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Showing 1 to 12 of 112 entries
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Fall and rise of behavioural pharmacology.

Drug discovery today. Technologies

de Graaf JS.
PMID: 24980406
Drug Discov Today Technol. 2006;3(2):181-5. doi: 10.1016/j.ddtec.2006.06.007.

Since the 1970s, a fortunate ensemble of technological and scientific developments has radically changed pharmacology, both in practice and imaginative thinking, towards a predominantly molecular science. Economic and political forces contributed to the undervaluation of in vivo experiments. The...

Corrigendum: Identification of the pollen self-incompatibility determinant in Papaver rhoeas.

Nature

Wheeler MJ, de Graaf BH, Hadjiosif N, Perry RM, Poulter NS, Osman K, Vatovec S, Harper A, Christopher F, Franklin H, Franklin-Tong VE.
PMID: 26633625
Nature. 2016 Mar 03;531(7592):126. doi: 10.1038/nature16181. Epub 2015 Dec 02.

No abstract available.

Development and application of a membrane cyclone reactor for in vivo NMR spectroscopy with high microbial cell densities.

Biotechnology and bioengineering

Hartbrich A, Schmitz G, Weuster-Botz D, de Graaf AA, Wandrey C.
PMID: 18629829
Biotechnol Bioeng. 1996 Sep 20;51(6):624-35. doi: 10.1002/(SICI)1097-0290(19960920)51:6<624::AID-BIT2>3.0.CO;2-J.

A new bioreactor system has been developed for in vivo NMR spectroscopy of microorganisms under defined physiological conditions. This cyclone reactor with an integrated NMR flow cell is continuously operated in the magnet of a 400-MHz wide-bore NMR spectrometer...

Restoration of signal polarity in a set of inversion recovery NMR images.

IEEE transactions on medical imaging

Bakker CG, De Graaf CN, Van Dijk P.
PMID: 18234630
IEEE Trans Med Imaging. 1984;3(4):197-202. doi: 10.1109/TMI.1984.4307681.

A method is described which enables unambiguous retrieval of sign information in a set of magnetic resonance magnitude images of the inversion recovery type. The proposed method starts from the observation that the inversion recovery curve S is a...

Seven-pinhole tomography of the thyroid.

IEEE transactions on medical imaging

Van Giessen JW, Viergever MA, De Graaf CN.
PMID: 18243991
IEEE Trans Med Imaging. 1986;5(2):84-90. doi: 10.1109/TMI.1986.4307751.

In this paper we introduce a new application of the sevenpinhole (7P) collimator: tomographic imaging of the thyroid. The collimator design has been reoptimized for this particular application by diminishing the distance from the collimator plate to the crystal...

Time-coded aperture tomography: experimental results.

IEEE transactions on medical imaging

Van Giessen JW, Viergever MA, De Graaf CN, Dane HJ.
PMID: 18244014
IEEE Trans Med Imaging. 1986;5(4):222-8. doi: 10.1109/TMI.1986.4307780.

In this paper, we discuss the applicability of a time-coded aperture system especially designed for thyroid tomography on the basis of phantom experiments. Our studies show that 1) the quality of the reconstructions is high (e.g., a cold spot...

Developing computational model-based diagnostics to analyse clinical chemistry data.

Briefings in bioinformatics

van Schalkwijk DB, van Bochove K, van Ommen B, Freidig AP, van Someren EP, van der Greef J, de Graaf AA.
PMID: 20056728
Brief Bioinform. 2010 Jul;11(4):403-16. doi: 10.1093/bib/bbp071. Epub 2010 Jan 07.

This article provides methodological and technical considerations to researchers starting to develop computational model-based diagnostics using clinical chemistry data. These models are of increasing importance, since novel metabolomics and proteomics measuring technologies are able to produce large amounts of...

Near-Field Scanning Microwave Microscopy in the Single Photon Regime.

Scientific reports

Geaney S, Cox D, Hönigl-Decrinis T, Shaikhaidarov R, Kubatkin SE, Lindström T, Danilov AV, de Graaf SE.
PMID: 31467310
Sci Rep. 2019 Aug 29;9(1):12539. doi: 10.1038/s41598-019-48780-3.

The microwave properties of nano-scale structures are important in a wide variety of applications in quantum technology. Here we describe a low-power cryogenic near-field scanning microwave microscope (NSMM) which maintains nano-scale dielectric contrast down to the single microwave photon...

From One Ejaculate to Another: Transference of Sperm Traits via Seminal Plasma Supplementation in the Ram.

Biology

Green C, Rickard JP, de Graaf SP, Crean AJ.
PMID: 32085377
Biology (Basel). 2020 Feb 18;9(2). doi: 10.3390/biology9020033.

Males can adjust sperm motility instantaneously in response to the perceived risk of sperm competition. The speed of this response suggests that sperm motility is regulated by changes in seminal plasma rather than changes in the sperm cells themselves....

Phantom-Mobility-Based Prosthesis Control in Transhumeral Amputees Without Surgical Reinnervation: A Preliminary Study.

Frontiers in bioengineering and biotechnology

Jarrassé N, de Montalivet E, Richer F, Nicol C, Touillet A, Martinet N, Paysant J, de Graaf JB.
PMID: 30555823
Front Bioeng Biotechnol. 2018 Nov 29;6:164. doi: 10.3389/fbioe.2018.00164. eCollection 2018.

Transhumeral amputees face substantial difficulties in efficiently controlling their prosthetic limb, leading to a high rate of rejection of these devices. Actual myoelectric control approaches make their use slow, sequential and unnatural, especially for these patients with a high...

Development of a Blueprint for Integrated Care for Vulnerable Pregnant Women.

Maternal and child health journal

Harmsen van der Vliet-Torij HW, Venekamp AA, van Heijningen-Tousain HJM, Wingelaar-Loomans E, Scheele J, de Graaf JP, Lambregtse-van den Berg MP, Steegers EAP, Goumans MJBM.
PMID: 35000072
Matern Child Health J. 2022 Jan 09; doi: 10.1007/s10995-021-03340-y. Epub 2022 Jan 09.

PURPOSE: There has been increasing awareness of perinatal health and organisation of maternal and child health care in the Netherlands as a result of poor perinatal outcomes. Vulnerable women have a higher risk of these poor perinatal outcomes and...

Tuning the donor-acceptor interactions in phase-segregated block molecules.

Materials horizons

Lamers BAG, van Son MHC, de Graaf FV, van den Bersselaar BWL, de Waal BFM, Komatsu K, Sato H, Aida T, Berrocal JA, Palmans ARA, Vantomme G, Meskers SCJ, Meijer EW.
PMID: 34611679
Mater Horiz. 2022 Jan 04;9(1):294-302. doi: 10.1039/d1mh01141c.

The assembly of donor-acceptor molecules

Showing 1 to 12 of 112 entries