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Podoplanin: emerging functions in development, the immune system, and cancer.

Frontiers in immunology

Astarita JL, Acton SE, Turley SJ.
PMID: 22988448
Front Immunol. 2012 Sep 12;3:283. doi: 10.3389/fimmu.2012.00283. eCollection 2012.

Podoplanin (PDPN) is a well-conserved, mucin-type transmembrane protein expressed in multiple tissues during ontogeny and in adult animals, including the brain, heart, kidney, lungs, osteoblasts, and lymphoid organs. Studies of PDPN-deficient mice have demonstrated that this molecule plays a...

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Astarita JL, Acton SE, Turley SJ. Podoplanin: emerging functions in development, the immune system, and cancer. Front Immunol. 2012;3:283doi: 10.3389/fimmu.2012.00283.
Astarita, J. L., Acton, S. E., & Turley, S. J. (2012). Podoplanin: emerging functions in development, the immune system, and cancer. Frontiers in immunology, 3283. https://doi.org/10.3389/fimmu.2012.00283
Astarita, Jillian L, et al. "Podoplanin: emerging functions in development, the immune system, and cancer." Frontiers in immunology vol. 3 (2012): 283. doi: https://doi.org/10.3389/fimmu.2012.00283
Astarita JL, Acton SE, Turley SJ. Podoplanin: emerging functions in development, the immune system, and cancer. Front Immunol. 2012 Sep 12;3:283. doi: 10.3389/fimmu.2012.00283. eCollection 2012. PMID: 22988448; PMCID: PMC3439854.
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IL4RA on lymphatic endothelial cells promotes T cell egress during sclerodermatous graft versus host disease.

JCI insight

Urso K, Alvarez D, Cremasco V, Tsang K, Grauel A, Lafyatis R, von Andrian UH, Ermann J, Aliprantis AO.
PMID: 27547823
JCI Insight. 2016 Aug 04;1(12). doi: 10.1172/jci.insight.88057.

Systemic sclerosis (SSc) is a potentially fatal autoimmune disorder with limited therapeutic options. Sclerodermatous graft versus host disease (sclGvHD), induced by transfer of B10.D2 splenocytes into BALB/c

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Urso K, Alvarez D, Cremasco V, et al. IL4RA on lymphatic endothelial cells promotes T cell egress during sclerodermatous graft versus host disease. JCI Insight. 2016;1(12)doi: 10.1172/jci.insight.88057.
Urso, K., Alvarez, D., Cremasco, V., Tsang, K., Grauel, A., Lafyatis, R., von Andrian, U. H., Ermann, J., & Aliprantis, A. O. (2016). IL4RA on lymphatic endothelial cells promotes T cell egress during sclerodermatous graft versus host disease. JCI insight, 1(12), . https://doi.org/10.1172/jci.insight.88057
Urso, Katia, et al. "IL4RA on lymphatic endothelial cells promotes T cell egress during sclerodermatous graft versus host disease." JCI insight vol. 1,12 (2016). doi: https://doi.org/10.1172/jci.insight.88057
Urso K, Alvarez D, Cremasco V, Tsang K, Grauel A, Lafyatis R, von Andrian UH, Ermann J, Aliprantis AO. IL4RA on lymphatic endothelial cells promotes T cell egress during sclerodermatous graft versus host disease. JCI Insight. 2016 Aug 04;1(12). doi: 10.1172/jci.insight.88057. PMID: 27547823; PMCID: PMC4988402.
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TIGIT signaling restores suppressor function of Th1 Tregs.

JCI insight

Lucca LE, Axisa PP, Singer ER, Nolan NM, Dominguez-Villar M, Hafler DA.
PMID: 30728325
JCI Insight. 2019 Feb 07;4(3). doi: 10.1172/jci.insight.124427. Epub 2019 Feb 07.

Th1 Tregs are characterized by the acquisition of proinflammatory cytokine secretion and reduced suppressor activity. Th1 Tregs are found at increased frequency in autoimmune diseases, including type 1 diabetes and multiple sclerosis (MS). We have previously reported that in...

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Lucca LE, Axisa PP, Singer ER, et al. TIGIT signaling restores suppressor function of Th1 Tregs. JCI Insight. 2019;4(3)doi: 10.1172/jci.insight.124427.
Lucca, L. E., Axisa, P. P., Singer, E. R., Nolan, N. M., Dominguez-Villar, M., & Hafler, D. A. (2019). TIGIT signaling restores suppressor function of Th1 Tregs. JCI insight, 4(3), . https://doi.org/10.1172/jci.insight.124427
Lucca, Liliana E, et al. "TIGIT signaling restores suppressor function of Th1 Tregs." JCI insight vol. 4,3 (2019). doi: https://doi.org/10.1172/jci.insight.124427
Lucca LE, Axisa PP, Singer ER, Nolan NM, Dominguez-Villar M, Hafler DA. TIGIT signaling restores suppressor function of Th1 Tregs. JCI Insight. 2019 Feb 07;4(3). doi: 10.1172/jci.insight.124427. Epub 2019 Feb 07. PMID: 30728325; PMCID: PMC6413794.
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IgE/FcεRI-Mediated Antigen Cross-Presentation by Dendritic Cells Enhances Anti-Tumor Immune Responses.

Cell reports

Platzer B, Elpek KG, Cremasco V, Baker K, Stout MM, Schultz C, Dehlink E, Shade KC, Anthony RM, Blumberg RS, Turley SJ, Fiebiger E.
PMID: 25753415
Cell Rep. 2015 Mar 10;10(9):1487-1495. doi: 10.1016/j.celrep.2015.02.015. Epub 2015 Mar 05.

Epidemiologic studies discovered an inverse association between immunoglobulin E (IgE)-mediated allergies and cancer, implying tumor-protective properties of IgE. However, the underlying immunologic mechanisms remain poorly understood. Antigen cross-presentation by dendritic cells (DCs) is of key importance for anti-tumor immunity...

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Platzer B, Elpek KG, Cremasco V, et al. IgE/FcεRI-Mediated Antigen Cross-Presentation by Dendritic Cells Enhances Anti-Tumor Immune Responses. Cell Rep. 2015;10(9):1487-1495doi: 10.1016/j.celrep.2015.02.015.
Platzer, B., Elpek, K. G., Cremasco, V., Baker, K., Stout, M. M., Schultz, C., Dehlink, E., Shade, K. C., Anthony, R. M., Blumberg, R. S., Turley, S. J., & Fiebiger, E. (2015). IgE/FcεRI-Mediated Antigen Cross-Presentation by Dendritic Cells Enhances Anti-Tumor Immune Responses. Cell reports, 10(9), 1487-1495. https://doi.org/10.1016/j.celrep.2015.02.015
Platzer, Barbara, et al. "IgE/FcεRI-Mediated Antigen Cross-Presentation by Dendritic Cells Enhances Anti-Tumor Immune Responses." Cell reports vol. 10,9 (2015): 1487-1495. doi: https://doi.org/10.1016/j.celrep.2015.02.015
Platzer B, Elpek KG, Cremasco V, Baker K, Stout MM, Schultz C, Dehlink E, Shade KC, Anthony RM, Blumberg RS, Turley SJ, Fiebiger E. IgE/FcεRI-Mediated Antigen Cross-Presentation by Dendritic Cells Enhances Anti-Tumor Immune Responses. Cell Rep. 2015 Mar 10;10(9):1487-1495. doi: 10.1016/j.celrep.2015.02.015. Epub 2015 Mar 05. PMID: 25753415; PMCID: PMC4559493.
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PD-1 marks dysfunctional regulatory T cells in malignant gliomas.

JCI insight

Lowther DE, Goods BA, Lucca LE, Lerner BA, Raddassi K, van Dijk D, Hernandez AL, Duan X, Gunel M, Coric V, Krishnaswamy S, Love JC, Hafler DA.
PMID: 27182555
JCI Insight. 2016 Apr 21;1(5). doi: 10.1172/jci.insight.85935.

Immunotherapies targeting the immune checkpoint receptor programmed cell death protein 1 (PD-1) have shown remarkable efficacy in treating cancer. CD4

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Lowther DE, Goods BA, Lucca LE, et al. PD-1 marks dysfunctional regulatory T cells in malignant gliomas. JCI Insight. 2016;1(5)doi: 10.1172/jci.insight.85935.
Lowther, D. E., Goods, B. A., Lucca, L. E., Lerner, B. A., Raddassi, K., van Dijk, D., Hernandez, A. L., Duan, X., Gunel, M., Coric, V., Krishnaswamy, S., Love, J. C., & Hafler, D. A. (2016). PD-1 marks dysfunctional regulatory T cells in malignant gliomas. JCI insight, 1(5), . https://doi.org/10.1172/jci.insight.85935
Lowther, Daniel E, et al. "PD-1 marks dysfunctional regulatory T cells in malignant gliomas." JCI insight vol. 1,5 (2016). doi: https://doi.org/10.1172/jci.insight.85935
Lowther DE, Goods BA, Lucca LE, Lerner BA, Raddassi K, van Dijk D, Hernandez AL, Duan X, Gunel M, Coric V, Krishnaswamy S, Love JC, Hafler DA. PD-1 marks dysfunctional regulatory T cells in malignant gliomas. JCI Insight. 2016 Apr 21;1(5). doi: 10.1172/jci.insight.85935. PMID: 27182555; PMCID: PMC4864991.
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Transcriptomic and clonal characterization of T cells in the human central nervous system.

Science immunology

Pappalardo JL, Zhang L, Pecsok MK, Perlman K, Zografou C, Raddassi K, Abulaban A, Krishnaswamy S, Antel J, van Dijk D, Hafler DA.
PMID: 32948672
Sci Immunol. 2020 Sep 18;5(51). doi: 10.1126/sciimmunol.abb8786.

T cells provide critical immune surveillance to the central nervous system (CNS), and the cerebrospinal fluid (CSF) is thought to be a main route for their entry. Further characterization of the state of T cells in the CSF in...

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Pappalardo JL, Zhang L, Pecsok MK, et al. Transcriptomic and clonal characterization of T cells in the human central nervous system. Sci Immunol. 2020;5(51)doi: 10.1126/sciimmunol.abb8786.
Pappalardo, J. L., Zhang, L., Pecsok, M. K., Perlman, K., Zografou, C., Raddassi, K., Abulaban, A., Krishnaswamy, S., Antel, J., van Dijk, D., & Hafler, D. A. (2020). Transcriptomic and clonal characterization of T cells in the human central nervous system. Science immunology, 5(51), . https://doi.org/10.1126/sciimmunol.abb8786
Pappalardo, Jenna L, et al. "Transcriptomic and clonal characterization of T cells in the human central nervous system." Science immunology vol. 5,51 (2020). doi: https://doi.org/10.1126/sciimmunol.abb8786
Pappalardo JL, Zhang L, Pecsok MK, Perlman K, Zografou C, Raddassi K, Abulaban A, Krishnaswamy S, Antel J, van Dijk D, Hafler DA. Transcriptomic and clonal characterization of T cells in the human central nervous system. Sci Immunol. 2020 Sep 18;5(51). doi: 10.1126/sciimmunol.abb8786. PMID: 32948672; PMCID: PMC8567322.
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Reproducible isolation of lymph node stromal cells reveals site-dependent differences in fibroblastic reticular cells.

Frontiers in immunology

Fletcher AL, Malhotra D, Acton SE, Lukacs-Kornek V, Bellemare-Pelletier A, Curry M, Armant M, Turley SJ.
PMID: 22566825
Front Immunol. 2011 Sep 12;2:35. doi: 10.3389/fimmu.2011.00035. eCollection 2011.

Within lymph nodes, non-hematopoietic stromal cells organize and interact with leukocytes in an immunologically important manner. In addition to organizing T and B cell segregation and expressing lymphocyte survival factors, several recent studies have shown that lymph node stromal...

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Fletcher AL, Malhotra D, Acton SE, et al. Reproducible isolation of lymph node stromal cells reveals site-dependent differences in fibroblastic reticular cells. Front Immunol. 2011;2:35doi: 10.3389/fimmu.2011.00035.
Fletcher, A. L., Malhotra, D., Acton, S. E., Lukacs-Kornek, V., Bellemare-Pelletier, A., Curry, M., Armant, M., & Turley, S. J. (2011). Reproducible isolation of lymph node stromal cells reveals site-dependent differences in fibroblastic reticular cells. Frontiers in immunology, 235. https://doi.org/10.3389/fimmu.2011.00035
Fletcher, Anne L, et al. "Reproducible isolation of lymph node stromal cells reveals site-dependent differences in fibroblastic reticular cells." Frontiers in immunology vol. 2 (2011): 35. doi: https://doi.org/10.3389/fimmu.2011.00035
Fletcher AL, Malhotra D, Acton SE, Lukacs-Kornek V, Bellemare-Pelletier A, Curry M, Armant M, Turley SJ. Reproducible isolation of lymph node stromal cells reveals site-dependent differences in fibroblastic reticular cells. Front Immunol. 2011 Sep 12;2:35. doi: 10.3389/fimmu.2011.00035. eCollection 2011. PMID: 22566825; PMCID: PMC3342056.
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Showing 1 to 7 of 7 entries