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Showing 1 to 12 of 208 entries
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Area-specific analysis of the distribution of hypothalamic neurons projecting to the rat ventral tegmental area, with special reference to the GABAergic and glutamatergic efferents.

Frontiers in neuroanatomy

Kalló I, Molnár CS, Szöke S, Fekete C, Hrabovszky E, Liposits Z.
PMID: 26388742
Front Neuroanat. 2015 Sep 04;9:112. doi: 10.3389/fnana.2015.00112. eCollection 2015.

The ventral tegmental area (VTA) is a main regulator of reward and integrates a wide scale of hormonal and neuronal information. Feeding-, energy expenditure-, stress, adaptation- and reproduction-related hypothalamic signals are processed in the VTA and influence the reward...

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology

Agrawal R, Kalmady SV, Venkatasubramanian G.
PMID: 28449558
Clin Psychopharmacol Neurosci. 2017 May 31;15(2):115-125. doi: 10.9758/cpn.2017.15.2.115.

OBJECTIVE: Deficient brain-derived neurotrophic factor (BDNF) is one of the important mechanisms underlying the neuroplasticity abnormalities in schizophrenia. Aberration in BDNF signaling pathways directly or circuitously influences neurotransmitters like glutamate and gamma-aminobutyric acid (GABA). For the first time, this...

γ-Aminobutyric Acid (GABA) Accumulation in Tea (Camellia sinensis L.) through the GABA Shunt and Polyamine Degradation Pathways under Anoxia.

Journal of agricultural and food chemistry

Liao J, Wu X, Xing Z, Li Q, Duan Y, Fang W, Zhu X.
PMID: 28355482
J Agric Food Chem. 2017 Apr 12;65(14):3013-3018. doi: 10.1021/acs.jafc.7b00304. Epub 2017 Apr 04.

γ-Aminobutyric acid (GABA) is an important bioactive component of tea (Camellia sinensis) providing various health benefits. We studied GABA accumulation via the GABA shunt and polyamine degradation pathways under anoxia in tea leaves. Anoxia caused a ∼20-fold increment in...

Identification of two .

PeerJ

Ji J, Zheng L, Yue J, Yao X, Chang E, Xie T, Deng N, Chen L, Huang Y, Jiang Z, Shi S.
PMID: 28626614
PeerJ. 2017 Jun 14;5:e3439. doi: 10.7717/peerj.3439. eCollection 2017.

BACKGROUND: Glutamate decarboxylase (GAD), as a key enzyme in the METHODS: Two full-length cDNAs encoding GADs (designated as RESULTS: The DISCUSSION: This study showed that two

Synthesis of affinity chromatography resins for the purification of brain glutamate decarboxylase.

Neurochemical research

Possani LD, Bayón A, Tapia R.
PMID: 24271849
Neurochem Res. 1977 Feb;2(1):51-7. doi: 10.1007/BF00966021.

In the present paper we describe the synthesis of Sepharose-boundN-(5'-phosphopyridoxyl)-amino-oxyacetic acid,N-(5'-phosphopyridoxyl)-canaline, andN-(5'-phosphopyridoxyl)-α,γ-diaminobutyric acid (Seph-DAB-PLP), designed for binding specifically brain glutamate decarboxylase (GAD). The three Sepharose-N-(phosphopyridoxyl)-amino acids were capable of binding GAD from a mouse brain soluble preparation. The enzyme...

Activation of CD4+ and CD8+ T-lymphocytes by insulin and GAD in patients with type 1 or 2 diabetes mellitus.

Endocrine connections

Arneth B.
PMID: 28986401
Endocr Connect. 2017 Nov;6(8):758-765. doi: 10.1530/EC-17-0230. Epub 2017 Oct 06.

BACKGROUND: The origin of autoimmune disease type 1 diabetes is still unknown.AIM: This study assessed the activation of CD4+ and CD8+ T-lymphocytes by human insulin and human glutamate decarboxylase (GAD) in patients with type 1 or type 2 diabetes...

Extracellular expression of glutamate decarboxylase B in Escherichia coli to improve gamma-aminobutyric acid production.

AMB Express

Zhao A, Hu X, Li Y, Chen C, Wang X.
PMID: 27549808
AMB Express. 2016 Dec;6(1):55. doi: 10.1186/s13568-016-0231-y. Epub 2016 Aug 22.

Escherichia coli overexpressing glutamate decarboxylase GadB can produce gamma-aminobutyric acid with addition of monosodium glutamate. The yield and productivity of gamma-aminobutyric acid might be significantly improved if the overexpressed GadB in E. coli cells can be excreted outside, where...

Immunohistochemical and ultrastructural properties of the larval ciliary band-associated strand in the sea urchin Hemicentrotus pulcherrimus.

Frontiers in zoology

Katow H, Katow T, Yoshida H, Kiyomoto M, Uemura I.
PMID: 27313654
Front Zool. 2016 Jun 16;13:27. doi: 10.1186/s12983-016-0159-8. eCollection 2016.

BACKGROUND: The swimming activity of sea urchin larvae is dependent on the ciliary band (CB) on the larval surface and is regulated by several neurotransmitters, including serotonin (5HT), dopamine, and γ-aminobutyric acid (GABA). However, the CB signal transmission mechanism...

Transmitter inputs to different motoneuron subgroups in the oculomotor and trochlear nucleus in monkey.

Frontiers in neuroanatomy

Zeeh C, Mustari MJ, Hess BJ, Horn AK.
PMID: 26257611
Front Neuroanat. 2015 Jul 24;9:95. doi: 10.3389/fnana.2015.00095. eCollection 2015.

In all vertebrates the eyes are moved by six pairs of extraocular muscles enabling horizontal, vertical and rotatory movements. Recent work showed that each extraocular muscle is controlled by two motoneuronal groups: (1) Motoneurons of singly-innervated muscle fibers (SIF)...

Insect Herbivory-Elicited GABA Accumulation in Plants is a Wound-Induced, Direct, Systemic, and Jasmonate-Independent Defense Response.

Frontiers in plant science

Scholz SS, Reichelt M, Mekonnen DW, Ludewig F, Mithöfer A.
PMID: 26734035
Front Plant Sci. 2015 Dec 22;6:1128. doi: 10.3389/fpls.2015.01128. eCollection 2015.

The non-proteinogenic amino acid γ-aminobutyric acid (GABA) is present in all organisms analyzed so far. In invertebrates GABA acts as a neurotransmitter; in plants different functions are under discussion. Among others, its involvement in abiotic stress reactions and as...

Off-the-Vine Ripening of Tomato Fruit Causes Alteration in the Primary Metabolite Composition.

Metabolites

Sorrequieta A, Abriata LA, Boggio SB, Valle EM.
PMID: 24958260
Metabolites. 2013 Oct 16;3(4):967-78. doi: 10.3390/metabo3040967.

The influence of postharvest fruit ripening in the composition of metabolites, transcripts and enzymes in tomato (Solanum lycopersicum L.) is poorly understood. The goal of this work was to study the changes in the metabolite composition of the tomato...

Disruption of pknG enhances production of gamma-aminobutyric acid by Corynebacterium glutamicum expressing glutamate decarboxylase.

AMB Express

Okai N, Takahashi C, Hatada K, Ogino C, Kondo A.
PMID: 24949255
AMB Express. 2014 Apr 01;4:20. doi: 10.1186/s13568-014-0020-4. eCollection 2014.

Gamma-aminobutyric acid (GABA), a building block of the biodegradable plastic polyamide 4, is synthesized from glucose by Corynebacterium glutamicum that expresses Escherichia coli glutamate decarboxylase (GAD) B encoded by gadB. This strain was engineered to produce GABA more efficiently...

Showing 1 to 12 of 208 entries