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Showing 1 to 12 of 3826 entries
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RTOG 0529: a phase 2 evaluation of dose-painted intensity modulated radiation therapy in combination with 5-fluorouracil and mitomycin-C for the reduction of acute …

evaluation

[No authors listed]
GSID: r6uYuC2e-1sJ
LA Kachnic, K Winter, RJ Myerson… - International Journal of …, 2013 - Elsevier

Purpose A multi-institutional phase 2 trial assessed the utility of dose-painted intensity modulated radiation therapy (DP-IMRT) in reducing grade 2+ combined acute gastrointestinal and genitourinary adverse events (AEs) of 5-fluorouracil (5FU) and mitomycin-C (MMC) …

Immunomodulatory effects of the botanical compound LCS101: implications for cancer treatment.

OncoTargets and therapy

Rachmut IH, Samuels N, Melnick SJ, Ramachandran C, Sharabi Y, Pavlovsky A, Maimon Y, Shoham J.
PMID: 23637542
Onco Targets Ther. 2013 Apr 24;6:437-45. doi: 10.2147/OTT.S42038. Print 2013.

OBJECTIVE: To examine the effects of LSC101, a botanical compound, on adaptive and innate immunity.MATERIALS AND METHODS: LCS101 preparations were tested for batch-to-batch consistency using high-performance liquid chromatography. T-cell activation was quantified in murine spleen cells using 3H-thymidine incorporation,...

Response to 5-Fluorouracil-based chemotherapy in a patient with metastatic colonic-type adenocarcinoma arising in a primary mediastinal teratoma.

Case reports in oncological medicine

Dechaphunkul A, Bigras G, Sawyer M.
PMID: 23050178
Case Rep Oncol Med. 2012;2012:729278. doi: 10.1155/2012/729278. Epub 2012 Sep 23.

Germ cell tumor with somatic malignant transformation is an uncommon phenomenon occurring about 7% of all mediastinal teratomas. Among all transformed component, sarcoma appears to be the most frequent histology, followed by primitive neuroectodermal tumor (PNET) and adenocarcinoma. To...

Rapid tumor necrosis and massive hemorrhage induced by bevacizumab and paclitaxel combination therapy in a case of advanced breast cancer.

OncoTargets and therapy

Ono M, Ito T, Kanai T, Murayama K, Koyama H, Maeno K, Mochizuki Y, Iesato A, Hanamura T, Okada T, Watanabe T, Ito K.
PMID: 24124381
Onco Targets Ther. 2013 Oct 07;6:1393-8. doi: 10.2147/OTT.S51164. eCollection 2013.

Bevacizumab when combined with chemotherapy exerts significant activity against many solid tumors through tumor angiogenesis inhibition; however, it can induce severe side effects. We report the rare case of a 27-year-old premenopausal woman with locally advanced breast cancer that...

Retrospective analysis of chronomodulated chemotherapy versus conventional chemotherapy with paclitaxel, carboplatin, and 5-fluorouracil in patients with recurrent and/or metastatic head and neck squamous cell carcinoma.

OncoTargets and therapy

Chen D, Cheng J, Yang K, Ma Y, Yang F.
PMID: 24187501
Onco Targets Ther. 2013 Oct 24;6:1507-14. doi: 10.2147/OTT.S53098. eCollection 2013.

BACKGROUND: Chronomodulated chemotherapy has emerged as a new therapy as a result of recent studies focusing on the biological clock. It has been demonstrated that combination chronomodulated chemotherapy of platinum-based drugs and 5-fluorouracil (5-Fu) can significantly improve efficacy and...

Serpentine supravenous hyperpigmentation.

Clinical case reports

Jamalpur I, Mogili HR, Koratala A.
PMID: 28878924
Clin Case Rep. 2017 Jul 25;5(9):1546-1547. doi: 10.1002/ccr3.1102. eCollection 2017 Sep.

Serpentine supravenous hyperpigmentation is a peculiar cutaneous eruption that follows the path of vein after intravenous injection of the chemotherapeutic agent. The lesions gradually resolve spontaneously if administration of the offending agent is stopped through the affected limb. Drugs...

The role of GLI1 for 5-Fu resistance in colorectal cancer.

Cell & bioscience

Zhang L, Song R, Gu D, Zhang X, Yu B, Liu B, Xie J.
PMID: 28413604
Cell Biosci. 2017 Apr 13;7:17. doi: 10.1186/s13578-017-0145-7. eCollection 2017.

Colorectal cancer is a leading cause of cancer-related mortality worldwide, with Fluorouracil (5-FU)-based chemotherapy as the major treatment for advanced disease. Many patients with advanced colorectal cancer eventually succumb to the disease despite some patients responded initially to chemotherapy....

Wnt/Beta-Catenin Signal Inhibitor HC-1 Sensitizes Oral Squamous Cell Carcinoma Cells to 5-Fluorouracil through Reduction of CD44-Positive Population.

Yonago acta medica

Yokogi S, Tsubota T, Kanki K, Azumi J, Itaba N, Oka H, Morimoto M, Ryoke K, Shiota G.
PMID: 27493479
Yonago Acta Med. 2016 Jun 29;59(2):93-9. eCollection 2016 Jun.

BACKGROUND: Oral squamous cell carcinoma is a prevalent and frequently lethal malignancy worldwide. Existence of treatment-resistant cancer stem cells is considered to be associated with tumor formation, recurrence and metastasis. Wnt/beta-catenin signal is one of the crucial signaling pathways...

MRI in Chemotherapy induced Leukoencephalopathy: Report of Two Cases and Radiologist's Perspective.

Journal of clinical and diagnostic research : JCDR

Sindhwani G, Arora M, Thakker VD, Jain A.
PMID: 28893007
J Clin Diagn Res. 2017 Jul;11(7):TD08-TD09. doi: 10.7860/JCDR/2017/29164.10248. Epub 2017 Jul 01.

Leukoencephalopathy is a progressive white matter disease primarily caused due to myelin damage by a variety of factors. Chemotherapy for oncological treatment is an uncommon but important cause of potentially reversible leukoencephalopathy. In current radiological setting, conventional and diffusion...

Gimeracil enhances the antitumor effect of cisplatin in oral squamous cell carcinoma cells .

Oncology letters

Harada K, Ferdous T, Harada T, Takenawa T, Ueyama Y.
PMID: 28927087
Oncol Lett. 2017 Sep;14(3):3349-3356. doi: 10.3892/ol.2017.6602. Epub 2017 Jul 18.

Gimeracil or 5-chloro-2,4-dihydroxypyridine (CDHP) enhances the antitumor effects of 5-fluorouracil (5-FU) by inhibiting dihydropyrimidine dehydrogenase (DPD), which is involved in the degradation of 5-FU. CDHP, as part of a combination therapy, was also reported to exert a radiosensitizing effect....

Evaluation of the cytotoxic effects of hyperthermia and 5-fluorouracil-loaded magnetic nanoparticles on human colon cancer cell line HT-29.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group

Eynali S, Khoei S, Khoee S, Esmaelbeygi E.
PMID: 27701929
Int J Hyperthermia. 2017 May;33(3):327-335. doi: 10.1080/02656736.2016.1243260. Epub 2016 Oct 23.

The purpose of this study was to evaluate the combined effects of heat and polylactic-co-glycolic acid (PLGA) nanoparticles, as 5-fluorouracil carriers with/without iron oxide core, on the viability and proliferation capacity of human colon cancer cell line HT-29 in...

Bleb needling outcomes for failed trabeculectomy blebs in Asian eyes: a 2-year follow up.

International journal of ophthalmology

Tsai AS, Boey PY, Htoon HM, Wong TT.
PMID: 26309874
Int J Ophthalmol. 2015 Aug 18;8(4):748-53. doi: 10.3980/j.issn.2222-3959.2015.04.19. eCollection 2015.

AIM: To describe the outcomes of bleb needling in primary glaucoma in an Asian tertiary eye centre over a 2y period. To compare the success rates between primary angle-closure glaucoma (PACG) and primary open angle glaucoma (POAG). Lastly, to...

Showing 1 to 12 of 3826 entries