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Immunoglobulin Light Chains Form an Extensive and Highly Ordered Fibril Involving the N- and C-Termini.

ACS omega

Piehl DW, Blancas-Mejía LM, Wall JS, Kennel SJ, Ramirez-Alvarado M, Rienstra CM.
PMID: 28261692
ACS Omega. 2017 Feb 28;2(2):712-720. doi: 10.1021/acsomega.6b00494. Epub 2017 Feb 27.

Light-chain (AL)-associated amyloidosis is a systemic disorder involving the formation and deposition of immunoglobulin AL fibrils in various bodily organs. One severe instance of AL disease is exhibited by the patient-derived variable domain (V

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Piehl DW, Blancas-Mejía LM, Wall JS, et al. Immunoglobulin Light Chains Form an Extensive and Highly Ordered Fibril Involving the N- and C-Termini. ACS Omega. 2017;2(2):712-720doi: 10.1021/acsomega.6b00494.
Piehl, D. W., Blancas-Mejía, L. M., Wall, J. S., Kennel, S. J., Ramirez-Alvarado, M., & Rienstra, C. M. (2017). Immunoglobulin Light Chains Form an Extensive and Highly Ordered Fibril Involving the N- and C-Termini. ACS omega, 2(2), 712-720. https://doi.org/10.1021/acsomega.6b00494
Piehl, Dennis W, et al. "Immunoglobulin Light Chains Form an Extensive and Highly Ordered Fibril Involving the N- and C-Termini." ACS omega vol. 2,2 (2017): 712-720. doi: https://doi.org/10.1021/acsomega.6b00494
Piehl DW, Blancas-Mejía LM, Wall JS, Kennel SJ, Ramirez-Alvarado M, Rienstra CM. Immunoglobulin Light Chains Form an Extensive and Highly Ordered Fibril Involving the N- and C-Termini. ACS Omega. 2017 Feb 28;2(2):712-720. doi: 10.1021/acsomega.6b00494. Epub 2017 Feb 27. PMID: 28261692; PMCID: PMC5331457.
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Effect of specimen type on free immunoglobulin light chains analysis on the Roche Diagnostics cobas 8000 analyzer.

SpringerPlus

Nelson LS, Steussy B, Morris CS, Krasowski MD.
PMID: 26682113
Springerplus. 2015 Dec 08;4:760. doi: 10.1186/s40064-015-1546-x. eCollection 2015.

The measurement of free immunoglobulin light chains is typically performed on serum; however, the use of alternative specimen types has potential benefits. Using the Freelite™ kappa and lambda free light chains assay on a Roche Diagnostics cobas 8000 c502...

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Nelson LS, Steussy B, Morris CS, et al. Effect of specimen type on free immunoglobulin light chains analysis on the Roche Diagnostics cobas 8000 analyzer. Springerplus. 2015;4:760doi: 10.1186/s40064-015-1546-x.
Nelson, L. S., Steussy, B., Morris, C. S., & Krasowski, M. D. (2015). Effect of specimen type on free immunoglobulin light chains analysis on the Roche Diagnostics cobas 8000 analyzer. SpringerPlus, 4760. https://doi.org/10.1186/s40064-015-1546-x
Nelson, Louis S, et al. "Effect of specimen type on free immunoglobulin light chains analysis on the Roche Diagnostics cobas 8000 analyzer." SpringerPlus vol. 4 (2015): 760. doi: https://doi.org/10.1186/s40064-015-1546-x
Nelson LS, Steussy B, Morris CS, Krasowski MD. Effect of specimen type on free immunoglobulin light chains analysis on the Roche Diagnostics cobas 8000 analyzer. Springerplus. 2015 Dec 08;4:760. doi: 10.1186/s40064-015-1546-x. eCollection 2015. PMID: 26682113; PMCID: PMC4671985.
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Combined Riedel's Disease and Fibrosing Hashimoto's Thyroiditis: A Report of Three Cases with Two Showing Coexisting Papillary Carcinoma.

Endocrine pathology

Baloch ZW, Feldman MD, LiVolsi VA.
PMID: 12114821
Endocr Pathol. 2000;11(2):157-163. doi: 10.1385/ep:11:2:157.

Extensive sclerosis of the thyroid gland can be seen in both benign and malignant conditions. The benign sclerosing lesions of the thyroid include Riedel's disease and fibrosing Hashimoto's thyroiditis. Although these conditions usually occur separately, rarely can they occur...

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Baloch ZW, Feldman MD, LiVolsi VA. Combined Riedel's Disease and Fibrosing Hashimoto's Thyroiditis: A Report of Three Cases with Two Showing Coexisting Papillary Carcinoma. Endocr Pathol. 2000;11(2):157-163doi: 10.1385/ep:11:2:157.
Baloch, Z. W., Feldman, M. D., & LiVolsi, V. A. (2000). Combined Riedel's Disease and Fibrosing Hashimoto's Thyroiditis: A Report of Three Cases with Two Showing Coexisting Papillary Carcinoma. Endocrine pathology, 11(2), 157-163. https://doi.org/10.1385/ep:11:2:157
Baloch, Zubair W., et al. "Combined Riedel's Disease and Fibrosing Hashimoto's Thyroiditis: A Report of Three Cases with Two Showing Coexisting Papillary Carcinoma." Endocrine pathology vol. 11,2 (2000): 157-163. doi: https://doi.org/10.1385/ep:11:2:157
Baloch ZW, Feldman MD, LiVolsi VA. Combined Riedel's Disease and Fibrosing Hashimoto's Thyroiditis: A Report of Three Cases with Two Showing Coexisting Papillary Carcinoma. Endocr Pathol. 2000;11(2):157-163. doi: 10.1385/ep:11:2:157. PMID: 12114821.
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Immunophenotypic studies of monoclonal gammopathy of undetermined significance.

BMC clinical pathology

Olteanu H, Wang HY, Chen W, McKenna RW, Karandikar NJ.
PMID: 19040735
BMC Clin Pathol. 2008 Nov 28;8:13. doi: 10.1186/1472-6890-8-13.

BACKGROUND: Monoclonal gammopathy of undetermined significance (MGUS) is a common plasma cell dyscrasia, comprising the most indolent form of monoclonal gammopathy. However, approximately 25% of MGUS cases ultimately progress to plasma cell myeloma (PCM) or related diseases. It is...

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Olteanu H, Wang HY, Chen W, et al. Immunophenotypic studies of monoclonal gammopathy of undetermined significance. BMC Clin Pathol. 2008;8:13doi: 10.1186/1472-6890-8-13.
Olteanu, H., Wang, H. Y., Chen, W., McKenna, R. W., & Karandikar, N. J. (2008). Immunophenotypic studies of monoclonal gammopathy of undetermined significance. BMC clinical pathology, 813. https://doi.org/10.1186/1472-6890-8-13
Olteanu, Horatiu, et al. "Immunophenotypic studies of monoclonal gammopathy of undetermined significance." BMC clinical pathology vol. 8 (2008): 13. doi: https://doi.org/10.1186/1472-6890-8-13
Olteanu H, Wang HY, Chen W, McKenna RW, Karandikar NJ. Immunophenotypic studies of monoclonal gammopathy of undetermined significance. BMC Clin Pathol. 2008 Nov 28;8:13. doi: 10.1186/1472-6890-8-13. PMID: 19040735; PMCID: PMC2606678.
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Toxic Immunoglobulin Light Chain Autoantibodies are Associated with a Cluster of Severe Complications in Older Adult Type 2 Diabetes.

Journal of endocrinology and diabetes

Zimering MB, Mirkovic N, Pandya M, Zimering JH, Behnke JA, Thakker-Varia S, Alder J, Donnelly RJ.
PMID: 29796423
J Endocrinol Diabetes. 2016;3(1). doi: 10.15226/2374-6890/3/1/00141. Epub 2016 Mar 08.

AIMS: To assess neuronal depolarization evoked by autoantibodies in diabetic depression compared to depolarization evoked by autoantibodies in control patients. To determine whether a subset of severe (late-onset) diabetic complications may be mediated in part by toxic immunoglobulin light...

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Zimering MB, Mirkovic N, Pandya M, et al. Toxic Immunoglobulin Light Chain Autoantibodies are Associated with a Cluster of Severe Complications in Older Adult Type 2 Diabetes. J Endocrinol Diabetes. 2016;3(1)doi: 10.15226/2374-6890/3/1/00141.
Zimering, M. B., Mirkovic, N., Pandya, M., Zimering, J. H., Behnke, J. A., Thakker-Varia, S., Alder, J., & Donnelly, R. J. (2016). Toxic Immunoglobulin Light Chain Autoantibodies are Associated with a Cluster of Severe Complications in Older Adult Type 2 Diabetes. Journal of endocrinology and diabetes, 3(1), . https://doi.org/10.15226/2374-6890/3/1/00141
Zimering, Mark B, et al. "Toxic Immunoglobulin Light Chain Autoantibodies are Associated with a Cluster of Severe Complications in Older Adult Type 2 Diabetes." Journal of endocrinology and diabetes vol. 3,1 (2016). doi: https://doi.org/10.15226/2374-6890/3/1/00141
Zimering MB, Mirkovic N, Pandya M, Zimering JH, Behnke JA, Thakker-Varia S, Alder J, Donnelly RJ. Toxic Immunoglobulin Light Chain Autoantibodies are Associated with a Cluster of Severe Complications in Older Adult Type 2 Diabetes. J Endocrinol Diabetes. 2016;3(1). doi: 10.15226/2374-6890/3/1/00141. Epub 2016 Mar 08. PMID: 29796423; PMCID: PMC5963888.
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Pulmonary arterial hypertension in primary amyloidosis.

Pulmonary circulation

Cirulis MM, Emerson LL, Bull DA, Hatton N, Nativi-Nicolai J, Hildebrandt GC, Ryan JJ.
PMID: 27252852
Pulm Circ. 2016 Jun;6(2):244-8. doi: 10.1086/686172.

Amyloidosis involves extravascular deposition of fibrillar proteins within tissues and organs. Primary light chain amyloidosis represents the most common form of systemic amyloidosis involving deposition of monoclonal immunoglobulin light chains. Although pulmonary amyloid deposition is common in primary amyloidosis,...

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Cirulis MM, Emerson LL, Bull DA, et al. Pulmonary arterial hypertension in primary amyloidosis. Pulm Circ. 2016;6(2):244-8doi: 10.1086/686172.
Cirulis, M. M., Emerson, L. L., Bull, D. A., Hatton, N., Nativi-Nicolai, J., Hildebrandt, G. C., & Ryan, J. J. (2016). Pulmonary arterial hypertension in primary amyloidosis. Pulmonary circulation, 6(2), 244-8. https://doi.org/10.1086/686172
Cirulis, Meghan M, et al. "Pulmonary arterial hypertension in primary amyloidosis." Pulmonary circulation vol. 6,2 (2016): 244-8. doi: https://doi.org/10.1086/686172
Cirulis MM, Emerson LL, Bull DA, Hatton N, Nativi-Nicolai J, Hildebrandt GC, Ryan JJ. Pulmonary arterial hypertension in primary amyloidosis. Pulm Circ. 2016 Jun;6(2):244-8. doi: 10.1086/686172. PMID: 27252852; PMCID: PMC4869930.
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Primary conjunctival amyloidosis and allergic conjunctivitis.

Archivos de la Sociedad Espanola de Oftalmologia

Romero-Caballero MD, Pozo-Lorenzo FJ, Berrio-Campos R, Quilez-Franco P, Pastor-Quirante FA.
PMID: 32616371
Arch Soc Esp Oftalmol (Engl Ed). 2020 Sep;95(9):455-458. doi: 10.1016/j.oftal.2020.04.014. Epub 2020 Jun 29.

Primary conjunctival amyloidosis is a rare disease of unknown origin, secondary to the deposit of amyloid material within the conjunctiva itself, producing a tumour. In the case presented, the concurrence of allergic conjunctivitis and chronic eye scratching could be...

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Romero-Caballero MD, Pozo-Lorenzo FJ, Berrio-Campos R, et al. Amiloidosis conjuntival primaria y conjuntivitis alérgica. Primary conjunctival amyloidosis and allergic conjunctivitis. Arch Soc Esp Oftalmol (Engl Ed). 2020;95(9):455-458doi: 10.1016/j.oftal.2020.04.014.
Romero-Caballero, M. D., Pozo-Lorenzo, F. J., Berrio-Campos, R., Quilez-Franco, P., & Pastor-Quirante, F. A. (2020). Amiloidosis conjuntival primaria y conjuntivitis alérgica. Primary conjunctival amyloidosis and allergic conjunctivitis. Archivos de la Sociedad Espanola de Oftalmologia, 95(9), 455-458. https://doi.org/10.1016/j.oftal.2020.04.014
Romero-Caballero, M D, et al. "Amiloidosis conjuntival primaria y conjuntivitis alérgica." Primary conjunctival amyloidosis and allergic conjunctivitis. Archivos de la Sociedad Espanola de Oftalmologia vol. 95,9 (2020): 455-458. doi: https://doi.org/10.1016/j.oftal.2020.04.014
Romero-Caballero MD, Pozo-Lorenzo FJ, Berrio-Campos R, Quilez-Franco P, Pastor-Quirante FA. Amiloidosis conjuntival primaria y conjuntivitis alérgica. Primary conjunctival amyloidosis and allergic conjunctivitis. Arch Soc Esp Oftalmol (Engl Ed). 2020 Sep;95(9):455-458. doi: 10.1016/j.oftal.2020.04.014. Epub 2020 Jun 29. Spanish. PMID: 32616371.
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Phase 1a/b study of monoclonal antibody CAEL-101 (11-1F4) in patients with AL amyloidosis.

Blood

Edwards CV, Rao N, Bhutani D, Mapara M, Radhakrishnan J, Shames S, Maurer MS, Leng S, Solomon A, Lentzsch S, Eisenberger A.
PMID: 34521113
Blood. 2021 Dec 23;138(25):2632-2641. doi: 10.1182/blood.2020009039.

Systemic immunoglobulin light-chain amyloidosis is characterized by pathologic deposition of immunoglobulin light chains as amyloid fibrils in vital organs, leading to organ impairment and eventual death. That the process is reversible was evidenced in an in vivo experimental model...

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Edwards CV, Rao N, Bhutani D, et al. Phase 1a/b study of monoclonal antibody CAEL-101 (11-1F4) in patients with AL amyloidosis. Blood. 2021;138(25):2632-2641doi: 10.1182/blood.2020009039.
Edwards, C. V., Rao, N., Bhutani, D., Mapara, M., Radhakrishnan, J., Shames, S., Maurer, M. S., Leng, S., Solomon, A., Lentzsch, S., & Eisenberger, A. (2021). Phase 1a/b study of monoclonal antibody CAEL-101 (11-1F4) in patients with AL amyloidosis. Blood, 138(25), 2632-2641. https://doi.org/10.1182/blood.2020009039
Edwards, Camille Vanessa, et al. "Phase 1a/b study of monoclonal antibody CAEL-101 (11-1F4) in patients with AL amyloidosis." Blood vol. 138,25 (2021): 2632-2641. doi: https://doi.org/10.1182/blood.2020009039
Edwards CV, Rao N, Bhutani D, Mapara M, Radhakrishnan J, Shames S, Maurer MS, Leng S, Solomon A, Lentzsch S, Eisenberger A. Phase 1a/b study of monoclonal antibody CAEL-101 (11-1F4) in patients with AL amyloidosis. Blood. 2021 Dec 23;138(25):2632-2641. doi: 10.1182/blood.2020009039. PMID: 34521113; PMCID: PMC8703360.
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Light Chain-Predominant Multiple Myeloma Subgroup: Impaired Renal Function Correlates with Decreased Survival.

Laboratory medicine

Singh G, Savage NM, Jillella AP, Bollag RJ.
PMID: 34388245
Lab Med. 2021 Aug 13; doi: 10.1093/labmed/lmab054. Epub 2021 Aug 13.

OBJECTIVE: Patients with light chain-predominant multiple myeloma have been shown to exhibit shorter survival. Retrospective comparison of clinical and laboratory data was undertaken to ascertain the likely cause(s) of this observation.METHODS: Records of patients with multiple myeloma seen at...

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Singh G, Savage NM, Jillella AP, et al. Light Chain-Predominant Multiple Myeloma Subgroup: Impaired Renal Function Correlates with Decreased Survival. Lab Med. 2021;doi: 10.1093/labmed/lmab054.
Singh, G., Savage, N. M., Jillella, A. P., & Bollag, R. J. (2021). Light Chain-Predominant Multiple Myeloma Subgroup: Impaired Renal Function Correlates with Decreased Survival. Laboratory medicine, . https://doi.org/10.1093/labmed/lmab054
Singh, Gurmukh, et al. "Light Chain-Predominant Multiple Myeloma Subgroup: Impaired Renal Function Correlates with Decreased Survival." Laboratory medicine vol. (2021). doi: https://doi.org/10.1093/labmed/lmab054
Singh G, Savage NM, Jillella AP, Bollag RJ. Light Chain-Predominant Multiple Myeloma Subgroup: Impaired Renal Function Correlates with Decreased Survival. Lab Med. 2021 Aug 13; doi: 10.1093/labmed/lmab054. Epub 2021 Aug 13. PMID: 34388245.
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Toxic Immunoglobulin Light Chain Autoantibodies are Associated with a Cluster of Severe Complications in Older Adult Type 2 Diabetes.

Journal of endocrinology and diabetes

Zimering MB, Mirkovic N, Pandya M, Zimering JH, Behnke JA, Thakker-Varia S, Alder J, Donnelly RJ.
PMID: 29796423
J Endocrinol Diabetes. 2016;3(1). doi: 10.15226/2374-6890/3/1/00141. Epub 2016 Mar 08.

AIMS: To assess neuronal depolarization evoked by autoantibodies in diabetic depression compared to depolarization evoked by autoantibodies in control patients. To determine whether a subset of severe (late-onset) diabetic complications may be mediated in part by toxic immunoglobulin light...

Cite
Zimering MB, Mirkovic N, Pandya M, et al. Toxic Immunoglobulin Light Chain Autoantibodies are Associated with a Cluster of Severe Complications in Older Adult Type 2 Diabetes. J Endocrinol Diabetes. 2016;3(1)doi: 10.15226/2374-6890/3/1/00141.
Zimering, M. B., Mirkovic, N., Pandya, M., Zimering, J. H., Behnke, J. A., Thakker-Varia, S., Alder, J., & Donnelly, R. J. (2016). Toxic Immunoglobulin Light Chain Autoantibodies are Associated with a Cluster of Severe Complications in Older Adult Type 2 Diabetes. Journal of endocrinology and diabetes, 3(1), . https://doi.org/10.15226/2374-6890/3/1/00141
Zimering, Mark B, et al. "Toxic Immunoglobulin Light Chain Autoantibodies are Associated with a Cluster of Severe Complications in Older Adult Type 2 Diabetes." Journal of endocrinology and diabetes vol. 3,1 (2016). doi: https://doi.org/10.15226/2374-6890/3/1/00141
Zimering MB, Mirkovic N, Pandya M, Zimering JH, Behnke JA, Thakker-Varia S, Alder J, Donnelly RJ. Toxic Immunoglobulin Light Chain Autoantibodies are Associated with a Cluster of Severe Complications in Older Adult Type 2 Diabetes. J Endocrinol Diabetes. 2016;3(1). doi: 10.15226/2374-6890/3/1/00141. Epub 2016 Mar 08. PMID: 29796423; PMCID: PMC5963888.
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Light Chain Deposition Disease Diagnosed Using Computed Tomography-Guided Kidney Biopsy.

Cureus

Shimamura Y, Ogawa Y, Takizawa H, Hayashi T, Sakurai Y.
PMID: 34159010
Cureus. 2021 May 18;13(5):e15102. doi: 10.7759/cureus.15102.

Light chain deposition disease (LCDD) is characterized by the deposition of monoclonal immunoglobulin light chains in the kidney, which can cause end-stage kidney disease if not treated. While kidney biopsy is required for definitive diagnosis, choosing an appropriate biopsy...

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Shimamura Y, Ogawa Y, Takizawa H, et al. Light Chain Deposition Disease Diagnosed Using Computed Tomography-Guided Kidney Biopsy. Cureus. 2021;13(5):e15102doi: 10.7759/cureus.15102.
Shimamura, Y., Ogawa, Y., Takizawa, H., Hayashi, T., & Sakurai, Y. (2021). Light Chain Deposition Disease Diagnosed Using Computed Tomography-Guided Kidney Biopsy. Cureus, 13(5), e15102. https://doi.org/10.7759/cureus.15102
Shimamura, Yoshinosuke, et al. "Light Chain Deposition Disease Diagnosed Using Computed Tomography-Guided Kidney Biopsy." Cureus vol. 13,5 (2021): e15102. doi: https://doi.org/10.7759/cureus.15102
Shimamura Y, Ogawa Y, Takizawa H, Hayashi T, Sakurai Y. Light Chain Deposition Disease Diagnosed Using Computed Tomography-Guided Kidney Biopsy. Cureus. 2021 May 18;13(5):e15102. doi: 10.7759/cureus.15102. PMID: 34159010; PMCID: PMC8212893.
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Free Immunoglobulin Light Chains in Patients with Tick-Borne Encephalitis: Before and after Treatment.

Journal of clinical medicine

Gudowska-Sawczuk M, Czupryna P, Moniuszko-Malinowska A, Pancewicz S, Mroczko B.
PMID: 34209994
J Clin Med. 2021 Jun 29;10(13). doi: 10.3390/jcm10132922.

BACKGROUND: Tick-borne encephalitis (TBE) is inflammation of the central nervous system (CNS) caused by a viral infection which may be associated with increased synthesis of immunoglobulins. It can lead to inter alia, breakdown of the blood-brain barrier (BBB), or...

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Gudowska-Sawczuk M, Czupryna P, Moniuszko-Malinowska A, et al. Free Immunoglobulin Light Chains in Patients with Tick-Borne Encephalitis: Before and after Treatment. J Clin Med. 2021;10(13)doi: 10.3390/jcm10132922.
Gudowska-Sawczuk, M., Czupryna, P., Moniuszko-Malinowska, A., Pancewicz, S., & Mroczko, B. (2021). Free Immunoglobulin Light Chains in Patients with Tick-Borne Encephalitis: Before and after Treatment. Journal of clinical medicine, 10(13), . https://doi.org/10.3390/jcm10132922
Gudowska-Sawczuk, Monika, et al. "Free Immunoglobulin Light Chains in Patients with Tick-Borne Encephalitis: Before and after Treatment." Journal of clinical medicine vol. 10,13 (2021). doi: https://doi.org/10.3390/jcm10132922
Gudowska-Sawczuk M, Czupryna P, Moniuszko-Malinowska A, Pancewicz S, Mroczko B. Free Immunoglobulin Light Chains in Patients with Tick-Borne Encephalitis: Before and after Treatment. J Clin Med. 2021 Jun 29;10(13). doi: 10.3390/jcm10132922. PMID: 34209994; PMCID: PMC8269011.
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Showing 1 to 12 of 75 entries