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Showing 1 to 12 of 14 entries
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Interaction of some charged amphiphilic drugs with phosphatidylcholine vesicles. A spin label study of surface potential effects.

Biophysical chemistry

Eriksson LE, Westman J.
PMID: 17000169
Biophys Chem. 1981 Jun;13(3):253-64. doi: 10.1016/0301-4622(81)80007-5.

Adsorptions of amphiphilic drugs (propranolol, alprenolol, metoprolol and tetracaine) to phosphalidylcholine vesicles in media of different pH and NaCl concentrations have been studied. A positively charged spin label amphiphile, N,N-di-methyl-N-nonyl-N-tempoylammoniumbromide, was used to follow the variation in the surface...

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Eriksson LE, Westman J. Interaction of some charged amphiphilic drugs with phosphatidylcholine vesicles. A spin label study of surface potential effects. Biophys Chem. 1981;13(3):253-64doi: 10.1016/0301-4622(81)80007-5.
Eriksson, L. E., & Westman, J. (1981). Interaction of some charged amphiphilic drugs with phosphatidylcholine vesicles. A spin label study of surface potential effects. Biophysical chemistry, 13(3), 253-64. https://doi.org/10.1016/0301-4622(81)80007-5
Eriksson, L E, and Westman, J. "Interaction of some charged amphiphilic drugs with phosphatidylcholine vesicles. A spin label study of surface potential effects." Biophysical chemistry vol. 13,3 (1981): 253-64. doi: https://doi.org/10.1016/0301-4622(81)80007-5
Eriksson LE, Westman J. Interaction of some charged amphiphilic drugs with phosphatidylcholine vesicles. A spin label study of surface potential effects. Biophys Chem. 1981 Jun;13(3):253-64. doi: 10.1016/0301-4622(81)80007-5. PMID: 17000169.
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Antiaggregatory Properties of Beta-adrenoceptor Blocking Drugs are Related to their Physico-chemical Properties.

Platelets

Nosál R, Jancinová V, Petriková M.
PMID: 21043897
Platelets. 1992;3(1):29-33. doi: 10.3109/09537109209013165.

The effects of the beta-adrenoceptor blockers (BAB) alprenolol, atenolol, metipranolol, oxprenolol, practolol and propranolol on platelet aggregation stimulated by ADP, thrombin and collagen were investigated. The BAB were divided into three groups according to their liposolubility and antiaggregatory activity....

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Nosál R, Jancinová V, Petriková M. Antiaggregatory Properties of Beta-adrenoceptor Blocking Drugs are Related to their Physico-chemical Properties. Platelets. 1992;3(1):29-33doi: 10.3109/09537109209013165.
Nosál, R., Jancinová, V., & Petriková, M. (1992). Antiaggregatory Properties of Beta-adrenoceptor Blocking Drugs are Related to their Physico-chemical Properties. Platelets, 3(1), 29-33. https://doi.org/10.3109/09537109209013165
Nosál, R, et al. "Antiaggregatory Properties of Beta-adrenoceptor Blocking Drugs are Related to their Physico-chemical Properties." Platelets vol. 3,1 (1992): 29-33. doi: https://doi.org/10.3109/09537109209013165
Nosál R, Jancinová V, Petriková M. Antiaggregatory Properties of Beta-adrenoceptor Blocking Drugs are Related to their Physico-chemical Properties. Platelets. 1992;3(1):29-33. doi: 10.3109/09537109209013165. PMID: 21043897.
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Global chemical reactivity parameters for several chiral beta-blockers from the Density Functional Theory viewpoint.

Clujul medical (1957)

Talmaciu MM, Bodoki E, Oprean R.
PMID: 27857521
Clujul Med. 2016;89(4):513-518. doi: 10.15386/cjmed-610. Epub 2016 Oct 20.

BACKGROUND AND AIM: Beta-adrenergic antagonists have been established as first line treatment in the medical management of hypertension, acute coronary syndrome and other cardiovascular diseases, as well as for the prevention of initial episodes of gastrointestinal bleeding in patients...

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Talmaciu MM, Bodoki E, Oprean R. Global chemical reactivity parameters for several chiral beta-blockers from the Density Functional Theory viewpoint. Clujul Med. 2016;89(4):513-518doi: 10.15386/cjmed-610.
Talmaciu, M. M., Bodoki, E., & Oprean, R. (2016). Global chemical reactivity parameters for several chiral beta-blockers from the Density Functional Theory viewpoint. Clujul medical (1957), 89(4), 513-518. https://doi.org/10.15386/cjmed-610
Talmaciu, Mona Maria, et al. "Global chemical reactivity parameters for several chiral beta-blockers from the Density Functional Theory viewpoint." Clujul medical (1957) vol. 89,4 (2016): 513-518. doi: https://doi.org/10.15386/cjmed-610
Talmaciu MM, Bodoki E, Oprean R. Global chemical reactivity parameters for several chiral beta-blockers from the Density Functional Theory viewpoint. Clujul Med. 2016;89(4):513-518. doi: 10.15386/cjmed-610. Epub 2016 Oct 20. PMID: 27857521; PMCID: PMC5111492.
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The unique effect of methiothepin on the terminal serotonin autoreceptor in the rat hypothalamus could be an example of inverse agonism.

Journal of psychopharmacology (Oxford, England)

Moret C, Briley M.
PMID: 22290996
J Psychopharmacol. 1993 Jan;7(4):331-7. doi: 10.1177/026988119300700404.

Slices of rat hypothalamus were pre-incubated with [(3)H] 5-hydroxytryptamine ([(3)H ] 5-HT), then superfused continuously and twice stimulated electrically. The effects of methiothepin, metergoline and alprenolol, all considered to be terminal 5-HT autoreceptor antagonists (although they also act at...

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Moret C, Briley M. The unique effect of methiothepin on the terminal serotonin autoreceptor in the rat hypothalamus could be an example of inverse agonism. J Psychopharmacol. 1993;7(4):331-7doi: 10.1177/026988119300700404.
Moret, C., & Briley, M. (1993). The unique effect of methiothepin on the terminal serotonin autoreceptor in the rat hypothalamus could be an example of inverse agonism. Journal of psychopharmacology (Oxford, England), 7(4), 331-7. https://doi.org/10.1177/026988119300700404
Moret, C, and Briley, M. "The unique effect of methiothepin on the terminal serotonin autoreceptor in the rat hypothalamus could be an example of inverse agonism." Journal of psychopharmacology (Oxford, England) vol. 7,4 (1993): 331-7. doi: https://doi.org/10.1177/026988119300700404
Moret C, Briley M. The unique effect of methiothepin on the terminal serotonin autoreceptor in the rat hypothalamus could be an example of inverse agonism. J Psychopharmacol. 1993 Jan;7(4):331-7. doi: 10.1177/026988119300700404. PMID: 22290996.
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A rational approach to the design of highly effective chiral stationary phases for the liquid chromatographic separation of enantiomers.

Journal of pharmaceutical and biomedical analysis

Pirkle WH, Hyun MH, Tsipouras A, Hamper BC, Banks B.
PMID: 16867745
J Pharm Biomed Anal. 1984;2(2):173-81. doi: 10.1016/0731-7085(84)80068-0.

The design and rationale of some novel chiral stationary phases (CSPs) are discussed with respect to methods for determining enantiomeric purity, absolute configuration and for obtaining enantiomerically pure materials by liquid chromatography. The commercially-available dinitrobenzoylamino CSP type 1 is...

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Pirkle WH, Hyun MH, Tsipouras A, et al. A rational approach to the design of highly effective chiral stationary phases for the liquid chromatographic separation of enantiomers. J Pharm Biomed Anal. 1984;2(2):173-81doi: 10.1016/0731-7085(84)80068-0.
Pirkle, W. H., Hyun, M. H., Tsipouras, A., Hamper, B. C., & Banks, B. (1984). A rational approach to the design of highly effective chiral stationary phases for the liquid chromatographic separation of enantiomers. Journal of pharmaceutical and biomedical analysis, 2(2), 173-81. https://doi.org/10.1016/0731-7085(84)80068-0
Pirkle, W H, et al. "A rational approach to the design of highly effective chiral stationary phases for the liquid chromatographic separation of enantiomers." Journal of pharmaceutical and biomedical analysis vol. 2,2 (1984): 173-81. doi: https://doi.org/10.1016/0731-7085(84)80068-0
Pirkle WH, Hyun MH, Tsipouras A, Hamper BC, Banks B. A rational approach to the design of highly effective chiral stationary phases for the liquid chromatographic separation of enantiomers. J Pharm Biomed Anal. 1984;2(2):173-81. doi: 10.1016/0731-7085(84)80068-0. PMID: 16867745.
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Natural abundance (14)N and (15)N solid-state NMR of pharmaceuticals and their polymorphs.

Physical chemistry chemical physics : PCCP

Veinberg SL, Johnston KE, Jaroszewicz MJ, Kispal BM, Mireault CR, Kobayashi T, Pruski M, Schurko RW.
PMID: 27314503
Phys Chem Chem Phys. 2016 Jun 29;18(26):17713-30. doi: 10.1039/c6cp02855a.

(14)N ultra-wideline (UW), (1)H{(15)N} indirectly-detected HETCOR (idHETCOR) and (15)N dynamic nuclear polarization (DNP) solid-state NMR (SSNMR) experiments, in combination with plane-wave density functional theory (DFT) calculations of (14)N EFG tensors, were utilized to characterize a series of nitrogen-containing active...

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Veinberg SL, Johnston KE, Jaroszewicz MJ, et al. Natural abundance (14)N and (15)N solid-state NMR of pharmaceuticals and their polymorphs. Phys Chem Chem Phys. 2016;18(26):17713-30doi: 10.1039/c6cp02855a.
Veinberg, S. L., Johnston, K. E., Jaroszewicz, M. J., Kispal, B. M., Mireault, C. R., Kobayashi, T., Pruski, M., & Schurko, R. W. (2016). Natural abundance (14)N and (15)N solid-state NMR of pharmaceuticals and their polymorphs. Physical chemistry chemical physics : PCCP, 18(26), 17713-30. https://doi.org/10.1039/c6cp02855a
Veinberg, Stanislav L, et al. "Natural abundance (14)N and (15)N solid-state NMR of pharmaceuticals and their polymorphs." Physical chemistry chemical physics : PCCP vol. 18,26 (2016): 17713-30. doi: https://doi.org/10.1039/c6cp02855a
Veinberg SL, Johnston KE, Jaroszewicz MJ, Kispal BM, Mireault CR, Kobayashi T, Pruski M, Schurko RW. Natural abundance (14)N and (15)N solid-state NMR of pharmaceuticals and their polymorphs. Phys Chem Chem Phys. 2016 Jun 29;18(26):17713-30. doi: 10.1039/c6cp02855a. PMID: 27314503.
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Interaction of the cationic form of amphiphilic drugs with phosphatidylcholine model membranes. Competition with lanthanide ions.

Biophysical chemistry

Westman J, Eriksson LE, Ehrenberg A.
PMID: 17005132
Biophys Chem. 1984 Jan;19(1):57-68. doi: 10.1016/0301-4622(84)85006-1.

Model membranes (liposomes) of egg yolk phosphatidylcholine were exposed to the charged (cationic) form of amphiphilic drugs (procaine, tetracaine, metroprolol, alprenolol and propranolol). Drug analysis by ultraviolet light absorption of the bulk solution after centrifugation separation was used to...

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Westman J, Eriksson LE, Ehrenberg A. Interaction of the cationic form of amphiphilic drugs with phosphatidylcholine model membranes. Competition with lanthanide ions. Biophys Chem. 1984;19(1):57-68doi: 10.1016/0301-4622(84)85006-1.
Westman, J., Eriksson, L. E., & Ehrenberg, A. (1984). Interaction of the cationic form of amphiphilic drugs with phosphatidylcholine model membranes. Competition with lanthanide ions. Biophysical chemistry, 19(1), 57-68. https://doi.org/10.1016/0301-4622(84)85006-1
Westman, J, et al. "Interaction of the cationic form of amphiphilic drugs with phosphatidylcholine model membranes. Competition with lanthanide ions." Biophysical chemistry vol. 19,1 (1984): 57-68. doi: https://doi.org/10.1016/0301-4622(84)85006-1
Westman J, Eriksson LE, Ehrenberg A. Interaction of the cationic form of amphiphilic drugs with phosphatidylcholine model membranes. Competition with lanthanide ions. Biophys Chem. 1984 Jan;19(1):57-68. doi: 10.1016/0301-4622(84)85006-1. PMID: 17005132.
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Studies on sleep/wake effects of serotonin reuptake inhibitors and receptor subtype involvement.

Journal of sleep research

Ursin R, Bjorvatn B, Sommerfelt L, Neckelmann D, Bjørkum AA.
PMID: 10607045
J Sleep Res. 1992 Sep;1(3):157-162. doi: 10.1111/j.1365-2869.1992.tb00031.x.

Studies with the serotonin uptake inhibitors zimeldine and alaproclate show biphasic effects on the sleep/wake axis in rats and cats. Zimeldine induced an initial waking response succeeded by a small SWS-2 increase in rats. The waking increase was not...

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Ursin R, Bjorvatn B, Sommerfelt L, et al. Studies on sleep/wake effects of serotonin reuptake inhibitors and receptor subtype involvement. J Sleep Res. 1992;1(3):157-162doi: 10.1111/j.1365-2869.1992.tb00031.x.
Ursin, R., Bjorvatn, B., Sommerfelt, L., Neckelmann, D., & Bjørkum, A. A. (1992). Studies on sleep/wake effects of serotonin reuptake inhibitors and receptor subtype involvement. Journal of sleep research, 1(3), 157-162. https://doi.org/10.1111/j.1365-2869.1992.tb00031.x
Ursin, et al. "Studies on sleep/wake effects of serotonin reuptake inhibitors and receptor subtype involvement." Journal of sleep research vol. 1,3 (1992): 157-162. doi: https://doi.org/10.1111/j.1365-2869.1992.tb00031.x
Ursin R, Bjorvatn B, Sommerfelt L, Neckelmann D, Bjørkum AA. Studies on sleep/wake effects of serotonin reuptake inhibitors and receptor subtype involvement. J Sleep Res. 1992 Sep;1(3):157-162. doi: 10.1111/j.1365-2869.1992.tb00031.x. PMID: 10607045.
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Effect of serotonergic drugs on footshock-induced ultrasonic vocalization in adult male rats.

Behavioural pharmacology

Sánchez C.
PMID: 11224195
Behav Pharmacol. 1993 Jun;4(3):269-277.

Modulation of ultrasonic vocalization (20-30kHz) emitted by adult rats under stressful conditions such as unavoidable foot-shock has been evaluated as a model of anxiety. The effects of 5-HT(1A) receptor agonists with different intrinsic activities and the role of other...

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Sánchez C. Effect of serotonergic drugs on footshock-induced ultrasonic vocalization in adult male rats. Behav Pharmacol. 1993;4(3):269-277
Sánchez, C. (1993). Effect of serotonergic drugs on footshock-induced ultrasonic vocalization in adult male rats. Behavioural pharmacology, 4(3), 269-277.
Sánchez, C.. "Effect of serotonergic drugs on footshock-induced ultrasonic vocalization in adult male rats." Behavioural pharmacology vol. 4,3 (1993): 269-277.
Sánchez C. Effect of serotonergic drugs on footshock-induced ultrasonic vocalization in adult male rats. Behav Pharmacol. 1993 Jun;4(3):269-277. PMID: 11224195.
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Effects of beta-adrenoceptor ligands in the elevated X-maze 'anxiety' model and antagonism of the 'anxiogenic' response to 8-OH-DPAT.

Journal of psychopharmacology (Oxford, England)

Njung'e K, Critchley MA, Handley SL.
PMID: 22290664
J Psychopharmacol. 1993 Jan;7(2):173-80. doi: 10.1177/026988119300700205.

Effects of β-adrenoceptor agonists and antagonists have been examined on open/total arm entry ratio (OTR) over a wide range of doses in the rat elevated X-maze 'anxiety' model. For clenbuterol, terbutaline and adrenaline, OTR was reduced only at doses...

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Njung'e K, Critchley MA, Handley SL. Effects of beta-adrenoceptor ligands in the elevated X-maze 'anxiety' model and antagonism of the 'anxiogenic' response to 8-OH-DPAT. J Psychopharmacol. 1993;7(2):173-80doi: 10.1177/026988119300700205.
Njung'e, K., Critchley, M. A., & Handley, S. L. (1993). Effects of beta-adrenoceptor ligands in the elevated X-maze 'anxiety' model and antagonism of the 'anxiogenic' response to 8-OH-DPAT. Journal of psychopharmacology (Oxford, England), 7(2), 173-80. https://doi.org/10.1177/026988119300700205
Njung'e, K, et al. "Effects of beta-adrenoceptor ligands in the elevated X-maze 'anxiety' model and antagonism of the 'anxiogenic' response to 8-OH-DPAT." Journal of psychopharmacology (Oxford, England) vol. 7,2 (1993): 173-80. doi: https://doi.org/10.1177/026988119300700205
Njung'e K, Critchley MA, Handley SL. Effects of beta-adrenoceptor ligands in the elevated X-maze 'anxiety' model and antagonism of the 'anxiogenic' response to 8-OH-DPAT. J Psychopharmacol. 1993 Jan;7(2):173-80. doi: 10.1177/026988119300700205. PMID: 22290664.
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A Review on Pharmacokinetic and Pharmacodynamic Drug Interactions of Adrenergic β-blockers with Clinically Relevant Drugs-An Overview.

Current drug metabolism

Maideen NMP, Rajkapoor B, Muthusamy S, Ramanathan S, Thangadurai SA, Sughir AA.
PMID: 34182907
Curr Drug Metab. 2021;22(9):672-682. doi: 10.2174/1389200222666210614112529.

Adrenergic β-blockers are used to treat many conditions, including hypertension, cardiac arrhythmias, heart failure, angina pectoris, migraine, and tremors. The majority of the β-blockers including Propranolol, Metoprolol, Acebutolol, Alprenolol, Betaxolol, Carvedilol, Nebivolol and Oxprenolol are metabolised majorly by CYP2D6,...

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Maideen NMP, Rajkapoor B, Muthusamy S, et al. A Review on Pharmacokinetic and Pharmacodynamic Drug Interactions of Adrenergic β-blockers with Clinically Relevant Drugs-An Overview. Curr Drug Metab. 2021;22(9):672-682doi: 10.2174/1389200222666210614112529.
Maideen, N. M. P., Rajkapoor, B., Muthusamy, S., Ramanathan, S., Thangadurai, S. A., & Sughir, A. A. (2021). A Review on Pharmacokinetic and Pharmacodynamic Drug Interactions of Adrenergic β-blockers with Clinically Relevant Drugs-An Overview. Current drug metabolism, 22(9), 672-682. https://doi.org/10.2174/1389200222666210614112529
Maideen, Naina Mohamed Pakkir, et al. "A Review on Pharmacokinetic and Pharmacodynamic Drug Interactions of Adrenergic β-blockers with Clinically Relevant Drugs-An Overview." Current drug metabolism vol. 22,9 (2021): 672-682. doi: https://doi.org/10.2174/1389200222666210614112529
Maideen NMP, Rajkapoor B, Muthusamy S, Ramanathan S, Thangadurai SA, Sughir AA. A Review on Pharmacokinetic and Pharmacodynamic Drug Interactions of Adrenergic β-blockers with Clinically Relevant Drugs-An Overview. Curr Drug Metab. 2021;22(9):672-682. doi: 10.2174/1389200222666210614112529. PMID: 34182907.
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Characteristic interactivity of landiolol, an ultra-short-acting highly selective β1-blocker, with biomimetic membranes: Comparisons with β1-selective esmolol and non-selective propranolol and alprenolol.

Frontiers in pharmacology

Tsuchiya H, Mizogami M.
PMID: 24339816
Front Pharmacol. 2013 Dec 02;4:150. doi: 10.3389/fphar.2013.00150. eCollection 2013.

Although β1-blockers have been perioperatively used to reduce the cardiac disorders associated with general anesthesia, little is known about the mechanistic characteristics of ultra-short-acting highly selective β1-blocker landiolol. We studied its membrane-interacting property in comparison with other selective and...

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Tsuchiya H, Mizogami M. Characteristic interactivity of landiolol, an ultra-short-acting highly selective β1-blocker, with biomimetic membranes: Comparisons with β1-selective esmolol and non-selective propranolol and alprenolol. Front Pharmacol. 2013;4:150doi: 10.3389/fphar.2013.00150.
Tsuchiya, H., & Mizogami, M. (2013). Characteristic interactivity of landiolol, an ultra-short-acting highly selective β1-blocker, with biomimetic membranes: Comparisons with β1-selective esmolol and non-selective propranolol and alprenolol. Frontiers in pharmacology, 4150. https://doi.org/10.3389/fphar.2013.00150
Tsuchiya, Hironori, and Mizogami, Maki. "Characteristic interactivity of landiolol, an ultra-short-acting highly selective β1-blocker, with biomimetic membranes: Comparisons with β1-selective esmolol and non-selective propranolol and alprenolol." Frontiers in pharmacology vol. 4 (2013): 150. doi: https://doi.org/10.3389/fphar.2013.00150
Tsuchiya H, Mizogami M. Characteristic interactivity of landiolol, an ultra-short-acting highly selective β1-blocker, with biomimetic membranes: Comparisons with β1-selective esmolol and non-selective propranolol and alprenolol. Front Pharmacol. 2013 Dec 02;4:150. doi: 10.3389/fphar.2013.00150. eCollection 2013. PMID: 24339816; PMCID: PMC3857573.
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