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Showing 1 to 12 of 3819 entries
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Nanoencapsulation for drug delivery.

EXCLI journal

Kumari A, Singla R, Guliani A, Yadav SK.
PMID: 26417260
EXCLI J. 2014 Mar 20;13:265-86. eCollection 2014.

Nanoencapsulation of drug/small molecules in nanocarriers (NCs) is a very promising approach for development of nanomedicine. Modern drug encapsulation methods allow efficient loading of drug molecules inside the NCs thereby reducing systemic toxicity associated with drugs. Targeting of NCs...

Vaccine Potentiation by Combination Adjuvants.

Vaccines

Levast B, Awate S, Babiuk L, Mutwiri G, Gerdts V, van Drunen Littel-van den Hurk S.
PMID: 26344621
Vaccines (Basel). 2014 Apr 14;2(2):297-322. doi: 10.3390/vaccines2020297.

Adjuvants are crucial components of vaccines. They significantly improve vaccine efficacy by modulating, enhancing, or extending the immune response and at the same time reducing the amount of antigen needed. In contrast to previously licensed adjuvants, current successful adjuvant...

Practical Liposomal Formulation for Taxanes with Polyethoxylated Castor Oil and Ethanol with Complete Encapsulation Efficiency and High Loading Efficiency.

Nanomaterials (Basel, Switzerland)

Shigehiro T, Masuda J, Saito S, Khayrani AC, Jinno K, Seno A, Vaidyanath A, Mizutani A, Kasai T, Murakami H, Satoh A, Ito T, Hamada H, Seno Y, Mandai T, Seno M.
PMID: 28946623
Nanomaterials (Basel). 2017 Sep 23;7(10). doi: 10.3390/nano7100290.

Taxanes including paclitaxel and docetaxel are effective anticancer agents preferably sufficient for liposomal drug delivery. However, the encapsulation of these drugs with effective amounts into conventional liposomes is difficult due to their high hydrophobicity. Therefore, an effective encapsulation strategy...

Effect of molecular adjuvant inclusion in pH-sensitive polymer-modified liposomes on their performance as antigen delivery carriers for cancer immunotherapy.

Journal of controlled release : official journal of the Controlled Release Society

Yoshizaki Y, Yuba E, Sakaguchi N, Koiwai K, Harada A, Kono K.
PMID: 27005105
J Control Release. 2015 Sep 10;213:e143. doi: 10.1016/j.jconrel.2015.05.242. Epub 2015 Aug 19.

No abstract available.

Comparative efficacy of whole-brain radiotherapy with and without elemene liposomes in patients with multiple brain metastases from non-small-cell lung carcinoma.

Current oncology (Toronto, Ont.)

Sun YN, Zhang ZY, Zeng YC, Chi F, Jin XY, Wu R.
PMID: 27536187
Curr Oncol. 2016 Aug;23(4):e377-82. doi: 10.3747/co.23.3183. Epub 2016 Aug 12.

PURPOSE: We explored and compared the clinical effects of whole-brain radiotherapy (wbrt) with and without elemene liposomes in patients with multiple brain metastases from non-small-cell lung carcinoma (nsclc).METHODS: We retrospectively analyzed 62 patients with multiple brain metastases from nsclc...

Compartmentalization and Transport in Synthetic Vesicles.

Frontiers in bioengineering and biotechnology

Schmitt C, Lippert AH, Bonakdar N, Sandoghdar V, Voll LM.
PMID: 26973834
Front Bioeng Biotechnol. 2016 Feb 29;4:19. doi: 10.3389/fbioe.2016.00019. eCollection 2016.

Nanoscale vesicles have become a popular tool in life sciences. Besides liposomes that are generated from phospholipids of natural origin, polymersomes fabricated of synthetic block copolymers enjoy increasing popularity, as they represent more versatile membrane building blocks that can...

Structural and lipid-binding characterization of human annexin A13a reveals strong differences with its long A13b isoform.

Biological chemistry

Fernández-Lizarbe S, Lecona E, Santiago-Gómez A, Olmo N, Lizarbe MA, Turnay J.
PMID: 27676605
Biol Chem. 2017 Mar;398(3):359-371. doi: 10.1515/hsz-2016-0242.

Annexin A13 is the founder member of the vertebrate family of annexins, which are comprised of a tetrad of unique conserved domains responsible for calcium-dependent binding to membranes. Its expression is restricted to epithelial intestinal and kidney cells. Alternative...

Nano Liposomes Labeled with (99m)Tc-HMPAO, a Novel Agent for Blood Pool Imaging.

Iranian journal of pharmaceutical research : IJPR

Sadri K, Momenypoor S, Dabbagh Kakhki VR, Sadeghi R, Aryana K, Johari Daha F, Zakavi SR, Jaafari MR.
PMID: 26664365
Iran J Pharm Res. 2015;14(4):981-8.

In-vitro labeling of RBC with (99m)Tc is an intricate procedure and there is always a need for an alternate blood pool imaging agent. The aim of this study was to prepare an effective nano sized liposome (NLs) similar to...

In vitro antioxidant properties of the iron chelator pyridoxal isonicotinoyl hydrazone and some of its analogs.

Redox report : communications in free radical research

Schulman HM, Hermes-Lima M, Wang EM, Ponka P.
PMID: 27405837
Redox Rep. 1995 Nov;1(5):373-8. doi: 10.1080/13510002.1995.11747014.

Since there are several problems with desferrioxamine (DFO) therapy, pyridoxal isonicotinoyl hydrazone (PIH) has been studied for more than 10 years as a promising new candidate for iron chelation therapy in iron-overload diseases. Iron chelation could also be helpful...

Antioxidative and Prooxidative Actions of Xylose-Lysine Maillard Reaction Products.

Bioscience, biotechnology, and biochemistry

Yen GC, Liu ML.
PMID: 27392586
Biosci Biotechnol Biochem. 1998;62(5):864-9. doi: 10.1271/bbb.62.864.

Maillard reaction products were prepared by heating xylose and lysine at pH 9.0 and 100°C for 3 h, and then fractionated by ethyl ether and ethanol into acidic, neutral and basic low-molecular-weight, ethanol-soluble and ethanol-insoluble fractions. The ethanol-soluble and...

Inhibitory effect of some natural and semisynthetic phenolic lipids upon acetylcholinesterase activity.

Food chemistry

Stasiuk M, Bartosiewicz D, Kozubek A.
PMID: 26065763
Food Chem. 2008 Jun 01;108(3):996-1001. doi: 10.1016/j.foodchem.2007.12.011. Epub 2007 Dec 14.

The effect of phenolic lipids isolated from rye grains and cashew nut shell liquid (CNSL) from Anacardium occidentale and their semisynthetic derivatives on erythrocyte ghost's acetylcholinesterase activity was studied. It has been shown that all tested compounds decreased the...

Science and technology of the emerging nanomedicines in cancer therapy: A primer for physicians and pharmacists.

SAGE open medicine

Pillai G, Ceballos-Coronel ML.
PMID: 26770691
SAGE Open Med. 2013 Nov 23;1:2050312113513759. doi: 10.1177/2050312113513759. eCollection 2013.

Nanomedicine, the medical applications of devices based on nanotechnology, promises an endless range of applications from biomedical imaging to drug and gene delivery. The size range of the nanomaterials is strictly defined as 1-100 nm, although many marketed nanomedicines...

Showing 1 to 12 of 3819 entries