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Showing 1 to 4 of 4 entries
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Thirty years of intracrinology.

The Ochsner journal

Re RN.
PMID: 25598734
Ochsner J. 2014;14(4):673-80.

BACKGROUND: Intracrinology is the study of the intracellular actions, regulation, trafficking, and interactions of extracellular signaling peptides/proteins.METHODS: We describe the development of intracrine biology since the term was defined in 1984.RESULTS: Intracrine biology plays a role in many normal...

Host Intracellular Signaling Events and Pro-inflammatory Cytokine Production in African Trypanosomiasis.

Frontiers in immunology

Kuriakose SM, Singh R, Uzonna JE.
PMID: 27242788
Front Immunol. 2016 May 19;7:181. doi: 10.3389/fimmu.2016.00181. eCollection 2016.

Pathogens, such as bacteria, viruses, and parasites, possess specific molecules or proteins that are recognized by several host innate immune receptors, leading to the activation of several intracellular signaling molecules and pathways. The magnitude and quality of these events...

Evolution of breast cancer therapeutics: Breast tumour kinase's role in breast cancer and hope for breast tumour kinase targeted therapy.

World journal of clinical oncology

Hussain HA, Harvey AJ.
PMID: 25114846
World J Clin Oncol. 2014 Aug 10;5(3):299-310. doi: 10.5306/wjco.v5.i3.299.

There have been significant improvements in the detection and treatment of breast cancer in recent decades. However, there is still a need to develop more effective therapeutic techniques that are patient specific with reduced toxicity leading to further increases...

Can oliceridine (TRV130), an ideal novel µ receptor G protein pathway selective (µ-GPS) modulator, provide analgesia without opioid-related adverse reactions?.

The Korean journal of pain

Ok HG, Kim SY, Lee SJ, Kim TK, Huh BK, Kim KH.
PMID: 29686804
Korean J Pain. 2018 Apr;31(2):73-79. doi: 10.3344/kjp.2018.31.2.73. Epub 2018 Apr 02.

All drugs have both favorable therapeutic and untoward adverse effects. Conventional opioid analgesics possess both analgesia and adverse reactions, such as nausea, vomiting, and respiratory depression. The opioid ligand binds to µ opioid receptor and non-selectively activates two intracellular...

Showing 1 to 4 of 4 entries