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Effect of Low versus Moderate Dose of Clofibrate on Serum Bilirubin in Healthy Term Neonates with Indirect Hyperbilirubinemia.

Iranian journal of medical sciences

Eghbalian F, Monsef F, Alam Ghomi N, Monsef A.
PMID: 24293792
Iran J Med Sci. 2013 Dec;38(4):349-50.

No abstract available.

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Eghbalian F, Monsef F, Alam Ghomi N, et al. Effect of Low versus Moderate Dose of Clofibrate on Serum Bilirubin in Healthy Term Neonates with Indirect Hyperbilirubinemia. Iran J Med Sci. 2013;38(4):349-50
Eghbalian, F., Monsef, F., Alam Ghomi, N., & Monsef, A. (2013). Effect of Low versus Moderate Dose of Clofibrate on Serum Bilirubin in Healthy Term Neonates with Indirect Hyperbilirubinemia. Iranian journal of medical sciences, 38(4), 349-50.
Eghbalian, Fatemeh, et al. "Effect of Low versus Moderate Dose of Clofibrate on Serum Bilirubin in Healthy Term Neonates with Indirect Hyperbilirubinemia." Iranian journal of medical sciences vol. 38,4 (2013): 349-50.
Eghbalian F, Monsef F, Alam Ghomi N, Monsef A. Effect of Low versus Moderate Dose of Clofibrate on Serum Bilirubin in Healthy Term Neonates with Indirect Hyperbilirubinemia. Iran J Med Sci. 2013 Dec;38(4):349-50. PMID: 24293792; PMCID: PMC3838990.
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Diabetes insipidus: The other diabetes.

Indian journal of endocrinology and metabolism

Kalra S, Zargar AH, Jain SM, Sethi B, Chowdhury S, Singh AK, Thomas N, Unnikrishnan AG, Thakkar PB, Malve H.
PMID: 26904464
Indian J Endocrinol Metab. 2016 Jan-Feb;20(1):9-21. doi: 10.4103/2230-8210.172273.

Diabetes insipidus (DI) is a hereditary or acquired condition which disrupts normal life of persons with the condition; disruption is due to increased thirst and passing of large volumes of urine, even at night. A systematic search of literature...

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Kalra S, Zargar AH, Jain SM, et al. Diabetes insipidus: The other diabetes. Indian J Endocrinol Metab. 2016;20(1):9-21doi: 10.4103/2230-8210.172273.
Kalra, S., Zargar, A. H., Jain, S. M., Sethi, B., Chowdhury, S., Singh, A. K., Thomas, N., Unnikrishnan, A. G., Thakkar, P. B., & Malve, H. (2016). Diabetes insipidus: The other diabetes. Indian journal of endocrinology and metabolism, 20(1), 9-21. https://doi.org/10.4103/2230-8210.172273
Kalra, Sanjay, et al. "Diabetes insipidus: The other diabetes." Indian journal of endocrinology and metabolism vol. 20,1 (2016): 9-21. doi: https://doi.org/10.4103/2230-8210.172273
Kalra S, Zargar AH, Jain SM, Sethi B, Chowdhury S, Singh AK, Thomas N, Unnikrishnan AG, Thakkar PB, Malve H. Diabetes insipidus: The other diabetes. Indian J Endocrinol Metab. 2016 Jan-Feb;20(1):9-21. doi: 10.4103/2230-8210.172273. PMID: 26904464; PMCID: PMC4743391.
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The possible relationship between hepatomegaly and release of HGF into plasma induced by clofibrate in rats.

World journal of gastroenterology

Xu W, Wu SG.
PMID: 11819485
World J Gastroenterol. 1999 Oct;5(5):440-442. doi: 10.3748/wjg.v5.i5.440.

No abstract available.

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Xu W, Wu SG. The possible relationship between hepatomegaly and release of HGF into plasma induced by clofibrate in rats. World J Gastroenterol. 1999;5(5):440-442doi: 10.3748/wjg.v5.i5.440.
Xu, W., & Wu, S. G. (1999). The possible relationship between hepatomegaly and release of HGF into plasma induced by clofibrate in rats. World journal of gastroenterology, 5(5), 440-442. https://doi.org/10.3748/wjg.v5.i5.440
Xu, Wei, and Wu, Shu-Guang. "The possible relationship between hepatomegaly and release of HGF into plasma induced by clofibrate in rats." World journal of gastroenterology vol. 5,5 (1999): 440-442. doi: https://doi.org/10.3748/wjg.v5.i5.440
Xu W, Wu SG. The possible relationship between hepatomegaly and release of HGF into plasma induced by clofibrate in rats. World J Gastroenterol. 1999 Oct;5(5):440-442. doi: 10.3748/wjg.v5.i5.440. PMID: 11819485; PMCID: PMC4688617.
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Rapid and extensive lethal action of clofibrate on hepatoma cells in vitro.

Cell death and differentiation

Canuto RA, Muzio G, Maggiora M, Autelli R, Barbiero G, Costelli P, Bonelli G, Baccino FM.
PMID: 16465232
Cell Death Differ. 1997 Apr;4(3):224-32. doi: 10.1038/sj.cdd.4400224.

Clofibrate, for a long time in use as a hypolipidemic drug, is a well known peroxisomal proliferator (PP) and hepatocarcinogen in rodents. We show here that in vitro 1 mM clofibrate induces a rapid and massive death of rat...

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Canuto RA, Muzio G, Maggiora M, et al. Rapid and extensive lethal action of clofibrate on hepatoma cells in vitro. Cell Death Differ. 1997;4(3):224-32doi: 10.1038/sj.cdd.4400224.
Canuto, R. A., Muzio, G., Maggiora, M., Autelli, R., Barbiero, G., Costelli, P., Bonelli, G., & Baccino, F. M. (1997). Rapid and extensive lethal action of clofibrate on hepatoma cells in vitro. Cell death and differentiation, 4(3), 224-32. https://doi.org/10.1038/sj.cdd.4400224
Canuto, R A, et al. "Rapid and extensive lethal action of clofibrate on hepatoma cells in vitro." Cell death and differentiation vol. 4,3 (1997): 224-32. doi: https://doi.org/10.1038/sj.cdd.4400224
Canuto RA, Muzio G, Maggiora M, Autelli R, Barbiero G, Costelli P, Bonelli G, Baccino FM. Rapid and extensive lethal action of clofibrate on hepatoma cells in vitro. Cell Death Differ. 1997 Apr;4(3):224-32. doi: 10.1038/sj.cdd.4400224. PMID: 16465232.
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Sensitive detection of growth stimulating tumour promoters in perifused primary rat hepatocyte cultures.

Toxicology in vitro : an international journal published in association with BIBRA

Klein S, Gebhardt R.
PMID: 20654349
Toxicol In Vitro. 1997 Oct;11(5):543-7. doi: 10.1016/s0887-2333(97)00063-5.

Comparison of stationary cultivation with discrete changes of the medium with perifusion, where the hepatocytes are cultivated under a continuous flow of medium showed an enhanced sensitivity of perifused hepatocytes towards the mitogen cyproterone acetate (CPA) and the potential...

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Klein S, Gebhardt R. Sensitive detection of growth stimulating tumour promoters in perifused primary rat hepatocyte cultures. Toxicol In Vitro. 1997;11(5):543-7doi: 10.1016/s0887-2333(97)00063-5.
Klein, S., & Gebhardt, R. (1997). Sensitive detection of growth stimulating tumour promoters in perifused primary rat hepatocyte cultures. Toxicology in vitro : an international journal published in association with BIBRA, 11(5), 543-7. https://doi.org/10.1016/s0887-2333(97)00063-5
Klein, S, and Gebhardt, R. "Sensitive detection of growth stimulating tumour promoters in perifused primary rat hepatocyte cultures." Toxicology in vitro : an international journal published in association with BIBRA vol. 11,5 (1997): 543-7. doi: https://doi.org/10.1016/s0887-2333(97)00063-5
Klein S, Gebhardt R. Sensitive detection of growth stimulating tumour promoters in perifused primary rat hepatocyte cultures. Toxicol In Vitro. 1997 Oct;11(5):543-7. doi: 10.1016/s0887-2333(97)00063-5. PMID: 20654349.
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An in vitro model for peroxisome proliferation utilizing primary hepatocytes in sandwich culture.

Toxicology in vitro : an international journal published in association with BIBRA

Hildebrand H, Schmidt U, Kempka G, Jacob R, Ahr HJ, Ebener C, Goretzki PE, Bader A.
PMID: 20654484
Toxicol In Vitro. 1999 Apr;13(2):265-73. doi: 10.1016/s0887-2333(98)00078-2.

Peroxisome proliferators comprise a group of structurally diverse chemicals which share as a common biologic effect the induction of peroxisomal fatty acid degrading enzymes. Concomitantly, the number and size of peroxisomes within hepatocytes increases. Following chronic administration some peroxisome...

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Hildebrand H, Schmidt U, Kempka G, et al. An in vitro model for peroxisome proliferation utilizing primary hepatocytes in sandwich culture. Toxicol In Vitro. 1999;13(2):265-73doi: 10.1016/s0887-2333(98)00078-2.
Hildebrand, H., Schmidt, U., Kempka, G., Jacob, R., Ahr, H. J., Ebener, C., Goretzki, P. E., & Bader, A. (1999). An in vitro model for peroxisome proliferation utilizing primary hepatocytes in sandwich culture. Toxicology in vitro : an international journal published in association with BIBRA, 13(2), 265-73. https://doi.org/10.1016/s0887-2333(98)00078-2
Hildebrand, H, et al. "An in vitro model for peroxisome proliferation utilizing primary hepatocytes in sandwich culture." Toxicology in vitro : an international journal published in association with BIBRA vol. 13,2 (1999): 265-73. doi: https://doi.org/10.1016/s0887-2333(98)00078-2
Hildebrand H, Schmidt U, Kempka G, Jacob R, Ahr HJ, Ebener C, Goretzki PE, Bader A. An in vitro model for peroxisome proliferation utilizing primary hepatocytes in sandwich culture. Toxicol In Vitro. 1999 Apr;13(2):265-73. doi: 10.1016/s0887-2333(98)00078-2. PMID: 20654484.
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The role of calcium in the tumor promoter-induced inhibition of gap junctional intercellular communication.

Environmental toxicology and pharmacology

Jansen LA, de Vrije T, Koeman JH, Jongen WM.
PMID: 21781752
Environ Toxicol Pharmacol. 1997 Feb 15;3(1):13-6. doi: 10.1016/s1382-6689(96)00132-9.

The effect of several tumor promoters (12-O-tetradecanoyl-phorbol-13-acetate (TPA); 1,1'-(2,2,2-trichloroethylidene)bis[4-chlorobenzene] (DDT); Aroclor1260, and clofibrate) on the inhibition of gap junctional intercellular communication (GJIC) and intracellular calcium concentration ([Ca(2+)](i)) was studied in a cell line consisting of initiated cells (3PC). In...

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Jansen LA, de Vrije T, Koeman JH, et al. The role of calcium in the tumor promoter-induced inhibition of gap junctional intercellular communication. Environ Toxicol Pharmacol. 1997;3(1):13-6doi: 10.1016/s1382-6689(96)00132-9.
Jansen, L. A., de Vrije, T., Koeman, J. H., & Jongen, W. M. (1997). The role of calcium in the tumor promoter-induced inhibition of gap junctional intercellular communication. Environmental toxicology and pharmacology, 3(1), 13-6. https://doi.org/10.1016/s1382-6689(96)00132-9
Jansen, L A, et al. "The role of calcium in the tumor promoter-induced inhibition of gap junctional intercellular communication." Environmental toxicology and pharmacology vol. 3,1 (1997): 13-6. doi: https://doi.org/10.1016/s1382-6689(96)00132-9
Jansen LA, de Vrije T, Koeman JH, Jongen WM. The role of calcium in the tumor promoter-induced inhibition of gap junctional intercellular communication. Environ Toxicol Pharmacol. 1997 Feb 15;3(1):13-6. doi: 10.1016/s1382-6689(96)00132-9. PMID: 21781752.
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Biological evaluation of a siliconized analog of clofibrate (silafibrate) in rodents.

Iranian journal of pharmaceutical research : IJPR

Ziaee M, Eghbal MA, Rahmani J, Ghaffarzadeh M, Khorrami A, Garjani A.
PMID: 24250653
Iran J Pharm Res. 2013;12(3):471-81.

Silicon is the element very similar to carbon, and bioactive siliconized compounds have therefore received much attention. Siliconization of a compound enhances its biological activities. In the present study the hypolipidemic effect and toxicity of clofibrate and its siliconized...

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Ziaee M, Eghbal MA, Rahmani J, et al. Biological evaluation of a siliconized analog of clofibrate (silafibrate) in rodents. Iran J Pharm Res. 2013;12(3):471-81
Ziaee, M., Eghbal, M. A., Rahmani, J., Ghaffarzadeh, M., Khorrami, A., & Garjani, A. (2013). Biological evaluation of a siliconized analog of clofibrate (silafibrate) in rodents. Iranian journal of pharmaceutical research : IJPR, 12(3), 471-81.
Ziaee, Mojtaba, et al. "Biological evaluation of a siliconized analog of clofibrate (silafibrate) in rodents." Iranian journal of pharmaceutical research : IJPR vol. 12,3 (2013): 471-81.
Ziaee M, Eghbal MA, Rahmani J, Ghaffarzadeh M, Khorrami A, Garjani A. Biological evaluation of a siliconized analog of clofibrate (silafibrate) in rodents. Iran J Pharm Res. 2013;12(3):471-81. PMID: 24250653; PMCID: PMC3813287.
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AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells.

PPAR research

Cerbone A, Toaldo C, Pizzimenti S, Pettazzoni P, Dianzani C, Minelli R, Ciamporcero E, Roma G, Dianzani MU, Canaparo R, Ferretti C, Barrera G.
PMID: 22619672
PPAR Res. 2012;2012:269751. doi: 10.1155/2012/269751. Epub 2012 Feb 29.

PPARαs are nuclear receptors highly expressed in colon cells. They can be activated by the fibrates (clofibrate, ciprofibrate etc.) used to treat hyperlipidemia. Since PPARα transcriptional activity can be negatively regulated by JNK, the inhibition of JNK activity could...

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Cerbone A, Toaldo C, Pizzimenti S, et al. AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells. PPAR Res. 2012;2012:269751doi: 10.1155/2012/269751.
Cerbone, A., Toaldo, C., Pizzimenti, S., Pettazzoni, P., Dianzani, C., Minelli, R., Ciamporcero, E., Roma, G., Dianzani, M. U., Canaparo, R., Ferretti, C., & Barrera, G. (2012). AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells. PPAR research, 2012269751. https://doi.org/10.1155/2012/269751
Cerbone, Angelo, et al. "AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells." PPAR research vol. 2012 (2012): 269751. doi: https://doi.org/10.1155/2012/269751
Cerbone A, Toaldo C, Pizzimenti S, Pettazzoni P, Dianzani C, Minelli R, Ciamporcero E, Roma G, Dianzani MU, Canaparo R, Ferretti C, Barrera G. AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells. PPAR Res. 2012;2012:269751. doi: 10.1155/2012/269751. Epub 2012 Feb 29. PMID: 22619672; PMCID: PMC3349252.
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E1a-3y1 cell-specific toxicity of tea polyphenols and their killing mechanism.

International journal of oncology

Mitsui T, Yamada K, Yamashita K, Matsuo N, Okuda A, Kimura G, Sugano M.
PMID: 21556548
Int J Oncol. 1995 Feb;6(2):377-83.

To screen carcinostatic components in foodstuffs, the toxicity of tea polyphenols was compared between rat 3Y1 diploid fibroblasts and a variety of their virally transformed cells. Among tea polyphenols tested, epigallocatechin gallate killed 3Y1 cells transformed by E1A gene...

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Mitsui T, Yamada K, Yamashita K, et al. E1a-3y1 cell-specific toxicity of tea polyphenols and their killing mechanism. Int J Oncol. 1995;6(2):377-83
Mitsui, T., Yamada, K., Yamashita, K., Matsuo, N., Okuda, A., Kimura, G., & Sugano, M. (1995). E1a-3y1 cell-specific toxicity of tea polyphenols and their killing mechanism. International journal of oncology, 6(2), 377-83.
Mitsui, T, et al. "E1a-3y1 cell-specific toxicity of tea polyphenols and their killing mechanism." International journal of oncology vol. 6,2 (1995): 377-83.
Mitsui T, Yamada K, Yamashita K, Matsuo N, Okuda A, Kimura G, Sugano M. E1a-3y1 cell-specific toxicity of tea polyphenols and their killing mechanism. Int J Oncol. 1995 Feb;6(2):377-83. PMID: 21556548.
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Chemistory of Fibrates.

Current chemical biology

Balendiran GK, Verma M, Perry E.
PMID: 34485047
Curr Chem Biol. 2007 Sep;1(3):311-316. doi: 10.2174/187231307781662198.

Since the description of the synthetic chemical clofibrate in 1962, various derivatives of fibrates with a diversity of chemical structures have been developed. Several of these are used clinically to treat dyslipidemia because they are generally effective in lowering...

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Balendiran GK, Verma M, Perry E. Chemistory of Fibrates. Curr Chem Biol. 2007;1(3):311-316doi: 10.2174/187231307781662198.
Balendiran, G. K., Verma, M., & Perry, E. (2007). Chemistory of Fibrates. Current chemical biology, 1(3), 311-316. https://doi.org/10.2174/187231307781662198
Balendiran, Ganesaratnam K, et al. "Chemistory of Fibrates." Current chemical biology vol. 1,3 (2007): 311-316. doi: https://doi.org/10.2174/187231307781662198
Balendiran GK, Verma M, Perry E. Chemistory of Fibrates. Curr Chem Biol. 2007 Sep;1(3):311-316. doi: 10.2174/187231307781662198. PMID: 34485047; PMCID: PMC8412053.
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The Role of PPARs in the Transcriptional Control of Cellular Processes.

Drug news & perspectives

Guan Y, Zhang Y, Breyer MD.
PMID: 12677257
Drug News Perspect. 2002 Apr;15(3):147-154. doi: 10.1358/dnp.2002.15.3.840011.

Peroxisome proliferator-activated receptors (PPARs) are transcription factors that belong to the nuclear hormone receptor superfamily. PPAR has three isoforms designated PPARalpha, PPARbeta/delta and PPARgamma. Although all three isoforms share similar protein sequence and structure, they differ in tissue distribution,...

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Guan Y, Zhang Y, Breyer MD. The Role of PPARs in the Transcriptional Control of Cellular Processes. Drug News Perspect. 2002;15(3):147-154doi: 10.1358/dnp.2002.15.3.840011.
Guan, Y., Zhang, Y., & Breyer, M. D. (2002). The Role of PPARs in the Transcriptional Control of Cellular Processes. Drug news & perspectives, 15(3), 147-154. https://doi.org/10.1358/dnp.2002.15.3.840011
Guan, Youfei, et al. "The Role of PPARs in the Transcriptional Control of Cellular Processes." Drug news & perspectives vol. 15,3 (2002): 147-154. doi: https://doi.org/10.1358/dnp.2002.15.3.840011
Guan Y, Zhang Y, Breyer MD. The Role of PPARs in the Transcriptional Control of Cellular Processes. Drug News Perspect. 2002 Apr;15(3):147-154. doi: 10.1358/dnp.2002.15.3.840011. PMID: 12677257.
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Showing 1 to 12 of 61 entries