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Preliminary toxicity and phytochemical studies of the stem bark aqueous extract of Musanga cecropioides in rats

STEM and males

Adeneye AA, Ajagbonna OP.
GSID: Hzjfr5ahgvsJ
AA Adeneye, OP Ajagbonna, TI Adeleke… - Journal of …, 2006 - Elsevier

These studies were designed to determine the preliminary oral toxicity profile of the crude aqueous stem bark extract of Musanga cecropioides (MCW) in adult Sprague–Dawley rats …

The PurR regulon in Escherichia coli K-12 MG1655

k-12

Cho BK, Embree M.
GSID: 77FsoKXzrk8J
BK Cho, SA Federowicz, M Embree… - Nucleic acids …, 2011 - academic.oup.com

The PurR transcription factor plays a critical role in transcriptional regulation of purine metabolism in enterobacteria. Here, we elucidate the role of PurR under exogenous adenine stimulation at the genome-scale using high-resolution chromatin immunoprecipitation (ChIP)–…

Occult renal cell carcinoma manifesting with epistaxis in a woman: a case report.

Journal of medical case reports

Fyrmpas G, Adeniyi A, Baer S.
PMID: 21349191
J Med Case Rep. 2011 Feb 24;5:79. doi: 10.1186/1752-1947-5-79.

INTRODUCTION: Metastatic disease in the sinonasal region occurs rarely and the primary site may be elusive. This case highlights the possibility of an occult renal tumor manifesting with nasal symptoms and the risk of severe bleeding following nasal biopsy.CASE...

Clinical monitoring and correlates of nephropathy in SIV-infected macaques during high-dose antiretroviral therapy.

AIDS research and therapy

Sanders-Beer BE, Spano YY, Golighty D, Lara A, Hebblewaite D, Nieves-Duran L, Rhodes L, Mansfield KG.
PMID: 21255437
AIDS Res Ther. 2011 Jan 21;8(1):3. doi: 10.1186/1742-6405-8-3.

BACKGROUND: In many preclinical AIDS research studies, antiretroviral therapy (ART) is administered to experimentally simian immunodeficiency (SIV)-infected rhesus macaques for reduction of viral load to undetectable levels. Prolonged treatment of macaques with a high dose of PMPA (9-[2-(r)-(phosphonomethoxy) propyl]...

Partial characterization of two stable auxotrophic cell strains of Datura innoxia Mill.

Planta

King J, Horsch RB, Savage AD.
PMID: 24306477
Planta. 1980 Oct;149(5):480-4. doi: 10.1007/BF00385752.

A growth analysis of several presumptive "leaky" auxotrophs from Datura innoxia suspension cultures led to the discovery of an adenine-requiring cultures led to the discovery of an adenine-requiring cell strain (Ad1). Both Ad1 and Pn1, a pantothenate-requiring strain isolated...

SERS, XPS, and DFT Study of Adenine Adsorption on Silver and Gold Surfaces.

The journal of physical chemistry letters

Pagliai M, Caporali S, Muniz-Miranda M, Pratesi G, Schettino V.
PMID: 26698601
J Phys Chem Lett. 2012 Jan 19;3(2):242-5. doi: 10.1021/jz201526v. Epub 2012 Jan 09.

The adsorption of adenine on silver and gold surfaces has been investigated combining density functional theory calculations with surface-enhanced Raman scattering and angle-resolved X-ray photoelectron spectroscopy measurements, obtaining useful insight into the orientation and interaction of the nucleobase with...

Effects of aqueous extract of Ruta graveolens and its ingredients on cytochrome P450, uridine diphosphate (UDP)-glucuronosyltransferase, and reduced nicotinamide adenine dinucleotide (phosphate) (NAD(P)H)-quinone oxidoreductase in mice.

Journal of food and drug analysis

Ueng YF, Chen CC, Huang YL, Lee IJ, Yun CH, Chen YH, Huang CC.
PMID: 28911711
J Food Drug Anal. 2015 Sep;23(3):516-528. doi: 10.1016/j.jfda.2015.03.005. Epub 2015 May 21.

Ruta graveolens (the common rue) has been used for various therapeutic purposes, including relief of rheumatism and treatment of circulatory disorder. To elucidate the effects of rue on main drug-metabolizing enzymes, effects of an aqueous extract of the aerial...

Nicotinamide metabolism regulates glioblastoma stem cell maintenance.

JCI insight

Jung J, Kim LJ, Wang X, Wu Q, Sanvoranart T, Hubert CG, Prager BC, Wallace LC, Jin X, Mack SC, Rich JN.
PMID: 28515364
JCI Insight. 2017 May 18;2(10). doi: 10.1172/jci.insight.90019. eCollection 2017 May 18.

Metabolic dysregulation promotes cancer growth through not only energy production, but also epigenetic reprogramming. Here, we report that a critical node in methyl donor metabolism, nicotinamide N-methyltransferase (NNMT), ranked among the most consistently overexpressed metabolism genes in glioblastoma relative...

Tumor Necrosis Factor Gene Polymorphisms in Advanced Non-exudative Age-related Macular Degeneration.

Journal of ophthalmic & vision research

Bonyadi MH, Bonyadi M, Ahmadieh H, Fotuhi N, Shoeibi N, Saadat S, Yagubi Z.
PMID: 26425318
J Ophthalmic Vis Res. 2015 Apr-Jun;10(2):155-9. doi: 10.4103/2008-322X.163781.

PURPOSE: To investigate tumor necrosis factor (TNF)-α gene polymorphisms in advanced dry-type age-related macular degeneration (AMD) in a population from Northeastern Iran.METHODS: In this case-control study, 50 patients with geographic macular atrophy and 73 gender-matched controls were enrolled. Genomic...

Double deletion of a chromosome 21 inserted in a chromosome 22 in an azoospermic patient.

Clinical case reports

Marquet V, Bourgeois D, De Mas P, Bouneau L, Vigouroux-Castera A, Molignier R, Calvas P.
PMID: 26401282
Clin Case Rep. 2015 Sep;3(9):757-61. doi: 10.1002/ccr3.313. Epub 2015 Aug 20.

We report on a phenotypically normal 41-year-old azoospermic man with a 45 chromosomes karyotype including one normal chromosome 21, one normal chromosome 22, and a der(22)ins(22;21). Array CGH showed a 1.8 Mb terminal deletion of bands 21pter to 21q21.1...

A physical association between the human mutY homolog (hMYH) and DNA topoisomerase II-binding protein 1 (hTopBP1) regulates Chk1-induced cell cycle arrest in HEK293 cells.

Cell & bioscience

Han SH, Hahm SH, Tran AH, Chung JH, Hong MK, Paik HD, Kim KS, Han YS.
PMID: 26312135
Cell Biosci. 2015 Aug 27;5:50. doi: 10.1186/s13578-015-0042-x. eCollection 2015.

BACKGROUND: Human DNA topoisomerase II-binding protein 1 (hTopBP1) plays an important role in DNA replication and the DNA damage checkpoint pathway. The human mutY homolog (hMYH) is a base excision repair DNA glycosylase that excises adenines or 2-hydroxyadenines that...

Cadmium decontamination and reversal potential of teratological forms of the diatom Planothidium frequentissimum (Bacillariophyceae) after experimental contamination.

Journal of phycology

Arini A, Durant F, Coste M, Delmas F, Feurtet-Mazel A.
PMID: 27008522
J Phycol. 2013 Apr;49(2):361-70. doi: 10.1111/jpy.12044. Epub 2013 Feb 25.

While the induction of teratology by cadmium (Cd) on diatoms is already known, reversal kinetics are not well documented. This study aims to understand the viability of diatoms exhibiting teratological frustules and their reproduction capacities within a Cd-impacted population...

Showing 1 to 12 of 5404 entries