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NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy.

The Journal of experimental medicine

Lewis EL, Xu R, Beltra JC, Ngiow SF, Cohen J, Telange R, Crane A, Sawinski D, Wherry EJ, Porrett PM.
PMID: 34882194
J Exp Med. 2022 Jan 03;219(1). doi: 10.1084/jem.20201599. Epub 2021 Dec 09.

Pregnancy is a common immunization event, but the molecular mechanisms and immunological consequences provoked by pregnancy remain largely unknown. We used mouse models and human transplant registry data to reveal that pregnancy induced exhausted CD8 T cells (Preg-TEX), which...

Cite
Lewis EL, Xu R, Beltra JC, et al. NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy. J Exp Med. 2021;219(1)doi: 10.1084/jem.20201599.
Lewis, E. L., Xu, R., Beltra, J. C., Ngiow, S. F., Cohen, J., Telange, R., Crane, A., Sawinski, D., Wherry, E. J., & Porrett, P. M. (2022). NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy. The Journal of experimental medicine, 219(1), . https://doi.org/10.1084/jem.20201599
Lewis, Emma L, et al. "NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy." The Journal of experimental medicine vol. 219,1 (2022). doi: https://doi.org/10.1084/jem.20201599
Lewis EL, Xu R, Beltra JC, Ngiow SF, Cohen J, Telange R, Crane A, Sawinski D, Wherry EJ, Porrett PM. NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy. J Exp Med. 2022 Jan 03;219(1). doi: 10.1084/jem.20201599. Epub 2021 Dec 09. PMID: 34882194; PMCID: PMC8666877.
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NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy.

The Journal of experimental medicine

Lewis EL, Xu R, Beltra JC, Ngiow SF, Cohen J, Telange R, Crane A, Sawinski D, Wherry EJ, Porrett PM.
PMID: 34882194
J Exp Med. 2022 Jan 03;219(1). doi: 10.1084/jem.20201599. Epub 2021 Dec 09.

Pregnancy is a common immunization event, but the molecular mechanisms and immunological consequences provoked by pregnancy remain largely unknown. We used mouse models and human transplant registry data to reveal that pregnancy induced exhausted CD8 T cells (Preg-TEX), which...

Cite
Lewis EL, Xu R, Beltra JC, et al. NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy. J Exp Med. 2021;219(1)doi: 10.1084/jem.20201599.
Lewis, E. L., Xu, R., Beltra, J. C., Ngiow, S. F., Cohen, J., Telange, R., Crane, A., Sawinski, D., Wherry, E. J., & Porrett, P. M. (2022). NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy. The Journal of experimental medicine, 219(1), . https://doi.org/10.1084/jem.20201599
Lewis, Emma L, et al. "NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy." The Journal of experimental medicine vol. 219,1 (2022). doi: https://doi.org/10.1084/jem.20201599
Lewis EL, Xu R, Beltra JC, Ngiow SF, Cohen J, Telange R, Crane A, Sawinski D, Wherry EJ, Porrett PM. NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy. J Exp Med. 2022 Jan 03;219(1). doi: 10.1084/jem.20201599. Epub 2021 Dec 09. PMID: 34882194; PMCID: PMC8666877.
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NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy.

The Journal of experimental medicine

Lewis EL, Xu R, Beltra JC, Ngiow SF, Cohen J, Telange R, Crane A, Sawinski D, Wherry EJ, Porrett PM.
PMID: 34882194
J Exp Med. 2022 Jan 03;219(1). doi: 10.1084/jem.20201599. Epub 2021 Dec 09.

Pregnancy is a common immunization event, but the molecular mechanisms and immunological consequences provoked by pregnancy remain largely unknown. We used mouse models and human transplant registry data to reveal that pregnancy induced exhausted CD8 T cells (Preg-TEX), which...

Cite
Lewis EL, Xu R, Beltra JC, et al. NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy. J Exp Med. 2021;219(1)doi: 10.1084/jem.20201599.
Lewis, E. L., Xu, R., Beltra, J. C., Ngiow, S. F., Cohen, J., Telange, R., Crane, A., Sawinski, D., Wherry, E. J., & Porrett, P. M. (2022). NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy. The Journal of experimental medicine, 219(1), . https://doi.org/10.1084/jem.20201599
Lewis, Emma L, et al. "NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy." The Journal of experimental medicine vol. 219,1 (2022). doi: https://doi.org/10.1084/jem.20201599
Lewis EL, Xu R, Beltra JC, Ngiow SF, Cohen J, Telange R, Crane A, Sawinski D, Wherry EJ, Porrett PM. NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy. J Exp Med. 2022 Jan 03;219(1). doi: 10.1084/jem.20201599. Epub 2021 Dec 09. PMID: 34882194; PMCID: PMC8666877.
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Dichotomous and stable gamma delta T-cell number and function in healthy individuals.

Journal for immunotherapy of cancer

Ou L, Wang H, Liu Q, Zhang J, Lu H, Luo L, Shi C, Lin S, Dong L, Guo Y, Huang L, Zhu J, Yin X, Huang AC, Karakousis G, Schuchter L, Amaravadi R, Zheng C, Fan Y, Guo W, Xu X.
PMID: 34011536
J Immunother Cancer. 2021 May;9(5). doi: 10.1136/jitc-2020-002274.

BACKGROUND: Gamma-delta (γδ) T lymphocytes are primed to potently respond to pathogens and transformed cells by recognizing a broad range of antigens. However, adoptive immunotherapy with γδT cells has exhibited mixed treatment responses. Better understanding of γδT cell biology...

Cite
Ou L, Wang H, Liu Q, et al. Dichotomous and stable gamma delta T-cell number and function in healthy individuals. J Immunother Cancer. 2021;9(5)doi: 10.1136/jitc-2020-002274.
Ou, L., Wang, H., Liu, Q., Zhang, J., Lu, H., Luo, L., Shi, C., Lin, S., Dong, L., Guo, Y., Huang, L., Zhu, J., Yin, X., Huang, A. C., Karakousis, G., Schuchter, L., Amaravadi, R., Zheng, C., Fan, Y., Guo, W., & Xu, X. (2021). Dichotomous and stable gamma delta T-cell number and function in healthy individuals. Journal for immunotherapy of cancer, 9(5), . https://doi.org/10.1136/jitc-2020-002274
Ou, Lingling, et al. "Dichotomous and stable gamma delta T-cell number and function in healthy individuals." Journal for immunotherapy of cancer vol. 9,5 (2021). doi: https://doi.org/10.1136/jitc-2020-002274
Ou L, Wang H, Liu Q, Zhang J, Lu H, Luo L, Shi C, Lin S, Dong L, Guo Y, Huang L, Zhu J, Yin X, Huang AC, Karakousis G, Schuchter L, Amaravadi R, Zheng C, Fan Y, Guo W, Xu X. Dichotomous and stable gamma delta T-cell number and function in healthy individuals. J Immunother Cancer. 2021 May;9(5). doi: 10.1136/jitc-2020-002274. PMID: 34011536; PMCID: PMC8137237.
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NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy.

The Journal of experimental medicine

Lewis EL, Xu R, Beltra JC, Ngiow SF, Cohen J, Telange R, Crane A, Sawinski D, Wherry EJ, Porrett PM.
PMID: 34882194
J Exp Med. 2022 Jan 03;219(1). doi: 10.1084/jem.20201599. Epub 2021 Dec 09.

Pregnancy is a common immunization event, but the molecular mechanisms and immunological consequences provoked by pregnancy remain largely unknown. We used mouse models and human transplant registry data to reveal that pregnancy induced exhausted CD8 T cells (Preg-TEX), which...

Cite
Lewis EL, Xu R, Beltra JC, et al. NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy. J Exp Med. 2021;219(1)doi: 10.1084/jem.20201599.
Lewis, E. L., Xu, R., Beltra, J. C., Ngiow, S. F., Cohen, J., Telange, R., Crane, A., Sawinski, D., Wherry, E. J., & Porrett, P. M. (2022). NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy. The Journal of experimental medicine, 219(1), . https://doi.org/10.1084/jem.20201599
Lewis, Emma L, et al. "NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy." The Journal of experimental medicine vol. 219,1 (2022). doi: https://doi.org/10.1084/jem.20201599
Lewis EL, Xu R, Beltra JC, Ngiow SF, Cohen J, Telange R, Crane A, Sawinski D, Wherry EJ, Porrett PM. NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy. J Exp Med. 2022 Jan 03;219(1). doi: 10.1084/jem.20201599. Epub 2021 Dec 09. PMID: 34882194; PMCID: PMC8666877.
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Inhibitory signaling sustains a distinct early memory CD8.

Science immunology

Johnnidis JB, Muroyama Y, Ngiow SF, Chen Z, Manne S, Cai Z, Song S, Platt JM, Schenkel JM, Abdel-Hakeem M, Beltra JC, Greenplate AR, Ali MA, Nzingha K, Giles JR, Harly C, Attanasio J, Pauken KE, Bengsch B, Paley MA, Tomov VT, Kurachi M, Vignali DAA, Sharpe AH, Reiner SL, Bhandoola A, Johnson FB, Wherry EJ.
PMID: 33452106
Sci Immunol. 2021 Jan 15;6(55). doi: 10.1126/sciimmunol.abe3702.

The developmental origins of memory T cells remain incompletely understood. During the expansion phase of acute viral infection, we identified a distinct subset of virus-specific CD8

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Johnnidis JB, Muroyama Y, Ngiow SF, et al. Inhibitory signaling sustains a distinct early memory CD8. Sci Immunol. 2021;6(55)doi: 10.1126/sciimmunol.abe3702.
Johnnidis, J. B., Muroyama, Y., Ngiow, S. F., Chen, Z., Manne, S., Cai, Z., Song, S., Platt, J. M., Schenkel, J. M., Abdel-Hakeem, M., Beltra, J. C., Greenplate, A. R., Ali, M. A., Nzingha, K., Giles, J. R., Harly, C., Attanasio, J., Pauken, K. E., Bengsch, B., Paley, M. A., Tomov, V. T., Kurachi, M., Vignali, D. A. A., Sharpe, A. H., Reiner, S. L., Bhandoola, A., Johnson, F. B., & Wherry, E. J. (2021). Inhibitory signaling sustains a distinct early memory CD8. Science immunology, 6(55), . https://doi.org/10.1126/sciimmunol.abe3702
Johnnidis, Jonathan B, et al. "Inhibitory signaling sustains a distinct early memory CD8." Science immunology vol. 6,55 (2021). doi: https://doi.org/10.1126/sciimmunol.abe3702
Johnnidis JB, Muroyama Y, Ngiow SF, Chen Z, Manne S, Cai Z, Song S, Platt JM, Schenkel JM, Abdel-Hakeem M, Beltra JC, Greenplate AR, Ali MA, Nzingha K, Giles JR, Harly C, Attanasio J, Pauken KE, Bengsch B, Paley MA, Tomov VT, Kurachi M, Vignali DAA, Sharpe AH, Reiner SL, Bhandoola A, Johnson FB, Wherry EJ. Inhibitory signaling sustains a distinct early memory CD8. Sci Immunol. 2021 Jan 15;6(55). doi: 10.1126/sciimmunol.abe3702. PMID: 33452106; PMCID: PMC8258400.
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Targeting regulatory T cells for immunotherapy in melanoma.

Molecular Biomedicine (Online)

Huang L, Guo Y, Liu S, Wang H, Zhu J, Ou L, Xu X.
PMID: 34806028
Mol Biomed. 2021;2(1):11. doi: 10.1186/s43556-021-00038-z. Epub 2021 Apr 19.

Regulatory T cells (Tregs) are essential in the maintenance of immunity, and they are also a key to immune suppressive microenvironment in solid tumors. Many studies have revealed the biology of Tregs in various human pathologies. Here we review...

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Huang L, Guo Y, Liu S, et al. Targeting regulatory T cells for immunotherapy in melanoma. Mol Biomed. 2021;2(1):11doi: 10.1186/s43556-021-00038-z.
Huang, L., Guo, Y., Liu, S., Wang, H., Zhu, J., Ou, L., & Xu, X. (2021). Targeting regulatory T cells for immunotherapy in melanoma. Molecular Biomedicine (Online), 2(1), 11. https://doi.org/10.1186/s43556-021-00038-z
Huang, Lili, et al. "Targeting regulatory T cells for immunotherapy in melanoma." Molecular Biomedicine (Online) vol. 2,1 (2021): 11. doi: https://doi.org/10.1186/s43556-021-00038-z
Huang L, Guo Y, Liu S, Wang H, Zhu J, Ou L, Xu X. Targeting regulatory T cells for immunotherapy in melanoma. Mol Biomed. 2021;2(1):11. doi: 10.1186/s43556-021-00038-z. Epub 2021 Apr 19. PMID: 34806028; PMCID: PMC8591697.
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Small extracellular vesicles-based cell-free strategies for therapy.

MedComm

Guo Y, Wang H, Huang L, Ou L, Zhu J, Liu S, Xu X.
PMID: 34766134
MedComm (2020). 2021 Feb 18;2(1):17-26. doi: 10.1002/mco2.57. eCollection 2021 Mar.

Small extracellular vesicles (sEVs) are extracellular nanovesicles that contain bioactive proteins, lipids, RNA, and DNA. A variety of biological process is regulated with sEVs. sEVs are an intercellular messenger regulating recipient cell function and play a role in disease...

Cite
Guo Y, Wang H, Huang L, et al. Small extracellular vesicles-based cell-free strategies for therapy. MedComm (2020). 2021;2(1):17-26doi: 10.1002/mco2.57.
Guo, Y., Wang, H., Huang, L., Ou, L., Zhu, J., Liu, S., & Xu, X. (2021). Small extracellular vesicles-based cell-free strategies for therapy. MedComm, 2(1), 17-26. https://doi.org/10.1002/mco2.57
Guo, Yeye, et al. "Small extracellular vesicles-based cell-free strategies for therapy." MedComm vol. 2,1 (2021): 17-26. doi: https://doi.org/10.1002/mco2.57
Guo Y, Wang H, Huang L, Ou L, Zhu J, Liu S, Xu X. Small extracellular vesicles-based cell-free strategies for therapy. MedComm (2020). 2021 Feb 18;2(1):17-26. doi: 10.1002/mco2.57. eCollection 2021 Mar. PMID: 34766134; PMCID: PMC8491241.
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Showing 1 to 8 of 8 entries