterson M, Podrižnik B, Rašić S, Retschnig G, Schiesser A, Tosi S, Vejsnæs F, Williams G, van der Steen JJM.
Insects. 2021 Nov 02;12(11). doi: 10.3390/insects12110987.
A diverse supply of pollen is an important factor for honey bee health, but information about the pollen diversity available to colonies at the landscape scale is largely missing. In this COLOSS study, beekeeper citizen scientists sampled and analyzed...
International journal of molecular sciences
MacKenzie KC, Garritsen R, Chauhan RK, Sribudiani Y, de Graaf BM, Rugenbrink T, Brouwer R, van Ijcken WFJ, de Blaauw I, Brooks AS, Sloots CEJ, Meeuwsen CJHM, Wijnen RM, Newgreen DF, Burns AJ, Hofstra RMW, Alves MM, Brosens E.
Int J Mol Sci. 2021 Nov 16;22(22). doi: 10.3390/ijms222212354.
Patients with Hirschsprung disease (HSCR) do not always receive a genetic diagnosis after routine screening in clinical practice. One of the reasons for this could be that the causal mutation is not present in the cell types that are...
Meeus I, Parmentier L, Pisman M, de Graaf DC, Smagghe G.
Sci Rep. 2021 Feb 12;11(1):3755. doi: 10.1038/s41598-021-82540-6.
Wild bees are in decline on a local to global scale. The presence of managed honey bees can lead to competition for resources with wild bee species, which has not been investigated so far for human-modified landscapes. In this...
Analytica chimica acta
Abbas Y, de Graaf DB, Olthuis W, van den Berg A.
Anal Chim Acta. 2014 Apr 22;821:81-8. doi: 10.1016/j.aca.2014.03.013. Epub 2014 Mar 14.
Ion selective electrodes (ISE) are used extensively for the potentiometric determination of ion concentrations in electrolytes. However, the inherent drift in these measurements and the requirement of a stable reference electrode restrict the feasibility of this method for long-term...
Belov ME, Ellis SR, Dilillo M, Paine MRL, Danielson WF, Anderson GA, de Graaf EL, Eijkel GB, Heeren RMA, McDonnell LA.
Anal Chem. 2017 Jul 18;89(14):7493-7501. doi: 10.1021/acs.analchem.7b01168. Epub 2017 Jun 28.
Matrix-Assisted Laser Desorption Ionization, MALDI, has been increasingly used in a variety of biomedical applications, including tissue imaging of clinical tissue samples, and in drug discovery and development. These studies strongly depend on the performance of the analytical instrumentation...
Biotechnology and bioengineering
de Graaf AA, Marx A, Nielsen J, Sahm H, Schmidt K, Villadsen J, Wiechert W.
Biotechnol Bioeng. 1998 Apr 05;58(2):254-7. doi: 10.1002/(sici)1097-0290(19980420)58:2/3<254::aid-bit19>3.0.co;2-c.
Conventional metabolic flux analysis uses the information gained from determination of measurable fluxes and a steady-state assumption for intracellular metabolites to calculate the metabolic fluxes in a given metabolic network. The determination of intracellular fluxes depends heavily on the...
BMC biomedical engineering
van Stee MF, Krishnan S, Groen AK, de Graaf AA.
BMC Biomed Eng. 2019 Nov 15;1:29. doi: 10.1186/s42490-019-0030-z. eCollection 2019.
BACKGROUND: Triple tracer meal experiments used to investigate organ glucose-insulin dynamics, such as endogenous glucose production (EGP) of the liver are labor intensive and expensive. A procedure was developed to obtain individual liver related parameters to describe EGP dynamics...
Current opinion in psychology
de Graaf BA, van den Bos K.
Curr Opin Psychol. 2021 Aug;40:56-60. doi: 10.1016/j.copsyc.2020.08.028. Epub 2020 Sep 10.
In this article, we review the psychology of religion and radicalization. In doing so, we note that both macro-level approaches (that study structural conditions in society) and micro-level approaches (that focus on psychological coping and personal appraisal of individual...
Angewandte Chemie (International ed. in English)
Rothenberg G, de Graaf EA, Bliek A.
Angew Chem Int Ed Engl. 2003 Jul 28;42(29):3366-8. doi: 10.1002/anie.200351545.
No abstract available.
Biotechnology and bioengineering
Wiechert W, de Graaf AA.
Biotechnol Bioeng. 1997 Jul 05;55(1):101-17. doi: 10.1002/(SICI)1097-0290(19970705)55:1<101::AID-BIT12>3.0.CO;2-P.
The extension of metabolite balancing with carbon labeling experiments, as described by Marx et al. (Biotechnol. Bioeng. 49: 11-29), results in a much more detailed stationary metabolic flux analysis. As opposed to basic metabolite flux balancing alone, this method...
Journal of clinical bioinformatics
van Schalkwijk DB, van Ommen B, Freidig AP, van der Greef J, de Graaf AA.
J Clin Bioinforma. 2011 Oct 26;1(1):29. doi: 10.1186/2043-9113-1-29.
BACKGROUND: Dyslipidemia is an important risk factor for cardiovascular disease and type II diabetes. Lipoprotein diagnostics, such as LDL cholesterol and HDL cholesterol, help to diagnose these diseases. Lipoprotein profile measurements could improve lipoprotein diagnostics, but interpretational complexity has...