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Showing 1 to 12 of 839 entries
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An update of clinical management of acute intermittent porphyria.

The application of clinical genetics

Pischik E, Kauppinen R.
PMID: 26366103
Appl Clin Genet. 2015 Sep 01;8:201-14. doi: 10.2147/TACG.S48605. eCollection 2015.

Acute intermittent porphyria (AIP) is due to a deficiency of the third enzyme, the hydroxymethylbilane synthase, in heme biosynthesis. It manifests with occasional neuropsychiatric crises associated with overproduction of porphyrin precursors, aminolevulinic acid and porphobilinogen. The clinical criteria of...

Evaluation of photodynamic therapy using topical aminolevulinic acid hydrochloride in the treatment of condylomata acuminate.

International journal of clinical and experimental medicine

Zhang Z, Lu XN, Liang J, Tang H, Yang YS, Zhu XH, Du J, Shen YY, Xu JH.
PMID: 26131281
Int J Clin Exp Med. 2015 Apr 15;8(4):6517-21. eCollection 2015.

OBJECTIVES: To investigate the efficacy and safety of topical application of 5-aminolaevulinic acid (ALA) photodynamic therapy (PDT) for the treatment of condylomata acuminata (CA) in larger population.METHODS: Patients with CA were given a treatment of ALA-PDT once a week...

The IRP/IRE system in vivo: insights from mouse models.

Frontiers in pharmacology

Wilkinson N, Pantopoulos K.
PMID: 25120486
Front Pharmacol. 2014 Jul 28;5:176. doi: 10.3389/fphar.2014.00176. eCollection 2014.

Iron regulatory proteins 1 and 2 (IRP1 and IRP2) post-transcriptionally control the expression of several mRNAs encoding proteins of iron, oxygen and energy metabolism. The mechanism involves their binding to iron responsive elements (IREs) in the untranslated regions of...

Characterizing low fluence thresholds for in vitro photodynamic therapy.

Biomedical optics express

Hartl BA, Hirschberg H, Marcu L, Cherry SR.
PMID: 25798302
Biomed Opt Express. 2015 Feb 10;6(3):770-9. doi: 10.1364/BOE.6.000770. eCollection 2015 Mar 01.

The translation of photodynamic therapy (PDT) to the clinic has mostly been limited to superficial diseases where traditional light delivery is noninvasive. To overcome this limitation, a variety of mechanisms have been suggested to noninvasively deliver light to deep...

The nucleotide sequences of barley cytoplasmic glutamate transfer RNAs and structural features essential for formation of δ-aminolevulinic acid.

Plant molecular biology

Peterson D, Schön A, Söll D.
PMID: 24272342
Plant Mol Biol. 1988 May;11(3):293-9. doi: 10.1007/BF00027386.

In chloroplasts and a number of prokaryotes, δ-aminolevulinic acid (ALA), the universal precursor of porphyrins, is synthesized by a multistep enzymatic pathway with glutamyl-tRNA(Glu) as an intermediate. The ALA synthesizing system from barley chloroplasts is highly specific in its...

δ-Aminolevulinic acid-induced fluorescence-guided resection of brain tumors.

Neurology India

Moiyadi AV, Stummer W.
PMID: 25947978
Neurol India. 2015 Mar-Apr;63(2):155-65. doi: 10.4103/0028-3886.156275.

Maximal resection of gliomas is the current standard of care. Various technical adjuncts facilitate this. Aminolevulinic acid (ALA)-induced fluorescence guided resection (FGR) is one such strategy. We review the current literature related to ALA FGR. It is based on...

Photodynamic therapy in Argentina.

Photodiagnosis and photodynamic therapy

Casas A, Batlle A.
PMID: 25046985
Photodiagnosis Photodyn Ther. 2006 Dec;3(4):205-13. doi: 10.1016/j.pdpdt.2006.06.003. Epub 2006 Jul 27.

The use of endogenous Protoporphyrin IX generated through the heme biosynthetic pathway after administration of 5-aminolevulinic acid (ALA) has led to many applications in photodynamic therapy (PDT). In Buenos Aires, Argentina, the Centro de Investigaciones sobre Porfirinas y Porfirias...

Combination of immunotherapy and photodynamic therapy in the treatment of Bowenoid papulosis.

Photodiagnosis and photodynamic therapy

Wang XL, Wang HW, Guo MX, Huang Z.
PMID: 25047339
Photodiagnosis Photodyn Ther. 2007 Jun;4(2):88-93. doi: 10.1016/j.pdpdt.2007.01.002. Epub 2007 Feb 01.

OBJECTIVE: To investigate the feasibility and efficacy of combination of imiquimod and 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) for the treatment of genital Bowenoid papulosis (BP).MATERIALS AND METHODS: A total of 27 BP patients were randomized into two groups. Fifteen...

ALA-induced porphyrin formation and fluorescence in synovitis tissue In-vitro and in vivo studies.

Photodiagnosis and photodynamic therapy

Dietze A, Berg K.
PMID: 25048871
Photodiagnosis Photodyn Ther. 2005 Dec;2(4):299-307. doi: 10.1016/S1572-1000(05)00107-9. Epub 2005 Nov 11.

The synovial inflammatory process in rheumatoid arthritis (RA) is accompanied by massive tumor-like proliferation and activation of the connective stroma. These abnormal cells actively invade and destroy the peri-articular bone and cartilage at the margins of joints where synovium...

Quantitative spatial frequency fluorescence imaging in the sub-diffusive domain for image-guided glioma resection.

Biomedical optics express

Sibai M, Veilleux I, Elliott JT, Leblond F, Wilson BC.
PMID: 26713206
Biomed Opt Express. 2015 Nov 19;6(12):4923-33. doi: 10.1364/BOE.6.004923. eCollection 2015 Dec 01.

Intraoperative 5- aminolevulinic acid induced-Protoporphyrin IX (PpIX) fluorescence guidance enables maximum safe resection of glioblastomas by providing surgeons with real-time tumor optical contrast. However, visual assessment of PpIX fluorescence is subjective and limited by the distorting effects of light...

Mechanisms in photodynamic therapy: part one-photosensitizers, photochemistry and cellular localization.

Photodiagnosis and photodynamic therapy

Castano AP, Demidova TN, Hamblin MR.
PMID: 25048432
Photodiagnosis Photodyn Ther. 2004 Dec;1(4):279-93. doi: 10.1016/S1572-1000(05)00007-4.

The use of non-toxic dyes or photosensitizers (PS) in combination with harmless visible light that is known as photodynamic therapy (PDT) has been known for over a hundred years, but is only now becoming widely used. Originally developed as...

Photoinactivation of δ-aminolevulinic acid dehydratase from maize by flavin mononuclotide.

Photosynthesis research

Rao S, Kamath G, Maralihalli G, Bhagwat AS.
PMID: 24435638
Photosynth Res. 1987 Jan;12(2):155-64. doi: 10.1007/BF00047945.

The δ-aminolevulinic acid dehydratase activity was irreversibly inactivated by irradiation of the enzyme in presence of flavin mononucleotide. The loss of enzyme activity was dependent on time of irradiation, concentration of FMN and intensity of irradiance. It required oxygen...

Showing 1 to 12 of 839 entries