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Showing 1 to 12 of 275 entries
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Pharmacokinetic drug interactions with clopidogrel: updated review and risk management in combination therapy.

Therapeutics and clinical risk management

Wang ZY, Chen M, Zhu LL, Yu LS, Zeng S, Xiang MX, Zhou Q.
PMID: 25848291
Ther Clin Risk Manag. 2015 Mar 19;11:449-67. doi: 10.2147/TCRM.S80437. eCollection 2015.

BACKGROUND: Coprescribing of clopidogrel and other drugs is common. Available reviews have addressed the drug-drug interactions (DDIs) when clopidogrel is as an object drug, or focused on combination use of clopidogrel and a special class of drugs. Clinicians may...

Electrophoretic and histochemical analysis of esterase synthesis in the ovariole of the milkweed bugOncopeltus fasciatus (Dall.).

Wilhelm Roux' Archiv fur Entwicklungsmechanik der Organismen

Cho P, Davenport R, Whitt GS, Booth GM, Larsen JR.
PMID: 28304600
Wilhelm Roux Arch Entwickl Mech Org. 1972 Sep;170(3):209-220. doi: 10.1007/BF01380677.

The synthesis of esterases was analysed in the ovariole of the milkweed bug using electrophoretic and histochemical methods. We found a total of 12 esterases from whole ovaries. Using the inhibitors p-hydroxymercuribenzoate, diisopropyl phosphorofluoridate and eserine, 3 of the...

Intervention effect of traditional Chinese medicine Yi Tang Kang on metabolic syndrome of spleen deficiency.

Asian Pacific journal of tropical medicine

Liu XX, Shi Y.
PMID: 25902033
Asian Pac J Trop Med. 2015 Feb;8(2):162-8. doi: 10.1016/S1995-7645(14)60309-6.

OBJECTIVE: To investigate effects of herbal compound Yi Tang Kang on the spleen deficiency metabolic syndrome.METHODS: Forty male Wistar rats were randomly divided into two groups: the normal control group and the MS spleen deficiency syndrome group. The control...

Identification of a novel biomarker for oxidative stress induced by hydrogen peroxide in primary human hepatocytes using the 2-nitrobenzenesulfenyl chloride isotope labeling method.

Hepatology research : the official journal of the Japan Society of Hepatology

Takami Y, Uto H, Tamai T, Sato Y, Ishida Y, Morinaga H, Sakakibara Y, Moriuchi A, Oketani M, Ido A, Nakajima T, Okanoue T, Tsubouchi H.
PMID: 20236361
Hepatol Res. 2010 Apr;40(4):438-45. doi: 10.1111/j.1872-034X.2009.00615.x. Epub 2010 Mar 07.

AIM: Oxidative stress is involved in the progression of non-alcoholic steatohepatitis (NASH). However, there are few biomarkers that are easily measured and accurately reflect the disease states. The aim of this study was to identify novel oxidative stress markers...

Simultaneous ultrafiltration and affinity sorptive separation of proteins in a hollow fiber membrane module.

Biotechnology and bioengineering

Molinari R, Torres JL, Michaels AS, Kilpatrick PK, Carbonell RG.
PMID: 18595115
Biotechnol Bioeng. 1990 Sep;36(6):572-80. doi: 10.1002/bit.260360604.

A protein separation scheme combining affinity or ion exchange sorption with hollow fiber cross-flow filtration is described. Sorptive gel particles were loaded into the shell side of a hollow fiber membrane module. In the adsorption step, crude protein mixtures...

Horse carboxylesterases: evidence for six CES1 and four families of CES genes on chromosome 3.

Comparative biochemistry and physiology. Part D, Genomics & proteomics

Holmes RS, Cox LA, Vandeberg JL.
PMID: 20403742
Comp Biochem Physiol Part D Genomics Proteomics. 2009 Mar;4(1):54-65. doi: 10.1016/j.cbd.2008.10.004. Epub 2008 Nov 05.

Carboxylesterases (CES) are responsible for the detoxification of a wide range of drugs and xenobiotics, and may contribute to cholesterol, fatty acid and lung surfactant metabolism. In this study, in silico methods were used to predict the amino acid...

Effects of atrazine and chlorpyrifos on acetylcholinesterase and Carboxylesterase in brain and muscle of common carp.

Environmental toxicology and pharmacology

Xing H, Wang J, Li J, Fan Z, Wang M, Xu S.
PMID: 21787625
Environ Toxicol Pharmacol. 2010 Jul;30(1):26-30. doi: 10.1016/j.etap.2010.03.009. Epub 2010 Mar 16.

The aim of this study was to investigate the effects of chlorpyrifos (CPF), atrazine (ATR) and the mixture of them on acetylcholinesterase (AChE) and carboxylesterase (CbE) in brain and muscle of common carp, respectively. 220 carps were averagely divided...

Metabolism of ciclesonide in the upper and lower airways: review of available data.

Journal of asthma and allergy

Nave R, McCracken N.
PMID: 21436981
J Asthma Allergy. 2008 Sep 07;1:11-8. doi: 10.2147/jaa.s4051.

Ciclesonide is a novel corticosteroid (CS) for the treatment of asthma and allergic rhinitis. After administration, the parent compound ciclesonide is converted by intracellular airway esterases to its pharmacologically active metabolite desisobutyryl-ciclesonide (des-CIC). We investigated the in vitro activation...

A new class of mammalian carboxylesterase CES6.

Comparative biochemistry and physiology. Part D, Genomics & proteomics

Holmes RS, Cox LA, Vandeberg JL.
PMID: 20161041
Comp Biochem Physiol Part D Genomics Proteomics. 2009 Sep;4(3):209-17. doi: 10.1016/j.cbd.2009.03.002.

Mammalian carboxylesterases (CES) exhibit broad substrate specificities, catalyse hydrolytic and transesterification reactions with a wide range of drugs and xenobiotics and are widely distributed in the body. Four CES classes have been previously described, namely CES1 (major liver form);...

A carboxylesterase inhibition assay to estimate parathion, malathion and diazinon in lettuce extracts.

Bulletin of environmental contamination and toxicology

Villeneuve DC, Butterfield AG, McCully KA.
PMID: 24185498
Bull Environ Contam Toxicol. 1969 Jul;4(4):232-9. doi: 10.1007/BF01557981.

No abstract available.

Development of organophosphate hydrolase activity in a bacterial homolog of human cholinesterase.

Frontiers in chemistry

Legler PM, Boisvert SM, Compton JR, Millard CB.
PMID: 25077141
Front Chem. 2014 Jul 16;2:46. doi: 10.3389/fchem.2014.00046. eCollection 2014.

We applied a combination of rational design and directed evolution (DE) to Bacillus subtilis p-nitrobenzyl esterase (pNBE) with the goal of enhancing organophosphorus acid anhydride hydrolase (OPAAH) activity. DE started with a designed variant, pNBE A107H, carrying a histidine...

Expression of proteins associated with adipocyte lipolysis was significantly changed in the adipose tissues of the obese spontaneously hypertensive/NDmcr-cp rat.

Diabetology & metabolic syndrome

Chang J, Oikawa S, Iwahashi H, Kitagawa E, Takeuchi I, Yuda M, Aoki C, Yamada Y, Ichihara G, Kato M, Ichihara S.
PMID: 24468282
Diabetol Metab Syndr. 2014 Jan 27;6(1):8. doi: 10.1186/1758-5996-6-8.

BACKGROUND: The etiology of the metabolic syndrome is complex, and is determined by the interplay of both genetic and environmental factors. The present study was designed to identify genes and proteins in the adipose tissues with altered expression in...

Showing 1 to 12 of 275 entries