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Showing 1 to 12 of 263 entries
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Resolving Non-Specific and Specific Adhesive Interactions of Catechols at Solid/Liquid Interfaces at the Molecular Scale.

Angewandte Chemie (International ed. in English)

Utzig T, Stock P, Valtiner M.
PMID: 27374053
Angew Chem Int Ed Engl. 2016 Aug 08;55(33):9524-8. doi: 10.1002/anie.201601881. Epub 2016 Jul 04.

The adhesive system of mussels evolved into a powerful and adaptive system with affinity to a wide range of surfaces. It is widely known that thereby 3,4-dihydroxyphenylalanine (Dopa) plays a central role. However underlying binding energies remain unknown at...

Cytosolic and Nuclear Co-localization of Betalain Biosynthetic Enzymes in Tobacco Suggests that Betalains Are Synthesized in the Cytoplasm and/or Nucleus of Betalainic Plant Cells.

Frontiers in plant science

Chen N, Yu ZH, Xiao XG.
PMID: 28572813
Front Plant Sci. 2017 May 18;8:831. doi: 10.3389/fpls.2017.00831. eCollection 2017.

Betalains replace anthocyanins as color pigments in most families of Caryophyllales. Unlike anthocyanins, betalains are derived from tyrosine via three enzymatic steps: hydroxylation of L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA; step 1), and conversion of L-DOPA to betalamic acid (step 2),...

Visualization of Intracellular Tyrosinase Activity .

Bio-protocol

Atul Jani R, Nag S, Setty SRG.
PMID: 27231711
Bio Protoc. 2016 Apr 20;6(8). doi: 10.21769/bioprotoc.1794.

Melanocytes produce the melanin pigments in melanosomes and these organelles protect the skin against harmful ultraviolet rays. Tyrosinase is the key cuproenzyme which initiates the pigment synthesis using its substrate amino acid tyrosine or L-DOPA (L-3, 4-dihydroxyphenylalanine). Moreover, the...

Chemoselective O-acylation of hydroxyamino acids and amino alcohols under acidic reaction conditions: History, scope and applications.

Beilstein journal of organic chemistry

Kristensen TE.
PMID: 25977719
Beilstein J Org Chem. 2015 Apr 08;11:446-68. doi: 10.3762/bjoc.11.51. eCollection 2015.

Amino acids, whether natural, semisynthetic or synthetic, are among the most important and useful chiral building blocks available for organic chemical synthesis. In principle, they can function as inexpensive, chiral and densely functionalized starting materials. On the other hand,...

Interactions between parallel pathways during biosynthesis of rosmarinic acid in cell suspension cultures of Coleus blumei.

Planta

Ellis BE, Remmen S, Goeree G.
PMID: 24310974
Planta. 1979 Dec;147(2):163-7. doi: 10.1007/BF00389519.

Phenylalanine ammonia-lyase from an "over-producer" strain of Coleus blumei Benth. cell cultures accumulating high levels of rosmarinic acid (RA) has been shown to possess no special feed-back sensitivity to RA or its precursors. No tyrosine-3-hydroxylase activity could be detected...

Monoamine reuptake inhibitors in Parkinson's disease.

Parkinson's disease

Huot P, Fox SH, Brotchie JM.
PMID: 25810948
Parkinsons Dis. 2015;2015:609428. doi: 10.1155/2015/609428. Epub 2015 Feb 25.

The motor manifestations of Parkinson's disease (PD) are secondary to a dopamine deficiency in the striatum. However, the degenerative process in PD is not limited to the dopaminergic system and also affects serotonergic and noradrenergic neurons. Because they can...

Mid-gut ACTH-secreting neuroendocrine tumor unmasked with (18)F-dihydroxyphenylalanine-positron emission tomography.

Endocrinology, diabetes & metabolism case reports

Ducry J, Gomez F, Prior JO, Boubaker A, Matter M, Monti M, Pu Y, Pitteloud N, Portmann L.
PMID: 25861450
Endocrinol Diabetes Metab Case Rep. 2015;2015:140104. doi: 10.1530/EDM-14-0104. Epub 2015 Mar 01.

UNLABELLED: Ectopic ACTH Cushing's syndrome (EAS) is often caused by neuroendocrine tumors (NETs) of lungs, pancreas, thymus, and other less frequent locations. Localizing the source of ACTH can be challenging. A 64-year-old man presented with rapidly progressing fatigue, muscular...

Dopamine-Induced Changes in Gα.

Frontiers in cellular neuroscience

Morigaki R, Okita S, Goto S.
PMID: 28239340
Front Cell Neurosci. 2017 Feb 10;11:26. doi: 10.3389/fncel.2017.00026. eCollection 2017.

The dopamine precursor, l-3,4-dihydroxyphenylalanine (l-DOPA), exerts powerful therapeutic effects but eventually generates l-DOPA-induced dyskinesia (LID) in patients with Parkinson's disease (PD). LID has a close link with deregulation of striatal dopamine/cAMP signaling, which is integrated by medium spiny neurons...

Purification and some properties of tyrosinase from aspergillus flavipes 56003 .

Biochemistry. Biokhimiia

Gukasyan GS.
PMID: 10231595
Biochemistry (Mosc). 1999 Apr;64(4):417-20.

A method for isolation and purification of tyrosinase from the fungus Aspergillus flavipes 56003 was developed. The method includes extraction with water, concentration on DEAE-cellulose, gel-filtration on Acrylex P-150, and ion-exchange chromatography on DEAE-Toyopearl 650M. The tyrosinase was purified...

Synthetic Polypeptide Mimics of Marine Adhesives.

Macromolecules

Yu M, Deming TJ.
PMID: 9680407
Macromolecules. 1998 Jul 28;31(15):4739-45. doi: 10.1021/ma980268z.

Water soluble copolypeptides containing l-dihydroxyphenylalanine (DOPA) and l-lysine were prepared by ring-opening polymerization of alpha-amino acid N-carboxyanhydride (NCA) monomers. We have prepared a range of different copolymers to probe the effects of functional group composition on adhesive and cross-linking...

Ningalins A-D: Novel Aromatic Alkaloids from a Western Australian Ascidian of the Genus Didemnum.

The Journal of organic chemistry

Kang H, Fenical W.
PMID: 11671712
J Org Chem. 1997 May 16;62(10):3254-3262. doi: 10.1021/jo962132+.

Four aromatic alkaloids, ningalins A-D (1-4), three of which possess new carbon skeletons, were isolated from an undescribed ascidian of the genus Didemnumcollected in Western Australia near Ningaloo Reef. The structures of these new alkaloids were elucidated by interpretation...

NTP Toxicology and Carcinogenesis Studies of alpha-Methyldopa Sesquihydrate (CAS No. 41372-08-1) in F344/N Rats and B6C3F1 Mice (Feed Studies).

National Toxicology Program technical report series

[No authors listed]
PMID: 12704436
Natl Toxicol Program Tech Rep Ser. 1989 Mar;348:1-184.

a-Methyldopa sesquihydrate is used in the treatment of hypertension; over 20 million prescriptions are written annually for a -methyldopa or a-methyldopa sesquihydrate in the United States. a-Methyldopa sesquihydrate (USP grade, greater than 99% pure) was selected for study because...

Showing 1 to 12 of 263 entries