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Showing 1 to 12 of 435 entries
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Affective Correlates of Psychosis in Parkinson's Disease.

Movement disorders clinical practice

Factor SA, Scullin MK, Freeman A, Bliwise DL, McDonald WM, Goldstein FC.
PMID: 28944257
Mov Disord Clin Pract. 2017 Mar-Apr;4(2):225-230. doi: 10.1002/mdc3.12381. Epub 2016 Jun 16.

OBJECTIVE: To examine the nature of the association between affective disorders and psychosis in Parkinson's disease (PD).BACKGROUND: In PD, psychosis and affective disorders are common and independently impact quality of life and mortality. Both depression and psychosis are correlated...

Immune Modulatory Cell Therapy for Hemophilia B Based on CD20-Targeted Lentiviral Gene Transfer to Primary B Cells.

Molecular therapy. Methods & clinical development

Wang X, Herzog RW, Byrne BJ, Kumar SRP, Zhou Q, Buchholz CJ, Biswas M.
PMID: 28480307
Mol Ther Methods Clin Dev. 2017 Mar 29;5:76-82. doi: 10.1016/j.omtm.2017.03.005. eCollection 2017 Jun 16.

Gene-modified B cells expressing immunoglobulin G (IgG) fusion proteins have been shown to induce tolerance in several autoimmune and other disease models. However, lack of a vector suitable for gene transfer to human B cells has been an obstacle...

Preclinical and translational evaluation of coagulation factor IXa as a novel therapeutic target.

Pharmacology research & perspectives

Ankrom W, Wood HB, Xu J, Geissler W, Bateman T, Chatterjee MS, Feng KI, Metzger JM, Strapps WR, Tadin-Strapps M, Seiffert D, Andre P.
PMID: 26977298
Pharmacol Res Perspect. 2016 Jan 15;4(1):e00207. doi: 10.1002/prp2.207. eCollection 2016 Feb.

The benefits of novel oral anticoagulants are hampered by bleeding. Since coagulation factor IX (fIX) lies upstream of fX in the coagulation cascade, and intermediate levels have been associated with reduced incidence of thrombotic events, we evaluated the viability...

Prognostic significance of antithrombin activity in patients with crimean-congo hemorrhagic Fever.

The Eurasian journal of medicine

Ozkurt Z, Ozden K, Kiki I, Usanmaz M.
PMID: 25610169
Eurasian J Med. 2011 Aug;43(2):83-6. doi: 10.5152/eajm.2011.19.

OBJECTIVE: Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral hemorrhagic fever. Disseminated intravascular coagulation (DIC) is an important complication of this disease, especially in severe and fatal cases. Antithrombin (AT) acts as an anticoagulant by inactivating thrombin, Factor IX,...

Pharmacokinetic studies on a new purified factor IX concentrate.

Haemophilia : the official journal of the World Federation of Hemophilia

Thomas DP.
PMID: 27213707
Haemophilia. 1995;2:23-5. doi: 10.1111/j.1365-2516.1995.tb00098.x.

No abstract available.

Results in three Australian haemophilia B patients with high-responding inhibitors treated with the Malmö model.

Haemophilia : the official journal of the World Federation of Hemophilia

Nilsson IM, Berntorp E, Rickard KA.
PMID: 27214223
Haemophilia. 1995 Jan;1(1):59-66. doi: 10.1111/j.1365-2516.1995.tb00041.x.

Development of inhibitors to factor IX (F IX) is a serious complication of the treatment of patients with severe haemophilia B. Three Australian haemophilia B patients, a 22-year-old man and two 5-year-old identical twins, with high-responding inhibitors and resistant...

Recombinant coagulation factor products.

Haemophilia : the official journal of the World Federation of Hemophilia

Brettler DB.
PMID: 27214531
Haemophilia. 1995 Jul;1(3):155-8. doi: 10.1111/j.1365-2516.1995.tb00059.x.

There are numerous new coagulation factor concentrates that are being manufactured using recombinant technology. Some are available for use currently for the treatment of bleeding disorders and others are in clinical trials. Recombinant factor VIII concentrates are licenced in...

The impact of prenatal diagnosis on the incidence of haemophilia in Sweden.

Haemophilia : the official journal of the World Federation of Hemophilia

Ljung R, Kling S, Tedgird U.
PMID: 27214538
Haemophilia. 1995 Jul;1(3):190-3. doi: 10.1111/j.1365-2516.1995.tb00066.x.

A demographic survey was made of all children (n= 137) born with severe or moderate haemophilia in Sweden during the period 1970-92. Bn addition, all prenatal diagnoses (n= 86) performing during the period were evaluated. The annual incidence of...

A longitudinal study of immunological status in Chinese haemophiliacs: importance of the heat viral inactivation of factor concentrates. I. Immunological associations with the consumption of factor concentrates.

Haemophilia : the official journal of the World Federation of Hemophilia

Ming-Ching S, Fuei-Yuen L, Yen-Ping K, Ron-Fon H.
PMID: 27214631
Haemophilia. 1995 Oct;1(4):243-8. doi: 10.1111/j.1365-2516.1995.tb00083.x.

Twenty-four of 117 cases of haemophilia A (20.5%) and none of 18 cases of haemophilia B reported in this study had an antibody to the human immuno-deficiency virus (HIV). Both groups of patients showed similar immunological alterations. HIV-seropositive haemophilia...

Different types of cell cycle- and apoptosis-related gene expressions alter in corticosteroid-, vincristine-, and melphalan-resistant u-266 multiple myeloma cell lines.

Turkish journal of haematology : official journal of Turkish Society of Haematology

Mutlu P, Ural AU, Gündüz U.
PMID: 25330516
Turk J Haematol. 2014 Sep 05;31(3):231-8. doi: 10.4274/tjh.2013.0231.

OBJECTIVE: Hemophilia B is caused by coagulation defects in the factor IX gene located in Xq27.1 on the X chromosome. A wide range of mutations, showing extensive molecular heterogeneity, have been described in hemophilia B patients. Our study was...

Erratum to: Functional expression of the human coagulation factor IX using heterologous signal peptide and propeptide sequences in mammalian cell line.

Biotechnology letters

Khorshidi S, Zomorodipour A, Behmanesh M, Vatandoost J, Bos MH.
PMID: 26253300
Biotechnol Lett. 2015 Oct;37(10):2097. doi: 10.1007/s10529-015-1909-y.

No abstract available.

Cardiomyopathy in a male with cystinosis.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology

Edelman M, Silverstein D, Strom J, Factor SM.
PMID: 25943572
Cardiovasc Pathol. 1997 Jan;6(1):43-7. doi: 10.1016/S1054-8807(96)00047-6.

Cystinosis is a lysosomal storage disease classically associated with renal failure, photophobia, and hypothyroidism. Multi-organ dysfunction tends to develop over time, a factor of increasing significance as patient survival improves. Herein, we describe a male patient with cystinosis who...

Showing 1 to 12 of 435 entries