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Corrigendum: Pervasive computing technologies to continuously assess Alzheimer's disease progression and intervention efficacy.

Frontiers in aging neuroscience

Lyons BE, Austin D, Seelye A, Petersen J, Yeargers J, Riley T, Sharma N, Mattek N, Dodge H, Wild K, Kaye JA.
PMID: 26696884
Front Aging Neurosci. 2015 Dec 11;7:232. doi: 10.3389/fnagi.2015.00232. eCollection 2015.

[This corrects the article on p. 102 in vol. 7, PMID: 26113819.].

MONOMIALS AND BASIN CYLINDERS FOR NETWORK DYNAMICS.

SIAM journal on applied dynamical systems

Austin D, Dinwoodie IH.
PMID: 25620893
SIAM J Appl Dyn Syst. 2015;14(1):25-42. doi: 10.1137/140975929.

We describe methods to identify cylinder sets inside a basin of attraction for Boolean dynamics of biological networks. Such sets are used for designing regulatory interventions that make the system evolve towards a chosen attractor, for example initiating apoptosis...

The effects of noncoding aquaporin-4 single-nucleotide polymorphisms on cognition and functional progression of Alzheimer's disease.

Alzheimer's & dementia (New York, N. Y.)

Burfeind KG, Murchison CF, Westaway SK, Simon MJ, Erten-Lyons D, Kaye JA, Quinn JF, Iliff JJ.
PMID: 29067342
Alzheimers Dement (N Y). 2017 May 26;3(3):348-359. doi: 10.1016/j.trci.2017.05.001. eCollection 2017 Sep.

INTRODUCTION: The glymphatic system is a brain-wide perivascular network that facilitates clearance of proteins, including amyloid β, from the brain interstitium through the perivascular exchange of cerebrospinal fluid and interstitial fluid. The astrocytic water channel aquaporin-4 (AQP4) is required...

Serum Hepcidin Levels, Iron Dyshomeostasis and Cognitive Loss in Alzheimer's Disease.

Aging and disease

Sternberg Z, Hu Z, Sternberg D, Waseh S, Quinn JF, Wild K, Jeffrey K, Zhao L, Garrick M.
PMID: 28400987
Aging Dis. 2017 Apr 01;8(2):215-227. doi: 10.14336/AD.2016.0811. eCollection 2017 Apr.

This pilot study examined the status of the master iron regulatory peptide, hepcidin, and peripheral related iron parameters in Alzheimer's disease (AD) and mild cognitive impairment patients, and evaluated the relationship between iron dyshomeostasis and amyloid-beta (Aβ), cognitive assessment...

A simple method to rule out dementia with temporal orientation.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Tractenberg RE, Weiner MF, Aisen PS, Kaye JA, Fuh JL.
PMID: 19595914
Alzheimers Dement. 2007 Jan;3(1):28-32. doi: 10.1016/j.jalz.2006.10.005.

OBJECTIVE: To explore the performance of a test of temporal orientation (TTO) comprising four items derived from the Mini-Mental State Examination over 4 years.METHODS: Responses were obtained from two large cohorts participating in longitudinal studies of aging in the...

Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease: Investigation of a Possible Mechanism of Action.

International journal of Alzheimer's disease

Soumyanath A, Zhong YP, Henson E, Wadsworth T, Bishop J, Gold BG, Quinn JF.
PMID: 22506133
Int J Alzheimers Dis. 2012;2012:381974. doi: 10.1155/2012/381974. Epub 2012 Feb 15.

Centella asiatica (CA), commonly named gotu kola, is an Ayurvedic herb used to enhance memory and nerve function. To investigate the potential use of CA in Alzheimer's disease (AD), we examined the effects of a water extract of CA...

Gender effects on plasma and brain copper.

International journal of Alzheimer's disease

Quinn JF, Harris C, Kaye JA, Lind B, Carter R, Anekonda T, Ralle M.
PMID: 22028982
Int J Alzheimers Dis. 2011;2011:150916. doi: 10.4061/2011/150916. Epub 2011 Oct 19.

The effect of gender on systemic and brain levels of copper is relatively understudied. We examined gender effects in mice and human subjects. We observed a trend to higher serum copper levels in female compared to male LaFerla "triple...

Inferring Social Nature of Conversations from Words: Experiments on a Corpus of Everyday Telephone Conversations.

Computer speech & language

Stark A, Shafran I, Kaye J.
PMID: 24187435
Comput Speech Lang. 2014 Jan 01;28(1). doi: 10.1016/j.csl.2013.06.003.

Language is being increasingly harnessed to not only create natural human-machine interfaces but also to infer social behaviors and interactions. In the same vein, we investigate a novel spoken language task, of inferring social relationships in two-party conversations: whether...

Polypharmacy in an Elderly Population: Enhancing Medication Management Through the Use of Clinical Decision Support Software Platforms.

Neurology and therapy

Keine D, Zelek M, Walker JQ, Sabbagh MN.
PMID: 30900186
Neurol Ther. 2019 Jun;8(1):79-94. doi: 10.1007/s40120-019-0131-6. Epub 2019 Mar 21.

INTRODUCTION: Polypharmacy is a growing problem in the United States. The use of multiple medications increases the likelihood that a patient will experience potential drug interactions and adverse drug reactions (ADRs). Those individuals with dementia or Alzheimer's disease (AD)...

"It Took the Stress out of Getting Help": The STAR-C-Telemedicine Mixed Methods Pilot.

Care weekly

Lindauer A, Croff R, Mincks K, Mattek N, Shofner SJ, Bouranis N, Teri L.
PMID: 30393783
Care Wkly. 2018;2:7-14. doi: 10.14283/cw.2018.4. Epub 2018 Jul 03.

BACKGROUND: Caring for a family member with Alzheimer's disease and related dementias can be mentally and physically taxing. Support programs are available to mitigate the strain of care, but caregivers report access challenges (e.g., distance). STAR-C is an evidence-based,...

Making Pervasive Computing Technology Pervasive for Health & Wellness in Aging.

The Public policy and aging report

Kaye J.
PMID: 31148911
Public Policy Aging Rep. 2017;27(2):53-61. doi: 10.1093/ppar/prx005. Epub 2017 Jun 09.

No abstract available.

Reliability of Medical History Reporting in Older Adults With and Without Cognitive Impairment.

Journal of central nervous system disease

Curcio N, Wilmoth K, LoBue C, Cullum CM.
PMID: 31040738
J Cent Nerv Syst Dis. 2019 Apr 22;11:1179573519843874. doi: 10.1177/1179573519843874. eCollection 2019.

BACKGROUND: Clinical diagnosis of cognitive disorders depends on accurate reporting of medical history, yet little is known about the reliability and the validity of such reports, particularly in older patients with and without cognitive impairment.METHODS: In 2 studies, we...

Showing 1 to 12 of 129 entries