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Showing 1 to 12 of 117 entries
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Morphological comparison and functional reconstitution of rat hepatic parenchymal cells on various matrices.

Journal of gastroenterology and hepatology

Awata R, Sawai H, Imai K, Terada K, Senoo H, Sugiyama T.
PMID: 28976700
J Gastroenterol Hepatol. 1998 Sep;13:S55-S61. doi: 10.1111/jgh.1998.13.s1.55.

Four types of materials, type I collagen coat (Coat), acid-soluble type I collagen gel (Hardgel), pepsin-treated acid-soluble type I collagen gel (Softgel), and an extract of extracellular matrix of the murine Engelbreth-Holm-Swarm sarcoma (Matrigel), were used as matrices to...

Mesenchymal stem cells inhibited development of lung cancer induced by chemical carcinogens in a rat model.

American journal of translational research

Liu T, Zhu K, Ke C, Yang S, Yang F, Li Z, Zhang Z.
PMID: 28670377
Am J Transl Res. 2017 Jun 15;9(6):2891-2900. eCollection 2017.

Mesenchymal stem cells (MSCs) may play a significant role in carcinogenesis; however, data have shown that MSCs can both promote and inhibit tumor growth. We investigated the effect of MSCs on the development of lung cancer in a rat...

Tumour-promoting phorbol esters rapidly inhibit bud formation in hydra.

Roux's archives of developmental biology : the official organ of the EDBO

Shiba Y, Yamasaki H, Kanno Y.
PMID: 28305392
Rouxs Arch Dev Biol. 1987 Oct;196(7):445-449. doi: 10.1007/BF00399144.

The effects of tumour promoters and carcinogens on bud formation were investigated in an attempt to clarify the primary process of bud formation in hydra. Treatment with 1.0ng/ml 12-O-tetradecanoylphorbol-13-acetate (TPA), phorbol-12,13-didecanoate (PDD) or mezerein added immediately after feeding rapidly...

Correlation between in vivo antipyrine metabolite formation and theophylline metabolism in rats.

Pharmaceutical research

Teunissen MW, Brorens IO, De Langen HJ, Geerlings AM, Breimer DD.
PMID: 24271521
Pharm Res. 1986 Jun;3(3):156-61. doi: 10.1023/A:1016361907787.

Two model substrates for oxidative hepatic enzyme activity, viz. antipyrine (A) and theophylline (T), were given simultaneously to rats by iv administration. Blood concentrations of A and T were measured by a high-performance liquid chromatographic (HPLC) method. Urinary excretions...

Cloning and Sequencing of Cytochrome P450 1A Complementary DNA in Eel (Anguilla japonica).

Marine biotechnology (New York, N.Y.)

Mitsuo R, Itakura T, Sato M.
PMID: 10489411
Mar Biotechnol (NY). 1999 Jul;1(4):353-358. doi: 10.1007/pl00011786.

: Cytochrome P450 1A (CYP1A) complementary DNA was isolated from eel (Anguilla japonica) liver treated with 3-methylcholanthrene. The cDNA contained a 5' untranslated region of 163 bp, an open reading flame of 1560 bp coding for 519 amino acids...

An Eel Cytochrome P450 1A Gene Having No XRE Sequences in Its 5' Upstream Region of 1600 bp.

Marine biotechnology (New York, N.Y.)

Aoki J, Sato M, Itakura T.
PMID: 10811956
Mar Biotechnol (NY). 2000 Mar;2(2):167-172. doi: 10.1007/s101269900021.

The gene family cytochrome P450 (CYP) 1A is ubiquitous among animals, and CYP1A1 genes have been identified in teleost and mammals. We isolated another CYP1A gene, which is inducibly expressed by exposure to 3-methylcholanthrene, from the genomic library of...

L-arginine supplementation does not affect chemically induced carcinogenesis and tumor growth in BALB-c mice.

Hippokratia

Eleftheriadis T, Voyatzi S, Sparopoulou T, Kartsios C, Yiannaki E, Antoniadi G, Liakopoulos V, Galaktidou G.
PMID: 19582209
Hippokratia. 2007 Jul;11(3):142-4.

UNLABELLED: T-cell zeta-chain downregulation is common in various types of cancer and it is proposed as a mechanism of cancer immunosubversion. L-arginine consumption by arginase rich suppressor myeloid cells has been incriminated. The effect of L-arginine supplementation on chemically...

Stimulation of troutCYP1A gene expression in mouse HEPA-1 cells by 3-methylcholanthrene.

Archives of pharmacal research

Lee SY, Sheen YY.
PMID: 18982480
Arch Pharm Res. 1997 Oct;20(5):404-9. doi: 10.1007/BF02973930.

TroutCYP1A-CAT expression construct was generated by cloning approximately 3.5 Kb 5' flanking DNA of trout liverCYP1A gene in front of CAT gene at pCAT-basic vector. Hepa 1 cells, which are known to contain a functional arylhydrocarbon receptor' were transfected...

THE CARCINOGENIC EFFECT OF METHYLCHOLANTHRENE AND OF TAR ON RABBIT PAPILLOMAS DUE TO A VIRUS.

Science (New York, N.Y.)

Rous P, Friedewald WF.
PMID: 17755919
Science. 1941 Nov 21;94(2447):495-6. doi: 10.1126/science.94.2447.495.

No abstract available.

Effects of various inducers on the expression of cytochromes P-450 IIC8, 9, 10 and IIIA in cultured adult human hepatocytes.

Toxicology in vitro : an international journal published in association with BIBRA

Morel F, Beaune P, Ratanasavanh D, Flinois JP, Guengerich FP, Guillouzo A.
PMID: 20702214
Toxicol In Vitro. 1990;4(4):458-60. doi: 10.1016/0887-2333(90)90100-8.

Primary cultures of adult human hepatocytes were used to determine the capability of the human liver to respond to phenobarbital, 3-methylcholanthrene, troleandomycin and rifampicin, four compounds known to be potent inducers of hepatic cytochrome P-450 in various animal species....

Enhanced sensitivity of perifused primary rat hepatocytes to mitogens and growth modulation by carcinogens.

Toxicology in vitro : an international journal published in association with BIBRA

Gebhardt R, Fischer S.
PMID: 20650111
Toxicol In Vitro. 1995 Aug;9(4):445-51. doi: 10.1016/0887-2333(95)00050-i.

Comparison of stationary cultivation (repeated changes of medium) with perifusion (continuous flow of medium) revealed that perifused hepatocytes show enhanced basal proliferation and are more sensitive to insulin and EGF. Similarly, the sensitivity of bromodeoxyuridine incorporation to inhibition by...

Quantitative studies of the metabolism of furazolidone by rat liver microsomes.

Toxicology in vitro : an international journal published in association with BIBRA

Vroomen LH, van Ommen B, van Bladeren PJ.
PMID: 20647073
Toxicol In Vitro. 1987;1(2):97-104. doi: 10.1016/0887-2333(87)90007-5.

The nitrofuran, furazolidone, is metabolized by rat liver microsomes under both aerobic and anaerobic conditions, the rates for microsomes from 3-methylcholanthrene-induced male rats being 3.52 and 4.26 nmol/mg protein/min, respectively. The two major metabolites formed are the well-known 3-(4-cyano-2-oxobutylideneamino)-2-oxazolidone,...

Showing 1 to 12 of 117 entries