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Structure and function of mammalian DNA methyltransferases

science campus

Jurkowska RZ, Jurkowski TP, Jeltsch A.
GSID: ZdvSXilF-GkJ
RZ Jurkowska, TP Jurkowski, A Jeltsch - Chembiochem, 2011 - Wiley Online Library

DNA methylation plays an important role in epigenetic signalling, having an impact on gene regulation, chromatin structure, development and disease. Here, we review the structures and functions of the mammalian DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b, …

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Jurkowska, R. Z., Jurkowski, T. P., & Jeltsch, A. (2011). Structure and function of mammalian DNA methyltransferases. Chembiochem, 12(2), 206-222.
Jurkowska, Renata Zofia, Tomasz Piotr Jurkowski, and Albert Jeltsch. "Structure and function of mammalian DNA methyltransferases." Chembiochem 12.2 (2011): 206-222.
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Nicotinamide metabolism regulates glioblastoma stem cell maintenance.

JCI insight

Jung J, Kim LJ, Wang X, Wu Q, Sanvoranart T, Hubert CG, Prager BC, Wallace LC, Jin X, Mack SC, Rich JN.
PMID: 28515364
JCI Insight. 2017 May 18;2(10). doi: 10.1172/jci.insight.90019. eCollection 2017 May 18.

Metabolic dysregulation promotes cancer growth through not only energy production, but also epigenetic reprogramming. Here, we report that a critical node in methyl donor metabolism, nicotinamide N-methyltransferase (NNMT), ranked among the most consistently overexpressed metabolism genes in glioblastoma relative...

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Jung J, Kim LJ, Wang X, et al. Nicotinamide metabolism regulates glioblastoma stem cell maintenance. JCI Insight. 2017;2(10)doi: 10.1172/jci.insight.90019.
Jung, J., Kim, L. J., Wang, X., Wu, Q., Sanvoranart, T., Hubert, C. G., Prager, B. C., Wallace, L. C., Jin, X., Mack, S. C., & Rich, J. N. (2017). Nicotinamide metabolism regulates glioblastoma stem cell maintenance. JCI insight, 2(10), . https://doi.org/10.1172/jci.insight.90019
Jung, Jinkyu, et al. "Nicotinamide metabolism regulates glioblastoma stem cell maintenance." JCI insight vol. 2,10 (2017). doi: https://doi.org/10.1172/jci.insight.90019
Jung J, Kim LJ, Wang X, Wu Q, Sanvoranart T, Hubert CG, Prager BC, Wallace LC, Jin X, Mack SC, Rich JN. Nicotinamide metabolism regulates glioblastoma stem cell maintenance. JCI Insight. 2017 May 18;2(10). doi: 10.1172/jci.insight.90019. eCollection 2017 May 18. PMID: 28515364; PMCID: PMC5436539.
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Selective repression of SINE transcription by RNA polymerase III.

Mobile genetic elements

Varshney D, Vavrova-Anderson J, Oler AJ, Cairns BR, White RJ.
PMID: 26942044
Mob Genet Elements. 2015 Sep 23;5(6):86-91. doi: 10.1080/2159256X.2015.1096997. eCollection 2015.

A million copies of the Alu short interspersed nuclear element (SINE) are scattered throughout the human genome, providing ∼11% of our total DNA. SINEs spread by retrotransposition, using a transcript generated by RNA polymerase (pol) III from an internal...

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Varshney D, Vavrova-Anderson J, Oler AJ, et al. Selective repression of SINE transcription by RNA polymerase III. Mob Genet Elements. 2015;5(6):86-91doi: 10.1080/2159256X.2015.1096997.
Varshney, D., Vavrova-Anderson, J., Oler, A. J., Cairns, B. R., & White, R. J. (2015). Selective repression of SINE transcription by RNA polymerase III. Mobile genetic elements, 5(6), 86-91. https://doi.org/10.1080/2159256X.2015.1096997
Varshney, Dhaval, et al. "Selective repression of SINE transcription by RNA polymerase III." Mobile genetic elements vol. 5,6 (2015): 86-91. doi: https://doi.org/10.1080/2159256X.2015.1096997
Varshney D, Vavrova-Anderson J, Oler AJ, Cairns BR, White RJ. Selective repression of SINE transcription by RNA polymerase III. Mob Genet Elements. 2015 Sep 23;5(6):86-91. doi: 10.1080/2159256X.2015.1096997. eCollection 2015. PMID: 26942044; PMCID: PMC4755245.
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As(III) S-adenosylmethionine methyltransferases and other arsenic binding proteins.

Geomicrobiology journal

Ajees AA, Rosen BP.
PMID: 26366023
Geomicrobiol J. 2015;32(7):570-576. doi: 10.1080/01490451.2014.908983.

Efflux is by far the most common means of arsenic detoxification is by methylation catalyzed by a family of As(III) S-adenosylmethionine (SAM) methyltransferases (MTs) enzymes designated ArsM in microbes or AS3MT in higher eukaryotes. The protein sequence of more...

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Ajees AA, Rosen BP. As(III) S-adenosylmethionine methyltransferases and other arsenic binding proteins. Geomicrobiol J. 2015;32(7):570-576doi: 10.1080/01490451.2014.908983.
Ajees, A. A., & Rosen, B. P. (2015). As(III) S-adenosylmethionine methyltransferases and other arsenic binding proteins. Geomicrobiology journal, 32(7), 570-576. https://doi.org/10.1080/01490451.2014.908983
Ajees, A Abdul, and Rosen, Barry P. "As(III) S-adenosylmethionine methyltransferases and other arsenic binding proteins." Geomicrobiology journal vol. 32,7 (2015): 570-576. doi: https://doi.org/10.1080/01490451.2014.908983
Ajees AA, Rosen BP. As(III) S-adenosylmethionine methyltransferases and other arsenic binding proteins. Geomicrobiol J. 2015;32(7):570-576. doi: 10.1080/01490451.2014.908983. PMID: 26366023; PMCID: PMC4564252.
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5 Methylation and demethylation of his tone arg and lys residues in chromatin structure and function.

The Enzymes

Wang Y.
PMID: 26718039
Enzymes. 2006;24:123-53. doi: 10.1016/S1874-6047(06)80007-7. Epub 2010 Nov 08.

Chromatin is the physiological template of all eukaryotic genomic activities. Histone proteins are the fundamental building elements of chromatin, which are the subject of various posttranslational modifications, including methylation. Adding and removing the methyl moieties from histones plays an...

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Wang Y. 5 Methylation and demethylation of his tone arg and lys residues in chromatin structure and function. Enzymes. 2010;24:123-53doi: 10.1016/S1874-6047(06)80007-7.
Wang, Y. (2006). 5 Methylation and demethylation of his tone arg and lys residues in chromatin structure and function. The Enzymes, 24123-53. https://doi.org/10.1016/S1874-6047(06)80007-7
Wang, Yanming. "5 Methylation and demethylation of his tone arg and lys residues in chromatin structure and function." The Enzymes vol. 24 (2006): 123-53. doi: https://doi.org/10.1016/S1874-6047(06)80007-7
Wang Y. 5 Methylation and demethylation of his tone arg and lys residues in chromatin structure and function. Enzymes. 2006;24:123-53. doi: 10.1016/S1874-6047(06)80007-7. Epub 2010 Nov 08. PMID: 26718039.
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6 Structure of SET domain protein lysine methyltransferases.

The Enzymes

Xiao B, Gamblin SJ, Wilson JR.
PMID: 26718040
Enzymes. 2006;24:155-78. doi: 10.1016/S1874-6047(06)80008-9. Epub 2007 Jun 04.

Methylation of lysine residues is now understood to constitute a key component of the complex signaling paradigm referred to as the histone code hypothesis. Rapid progress has been made in the structural and functional biology of the enzymes responsible...

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Xiao B, Gamblin SJ, Wilson JR. 6 Structure of SET domain protein lysine methyltransferases. Enzymes. 2007;24:155-78doi: 10.1016/S1874-6047(06)80008-9.
Xiao, B., Gamblin, S. J., & Wilson, J. R. (2006). 6 Structure of SET domain protein lysine methyltransferases. The Enzymes, 24155-78. https://doi.org/10.1016/S1874-6047(06)80008-9
Xiao, Bing, et al. "6 Structure of SET domain protein lysine methyltransferases." The Enzymes vol. 24 (2006): 155-78. doi: https://doi.org/10.1016/S1874-6047(06)80008-9
Xiao B, Gamblin SJ, Wilson JR. 6 Structure of SET domain protein lysine methyltransferases. Enzymes. 2006;24:155-78. doi: 10.1016/S1874-6047(06)80008-9. Epub 2007 Jun 04. PMID: 26718040.
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DNA Demethylation Upregulated Nrf2 Expression in Alzheimer's Disease Cellular Model.

Frontiers in aging neuroscience

Cao H, Wang L, Chen B, Zheng P, He Y, Ding Y, Deng Y, Lu X, Guo X, Zhang Y, Li Y, Yu G.
PMID: 26779013
Front Aging Neurosci. 2016 Jan 05;7:244. doi: 10.3389/fnagi.2015.00244. eCollection 2015.

UNLABELLED: Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important transcription factor in the defense against oxidative stress. Cumulative evidence has shown that oxidative stress plays a key role in the pathogenesis of Alzheimer's disease (AD). Previous animal...

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Cao H, Wang L, Chen B, et al. DNA Demethylation Upregulated Nrf2 Expression in Alzheimer's Disease Cellular Model. Front Aging Neurosci. 2016;7:244doi: 10.3389/fnagi.2015.00244.
Cao, H., Wang, L., Chen, B., Zheng, P., He, Y., Ding, Y., Deng, Y., Lu, X., Guo, X., Zhang, Y., Li, Y., & Yu, G. (2015). DNA Demethylation Upregulated Nrf2 Expression in Alzheimer's Disease Cellular Model. Frontiers in aging neuroscience, 7244. https://doi.org/10.3389/fnagi.2015.00244
Cao, Huimin, et al. "DNA Demethylation Upregulated Nrf2 Expression in Alzheimer's Disease Cellular Model." Frontiers in aging neuroscience vol. 7 (2015): 244. doi: https://doi.org/10.3389/fnagi.2015.00244
Cao H, Wang L, Chen B, Zheng P, He Y, Ding Y, Deng Y, Lu X, Guo X, Zhang Y, Li Y, Yu G. DNA Demethylation Upregulated Nrf2 Expression in Alzheimer's Disease Cellular Model. Front Aging Neurosci. 2016 Jan 05;7:244. doi: 10.3389/fnagi.2015.00244. eCollection 2015. PMID: 26779013; PMCID: PMC4700271.
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A simplified characterization of .

Chemical science

Burgos ES, Walters RO, Huffman DM, Shechter D.
PMID: 29449933
Chem Sci. 2017 Sep 01;8(9):6601-6612. doi: 10.1039/c7sc02830j. Epub 2017 Jul 27.

Methyltransferases use

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Burgos ES, Walters RO, Huffman DM, et al. A simplified characterization of . Chem Sci. 2017;8(9):6601-6612doi: 10.1039/c7sc02830j.
Burgos, E. S., Walters, R. O., Huffman, D. M., & Shechter, D. (2017). A simplified characterization of . Chemical science, 8(9), 6601-6612. https://doi.org/10.1039/c7sc02830j
Burgos, Emmanuel S, et al. "A simplified characterization of ." Chemical science vol. 8,9 (2017): 6601-6612. doi: https://doi.org/10.1039/c7sc02830j
Burgos ES, Walters RO, Huffman DM, Shechter D. A simplified characterization of . Chem Sci. 2017 Sep 01;8(9):6601-6612. doi: 10.1039/c7sc02830j. Epub 2017 Jul 27. PMID: 29449933; PMCID: PMC5676521.
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[No title available]

Cancer cell international

Rabello DDA, Ferreira VDDS, Berzoti-Coelho MG, Burin SM, Magro CL, Cacemiro MDC, Simões BP, Saldanha-Araujo F, de Castro FA, Pittella-Silva F.
PMID: 29483845
Cancer Cell Int. 2018 Feb 20;18:26. doi: 10.1186/s12935-018-0523-1. eCollection 2018.

BACKGROUND: Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm whose pathogenesis is linked to the Philadelphia chromosome presence that generates the METHODS: Here we investigated the expression profile of both genes in CML patients in different stages of...

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Rabello DDA, Ferreira VDDS, Berzoti-Coelho MG, et al. . Cancer Cell Int. 2018;18:26doi: 10.1186/s12935-018-0523-1.
Rabello, D. D. A., Ferreira, V. D. D. S., Berzoti-Coelho, M. G., Burin, S. M., Magro, C. L., Cacemiro, M. D. C., Simões, B. P., Saldanha-Araujo, F., de Castro, F. A., & Pittella-Silva, F. (2018). . Cancer cell international, 1826. https://doi.org/10.1186/s12935-018-0523-1
Rabello, Doralina do Amaral, et al. "." Cancer cell international vol. 18 (2018): 26. doi: https://doi.org/10.1186/s12935-018-0523-1
Rabello DDA, Ferreira VDDS, Berzoti-Coelho MG, Burin SM, Magro CL, Cacemiro MDC, Simões BP, Saldanha-Araujo F, de Castro FA, Pittella-Silva F. . Cancer Cell Int. 2018 Feb 20;18:26. doi: 10.1186/s12935-018-0523-1. eCollection 2018. PMID: 29483845; PMCID: PMC5819641.
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DNA Methylation.

EcoSal Plus

Marinus MG, Løbner-Olesen A.
PMID: 26442938
EcoSal Plus. 2014 May;6(1). doi: 10.1128/ecosalplus.ESP-0003-2013.

The DNA of Escherichia coli contains 19,120 6-methyladenines and 12,045 5-methylcytosines in addition to the four regular bases, and these are formed by the postreplicative action of three DNA methyltransferases. The majority of the methylated bases are formed by...

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Marinus MG, Løbner-Olesen A. DNA Methylation. EcoSal Plus. 2014;6(1)doi: 10.1128/ecosalplus.ESP-0003-2013.
Marinus, M. G., & Løbner-Olesen, A. (2014). DNA Methylation. EcoSal Plus, 6(1), . https://doi.org/10.1128/ecosalplus.ESP-0003-2013
Marinus, M G, and Løbner-Olesen, A. "DNA Methylation." EcoSal Plus vol. 6,1 (2014). doi: https://doi.org/10.1128/ecosalplus.ESP-0003-2013
Marinus MG, Løbner-Olesen A. DNA Methylation. EcoSal Plus. 2014 May;6(1). doi: 10.1128/ecosalplus.ESP-0003-2013. PMID: 26442938; PMCID: PMC4231299.
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Genetic and Epigenetic of Medullary Thyroid Cancer.

Iranian biomedical journal

Khatami F, Tavangar SM.
PMID: 29126344
Iran Biomed J. 2018 May 01;22(3):142-50. doi: 10.22034/ibj.22.3.142. Epub 2017 Nov 11.

Medullary thyroid carcinoma (MTC) is an infrequent, calcitonin producing neuroendocrine tumor and initiates from the parafollicular C cells of the thyroid gland. Several genetic and epigenetic alterations are collaterally responsible for medullary thyroid carcinogenesis. In this review article, we...

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Khatami F, Tavangar SM. Genetic and Epigenetic of Medullary Thyroid Cancer. Iran Biomed J. 2017;22(3):142-50doi: 10.22034/ibj.22.3.142.
Khatami, F., & Tavangar, S. M. (2018). Genetic and Epigenetic of Medullary Thyroid Cancer. Iranian biomedical journal, 22(3), 142-50. https://doi.org/10.22034/ibj.22.3.142
Khatami, Fatemeh, and Tavangar, Seyed Mohammad. "Genetic and Epigenetic of Medullary Thyroid Cancer." Iranian biomedical journal vol. 22,3 (2018): 142-50. doi: https://doi.org/10.22034/ibj.22.3.142
Khatami F, Tavangar SM. Genetic and Epigenetic of Medullary Thyroid Cancer. Iran Biomed J. 2018 May 01;22(3):142-50. doi: 10.22034/ibj.22.3.142. Epub 2017 Nov 11. PMID: 29126344; PMCID: PMC5889499.
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O-diphenol O-methyltransferases of healthy and tobacco-mosaic-virus-infected hypersensitive tobacco.

Planta

Legrand M, Fritig B, Hirth L.
PMID: 24408651
Planta. 1978 Jan;144(1):101-8. doi: 10.1007/BF00385014.

Three distinct o-diphenol O-methyltransferases (OMTs) were found in leaves of Nicotiana tabacum, variety Samsun NN. They could be clearly distinguished by differences in elution pattern upon chromatography on DEAE-cellulose and in specificity towards 16 diphenolic substrates. The phenylpropanoids caffeic...

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Legrand M, Fritig B, Hirth L. O-diphenol O-methyltransferases of healthy and tobacco-mosaic-virus-infected hypersensitive tobacco. Planta. 1978;144(1):101-8doi: 10.1007/BF00385014.
Legrand, M., Fritig, B., & Hirth, L. (1978). O-diphenol O-methyltransferases of healthy and tobacco-mosaic-virus-infected hypersensitive tobacco. Planta, 144(1), 101-8. https://doi.org/10.1007/BF00385014
Legrand, M, et al. "O-diphenol O-methyltransferases of healthy and tobacco-mosaic-virus-infected hypersensitive tobacco." Planta vol. 144,1 (1978): 101-8. doi: https://doi.org/10.1007/BF00385014
Legrand M, Fritig B, Hirth L. O-diphenol O-methyltransferases of healthy and tobacco-mosaic-virus-infected hypersensitive tobacco. Planta. 1978 Jan;144(1):101-8. doi: 10.1007/BF00385014. PMID: 24408651.
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Showing 1 to 12 of 948 entries